Amorphous solid dispersion successfully improved oral exposure of ADX71943 in support of toxicology studies

Drug Development and Industrial Pharmacy

Volumn 39, Issue 9, 2013, Pages 1300-1305

  Ayad, Mohamad H ^a   Bonnet, Beatrice ^a   Quinton, Jacques ^b   Leigh, Matthew ^b   Poli, Sonia M ^a  

^a ADDEX PHARMACEUTICALS   (Switzerland)

^b Phares AG   (Switzerland)

Author keywords

Bioavailability; Drug delivery system; Enabling formulation; Formulation development; Solubility improvement

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; ADX 71943; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EXPOSURE; DRUG SOLUBILITY; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; RAT;

ADMINISTRATION, ORAL; ALLOSTERIC SITE; ANALGESICS; ANIMALS; BIOLOGICAL AVAILABILITY; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; DRUGS, INVESTIGATIONAL; GABA-B RECEPTOR AGONISTS; HALF-LIFE; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INJECTIONS, INTRAVENOUS; PHYSICOCHEMICAL PHENOMENA; RATS; RECEPTORS, GABA-B; SOLUBILITY; SOLVENTS; SUSPENSIONS;

EID: 84881131096     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2012.727829     Document Type: Article

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