A facile approach for dual-responsive prodrug nanogels based on dendritic polyglycerols with minimal leaching

Journal of Controlled Release

Volumn 174, Issue 1, 2014, Pages 209-216

  Zhang, Xuejiao ^a   Achazi, Katharina ^a,b   Steinhilber, Dirk ^a   Kratz, Felix ^c   Dernedde, Jens ^b   Haag, Rainer ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c PROQINASE GMBH   (Germany)

Author keywords

Cellular uptake; Controlled drug release; Nanogel degradation; Polyglycerol nanogel; Prodrug

Indexed keywords

CELLULAR UPTAKE; CONTROLLED DRUG RELEASE; ENHANCED PERMEATION AND RETENTIONS; HYPERBRANCHED POLYGLYCEROL; NANOGELS; NANOPRECIPITATION METHOD; PRODRUGS; THIOL-DISULFIDE EXCHANGE REACTION;

ADDITION REACTIONS; BIOCOMPATIBILITY; CELL CULTURE; CELL DEATH; COVALENT BONDS; CROSSLINKING; CYTOTOXICITY; LEACHING; POLYMER BLENDS; TUMORS;

NANOSTRUCTURED MATERIALS;

DOXORUBICIN; GLYCEROL; HYDRAZONE DERIVATIVE; NANOCARRIER; PRODRUG; THIOCTIC ACID;

ANIMAL CELL; ARTICLE; BIODEGRADABILITY; CANCER CELL CULTURE; CELL DEATH; CONCENTRATION RESPONSE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CROSS LINKING; CYTOSOL; DRUG CYTOTOXICITY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG UPTAKE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEACHING; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NUCLEAR PORE COMPLEX; PARTICLE SIZE; PH; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TARGET CELL; TRANSMISSION ELECTRON MICROSCOPY;

CELLULAR UPTAKE; CONTROLLED DRUG RELEASE; NANOGEL DEGRADATION; POLYGLYCEROL NANOGEL; PRODRUG;

ANTIBIOTICS, ANTINEOPLASTIC; CELL SURVIVAL; DOXORUBICIN; DRUG COMPOUNDING; GELS; GLYCEROL; HELA CELLS; HUMANS; NANOSTRUCTURES; POLYMERS; PRODRUGS;

EID: 84891553985     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.11.005     Document Type: Article

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