3-Heteroaryl-2-pyridones: Benzodiazepine site ligands with functional selectivity for α2/α3-subtypes of human GABAa receptor-ion channels

Journal of Medicinal Chemistry

Volumn 45, Issue 9, 2002, Pages 1887-1900

  Collins, Ian ^a   Wafford, Keith ^a   Dawson, Gerard R ^a   Moyes, Christopher ^a   Davey, William B ^a   Rowley, Michael ^a   Bromidge, Frances A ^a   Quirk, Kathleen ^a   Atack, John R ^a   McKernan, Ruth M ^a   Thompson, Sally Ann ^a   Pike, Andrew ^a   Sohal, Bindi ^a   Tsou, Nancy N ^a,b   Ball, Richard G ^a,b   Castro, José L ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 3 CYANO 2 PYRIDONE; 2 PYRIDONE DERIVATIVE; 3 CARBOMETHOXY 2 PYRIDONE; 3 CYANO 2 PYRIDONE; 4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE; ION CHANNEL; PYRIDONE DERIVATIVE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; NEUROTRANSMISSION; NONHUMAN; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; BIOLOGICAL AVAILABILITY; BRAIN; CELL LINE; CONVULSANTS; CRYSTALLOGRAPHY, X-RAY; EPILEPSY; GABA AGONISTS; HUMANS; LIGANDS; MAZE LEARNING; MICE; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; PYRIDONES; RADIOLIGAND ASSAY; RATS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 0037171775     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0110789     Document Type: Article

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