Enhanced anticancer activity of nanopreparation containing an MMP2-sensitive PEG-drug conjugate and cell-penetrating moiety

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 42, 2013, Pages 17047-17052

  Zhu, Lin ^a   Wang, Tao ^a   Perche, Federico ^a   Taigind, Anton ^a   Torchilin, Vladimir P ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Multifunctional; Nanomedicine; Non small cell lung cancer; Polymer drug conjugate; Polymeric micelles

Indexed keywords

GELATINASE A; MACROGOL 10000; MACROGOL 2000; PACLITAXEL; PHOSPHOETHANOLAMINE; PRODRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG PENETRATION; DRUG RETENTION; DRUG SENSITIVITY; DRUG TISSUE LEVEL; DRUG TUMOR LEVEL; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LUNG NON SMALL CELL CANCER; MICELLIZATION; MOUSE; NANOPHARMACEUTICS; NONHUMAN; PRIORITY JOURNAL; STIMULUS;

MULTIFUNCTIONAL; NANOMEDICINE; NON-SMALL CELL LUNG CANCER; POLYMER-DRUG CONJUGATE; POLYMERIC MICELLES;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL-PENETRATING PEPTIDES; DRUG DELIVERY SYSTEMS; HUMANS; MATRIX METALLOPROTEINASE 2; MICE; NANOPARTICLES; NEOPLASMS; PACLITAXEL; POLYETHYLENE GLYCOLS; PRODRUGS; RATS;

EID: 84885716472     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1304987110     Document Type: Article

References (34)

1. Sawant RM, et al. (2006) "SMART" drug delivery systems: Double-targeted pHresponsive pharmaceutical nanocarriers. Bioconjug Chem 17(4): 943-949.
2. Zhu L, Mahato RI (2010) Targeted delivery of siRNA to hepatocytes and hepatic stellate cells by bioconjugation. Bioconjug Chem 21(11): 2119-2127.
3. Zhu L, Kate P, Torchilin VP (2012) Matrix metalloprotease 2-responsive multifunctional liposomal nanocarrier for enhanced tumor targeting. ACS Nano 6(4): 3491-3498.
4. Zhu L, et al. (2009) Targeted delivery of methotrexate to skeletal muscular tissue by thermosensitive magnetoliposomes. Int J Pharm 370(1-2): 136-143.
5. Schroeder A, et al. (2009) Ultrasound triggered release of cisplatin from liposomes in murine tumors. J Control Release 137(1): 63-68.
6. Olson ES, et al. (2010) Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fluorescence and MR imaging of proteases. Proc Natl Acad Sci USA 107(9): 4311-4316.
7. Torchilin VP, Rammohan R, Weissig V, Levchenko TS (2001) TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors. Proc Natl Acad Sci USA 98(15): 8786-8791.
8. Jordan MA, Toso RJ, Thrower D, Wilson L (1993) Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. Proc Natl Acad Sci USA 90(20): 9552-9556.
9. Torchilin VP (2007) Micellar nanocarriers: Pharmaceutical perspectives. Pharm Res 24(1): 1-16.
10. Lukyanov AN, Torchilin VP (2004) Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs. Adv Drug Deliv Rev 56(9): 1273-1289.
11. Owen SC, Chan DP, Shoichet MS (2012) Polymeric micelle stability. Nano Today 7(1): 53-65.
12. Harris JM, Chess RB (2003) Effect of pegylation on pharmaceuticals. Nat Rev Drug Discov 2(3): 214-221.
13. Maeda H (2001) The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Adv Enzyme Regul 41: 189-207.
14. Chmurny GN, et al. (1992) 1H- and 13C-nmr assignments for taxol, 7-epi-taxol, and cephalomannine. J Nat Prod 55(4): 414-423.
15. Palladino P, Ragone R (2011) Ionic strength effects on the critical micellar concentration of ionic and nonionic surfactants: The binding model. Langmuir 27(23): 14065-14070.
16. Walkey CD, Olsen JB, Guo H, Emili A, Chan WC (2012) Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake. J Am Chem Soc 134(4): 2139-2147.
17. Matsuoka H, Furusawa M, Tomoda H, Seo Y (1994) Difference in cytotoxicity of paclitaxel against neoplastic and normal cells. Anticancer Res 14(1A): 163-167.
18. Deutsch HM, et al. (1989) Synthesis of congeners and prodrugs. 3. Water-soluble prodrugs of taxol with potent antitumor activity. J Med Chem 32(4): 788-792.
19. Yamada R, et al. (2010) Biological evaluation of paclitaxel-peptide conjugates as a model for MMP2-targeted drug delivery. Cancer Biol Ther 9(3): 192-203.
20. Hua H, Li M, Luo T, Yin Y, Jiang Y (2011) Matrix metalloproteinases in tumorigenesis: an evolving paradigm. Cell Mol Life Sci 68(23): 3853-3868.
21. Aggarwal BB, et al. (2005) Curcumin suppresses the paclitaxel-induced nuclear factorkappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res 11(20): 7490-7498.
22. Spallarossa P, et al. (2006) Matrix metalloproteinase-2 and -9 are induced differently by doxorubicin in H9c2 cells: The role of MAP kinases and NAD(P)H oxidase. Cardiovasc Res 69(3): 736-745.
23. Desoize B, Jardillier J (2000) Multicellular resistance: A paradigm for clinical resistance? Crit Rev Oncol Hematol 36(2-3): 193-207.
24. Hirschhaeuser F, et al. (2010) Multicellular tumor spheroids: An underestimated tool is catching up again. J Biotechnol 148(1): 3-15.
25. Kuh HJ, Jang SH, Wientjes MG, Weaver JR, Au JL (1999) Determinants of paclitaxel penetration and accumulation in human solid tumor. J Pharmacol Exp Ther 290(2): 871-880.
26. Leuschner F, et al. (2011) Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol 29(11): 1005-1010.
27. Kirpotin DB, et al. (2006) Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res 66(13): 6732-6740.
28. Kitamura T, et al. (2007) SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion. Nat Genet 39(4): 467-475.
29. Brooks PC, et al. (1996) Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3. Cell 85(5): 683-693.
30. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100(1): 57-70.
31. Sethuraman VA, Bae YH (2007) TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors. J Control Release 118(2): 216-224.
32. Spencer CM, Faulds D (1994) Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer. Drugs 48(5): 794-847.
33. Cabral H, et al. (2011) Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol 6(12): 815-823.
34. Matsumura Y, Kataoka K (2009) Preclinical and clinical studies of anticancer agentincorporating polymer micelles. Cancer Sci 100(4): 572-579.