Self-assembling doxorubicin-tocopherol succinate prodrug as a new drug delivery system: Synthesis, characterization, and in vitro and in vivo anticancer activity

Bioconjugate Chemistry

Volumn 25, Issue 1, 2014, Pages 72-81

  Duhem, Nicolas ^a   Danhier, Fabienne ^a   Pourcelle, Vincent ^a   Schumers, Jean Marc ^a   Bertrand, Olivier ^a   Leduff, Cécile S ^a   Hoeppener, Stephanie ^b   Schubert, Ulrich S ^b   Gohy, Jean François ^a   Marchand Brynaert, Jacqueline ^a   Préat, Véronique ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOTHERAPY; CONTROLLED DRUG DELIVERY; DRUG PRODUCTS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POLYETHYLENE GLYCOLS; TARGETED DRUG DELIVERY;

ANTI-TUMOR EFFICACY; ANTICANCER ACTIVITIES; DOXORUBICIN; DRUG-DELIVERY SYSTEMS; IN-VITRO; PRODRUGS; SELF-ASSEMBLING; SYSTEM SYNTHESIS; VITRO AND IN VIVO; Α-TOCOPHEROL;

NANOPARTICLES;

ALPHA TOCOPHEROL SUCCINATE; DOXORUBICIN; MACROGOL; NANOPARTICLE; PRODRUG; WATER; ALPHA TOCOPHEROL; ANTINEOPLASTIC AGENT; NANOMATERIAL;

ACTIVE TRANSPORT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER SURVIVAL; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN MCF 7; CELL VIABILITY; CELLULAR DISTRIBUTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; CYTOTOXICITY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG RELEASE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; SURFACE PROPERTY; SURVIVAL RATE; TUMOR GROWTH; ANIMAL; BAGG ALBINO MOUSE; CELL PROLIFERATION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HUMAN; MCF 7 CELL LINE; NEOPLASMS, EXPERIMENTAL; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ALPHA-TOCOPHEROL; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG DELIVERY SYSTEMS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MCF-7 CELLS; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; NANOSTRUCTURES; NEOPLASMS, EXPERIMENTAL; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84892710202     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc400326y     Document Type: Article

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