Effect of molecular weight of PGG-paclitaxel conjugates on in vitro and in vivo efficacy

Journal of Controlled Release

Volumn 161, Issue 1, 2012, Pages 124-131

  Yang, Danbo ^a   Liu, Xiaoqing ^a   Jiang, Xinguo ^c   Liu, Yun ^b   Ying, Wenbin ^b   Wang, Hai ^b   Bai, Hao ^b   Taylor, Wendy D ^b   Wang, Yuwei ^b   Clamme, Jean Pierre ^b   Co, Erick ^b   Chivukula, Padmanabh ^b   Tsang, Kwok Yin ^b   Jin, Yi ^b   Yu, Lei ^a,b  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b Biomedical Group   (United States)

^c FUDAN UNIVERSITY   (China)

Author keywords

Drug delivery; Drug release; PGG copolymer; Physicochemical characteristics; Polymers; Subcellular trafficking

Indexed keywords

ANTICANCER ACTIVITIES; CELL UPTAKE; CHEMOTHERAPEUTIC AGENTS; DESIGN AND DEVELOPMENT; DRUG RELEASE; DRUG RESISTANCE; DRUG STABILITY; IN-VITRO; LINEAR POLYMERS; MAXIMUM TOLERATED DOSE; MODEL SYSTEM; PACLITAXEL; PARTICLE FORMATIONS; PHYSICOCHEMICAL CHARACTERISTICS; POLYMERIC PRODRUGS; PRODRUGS; SERUM STABILITY; SUB-CELLULAR; THERAPEUTIC INDEX;

DRUG DELIVERY; MOLECULAR WEIGHT; POLYMERS;

FUNCTIONAL POLYMERS;

PACLITAXEL; POLY GAMMA GLUTAMYLGLUTAMINE; POLYMER; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG EFFICACY; DRUG RELEASE; FEMALE; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIGHT SCATTERING; LUNG NON SMALL CELL CANCER; MAXIMUM TOLERATED DOSE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SINGLE DRUG DOSE; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; HUMANS; LUNG; LUNG NEOPLASMS; MICE; MICE, NUDE; MOLECULAR WEIGHT; NEOPLASMS; PACLITAXEL; PRODRUGS; PROTEINS;

EID: 84862618443     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.04.010     Document Type: Article

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