Design, synthesis and biological assessment of a triazine dendrimer with approximately 16 paclitaxel groups and 8 PEG groups

Molecular Pharmaceutics

Volumn 10, Issue 12, 2013, Pages 4452-4461

  Lee, Changsuk ^a   Lo, Su Tang ^b   Lim, Jongdoo ^a   Da Costa, Viviana C P ^a   Ramezani, Saleh ^b   Öz, Orhan K ^b   Pavan, Giovanni M ^d   Annunziata, Onofrio ^a   Sun, Xiankai ^b,c   Simanek, Eric E ^a  

^a TEXAS CHRISTIAN UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

^d UNIVERSITY OF APPLIED SCIENCES AND ARTS OF SOUTHERN SWITZERLAND   (Switzerland)

Author keywords

biodistribution; dendrimer; disulfide linkage; drug delivery; molecular dynamics; paclitaxel; simulation; triazine

Indexed keywords

AMINOMETHYLPIPERIDINE; DENDRIMER; DIPIPERIDINE TRISMETHYLENE; IODINE 125; PACLITAXEL; PIPERAZINE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG ELIMINATION; DRUG HALF LIFE; DRUG RELEASE; DRUG SYNTHESIS; HYDRATION; HYDRODYNAMICS; IN VIVO STUDY; LIGHT SCATTERING; LIVER; LOW DRUG DOSE; LUNG; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NUCLEOPHILICITY; PRIORITY JOURNAL; PROSTATE CANCER; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SOLUBILITY; SPLEEN; STOICHIOMETRY;

ANIMALS; CELL LINE, TUMOR; DENDRIMERS; DISULFIDES; MICE; MICE, INBRED BALB C; MOLECULAR DYNAMICS SIMULATION; PACLITAXEL; POLYETHYLENE GLYCOLS; RATS; SOLUBILITY; TISSUE DISTRIBUTION; TRIAZINES;

EID: 84889243226     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400290u     Document Type: Article

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