Repeated administration of the GABAB receptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in rats

Psychopharmacology

Volumn 215, Issue 1, 2011, Pages 117-128

  Vlachou, Styliani ^a   Guery, Sebastien ^b,d   Froestl, Wolfgang ^b,e   Banerjee, Deboshri ^c,f   Benedict, Jessica ^a   Finn, M G ^c   Markou, Athina ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d AC Immune SA ^*  (Belgium)

^e AC IMMUNE SA   (Switzerland)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Addictive drugs; Medication; Nicotine dependence; Relapse prevention; Smoking cessation; Treatment

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; BHF 177; DRUGS USED IN THE TREATMENT OF ADDICTION; GABAERGIC RECEPTOR AFFECTING AGENT; N (BICYCLO[2.2.1]HEPT 2 YL) 2 METHYL 5 [4 (TRIFLUOROMETHYL)PHENYL] 4 PYRIMIDINAMINE; NICOTINE TARTRATE; UNCLASSIFIED DRUG; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; N (BICYCLO(2.2.1)HEPT 2 YL) 2 METHYL 5 (4 (TRIFLUOROMETHYL)PHENYL) 4 PYRIMIDINAMINE; N-(BICYCLO(2.2.1)HEPT-2-YL)-2-METHYL-5-(4-(TRIFLUOROMETHYL)PHENYL)-4-PYRIMIDINAMINE; NICOTINE; NORBORNANE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSOCIATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; DRUG SEEKING BEHAVIOR; DRUG SELF ADMINISTRATION; DRUG TOLERANCE; FEEDING BEHAVIOR; FOOD INTAKE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RELAPSE; REPEATED DRUG DOSE; TOBACCO DEPENDENCE; TREATMENT DURATION; TREATMENT RESPONSE; ADDICTION; ANIMAL; ANIMAL BEHAVIOR; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; RECURRENT DISEASE; REINFORCEMENT; WISTAR RAT;

ANIMALS; BEHAVIOR, ADDICTIVE; BEHAVIOR, ANIMAL; CUES; GABA MODULATORS; INJECTIONS, INTRAVENOUS; MALE; NICOTINE; NORBORNANES; PYRIMIDINES; RATS; RATS, WISTAR; RECEPTORS, GABA-B; RECURRENCE; REINFORCEMENT (PSYCHOLOGY); SELF ADMINISTRATION; TOBACCO USE DISORDER;

EID: 79954999122     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-010-2119-x     Document Type: Article

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