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Volumn 5, Issue 9, 2004, Pages 709-720

Molecular and neuronal substrates for general anaesthetics

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALFAXALONE; AMPA RECEPTOR; ANESTHETIC AGENT; BARBITURIC ACID; BENZODIAZEPINE; CHLOROFORM; CHOLINERGIC RECEPTOR; DIAZEPAM; ETOMIDATE; GLUCOCORTICOID; GLYCINE RECEPTOR; INHALATION ANESTHETIC AGENT; INTRAVENOUS ANESTHETIC AGENT; ION CHANNEL; ISOFLURANE; KAINIC ACID RECEPTOR; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITROUS OXIDE; PROPOFOL; RECEPTOR SUBTYPE; SEROTONIN 3 RECEPTOR; SEVOFLURANE; TETRODOTOXIN; THIOPENTAL;

EID: 4344574333     PISSN: 1471003X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrn1496     Document Type: Review
Times cited : (660)

References (118)
  • 1
    • 0033169052 scopus 로고    scopus 로고
    • Brain mechanisms of propofol-induced loss of consciousness in humans: A positron emission tomographic study
    • Fiset, P. et al. Brain mechanisms of propofol-induced loss of consciousness in humans: a positron emission tomographic study. J. Neurosci. 19, 5506-5513 (1999).
    • (1999) J. Neurosci. , vol.19 , pp. 5506-5513
    • Fiset, P.1
  • 2
    • 0028294705 scopus 로고
    • Synchronized sleep oscillations and their paroxysmal developments
    • Steriade, M., Contreras, D. & Amzica, F. Synchronized sleep oscillations and their paroxysmal developments. Trends Neurosci. 17, 199-208 (1994).
    • (1994) Trends Neurosci. , vol.17 , pp. 199-208
    • Steriade, M.1    Contreras, D.2    Amzica, F.3
  • 4
    • 0029905454 scopus 로고    scopus 로고
    • Synaptic mechanisms of thiopental-induced alterations in synchronized cortical activity
    • Lukatch, H. S. & Maclver, M. B. Synaptic mechanisms of thiopental-induced alterations in synchronized cortical activity. Anesthesiology 84, 1425-1434 (1996).
    • (1996) Anesthesiology , vol.84 , pp. 1425-1434
    • Lukatch, H.S.1    Maclver, M.B.2
  • 5
    • 0038623543 scopus 로고    scopus 로고
    • Mechanisms of actions of inhaled anesthetics
    • Campagna, J. A., Miller, K. W. & Forman, S. A. Mechanisms of actions of inhaled anesthetics. N. Engl. J. Med. 348, 2110-2124 (2003).
    • (2003) N. Engl. J. Med. , vol.348 , pp. 2110-2124
    • Campagna, J.A.1    Miller, K.W.2    Forman, S.A.3
  • 6
    • 0036067233 scopus 로고    scopus 로고
    • Concepts and correlations relevant to general anaesthesia
    • Urban, B. W. & Bleckwenn, M. Concepts and correlations relevant to general anaesthesia. Br. J. Anaesth. 89, 3-16 (2002).
    • (2002) Br. J. Anaesth. , vol.89 , pp. 3-16
    • Urban, B.W.1    Bleckwenn, M.2
  • 7
    • 0041375505 scopus 로고    scopus 로고
    • Inhaled anesthetics and immobility: Mechanisms, mysteries, and minimum alveolar anesthetic concentration
    • Sonner, J. M. et al. Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentration. Anesth. Analg. 97, 718-740 (2003).
    • (2003) Anesth. Analg. , vol.97 , pp. 718-740
    • Sonner, J.M.1
  • 8
    • 0015105598 scopus 로고
    • Claude Bemard and anesthesia
    • Leake, C. D. Claude Bemard and anesthesia. Anesthesiology 35, 112-113 (1971).
    • (1971) Anesthesiology , vol.35 , pp. 112-113
    • Leake, C.D.1
  • 9
    • 0010243675 scopus 로고
    • Welche eigenschaft der anästhetica bedingt ihre narkotische wirkung?
    • Meyer, H. Welche eigenschaft der anästhetica bedingt ihre narkotische wirkung? Arch. Exp. Pathol. Pharmakol. (Naunyn-Schmiedeberg's) 42, 109-118 (1899).
    • (1899) Arch. Exp. Pathol. Pharmakol. (Naunyn-Schmiedeberg's) , vol.42 , pp. 109-118
    • Meyer, H.1
  • 11
    • 0021211620 scopus 로고
    • Do general anaesthetics act by competitive binding to specific receptors?
    • Franks, N. P. & Lieb, W. R. Do general anaesthetics act by competitive binding to specific receptors? Nature 310, 599-601 (1984). This classic paper shows that general anaesthetics inhibit a water-soluble protein (firefly luciferase). Effects occur at clinically relevant concentrations and follow the Meyer-Overton rule.
    • (1984) Nature , vol.310 , pp. 599-601
    • Franks, N.P.1    Lieb, W.R.2
  • 12
    • 0028140369 scopus 로고
    • Molecular and cellular mechanisms of general anaesthesia
    • Franks, N. P. & Lieb, W. R. Molecular and cellular mechanisms of general anaesthesia. Nature 367, 607-614 (1994).
    • (1994) Nature , vol.367 , pp. 607-614
    • Franks, N.P.1    Lieb, W.R.2
  • 13
    • 0020394696 scopus 로고
    • Molecular mechanisms of general anaesthesia
    • Franks, N. P. & Lieb, W. R. Molecular mechanisms of general anaesthesia. Nature 300, 487-493 (1982).
    • (1982) Nature , vol.300 , pp. 487-493
    • Franks, N.P.1    Lieb, W.R.2
  • 14
    • 0028019452 scopus 로고
    • Polyhalogenated and perfluorinated compounds that disobey the Meyer-Overton hypothesis
    • Koblin, D. D. et al. Polyhalogenated and perfluorinated compounds that disobey the Meyer-Overton hypothesis. Anesth. Analg. 79, 1043-1048 (1994).
    • (1994) Anesth. Analg. , vol.79 , pp. 1043-1048
    • Koblin, D.D.1
  • 15
    • 0018141853 scopus 로고
    • Where do general anaesthetics act?
    • Franks, N. P. & Lieb, W. R. Where do general anaesthetics act? Nature 274, 339-342 (1978).
    • (1978) Nature , vol.274 , pp. 339-342
    • Franks, N.P.1    Lieb, W.R.2
  • 16
    • 0027287929 scopus 로고
    • W Anesthetic cutoff in cycloalkanemethanols. A test of current theories
    • Raines, D. E., Korten, S. E., Hill, A. G. & Miller, K. W Anesthetic cutoff in cycloalkanemethanols. A test of current theories. Anesthesiology 78, 918-927 (1993).
    • (1993) Anesthesiology , vol.78 , pp. 918-927
    • Raines, D.E.1    Korten, S.E.2    Hill, A.G.3    Miller, K.4
  • 17
    • 0036066435 scopus 로고    scopus 로고
    • In vivo characterization of clinical anaesthesia and its components
    • Antognini, J. F. & Carstens, E. In vivo characterization of clinical anaesthesia and its components. Br. J. Anaesth. 89, 156-166 (2002).
    • (2002) Br. J. Anaesth. , vol.89 , pp. 156-166
    • Antognini, J.F.1    Carstens, E.2
  • 18
    • 0027142553 scopus 로고
    • Spinal cord as a site of anesthetic action
    • Kendig, J. J. Spinal cord as a site of anesthetic action. Anesthesiology 79, 1161-1162 (1993).
    • (1993) Anesthesiology , vol.79 , pp. 1161-1162
    • Kendig, J.J.1
  • 19
    • 0030934678 scopus 로고    scopus 로고
    • Hypothesis: Inhaled anesthetics produce immobility and amnesia by different mechanisms at different sites
    • Eger, E. I. et al. Hypothesis: inhaled anesthetics produce immobility and amnesia by different mechanisms at different sites. Anesth. Analg. 84, 915-918 (1997).
    • (1997) Anesth. Analg. , vol.84 , pp. 915-918
    • Eger, E.I.1
  • 20
    • 0030748681 scopus 로고    scopus 로고
    • A concept for assessing interactions of general anesthetics
    • Kissin, I. A concept for assessing interactions of general anesthetics. Anesth. Analg. 85, 204-210 (1997).
    • (1997) Anesth. Analg. , vol.85 , pp. 204-210
    • Kissin, I.1
  • 22
    • 0028043659 scopus 로고
    • The interaction of fentanyl on the Cp50 of propofol for loss of consciousness and skin incision
    • Smith, C. et al. The interaction of fentanyl on the Cp50 of propofol for loss of consciousness and skin incision. Anesthesiology 81, 820-828 (1994).
    • (1994) Anesthesiology , vol.81 , pp. 820-828
    • Smith, C.1
  • 23
    • 0036785886 scopus 로고    scopus 로고
    • A receptors in an endogenous sleep pathway
    • A receptors in an endogenous sleep pathway. Nature Neurosci. 5, 979-984 (2002). The GABA antagonist gabazine was shown to attenuate the sedative response to GABA-containing agents when injected locally into the tuberomamillary nucleus, indicating that a discrete locus has a key role in the sedative response to anaesthetics that affect GABA-mediated neurotransmission.
    • (2002) Nature Neurosci. , vol.5 , pp. 979-984
    • Nelson, L.E.1
  • 24
    • 0035032014 scopus 로고    scopus 로고
    • Correlating in vivo anaesthetic effects with ex vivo receptor density data supports a GABAergic mechanism of action for propofol, but not for isoflurane
    • Alkire, M. T. & Haier, R. J. Correlating in vivo anaesthetic effects with ex vivo receptor density data supports a GABAergic mechanism of action for propofol, but not for isoflurane. Br. J. Anaesth. 86, 618-626 (2001).
    • (2001) Br. J. Anaesth. , vol.86 , pp. 618-626
    • Alkire, M.T.1    Haier, R.J.2
  • 26
    • 0031876291 scopus 로고    scopus 로고
    • Quantitative EEG correlations with brain glucose metabolic rate during anesthesia in volunteers
    • Alkire, M, T. Quantitative EEG correlations with brain glucose metabolic rate during anesthesia in volunteers. Anesthesiology 89, 323-333 (1998).
    • (1998) Anesthesiology , vol.89 , pp. 323-333
    • Alkire, M.T.1
  • 27
    • 0030729053 scopus 로고    scopus 로고
    • 15O positron emission tomography study
    • 15O positron emission tomography study. Anesthesiology 87, 1106-1117 (1997).
    • (1997) Anesthesiology , vol.87 , pp. 1106-1117
    • Veselis, R.A.1
  • 28
    • 0034844537 scopus 로고    scopus 로고
    • Quantitative EEG changes associated with loss and return of consciousness in healthy adult volunteers anaesthetized with propofol or sevoflurane
    • Gugino, L. D. et al. Quantitative EEG changes associated with loss and return of consciousness in healthy adult volunteers anaesthetized with propofol or sevoflurane. Br. J. Anaesth. 87, 421-428 (2001).
    • (2001) Br. J. Anaesth. , vol.87 , pp. 421-428
    • Gugino, L.D.1
  • 29
    • 0034268955 scopus 로고    scopus 로고
    • Toward a unifed theory of narcosis: Brain imaging evidence for a thalamocortical switch as the neurophysiologic basis of anesthetic-induced unconsciousness
    • Alkire, M. T. Haier, R. J. & Fallon, J. H. Toward a unifed theory of narcosis: brain imaging evidence for a thalamocortical switch as the neurophysiologic basis of anesthetic-induced unconsciousness. Conscious Cogn. 9, 370-386 (2000).
    • (2000) Conscious Cogn. , vol.9 , pp. 370-386
    • Alkire, M.T.1    Haier, R.J.2    Fallon, J.H.3
  • 30
    • 0029892036 scopus 로고    scopus 로고
    • Arousal: Revisiting the reticular activating system
    • Steriade, M. Arousal: revisiting the reticular activating system. Science 272, 225-226 (1996).
    • (1996) Science , vol.272 , pp. 225-226
    • Steriade, M.1
  • 31
    • 1642499298 scopus 로고    scopus 로고
    • Dose-dependent effects of propofol on the central processing of thermal pan
    • Hofbauer, R. K., Fiset, P., Plourde, G., Backman, S. B. & Bushnell, M. C. Dose-dependent effects of propofol on the central processing of thermal pan. Anesthesiology 100, 386-394 (2004). Provides clear evidence that loss of consciousness and pain sensation correlates with propofol-induced interruption of thalamic information processing.
    • (2004) Anesthesiology , vol.100 , pp. 386-394
    • Hofbauer, R.K.1    Fiset, P.2    Plourde, G.3    Backman, S.B.4    Bushnell, M.C.5
  • 32
    • 0035096950 scopus 로고    scopus 로고
    • Propofol anesthesia and cerebral blood flow changes elicited by vibrotactile stimulation: A positron emission tomography study
    • Bonhomme, V. et al. Propofol anesthesia and cerebral blood flow changes elicited by vibrotactile stimulation: a positron emission tomography study J. Neurophysiol. 85, 1299-1308 (2001).
    • (2001) J. Neurophysiol. , vol.85 , pp. 1299-1308
    • Bonhomme, V.1
  • 33
    • 0034761637 scopus 로고    scopus 로고
    • Wavelet analysis of middle latency auditory evoked responses: Calculation of an index for detection of awareness during propofol administration
    • Kochs, E., Stockmanns, G., Thornton, C., Nahm, W. & Kalkman, C. J. Wavelet analysis of middle latency auditory evoked responses: calculation of an index for detection of awareness during propofol administration. Anesthesiology 95, 1141-1150 (2001).
    • (2001) Anesthesiology , vol.95 , pp. 1141-1150
    • Kochs, E.1    Stockmanns, G.2    Thornton, C.3    Nahm, W.4    Kalkman, C.J.5
  • 35
    • 0026563986 scopus 로고
    • The divergent actions of volatile anaesthetics on background neuronal activity and reactive capability in the central nervous system in cats
    • Ogawa, T., Shingu, K., Shibata, M., Osawa, M. & Mori, K. The divergent actions of volatile anaesthetics on background neuronal activity and reactive capability in the central nervous system in cats. Can. J. Anaesth. 39, 862-872 (1992).
    • (1992) Can. J. Anaesth. , vol.39 , pp. 862-872
    • Ogawa, T.1    Shingu, K.2    Shibata, M.3    Osawa, M.4    Mori, K.5
  • 36
    • 0029866733 scopus 로고    scopus 로고
    • Pontine cholinergic mechanisms modulate the cortical electroencephalographic spindles of halothane anesthesia
    • Keifer, J. C., Baghdoyan, H. A. & Lydic, R. Pontine cholinergic mechanisms modulate the cortical electroencephalographic spindles of halothane anesthesia. Anesthesiology 84, 945-954 (1996).
    • (1996) Anesthesiology , vol.84 , pp. 945-954
    • Keifer, J.C.1    Baghdoyan, H.A.2    Lydic, R.3
  • 37
    • 0033018477 scopus 로고    scopus 로고
    • Acetylcholine in mind: A neurotransmitter correlate of consciousness?
    • Perry, E., Walker, M., Grace, J. & Perry, R. Acetylcholine in mind: a neurotransmitter correlate of consciousness? Trends Neurosci. 22, 273-280 (1999).
    • (1999) Trends Neurosci. , vol.22 , pp. 273-280
    • Perry, E.1    Walker, M.2    Grace, J.3    Perry, R.4
  • 38
    • 2542492937 scopus 로고    scopus 로고
    • Recovery from sleep deprivation occurs during propofol anesthesia
    • Tung, A., Bergmann, B. M., Herrera, S., Cao, D. & Mendelson, W. B. Recovery from sleep deprivation occurs during propofol anesthesia. Anesthesiology 100, 1419-1426 (2004).
    • (2004) Anesthesiology , vol.100 , pp. 1419-1426
    • Tung, A.1    Bergmann, B.M.2    Herrera, S.3    Cao, D.4    Mendelson, W.B.5
  • 39
    • 0034266462 scopus 로고    scopus 로고
    • Anesthesia, neural information processing, and conscious awareness
    • Cariani, P. Anesthesia, neural information processing, and conscious awareness. Conscious Cogn. 9, 387-395 (2000).
    • (2000) Conscious Cogn. , vol.9 , pp. 387-395
    • Cariani, P.1
  • 40
    • 1642540155 scopus 로고    scopus 로고
    • Consciousness unbound: Toward a paradigm of general anesthesia
    • Mashour, G. A. Consciousness unbound: toward a paradigm of general anesthesia. Anesthesiology 100, 428-433 (2004).
    • (2004) Anesthesiology , vol.100 , pp. 428-433
    • Mashour, G.A.1
  • 41
    • 0041324623 scopus 로고    scopus 로고
    • Effects of subanesthetic doses of ketamine on regional cerebral blood flow, oxygen consumption, and blood volume in humans
    • Langsjo, J. W. et al. Effects of subanesthetic doses of ketamine on regional cerebral blood flow, oxygen consumption, and blood volume in humans. Anesthesiology 99, 614-623 (2003).
    • (2003) Anesthesiology , vol.99 , pp. 614-623
    • Langsjo, J.W.1
  • 42
    • 0030900732 scopus 로고    scopus 로고
    • Activation of glutamatergic neurotransmission by ketamine: A novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex
    • Moghaddam, B., Adams, B., Verma, A. & Daly, D. Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J. Neurosci. 17, 2921-2927 (1997).
    • (1997) J. Neurosci. , vol.17 , pp. 2921-2927
    • Moghaddam, B.1    Adams, B.2    Verma, A.3    Daly, D.4
  • 43
    • 0027494605 scopus 로고
    • Mid-latency auditory evoked potentials during ketamine anaesthesia in humans
    • Schwender, D., Klasing, S., Madler, C., Poppel, E. & Peter, K. Mid-latency auditory evoked potentials during ketamine anaesthesia in humans. Br. J. Anaesth. 71, 629-632 (1993).
    • (1993) Br. J. Anaesth. , vol.71 , pp. 629-632
    • Schwender, D.1    Klasing, S.2    Madler, C.3    Poppel, E.4    Peter, K.5
  • 44
    • 0015318138 scopus 로고
    • A comparison of psychologic responses to ketamine and thiopental-nitrous oxide-halothane anesthesia
    • Garfield, J. M., Garfield, F. B., Stone, J. B., Hopkins, D. & Johns, L. A. A comparison of psychologic responses to ketamine and thiopental-nitrous oxide-halothane anesthesia. Anesthesiology 36, 329-338 (1972).
    • (1972) Anesthesiology , vol.36 , pp. 329-338
    • Garfield, J.M.1    Garfield, F.B.2    Stone, J.B.3    Hopkins, D.4    Johns, L.A.5
  • 45
    • 0028969330 scopus 로고
    • Visual feature integration and the temporal correlation hypothesis
    • Singer, W. & Gray, C. M. Visual feature integration and the temporal correlation hypothesis. Annu. Rev. Neurosci. 18, 555-586 (1995).
    • (1995) Annu. Rev. Neurosci. , vol.18 , pp. 555-586
    • Singer, W.1    Gray, C.M.2
  • 46
    • 0034919516 scopus 로고    scopus 로고
    • Invariant reversible QEEG effects of anesthetics
    • John, E. R. et al. Invariant reversible QEEG effects of anesthetics. Conscious Cogn. 10, 165-183 (2001).
    • (2001) Conscious Cogn. , vol.10 , pp. 165-183
    • John, E.R.1
  • 47
    • 0037410259 scopus 로고    scopus 로고
    • The effects of general anaesthetics on carbachol-evoked γ-oscillations in the rat hippocampus in vitro
    • Dickinson, R., Awaiz, S., Whittington, M. A., Lieb, W. R. & Franks, N. P. The effects of general anaesthetics on carbachol-evoked γ-oscillations in the rat hippocampus in vitro. Neuropharmacology 44, 864-872 (2003).
    • (2003) Neuropharmacology , vol.44 , pp. 864-872
    • Dickinson, R.1    Awaiz, S.2    Whittington, M.A.3    Lieb, W.R.4    Franks, N.P.5
  • 49
    • 0036260446 scopus 로고    scopus 로고
    • Effects of surgical levels of propofol and sevoflurane anesthesia on cerebral blood flow in healthy subjects studied with positron emission tomography
    • Kaisti, K. K. et al. Effects of surgical levels of propofol and sevoflurane anesthesia on cerebral blood flow in healthy subjects studied with positron emission tomography. Anesthesiology 96, 1358-1370 (2002).
    • (2002) Anesthesiology , vol.96 , pp. 1358-1370
    • Kaisti, K.K.1
  • 50
    • 2342522093 scopus 로고    scopus 로고
    • Sequential effects of propofol on functional brain activation induced by auditory language processing: An event-related functional magnetic resonance imaging study
    • Heinke, W. et al. Sequential effects of propofol on functional brain activation induced by auditory language processing: an event-related functional magnetic resonance imaging study. Br. J. Anaesth. 92, 641-650 (2004).
    • (2004) Br. J. Anaesth. , vol.92 , pp. 641-650
    • Heinke, W.1
  • 51
    • 0034986855 scopus 로고    scopus 로고
    • Subanesthetic isoflurane affects task-induced brain activation in a highly specific manner: A functional magnetic resonance imaging study
    • Heinke, W. & Schwarzbauer, C. Subanesthetic isoflurane affects task-induced brain activation in a highly specific manner: a functional magnetic resonance imaging study. Anesthesiology 94, 973-981 (2001). Reports that higher-level cortical information processing is more sensitive to anaesthetic treatment than sensory processing in primary cortices and subcortical structures.
    • (2001) Anesthesiology , vol.94 , pp. 973-981
    • Heinke, W.1    Schwarzbauer, C.2
  • 53
    • 0035924316 scopus 로고    scopus 로고
    • Dynamic properties of neurons in cortical area MT in alert and anaesthetized macaque monkeys
    • Pack, C. C., Berezovskii, V. K. & Born, R. T. Dynamic properties of neurons in cortical area MT in alert and anaesthetized macaque monkeys. Nature 414, 905-908 (2001).
    • (2001) Nature , vol.414 , pp. 905-908
    • Pack, C.C.1    Berezovskii, V.K.2    Born, R.T.3
  • 54
    • 0033768929 scopus 로고    scopus 로고
    • Propofol directly depresses lumbar dorsal horn neuronal responses to noxious stimulation in goats
    • Antognini, J. F., Wang, X. W., Piercy, M. & Carstens, E. Propofol directly depresses lumbar dorsal horn neuronal responses to noxious stimulation in goats. Can. J. Anaesth. 47, 273-279 (2000).
    • (2000) Can. J. Anaesth. , vol.47 , pp. 273-279
    • Antognini, J.F.1    Wang, X.W.2    Piercy, M.3    Carstens, E.4
  • 55
    • 0027467413 scopus 로고
    • Anesthetic potency (MAC) is independent of forebrain structures in the rat
    • Rampil, I. J., Mason, P. & Singh, H. Anesthetic potency (MAC) is independent of forebrain structures in the rat. Anesthesiology 78, 707-712 (1993). Pre-collicular decerebration in rats does not affect their sensitivity to the immobilizing action of isoflurane, indicating that anaesthetic-induced unresponsiveness to noxious stimuli does not depend on cortical or forebrain structures in the rat.
    • (1993) Anesthesiology , vol.78 , pp. 707-712
    • Rampil, I.J.1    Mason, P.2    Singh, H.3
  • 56
    • 0028297603 scopus 로고
    • Anesthetic potency is not altered after hypothermic spinal cord transection in rats
    • Rampil, I. J. Anesthetic potency is not altered after hypothermic spinal cord transection in rats. Anesthesiology 80, 606-610 (1994). After cervical laminectomy and hypothermic spinal cord transsection, the sensitivity to the immobilizing action of isoflurane was not changed, despite acute loss of descending supraspinal controls. So, the site of anaesthetic inhibition of motor response is probably in the spinal cord.
    • (1994) Anesthesiology , vol.80 , pp. 606-610
    • Rampil, I.J.1
  • 57
    • 0027136076 scopus 로고
    • Exaggerated anesthetic requirements in the preferentially anesthetized brain
    • Antognini, J. F. & Schwartz, K. Exaggerated anesthetic requirements in the preferentially anesthetized brain. Anesthesiology 79, 1244-1249 (1993). In goats, delivery of anaesthetic drugs specifically to the brain, compared with delivery to the spinal cord, increased the concentration that is needed to suppress noxious-stimuli-induced movements three-fourfold.
    • (1993) Anesthesiology , vol.79 , pp. 1244-1249
    • Antognini, J.F.1    Schwartz, K.2
  • 58
    • 0031896792 scopus 로고    scopus 로고
    • Suppression of spinal cord motoneuron excitability correlates with surgical immobility during isoflurane anesthesia
    • Zhou, H. H., Jin, T. T., Qin, B. & Tumdorf, H. Suppression of spinal cord motoneuron excitability correlates with surgical immobility during isoflurane anesthesia. Anesthesiology 88, 955-961 (1998).
    • (1998) Anesthesiology , vol.88 , pp. 955-961
    • Zhou, H.H.1    Jin, T.T.2    Qin, B.3    Tumdorf, H.4
  • 59
    • 0343775803 scopus 로고    scopus 로고
    • Isoflurane action in the spinal cord blunts electroencephalographic and thalamic-reticular formation responses to noxious stimulation in goats
    • Antognini, J. F., Wang, X. W. & Carstens, E. Isoflurane action in the spinal cord blunts electroencephalographic and thalamic-reticular formation responses to noxious stimulation in goats. Anesthesiology 92, 559-566 (2000).
    • (2000) Anesthesiology , vol.92 , pp. 559-566
    • Antognini, J.F.1    Wang, X.W.2    Carstens, E.3
  • 60
    • 17444446483 scopus 로고    scopus 로고
    • The septohippocampal system participates in general anesthesia
    • Ma, J., Shen, B., Stewart, L. S., Herrick, I. A. & Leung, L. S. The septohippocampal system participates in general anesthesia. J. Neurosci. 22, RC200 (2002).
    • (2002) J. Neurosci. , vol.22
    • Ma, J.1    Shen, B.2    Stewart, L.S.3    Herrick, I.A.4    Leung, L.S.5
  • 61
    • 0001363519 scopus 로고
    • A comparative study of halothane and halopropane anesthesia including method for determining equipotency
    • Merkel, G. & Eger, E. I. A comparative study of halothane and halopropane anesthesia including method for determining equipotency. Anesthesiology 24, 346-357 (1963).
    • (1963) Anesthesiology , vol.24 , pp. 346-357
    • Merkel, G.1    Eger, E.I.2
  • 62
    • 0037407761 scopus 로고    scopus 로고
    • Peri-MAC depression of a nociceptive withdrawal reflex is accompanied by reduced dorsal horn activity with halothane but not isoflurane
    • Jinks, S. L., Martin, J. T., Carstens, E., Jung, S. W. & Antognini, J. F. Peri-MAC depression of a nociceptive withdrawal reflex is accompanied by reduced dorsal horn activity with halothane but not isoflurane. Anesthesiology 98, 1128-1138 (2003).
    • (2003) Anesthesiology , vol.98 , pp. 1128-1138
    • Jinks, S.L.1    Martin, J.T.2    Carstens, E.3    Jung, S.W.4    Antognini, J.F.5
  • 63
    • 3042608463 scopus 로고    scopus 로고
    • A receptors do not mediate the immobility produced by isoflurane
    • A receptors do not mediate the immobility produced by isoflurane. Anesth. Analg. 99, 85-90 (2004).
    • (2004) Anesth. Analg. , vol.99 , pp. 85-90
    • Zhang, Y.1
  • 66
    • 0037315741 scopus 로고    scopus 로고
    • A receptor β3 subunit
    • A receptors in these responses.
    • (2003) FASEB J. , vol.17 , pp. 250-252
    • Jurd, R.1
  • 67
    • 0141569516 scopus 로고    scopus 로고
    • A receptor isoforms
    • A receptors mediate the sedative action of etomidate.
    • (2003) J. Neurosci. , vol.23 , pp. 8608-8617
    • Reynolds, D.S.1
  • 68
  • 70
    • 0345598083 scopus 로고    scopus 로고
    • 3δ γ-aminobutyric acid type A receptors at low concentrations known to affect humans
    • 3δ γ-aminobutyric acid type A receptors at low concentrations known to affect humans. Proc. Natl Acad. Sci. USA 100, 15218-13223 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 15218-13223
    • Wallner, M.1    Hanchar, H.J.2    Olsen, R.W.3
  • 71
    • 0026612363 scopus 로고
    • A receptor subunit mRNAs in the rat brain I. Telencephalon, diencephalon, mesencephalon
    • A receptor subunit mRNAs in the rat brain I. Telencephalon, diencephalon, mesencephalon. J. Neurosci. 12, 1040-1062 (1992).
    • (1992) J. Neurosci. , vol.12 , pp. 1040-1062
    • Wisden, W.1    Laurie, D.J.2    Monyer, H.3    Seeburg, P.H.4
  • 72
    • 0026612362 scopus 로고
    • A, receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum
    • A, receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J. Neurosci, 12, 1063-1076 (1992).
    • (1992) J. Neurosci. , vol.12 , pp. 1063-1076
    • Laurie, D.J.1    Seeburg, P.H.2    Wisden, W.3
  • 73
    • 0028977843 scopus 로고
    • A-receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits
    • A-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J. Comp. Neurol. 359, 154-194 (1995).
    • (1995) J. Comp. Neurol. , vol.359 , pp. 154-194
    • Fritschy, J.M.1    Möhler, H.2
  • 74
    • 0038362175 scopus 로고    scopus 로고
    • Formation and plasticity of GABAergic synapses: Physiological mechanisms and pathophysiological implications
    • Fritschy, J. M. & Brünig, I. Formation and plasticity of GABAergic synapses: physiological mechanisms and pathophysiological implications. Pharmacol. Ther. 98, 299-323 (2003).
    • (2003) Pharmacol. Ther. , vol.98 , pp. 299-323
    • Fritschy, J.M.1    Brünig, I.2
  • 75
    • 1342344806 scopus 로고    scopus 로고
    • A receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics
    • A receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics. Annu. Rev. Pharmacol. Toxicol. 44, 475-498 (2004).
    • (2004) Annu. Rev. Pharmacol. Toxicol. , vol.44 , pp. 475-498
    • Rudolph, U.1    Mühler, H.2
  • 76
    • 13044251823 scopus 로고    scopus 로고
    • Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor δ-subunit knockout mice
    • Mihalek, R. M. et al. Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor δ-subunit knockout mice. Proc. Natl Acad. Sci. USA 96, 12905-12910 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 12905-12910
    • Mihalek, R.M.1
  • 79
    • 1842328604 scopus 로고    scopus 로고
    • A and glycine receptors
    • A-receptor subunits near the transmembrane domains 2 and 3 have been identified.
    • (1997) Nature , vol.389 , pp. 385-389
    • Mihic, S.J.1
  • 80
    • 0030922807 scopus 로고    scopus 로고
    • The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid
    • A receptors etomidate-sensitive or insensitive. This electrophysiological study on recombinant receptors is the basis for the development of the β2(N265S) and β3(N265M) mouse models.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 11031-11036
    • Belelli, D.1    Lambert, J.J.2    Peters, J.A.3    Wafford, K.4    Whiting, P.J.5
  • 81
    • 0031967619 scopus 로고    scopus 로고
    • Propofol and other intravenous anesthetics have sites of action on the γ-aminobutyric acid type A receptor distinct from that for isoflurane
    • Krasowski, M. D. et al. Propofol and other intravenous anesthetics have sites of action on the γ-aminobutyric acid type A receptor distinct from that for isoflurane. Mol. Phamacol. 53, 530-538 (1998).
    • (1998) Mol. Phamacol. , vol.53 , pp. 530-538
    • Krasowski, M.D.1
  • 82
    • 0033557760 scopus 로고    scopus 로고
    • Complementary regulation of anaesthetic activation of human (α6β3γ2L) and Drosophila (RDL) GABA receptors by a single amino acid residue
    • Pistis, M., Belelli, D., McGurk, K., Peters, J. A. & Lambert, J. J. Complementary regulation of anaesthetic activation of human (α6β 3γ2L) and Drosophila (RDL) GABA receptors by a single amino acid residue. J. Physiol. 515, 3-18 (1999).
    • (1999) J. Physiol. , vol.515 , pp. 3-18
    • Pistis, M.1    Belelli, D.2    McGurk, K.3    Peters, J.A.4    Lambert, J.J.5
  • 85
    • 0345269286 scopus 로고    scopus 로고
    • 2-(3-methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5- carboxylate: A derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels
    • Husain, S. S. et al. 2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels. J. Med. Chem. 46, 1257-1265 (2003).
    • (2003) J. Med. Chem. , vol.46 , pp. 1257-1265
    • Husain, S.S.1
  • 86
    • 1542408736 scopus 로고    scopus 로고
    • A circuits for visual cortical plasticity
    • A circuits for visual cortical plasticity. Science 303, 1681-1683 (2004).
    • (2004) Science , vol.303 , pp. 1681-1683
    • Fagiolini, M.1
  • 87
    • 0033592682 scopus 로고    scopus 로고
    • A receptor subtypes
    • A-receptor subtype-specificity of diazepam action.
    • (1999) Nature , vol.401 , pp. 796-800
    • Rudolph, U.1
  • 89
    • 0034613173 scopus 로고    scopus 로고
    • Molecular and neuronal substrate for the selective attenuation of anxiety
    • Löw, K. et al. Molecular and neuronal substrate for the selective attenuation of anxiety. Science 290, 131-134 (2000).
    • (2000) Science , vol.290 , pp. 131-134
    • Löw, K.1
  • 90
    • 0035122824 scopus 로고    scopus 로고
    • Molecular targets for the myorelaxant action of diazepam
    • Crestani, F. et al. Molecular targets for the myorelaxant action of diazepam. Mol. Pharmacol. 59, 442-445 (2001).
    • (2001) Mol. Pharmacol. , vol.59 , pp. 442-445
    • Crestani, F.1
  • 92
    • 0036754319 scopus 로고    scopus 로고
    • A receptor α1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem
    • A receptor α1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem. Neuropharmacology 43, 685-694 (2002).
    • (2002) Neuropharmacology , vol.43 , pp. 685-694
    • Kralic, J.E.1
  • 93
    • 0037294417 scopus 로고    scopus 로고
    • A α1 subunit knock-out mice do not show a hyperlocomotor response following amphetamine or cocaine treatment
    • A α1 subunit knock-out mice do not show a hyperlocomotor response following amphetamine or cocaine treatment. Neuropharmacology 44, 190-198 (2003).
    • (2003) Neuropharmacology , vol.44 , pp. 190-198
    • Reynolds, D.S.1
  • 95
    • 0028067785 scopus 로고
    • Therapy of Cushing's syndrome with steroid biosynthesis inhibitors
    • Engelhardt, D. & Weber, M. M. Therapy of Cushing's syndrome with steroid biosynthesis inhibitors. J. Steroid Biochem. Mol. Biol. 49, 261-267 (1994).
    • (1994) J. Steroid Biochem. Mol. Biol. , vol.49 , pp. 261-267
    • Engelhardt, D.1    Weber, M.M.2
  • 96
    • 0141767046 scopus 로고    scopus 로고
    • Activation of α2B-adrenoceptors mediates the cardiovascular effects of etomidate
    • Paris, A. et al. Activation of α2B-adrenoceptors mediates the cardiovascular effects of etomidate. Anesthesiology 99, 889-895 (2003).
    • (2003) Anesthesiology , vol.99 , pp. 889-895
    • Paris, A.1
  • 97
    • 0032521675 scopus 로고    scopus 로고
    • Adrenergic α2C-receptors modulate the acoustic startle reflex, prepulse inhibition, and aggression in mice
    • Sallinen, J., Haapalinna, A., Viitamaa, T., Kobilka, B. K. & Scheinin, M. Adrenergic α2C-receptors modulate the acoustic startle reflex, prepulse inhibition, and aggression in mice. J. Neurosci. 18, 3035-3042 (1998).
    • (1998) J. Neurosci. , vol.18 , pp. 3035-3042
    • Sallinen, J.1    Haapalinna, A.2    Viitamaa, T.3    Kobilka, B.K.4    Scheinin, M.5
  • 98
    • 0030610424 scopus 로고    scopus 로고
    • Substitution of a mutant α2a-adrenergic receptor via 'hit and run' gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo
    • Lakhlani, P. P. et al. Substitution of a mutant α2a-adrenergic receptor via 'hit and run' gene targeting reveals the role of this subtype In sedative, analgesic, and anesthetic-sparing responses in vivo. Proc. Natl Acad. Sci. USA 94, 9950-9955 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 9950-9955
    • Lakhlani, P.P.1
  • 99
    • 0030895793 scopus 로고    scopus 로고
    • Subunit-dependent interaction of the general anaesthetic etomidate with the γ-aminobutyric acid type A receptor
    • Hill-Venning, C., Belelli, D., Peters, J. A. & Lambert, J. J. Subunit-dependent interaction of the general anaesthetic etomidate with the γ-aminobutyric acid type A receptor. Br. J. Pharmacol. 120, 749-756 (1997).
    • (1997) Br. J. Pharmacol. , vol.120 , pp. 749-756
    • Hill-Venning, C.1    Belelli, D.2    Peters, J.A.3    Lambert, J.J.4
  • 100
    • 0029078958 scopus 로고
    • A receptors: Influence of receptor subunits
    • A receptors: influence of receptor subunits. J. Pharmacol. Exp. Ther. 274, 353-360 (1995).
    • (1995) J. Pharmacol. Exp. Ther. , vol.274 , pp. 353-360
    • Sanna, E.1
  • 101
    • 0030470999 scopus 로고    scopus 로고
    • A receptor activity by the novel water-soluble aminosteroid Org 20599
    • A receptor activity by the novel water-soluble aminosteroid Org 20599. Neuropharmacology 35, 1209-1222 (1996).
    • (1996) Neuropharmacology , vol.35 , pp. 1209-1222
    • Hill-Venning, C.1
  • 102
    • 0031435538 scopus 로고    scopus 로고
    • A and glycine receptors expressed in Xenopus laevis oocytes: A comparative study
    • A and glycine receptors expressed in Xenopus laevis oocytes: a comparative study. Br. J. Phamacol. 122, 1707-1719 (1997).
    • (1997) Br. J. Phamacol. , vol.122 , pp. 1707-1719
    • Pistis, M.1    Belelli, D.2    Peters, J.A.3    Lambert, J.J.4
  • 103
    • 0032713541 scopus 로고    scopus 로고
    • Interaction of intravenous anesthetics with human neuronal potassium currents in relation to clinical concentrations
    • Friederich, P. & Urban, B. W. Interaction of intravenous anesthetics with human neuronal potassium currents in relation to clinical concentrations. Anesthesiology 91, 1853-1860 (1999).
    • (1999) Anesthesiology , vol.91 , pp. 1853-1860
    • Friederich, P.1    Urban, B.W.2
  • 104
    • 0035209147 scopus 로고    scopus 로고
    • Widespread inhibition of sodium channel-dependent glutamate release from isolated nerve terminals by isoflurane and propofol
    • Lingamaneni, R., Birch, M. L. & Hemmings, H. C. Widespread inhibition of sodium channel-dependent glutamate release from isolated nerve terminals by isoflurane and propofol. Anesthesiology 95, 1460-1466 (2001).
    • (2001) Anesthesiology , vol.95 , pp. 1460-1466
    • Lingamaneni, R.1    Birch, M.L.2    Hemmings, H.C.3
  • 106
    • 0032889649 scopus 로고    scopus 로고
    • Non-volatile general anaesthetics reduce spinal activity by suppressing plateau potentials
    • Guertin, P. A. & Hounsgaard, J. Non-volatile general anaesthetics reduce spinal activity by suppressing plateau potentials. Neuroscience 88, 353-358 (1999).
    • (1999) Neuroscience , vol.88 , pp. 353-358
    • Guertin, P.A.1    Hounsgaard, J.2
  • 107
    • 0033567181 scopus 로고    scopus 로고
    • General anaesthetic actions on ligand-gated ion channels
    • Krasowski, M. D. & Harrison, N. L. General anaesthetic actions on ligand-gated ion channels. Cell. Mol. Life Sci. 55, 1278-1303 (1999).
    • (1999) Cell. Mol. Life Sci. , vol.55 , pp. 1278-1303
    • Krasowski, M.D.1    Harrison, N.L.2
  • 108
    • 0035253460 scopus 로고    scopus 로고
    • Propofol action in both spinal cord and brain blunts electroencephalographic responses to noxious stimulation in goats
    • Antognini, J. F., Saadi, J., Wang, X. W., Carstens, E. & Piercy, M. Propofol action in both spinal cord and brain blunts electroencephalographic responses to noxious stimulation in goats. Sleep 24, 26-31 (2001).
    • (2001) Sleep , vol.24 , pp. 26-31
    • Antognini, J.F.1    Saadi, J.2    Wang, X.W.3    Carstens, E.4    Piercy, M.5
  • 109
    • 2542486282 scopus 로고    scopus 로고
    • γ-aminobutyric acid type A receptor β2 subunit mediates the hypothermic effect of etomidate in mice
    • Cirone, J. et al. γ-aminobutyric acid type A receptor β2 subunit mediates the hypothermic effect of etomidate in mice. Anesthesiology 100, 1438-1445 (2004).
    • (2004) Anesthesiology , vol.100 , pp. 1438-1445
    • Cirone, J.1
  • 110
    • 0033775502 scopus 로고    scopus 로고
    • Effects of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels. Comparison with isoflurane and ethanol
    • Yamakura, T. & Harris, R. A. Effects of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels. Comparison with isoflurane and ethanol. Anesthesiology 93, 1095-1101 (2000).
    • (2000) Anesthesiology , vol.93 , pp. 1095-1101
    • Yamakura, T.1    Harris, R.A.2
  • 111
    • 0031937874 scopus 로고    scopus 로고
    • Nitrous oxide-induced enhancement of γ-aminobutyric acidA-mediated chloride currents in acutely dissociated hippocampal neurons
    • Dzoljic, M. & Van Duijn, B. Nitrous oxide-induced enhancement of γ-aminobutyric acidA-mediated chloride currents in acutely dissociated hippocampal neurons. Anesthesiology 88, 473-480 (1998).
    • (1998) Anesthesiology , vol.88 , pp. 473-480
    • Dzoljic, M.1    Van Duijn, B.2
  • 113
    • 0032400787 scopus 로고    scopus 로고
    • Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures
    • Mennerick, S. et al. Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures. J. Neurosci. 18, 9716-9726 (1998).
    • (1998) J. Neurosci. , vol.18 , pp. 9716-9726
    • Mennerick, S.1
  • 114
    • 2642593034 scopus 로고    scopus 로고
    • Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin
    • Jevtovic-Todorovic, V. et al. Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nature Med. 4, 460-463 (1998).
    • (1998) Nature Med. , vol.4 , pp. 460-463
    • Jevtovic-Todorovic, V.1
  • 115
    • 0036894938 scopus 로고    scopus 로고
    • Propofol and sevoflurane in subanesthetic concentrations act preferentially on the spinal cord: Evidence from multimodal electrophysiological assessment
    • Kammer, T. et al. Propofol and sevoflurane in subanesthetic concentrations act preferentially on the spinal cord: evidence from multimodal electrophysiological assessment. Anesthesiology 97, 1416-1425 (2002).
    • (2002) Anesthesiology , vol.97 , pp. 1416-1425
    • Kammer, T.1
  • 116
    • 7244221691 scopus 로고    scopus 로고
    • Propofol and sevoflurane depress spinal neurons in vitro via different molecular targets
    • in the press
    • Grasshoff, C. & Antkowiak, B. Propofol and sevoflurane depress spinal neurons in vitro via different molecular targets. Anesthesiology (in the press).
    • Anesthesiology
    • Grasshoff, C.1    Antkowiak, B.2
  • 117
    • 0036068855 scopus 로고    scopus 로고
    • Current assessment of targets and theories of anaesthesia
    • Urban, B. W. Current assessment of targets and theories of anaesthesia. Br. J. Anaesth. 89, 167-183 (2002).
    • (2002) Br. J. Anaesth. , vol.89 , pp. 167-183
    • Urban, B.W.1


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