Physiology and pharmacology of the GABA system: Focus on GABA receptors

GABA and Sleep: Molecular, Functional and Clinical Aspects

Volumn 9783034602266, Issue , 2010, Pages 3-23

  Möhler, Hanns ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84908301527     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-0346-0226-6_1     Document Type: Chapter

References (95)

1. Saper CB, Scammeli TE, Lu J (2005) Hypothalamic regulation of sleep and circadian rhythms. Nature 437:1257-1263
2. Borbély AA (1982) A two process model of sleep regulation. Hum Neurobiol 1:195-204
3. Sherin JE, Shiromani PJ, McCarley RW, Saper CB (1996) Activation of ventrolateral preoptic neurons during sleep. Science 271:216-219
4. Pace-Schott EF, Hobson JA (2002) The neurobiology of sleep: genetics, cellular physiology and subcortical networks. Nat Rev Neurosci 3:591-605
5. Buszaki G, Draguhn A (2004) Neuronal oscillations and cortical networks. Science 304:1926-1929
6. Klausberger T, Somogyi P (2008) Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations. Science 321:53-57
7. A-benzodiazepine receptors as targets for novel hypnotics. In: Pandi SR et al (eds) Sleep disorders. Informa, London, pp 206-219
8. A receptors. J Neurochem 102:1-12
9. A receptors. Adv Pharmacol 54:231-263
10. A receptors: limits, insights, future developments. J Neurosci 4:933-943
11. Mody I, Pearce RA (2004) Diversity of inhibitory neurotransmission through GABA (A) receptors. Trends Neurosci 27:569-575
12. A receptors. In: Holsboer F, Ströhle A (eds) Anxiety and anxiolytic drugs, handbook of experimental pharmacology, vol 169. Springer, Berlin, pp 225-247
13. A receptors in cognition. Biochem Soc Trans 37:1328-1333
14. Olsen RW, Sieghart W (2008) International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid (A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update. Pharmacol Rev 60:243-260
15. Barnard EA, Skolnick P, Olsen RW, Möhler H, Sieghart W, Biggio G, Braestrup C, Bateson AN, Langer SZ (1998) Subtypes of γ-aminobutyric acidA receptors: classification on the bases of subunit structure and receptor function Pharmacol. Reviews 50:291-313
16. A receptors different from zolpidem, zopiclone and benzodiazepines. Neurosci Res Commun 25:139-148
17. Foster AC, Pelleymounter MA, Cullen MJ, Lewis D, Joppa M, Chen TK, Bozigian HP, Gross RS, Gogas KR (2004) In vivo pharmacological characterization of indiplon, a novel pyrazolopyrimidine sedative-hypnotic. J Pharmacol Exp Ther 311:547-559
18. A receptor a1 subtype. Nat Neurosci 3:587-592
19. A receptor subtypes. Nature 451:330-334
20. Lippa A, Czobor P, Stark J, Beer B, Kostakis E, Gravielle M, Bandyopadhyay S, Russek SJ, Gibbs TT, Farb DH, Skolnick P (2005) Selective anxiolytic activity produced by ocinaplon, a GABA (A) receptor modulator. Proc Natl Acad Sci USA 102:7380-7385
21. A receptor agonist with subtype-selective efficacy, as a potential treatment for generalized anxiety disorder and muscle spasms. CNS Drug Rev 9:3-20
22. Knabl J, Zeilhofer UB, Crestani F, Rudolph U, Zeilhofer HU (2009) Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABA-A receptor point-mutated mice. Pain 141:233-238
23. A receptors, is a non-sedating anxiolytic in rodents and primates. J Pharmacol Exp Ther 316:410-422
24. Sheppard DR, WF FRL, Garrett EM, Stanley JL, Tye SJ, Goodacre S, Lincoln RJ, Cook SM, Conley R (2005) Evidence for a significant role of alpha3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines. J Neurosci 25:10682-10688
25. Langen B, Egerland U, Bernoster K, Dost R, Unverferth K, Rundfeldt C (2005) Characterization in rats of the anxiolytic potential of ELB139 [1-(4-chlorophenyl)-4-piperidin-1-yl-1, 5-dihydro-imidazol-2-on], a new agonist at the benzodiazepine binding site of the GABAA receptor. J Pharmacol Exp Ther 314:717-724
26. A receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy. J Pharmcol Exp Ther 327:954-968
27. A receptorpositive allosteric modulator NS11394 with diazepam, zolpidem, bretazenil and gaboxadol in rat models of inflammatory and neuropathic pain. J Pharmcol Exp Ther 327:969-981
28. A receptors. Br J Pharmacol 144:357-366
29. A alpha5 receptors with cognition enhancing properties. J Med Chem 47:5829-5832
30. A receptors which contain the α5 subunit in social encounters between male mice. Aggress Behav 30:319-325
31. Nutt DJ, Besson M, Wilson SJ, Dawson GR, Lingford-Hughes R (2007) Blockade of alcohol's amnestic activity in humans by an alpha5 subtype benzodiazepine receptor inverse agonist. Neuropharmacology 53:810-820
32. Sternfeld F, Carling RW, Jelley RA, Ladduwahetty T, Merchant KJ, Moore KW, Reeve AJ, Street LJ, O'Connor D, Sohal B et al (2004) Selective, orally active gamma-amonobutyric acidA alpha5 receptor inverse agonists as cognition enhancers. J Med Chem 47:2176-2179
33. A receptor enhances cognition. J Pharmacol Exp Ther 316:1335-1345
34. A alpha5 subunit-containing receptors. Psychopharmacol (Berl) 202:207-223
35. Wallner M, Hanchar HJ, Olsen RW (2003) Ethanol enhances alpha 4 beta3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentration known to affect humans. Proc Natl Acad Sci USA 100:15218-15223
36. Belelli D, Lambert JJ (2005) Neurosteroids: endogenous regulators of the GABA (A) receptor. Nat Rev Neurosci 6:565-575
37. Rudolph U, Antkowiak B (2004) Molecular and neuronal substrates for general anaesthetics. Nat Rev Neurosci 5:709-720
38. Storustovu S, Ebert B (2003) Gaboxadol: in vitro interaction studies with benzodiazepines and ethanol suggest functional selectivity. Eur J Pharmacol 467:49-56
39. Krogsgaard-Larsen P, Frølund B, Liljefors T, Ebert B (2004) GABA (A) agonists and partial agonists: THiP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic. Biochem Pharmacol 68:1573-1580
40. Haefely W, Martin JR, Schoch P (1990) Novel anxiolytics that act as partial agonists at benzodiazepine receptors. Trends Pharmacol Sci 11:452-456
41. Atack JR, Pike A, Marshall G, Stanley J, Lincoln R, Cook SM, Lewis RT, Blackaby WP, Goodacre SC, McKernan RM (2006) The in vivo properties of pagoclone in rat are most likely mediated by 5'-hydroxy pagoclone. Neuropharmacology 50:677-689
42. Bianchi MT, McDonald RL (2003) Neurosteroids shift partial agonist activation of GABA (A) receptor channels from low- to high-efficacy gating patterns. J Neurosci 23:10934-10943
43. 3-subunits with serotonergic and GABAergic neurons. Neuroscience 54:881-892
44. A receptor subtypespecific modulation of the synchrony and duration of thalamic oscillations. J Neurosci 23:3649-3657
45. A receptor trafficking and its role in the dynamic modulation of neuronal inhibition. Nat Rev Neurosci 9:331-343
46. A receptors for the development of tolerance to the sedative action of diazepam in mice. J Neurosci 24:6785-6790
47. Vyazosvskiy VV, Tobler I (2005) Theta activity in the waking EEG is a marker of sleep propensity in the rat. Brain Res 1050:64-71
48. A receptor subtypes. Nature 401:796-800
49. Crestani F, Martin JR, Möhler H, Rudolph U (2000) Mechanism of action of the hypnotic zolpidem in vivo. Br J Pharmacol 131:1251-1254
50. Huckle R (2004) Gaboxadol. Curr Opin Investig Drugs 5:766-773
51. A receptor subtype. Proc Natl Acad Sci USA 98:6464-6469
52. Kopp C, Rudolph U, Löw K, Tobler I (2004) Modulation of rhythmic brain activity by diazepam: GABA (A) receptor subtype and state specificity. Proc Natl Acad Sci USA 101:3674-3679
53. Kopp C, Rudolph U, Tobler I (2004) Sleep EEG changes after zolpidem in mice. Neuroreport 15:2299-2302
54. A receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J Comp Neurol 359:154-194
55. A receptors: Immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 101:815-850
56. Kopp C, Rudolph U, Keist R (2003) Diazepam-induced changes on sleep and the EEG spectrum in mice: role of the alpha3-GABA (A) receptor subtype. Eur J Neurosci 17:2226-2230
57. A receptors to a dopamine hyperfunction. Proc Natl Acad Sci USA 102:17154-17159
58. Wafford KA, Ebert B (2006) Gaboxadol - a new awakening in sleep. Curr Opin Pharmacol 6:30-36
59. A receptor function. Angew Chem Int Ed Engl 111:2852-2864
60. Winsky-Sommerer R, Vyazovskiy VV, Homanics GE, Tobler I (2007) The EEG effects of THIP (Gaboxadol) on sleep and waking are mediated by the GABA (A) delta-subunitcontaining receptors. Eur J Neurosci 25:1893-1899
61. A receptor agonist ThiP alters the EEG in waking and sleep of mice. Neuropharmacology 48:617-626
62. Löw K, Crestani F, Keist R, Benke D, Brünig I, Benson JA, Fritschy JM, Rülicke T, Bluethmann H, Möhler H et al (2000) Molecular and neuronal substrate for the selective attenuation of anxiety. Science 290:131-134
63. A receptors. Proc Natl Acad Sci USA 99:8980-8985
64. Collins I, Moyes C, Davey WB, Rowley M, Bromidge FA, Quirk K, Atack JR, McKernan RM, Thompson SA, Wafford K et al (2002) 3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA (A) receptor-ion channels. J Med Chem 45:1887-900
65. A modulators. CNS Spectr 10:21-27
66. A receptor subtype functions. Curr Opin Pharmacol 6:18-23
67. A receptor subtype-selective efficacy: TPA023, an alpha2/alpha3 selective non-sedating anxiolytic and alpha5 IA, an alpha5 selective cognition enhancer. CNS Neurosci Ther 14:25-35
68. Zeilhofer HU, Möhler H, Di Lio A (2009) GABAergic analgesia - new insights from mutant mice and subtype-s selective agonists. Trends Pharmacol Sci 30:397-402
69. A receptor. J Neurosci 22:5572-5580
70. Stephan KE, Friston KJ, Frith CD (2009) Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring schizophrenia. Schizophr Bull 35:509-527
71. Lewis DA, Hashimoto T, Volk DW (2005) Cortical inhibitory neurons and schizophrenia. Nat Rev Neurosci 6:312-324
72. A receptor subtypes demonstrated in hippocampal and olfactory neurons in vivo. Neurosci Lett 249:99-102
73. Lewis DA, Cho RY, Carter CS, Erklund K, Forster S, Kelly MA, Montrose D (2008) Subunitselective modulation of GABA type A receptor neurotransmission and cognition in schizophrenia. Am J Psychiatry 165:1585-1593
74. Ator N, Weerts EM, Kaminski BJ, Kautz MA, Griffiths RR (2000) Zaleplon and triazolam physical dependence assessed across increasing doses under a once-daily dosing regimen in baboons. Drug Alcohol Depend 61:69-84
75. A receptor subtypes mediate the anxiolytic, abuse-related and motor effects of benzodiazepine-like drugs in primates. Proc Natl Acad Sci USA 102:915-920
76. A receptor subtype selectivity to abuse liability and dependence potential of pharmacological treatments for anxiety and sleep disorders. CNS Spectr 10:31-39
77. Licata SC, Platt DM, Cook JM, Sarma PV, Griebel G, Rowlett JK (2005) Contribution of GABAA receptor subtypes to the anxiolytic-like, motor and discriminative stimulus effects of benzodiazepines: studies with the functionally selective ligand SL 651 498. J Pharmacol Exp Ther 313:1118-1125
78. B receptors: synaptic functions and mechanisms of diversity. Curr Opin Neurobiol 17:298-303
79. 2+ spikes in layer 5 somatosensory pyramidal neurons. Neuron 50:603-616
80. B receptors to control rhythmic hippocampal activity. Neuron 25:673-681
81. B receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture. Proc Natl Acad Sci USA 106:4459-4464
82. B(1)-deficit mice. Eur J Neurosci 18:2722-2730
83. B receptors. Neuropharmacology 38:1667-1673
84. Feldman NT (2009) Xyrem safety. The debate continues. Sleep Med 10:405-406
85. Crunelli V, Emri Z, Leresche N (2006) Unravelling the brain targets of γ-hydroxybutyric acid. Curr Opin Pharmacol 6:44-52
86. Carter LP, Koek W, France CP (2009) Behavioral analyses of GHB: receptor mechanisms. Pharmacol Ther 121:100-111
87. B receptor: a site of therapeutic benefit. Curr Opin Pharmacol 6:37-47
88. B receptors in anxiety and depression. Trends Pharamcol Sci 26:36-43
89. B(1) receptor isoforms in cognition. Behav Brain Res 181:158-162
90. Tan KR, Brown M, Labouèbe G, Yvon C, Creton C, Fritschy JM, Rudolph U, Lüscher C (2010) Neural bases for addictive properties of benzodiazepines. Nature 463:769-774
91. B receptor positive modulator CGP7930 in rodents. Neuropharmacol 54:854-862
92. A benzodiazepine receptors as targets for new hypnotics In: Pandi-Perumal, Verster, Monit, Lader, Langer (eds) Sleep Pharmacology, basic science and clinical applications. pp 206-219
93. Spencer KM, Nestor PG, Perlmutter R et al (2004) Neural synchrony indexes disordered perception and cognition in schizophrenia. Proc Natl Acad Sci USA 101:17288-17293
94. Cho RY, Konecky RO, Carter CS (2006) Impairments in frontal cortical g-synchrony and cognitive control in schizophrenia. Proc Natl Acad Sci USA 103:19878-19883
95. Tan KR, Brown M, Labouèbe G, Yvon C, Fritschy JM, Rudolph U, Lüscher C (2010) Neural bases for addictive properties of benzodiazepines. Nature 463:769-774