An inverse agonist selective for α5 subunit-containing GABA A receptors enhances cognition

Journal of Pharmacology and Experimental Therapeutics

Volumn 316, Issue 3, 2006, Pages 1335-1345

  Dawson, G R ^a   Maubach, K A ^a   Collinson, N ^a   Cobain, M ^b   Everitt, B J ^b   MacLeod, A M ^a   Choudhury, H I ^a   McDonald, L M ^a   Pillai, G ^a   Rycroft, W ^a   Smith, A J ^a   Sternfeld, F ^a   Tattersall, F D ^a   Wafford, K A ^a   Reynolds, D S ^a   Seabrook, G R ^c   Atack, J R ^a,d  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b UK   (United Kingdom)

^c MERCK RESEARCH LABORATORIES   (United States)

^d NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA5; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 ETHYL 6,7 DIMETHOXY BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; BENZODIAZEPINE; DIAZEPAM; FLUMAZENIL; N METHYL BETA CARBOLINE 3 CARBOXAMIDE; PENTETRAZOLE; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG; WATER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN REGION; BRAIN SLICE; CHRONIC DRUG ADMINISTRATION; CLONIC SEIZURE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; CONVULSION; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG TARGETING; EXCITATORY POSTSYNAPTIC POTENTIAL; EXPERIMENTAL MODEL; FEAR; HIPPOCAMPUS; HUMAN; INFUSION; KINDLING; LEARNING; LONG TERM POTENTIATION; MALE; MAZE TEST; MEMORY; MOUSE; NEUROLOGIC EXAMINATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; ROTAROD TEST; TASK PERFORMANCE; THETA RHYTHM; TONIC SEIZURE;

ANIMALS; COGNITION; DOSE-RESPONSE RELATIONSHIP, DRUG; GABA AGONISTS; HIPPOCAMPUS; HUMANS; KINDLING, NEUROLOGIC; LONG-TERM POTENTIATION; MALE; MAZE LEARNING; MICE; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; XENOPUS LAEVIS;

EID: 33644749350     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.092320     Document Type: Article

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