Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice

Pain

Volumn 141, Issue 3, 2009, Pages 233-238

  Knabl, Julia ^a,b   Zeilhofer, Ulrike B ^a,b   Crestani, Florence ^a   Rudolph, Uwe ^c   Zeilhofer, Hanns Ulrich ^a,b,d  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c MCLEAN HOSPITAL   (United States)

^d ETH ZURICH   (Switzerland)

Author keywords

Benzodiazepine; Diazepam; GABAA receptor; Hyperalgesia; Pain; Point mutation; Spinal cord

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 6 FLUORO 2,9 DIHYDRO 9 METHYL 2 PHENYL 4 (1 PYRROLIDINYLCARBONYL) 1H PYRIDO[3,4 B]INDOL 1 ONE; BENZODIAZEPINE; DIAZEPAM; FLUMAZENIL; FORMALDEHYDE;

ALPHA CHAIN; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING; HYPERALGESIA; MALE; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SEDATION; WILD TYPE;

ANALYSIS OF VARIANCE; ANESTHETICS; ANIMALS; ARGININE; DIAZEPAM; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FORMALDEHYDE; HISTIDINE; HYPERALGESIA; INDOLES; MALE; MICE; MICE, MUTANT STRAINS; MOTOR ACTIVITY; PHYSICAL STIMULATION; POINT MUTATION; PROTEIN SUBUNITS; PYRROLES; RECEPTORS, GABA-A;

EID: 58749098563     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2008.10.015     Document Type: Article

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