Evidence for a significant role of α3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines

Journal of Neuroscience

Volumn 25, Issue 46, 2005, Pages 10682-10688

  Dias, Rebecca ^a   Sheppard, Wayne F A ^a   Fradley, Rosa L ^a   Garrett, Elizabeth M ^a   Stanley, Joanna L ^a   Tye, Spencer J ^a   Goodacre, Simon ^a   Lincoln, Rachael J ^a   Cook, Susan M ^a   Conley, Rachel ^a   Hallett, David ^a   Humphries, Alexander C ^a   Thompson, Sally A ^a   Wafford, Keith A ^a   Street, Leslie J ^a   Castro, J Luis ^a   Whiting, Paul J ^a   Rosahl, Thomas W ^a   Atack, John R ^a   McKernan, Ruth M ^a   Dawson, Gerard R ^a   Reynolds, David S ^a   more..

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

3 subunit; Agonist; Anxiety; Benzodiazepine; GABAA; Stress induced hyperthermia

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4,2' DIFLUORO 5' [8 FLUORO 7 (1 HYDROXY 1 METHYLETHYL)IMIDAZO[1,2 A]PYRIDIN 3 YL]BIPHENYL 2 CARBONITRILE; BENZODIAZEPINE DERIVATIVE; CHLORDIAZEPOXIDE; CYANIDE; DIAZEPAM; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; BINDING AFFINITY; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; HYPERTHERMIA; LIGHT DARK CYCLE; MAZE TEST; MOLECULAR GENETICS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RAT; STRESS; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; BENZODIAZEPINES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; MICE; MICE, TRANSGENIC; PROTEIN BINDING; PROTEIN SUBUNITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SAIMIRI;

EID: 27944507635     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1166-05.2005     Document Type: Article

References (33)

1. A receptors as a target for the development of novel anxiolytics. Expert Opin Investig Drugs 14:601-618.
2. A receptors. Neuropsychopharmacology 20:255-262.
3. A receptors. Br J Pharmacol 144:357-366.
4. A receptors. Br J Pharmacol 136:965-974.
5. A receptor. J Neurosci 22:5572-5580.
6. A receptors containing the α2-subunit. Trends Pharmacol Sci 22:403.
7. A receptors. Proc Natl Acad Sci USA 99:8980-8985.
8. Davis M (2000) The role of the amygdala in conditioned and unconditioned fear and anxiety. In: The amygdala (Aggleton JP, ed), pp 213-287. New York: Oxford UP.
9. Facklam M, Schoch P, Bonetti EP, Jenck F, Martin JR, Moreau JL, Haefely WE (1992) Relationship between benzodiazepine receptor occupancy and functional effects in vivo of four ligands of differing intrinsic efficacies. J Pharmacol Exp Ther 261:1113-1121.
10. Fendt M, Fanslow MS (1999) The neuroanatomical and neurochemical basis of conditioned fear. Neurosci Biobehav Rev 23:743-760.
11. A receptors. Mol Pharmacol 43:970-975.
12. Hadingham KL, Garrett EM, Wafford KA, Bain C, Heavens RP, Sirinathsinghji DJ, Whiting PJ (1996) Cloning of cDNAs encoding the human γ-aminobutyric acid type A receptor α6 subunit and characterization of the pharmacology of α6-containing receptors. Mol Pharmacol 49:253-259.
13. A receptors. Soc Neurosci Abstr 28:491.8.
14. Johnstone TB, Hogenkamp DJ, Coyne L, Su J, Halliwell RF, Tran MB, Yoshimura RF, Li WY, Wang J, Gee KW (2004) Modifying quinolone antibiotics yields new anxiolytics. Nat Med 10:31-32.
15. Kalin NH, Shelton SE, Davidson RJ, Kelley AE (2001) The primate amygdala mediates acute fear but not the behavioral and physiological components of anxious temperament. J Neurosci 21:2067-2074.
16. LeDoux JE (2000) The amygdala and emotion. In: The amygdala (Aggleton JP, ed), pp 289-310. New York: Oxford UP.
17. Low K, Crestani F, Keist R, Benke D, Brunig I, Benson JA, Fritschy JM, Rulicke T, Bluethmann H, Mohler H, Rudolph U (2000) Molecular and neuronal substrate for the selective attenuation of anxiety. Science 290:131-134.
18. Marazziti D, Di Muro A, Castrogiovanni P (1992) Psychological stress and body temperature changes in humans. Physiol Behav 52:393-395.
19. A receptor subtypes in the amygdala. Eur J Neurosci 20:1281-1289.
20. A receptor α1 subtype. Nat Neurosci 3:587-591.
21. Olivier B, Zethof T, Pattij T, van Boogaert M, van Oorschot R, Leahy C, Oosting R, Bouwknecht A, Veening J, van der Gugten J, Groenink L (2003) Stress-induced hyperthermia and anxiety: pharmacological validation. Eur J Pharmacol 463:117-132.
22. Pesold C, Treit D (1994) The septum and amygdala differentially mediate the anxiolytic effects of benzodiazepines. Brain Res 638:295-301.
23. A receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 101:815-850.
24. Pritchett DB, Seeburg PH (1990) Gamma-aminobutyric acid A receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology. J Neurochem 54:1802-1804.
25. A-benzodiazepine receptors produced in transfected cells. Science 245:1389-1392.
26. A receptor subtype is involved? Trends Pharmacol Sci 22:402-403.
27. A receptor subtype mediates the anxiolytic effects of benzodiazepines: is it alpha2 or alpha3? FENS Forum Abstr 1:154.13.
28. Rudolph U, Crestani F, Benke D, Brunig I, Benson JA, Fritschy JM, Martin JR, Bluethmann H, Mohler H (1999) Benzodiazepine actions mediated by specific γ-aminobutyric acid A receptor subtypes. Nature 401:796-800.
29. A receptor subtypes: dissecting their pharmacological functions. Trends Pharmacol Sci 22:188-194.
30. Schwenk F, Baron U, Rajewsky KA (1995) Cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res 23:5080-5081.
31. Wafford K, Thompson S, Thomas D, Sikela J, Wilcox A, Whiting P (1996) Functional characterization of human gamma-aminobutyric acid A receptors containing the α4 subunit. Mol Pharmacol 50:670-678.
32. A) receptor subtypes. Biochem Soc Trans 32:553-556.
33. Walker DL, Toufexis DJ, Davis M (2003) Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety. Eur J Pharmacol 463:199-216.