RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors

Psychopharmacology

Volumn 202, Issue 1-3, 2009, Pages 207-223

  Ballard, Theresa M ^a   Knoflach, Frédéric ^a   Prinssen, Eric ^a   Borroni, Edilio ^a   Vivian, Jeffrey A ^a,b,c   Basile, Jennifer ^a,b   Gasser, Rodolfo ^a   Moreau, Jean Luc ^a   Wettstein, Joseph G ^a   Buettelmann, Bernd ^a   Knust, Henner ^a   Thomas, Andrew W ^a   Trube, Gerhard ^a   Hernandez, Maria Clemencia ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b ROCHE BIOSCIENCE   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Benzodiazepine; Cognition; Delayed match to position; GABAA receptors; Inverse agonist; Long term potentiation; Monkey; Morris water maze; Object retrieval; Rat

Indexed keywords

3 BROMO 10 DIFLUOROMETHYL 9H IMIDAZO[1,5 A][1,2,4]TRIAZOLO[1,5 D][1,4]BENZODIAZEPINE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; DIAZEPAM; FLUMAZENIL; RO 0194603; RO 4938581; SCOPOLAMINE; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL TISSUE; ARTICLE; AUDIOGENIC SEIZURE; BRAIN SLICE; CELL STRAIN HEK293; COGNITION; CONTROLLED STUDY; EPILEPTOGENESIS; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN CELL; INVERSE AGONISM; LEARNING; LOCOMOTION; LONG TERM POTENTIATION; MACACA; MALE; MAZE TEST; MOUSE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY; RAT; RECEPTOR OCCUPANCY; SPATIAL DISCRIMINATION; SPATIAL MEMORY; WORKING MEMORY;

ANIMALS; BENZODIAZEPINES; CELL LINE; COGNITION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HAPLORHINI; HIPPOCAMPUS; IMIDAZOLES; LEARNING; LONG-TERM POTENTIATION; MALE; MEMBRANES; MEMORY; MICE; MICE, INBRED DBA; MOTOR ACTIVITY; NOOTROPIC AGENTS; PATCH-CLAMP TECHNIQUES; PLASMIDS; RATS; RATS, WISTAR; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; SEIZURES;

EID: 59449106007     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-008-1357-7     Document Type: Article

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