메뉴 건너뛰기




Volumn 18, Issue 9, 2014, Pages 1840-1850

Role of duodenal iron transporters and hepcidin in patients with alcoholic liver disease

Author keywords

Alcoholic liver disease; DCYTB; DMT1; FPN1; Gene expression; Hepcidin; HEPH; HFE; Iron; TFR1

Indexed keywords

CATION TRANSPORT PROTEIN; CYBRD1 PROTEIN, HUMAN; CYTOCHROME B; HEPCIDIN; HEPH PROTEIN, HUMAN; IRON; MEMBRANE PROTEIN; METAL TRANSPORTING PROTEIN 1; OXIDOREDUCTASE; SOLUTE CARRIER FAMILY 11- (PROTON-COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2;

EID: 84908247563     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12310     Document Type: Article
Times cited : (44)

References (62)
  • 1
    • 0019985082 scopus 로고
    • Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis
    • Chapman RW, Morgan MY, Laulicht M, et al. Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis. Dig Dis Sci. 1982; 27: 909-16.
    • (1982) Dig Dis Sci , vol.27 , pp. 909-916
    • Chapman, R.W.1    Morgan, M.Y.2    Laulicht, M.3
  • 2
    • 1942487211 scopus 로고    scopus 로고
    • Excess alcohol consumption is common in patients with cytopenia: studies in blood and bone marrow cells
    • Latvala J, Parkkila S, Niemelä O. Excess alcohol consumption is common in patients with cytopenia: studies in blood and bone marrow cells. Alcohol Clin Exp Res. 2004; 28: 619-24.
    • (2004) Alcohol Clin Exp Res , vol.28 , pp. 619-624
    • Latvala, J.1    Parkkila, S.2    Niemelä, O.3
  • 3
    • 0034954325 scopus 로고    scopus 로고
    • Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers
    • Whitfield JB, Zhu G, Heath AC, et al. Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers. Alcohol Clin Exp Res. 2001; 25: 1037-45.
    • (2001) Alcohol Clin Exp Res , vol.25 , pp. 1037-1045
    • Whitfield, J.B.1    Zhu, G.2    Heath, A.C.3
  • 4
    • 80051550534 scopus 로고    scopus 로고
    • Alcohol screening scores and the risk of new-onset gastrointestinal illness or related hospitalization
    • Lembke A, Bradley KA, Henderson P, et al. Alcohol screening scores and the risk of new-onset gastrointestinal illness or related hospitalization. J Gen Intern Med. 2011; 26: 777-82.
    • (2011) J Gen Intern Med , vol.26 , pp. 777-782
    • Lembke, A.1    Bradley, K.A.2    Henderson, P.3
  • 5
    • 0030813340 scopus 로고    scopus 로고
    • Relationship between portal pressure, esophageal varices, and variceal bleeding on the basis of the stage and cause of cirrhosis
    • Le Moine O, Hadengue A, Moreau R, et al. Relationship between portal pressure, esophageal varices, and variceal bleeding on the basis of the stage and cause of cirrhosis. Scand J Gastroenterol. 1997; 32: 731-5.
    • (1997) Scand J Gastroenterol , vol.32 , pp. 731-735
    • Le Moine, O.1    Hadengue, A.2    Moreau, R.3
  • 6
    • 36549090556 scopus 로고    scopus 로고
    • Hypersplenism is related to age of onset of liver disease
    • McCormick PA, Walker S, Benepal R. Hypersplenism is related to age of onset of liver disease. Ir J Med Sci. 2007; 176: 293-6.
    • (2007) Ir J Med Sci , vol.176 , pp. 293-296
    • McCormick, P.A.1    Walker, S.2    Benepal, R.3
  • 7
    • 0031985563 scopus 로고    scopus 로고
    • Haemodynamic parameters predicting variceal haemorrhage and survival in alcoholic cirrhosis
    • Stanley AJ, Robinson I, Forrest EH, et al. Haemodynamic parameters predicting variceal haemorrhage and survival in alcoholic cirrhosis. Q J Med. 1998; 91: 19-25.
    • (1998) Q J Med , vol.91 , pp. 19-25
    • Stanley, A.J.1    Robinson, I.2    Forrest, E.H.3
  • 8
    • 0018652845 scopus 로고
    • Splenic influences on the blood in chronic liver disease
    • Toghill PJ, Green S. Splenic influences on the blood in chronic liver disease. Q J Med. 1979; 48: 613-25.
    • (1979) Q J Med , vol.48 , pp. 613-625
    • Toghill, P.J.1    Green, S.2
  • 9
    • 0035171536 scopus 로고    scopus 로고
    • Red blood cell status in alcoholic and non-alcoholic liver disease
    • Maruyama S, Hirayama C, Yamamoto S, et al. Red blood cell status in alcoholic and non-alcoholic liver disease. J Lab Clin Med. 2001; 138: 332-7.
    • (2001) J Lab Clin Med , vol.138 , pp. 332-337
    • Maruyama, S.1    Hirayama, C.2    Yamamoto, S.3
  • 12
    • 33644930840 scopus 로고    scopus 로고
    • HFE genotypes in decompensated alcoholic liver disease: phenotypic expression and comparison with heavy drinking and with normal controls
    • Gleeson D, Evans S, Bradley M, et al. HFE genotypes in decompensated alcoholic liver disease: phenotypic expression and comparison with heavy drinking and with normal controls. Am J Gastroenterol. 2006; 101: 304-10.
    • (2006) Am J Gastroenterol , vol.101 , pp. 304-310
    • Gleeson, D.1    Evans, S.2    Bradley, M.3
  • 13
    • 2142809627 scopus 로고    scopus 로고
    • The effect of alcohol consumption on the prevalence of iron overload, iron deficiency, and iron deficiency anemia
    • Ioannou GN, Dominitz JA, Weiss NS, et al. The effect of alcohol consumption on the prevalence of iron overload, iron deficiency, and iron deficiency anemia. Gastroenterology. 2004; 126: 1293-301.
    • (2004) Gastroenterology , vol.126 , pp. 1293-1301
    • Ioannou, G.N.1    Dominitz, J.A.2    Weiss, N.S.3
  • 14
    • 0027053580 scopus 로고
    • Intestinal iron absorption in chronic alcoholics
    • Duane P, Raja KB, Simpson RJ, et al. Intestinal iron absorption in chronic alcoholics. Alcohol Alcohol. 1992; 27: 539-44.
    • (1992) Alcohol Alcohol , vol.27 , pp. 539-544
    • Duane, P.1    Raja, K.B.2    Simpson, R.J.3
  • 15
    • 0034800841 scopus 로고    scopus 로고
    • Serum thioredoxin elucidates the significance of serum ferritin as a marker of oxidative stress in chronic liver diseases
    • Sumida Y, Nakashima T, Yoh T, et al. Serum thioredoxin elucidates the significance of serum ferritin as a marker of oxidative stress in chronic liver diseases. Liver. 2001; 21: 295-9.
    • (2001) Liver , vol.21 , pp. 295-299
    • Sumida, Y.1    Nakashima, T.2    Yoh, T.3
  • 16
    • 4243607831 scopus 로고
    • Toxicity of iron and hydrogen peroxide: the Fenton reaction
    • Winterbourn CC. Toxicity of iron and hydrogen peroxide: the Fenton reaction. Toxicol Lett. 1995; 82-83: 969-74.
    • (1995) Toxicol Lett , vol.82-83 , pp. 969-974
    • Winterbourn, C.C.1
  • 17
    • 84864127033 scopus 로고    scopus 로고
    • Ferric citrate CYP2E1-independently promotes alcohol-induced apoptosis in HepG2 cells via oxidative/nitrative stress which is attenuated by pretreatment with baicalin
    • Xu Y, Feng Y, Li H, et al. Ferric citrate CYP2E1-independently promotes alcohol-induced apoptosis in HepG2 cells via oxidative/nitrative stress which is attenuated by pretreatment with baicalin. Food Chem Toxicol. 2012; 50: 3264-72.
    • (2012) Food Chem Toxicol , vol.50 , pp. 3264-3272
    • Xu, Y.1    Feng, Y.2    Li, H.3
  • 18
    • 0035793856 scopus 로고    scopus 로고
    • An iron-regulated ferric reductase associated with the absorption of dietary iron
    • McKie AT, Barrow D, Latunde-Dada GO, et al. An iron-regulated ferric reductase associated with the absorption of dietary iron. Science. 2001; 291: 1755-9.
    • (2001) Science , vol.291 , pp. 1755-1759
    • McKie, A.T.1    Barrow, D.2    Latunde-Dada, G.O.3
  • 19
    • 0030763856 scopus 로고    scopus 로고
    • Microcytic anemia mice have a mutation in Nramp2, a candidate iron transporter
    • Fleming MD, Trenor CC, Su MA, et al. Microcytic anemia mice have a mutation in Nramp2, a candidate iron transporter. Nat Genet. 1997; 16: 383-6.
    • (1997) Nat Genet , vol.16 , pp. 383-386
    • Fleming, M.D.1    Trenor, C.C.2    Su, M.A.3
  • 20
    • 0030755366 scopus 로고    scopus 로고
    • Cloning and characterization of a mammalian proton-coupled metal-ion transporter
    • Gunshin H, Mackenzie B, Berger UV, et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 1997; 388: 482-8.
    • (1997) Nature , vol.388 , pp. 482-488
    • Gunshin, H.1    Mackenzie, B.2    Berger, U.V.3
  • 21
    • 0034733635 scopus 로고    scopus 로고
    • A novel mammalian iron-regulated protein involved in intracellular iron metabolism
    • Abboud S, Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J BiolChem. 2000; 275: 19906-12.
    • (2000) J BiolChem , vol.275 , pp. 19906-19912
    • Abboud, S.1    Haile, D.J.2
  • 22
    • 0034677467 scopus 로고    scopus 로고
    • Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
    • Donovan A, Brownlie A, Zhou Y, et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000; 403: 776-81.
    • (2000) Nature , vol.403 , pp. 776-781
    • Donovan, A.1    Brownlie, A.2    Zhou, Y.3
  • 23
    • 0033861745 scopus 로고    scopus 로고
    • A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
    • McKie AT, Marciani P, Rolfs A, et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell. 2000; 5: 299-309.
    • (2000) Mol Cell , vol.5 , pp. 299-309
    • McKie, A.T.1    Marciani, P.2    Rolfs, A.3
  • 24
    • 0032875387 scopus 로고    scopus 로고
    • Targeted gene disruption reveals an essential rolefor ceruloplasmin in cellular iron efflux
    • Harris ZL, Durley AP, Man TK, et al. Targeted gene disruption reveals an essential rolefor ceruloplasmin in cellular iron efflux. Proc Natl Acad Sci USA. 1999; 96: 10812-7.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10812-10817
    • Harris, Z.L.1    Durley, A.P.2    Man, T.K.3
  • 25
    • 9344224529 scopus 로고    scopus 로고
    • A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
    • Feder JN, Gnirke A, Thomas W, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet. 1996; 13: 399-408.
    • (1996) Nat Genet , vol.13 , pp. 399-408
    • Feder, J.N.1    Gnirke, A.2    Thomas, W.3
  • 26
    • 13144282684 scopus 로고    scopus 로고
    • The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding
    • Feder JN, Penny DM, Irrinki A, et al. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci USA. 1998; 95: 1472-7.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 1472-1477
    • Feder, J.N.1    Penny, D.M.2    Irrinki, A.3
  • 27
    • 0030712463 scopus 로고    scopus 로고
    • Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis
    • Parkkila S, Waheed A, Britton RS, et al. Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis. Proc Natl Acad Sci USA. 1997; 94: 13198-202.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13198-13202
    • Parkkila, S.1    Waheed, A.2    Britton, R.S.3
  • 28
    • 33749393565 scopus 로고    scopus 로고
    • Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing
    • Goswami T, Andrews NC. Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. J Biol Chem. 2006; 281: 28494-8.
    • (2006) J Biol Chem , vol.281 , pp. 28494-28498
    • Goswami, T.1    Andrews, N.C.2
  • 29
    • 60649103774 scopus 로고    scopus 로고
    • Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression
    • Gao J, Chen J, Kramer M, et al. Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metab. 2009; 9: 217-27.
    • (2009) Cell Metab , vol.9 , pp. 217-227
    • Gao, J.1    Chen, J.2    Kramer, M.3
  • 30
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    • Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest. 2002; 110: 1037-44.
    • (2002) J Clin Invest , vol.110 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3
  • 31
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004; 306: 2090-3.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3
  • 32
    • 33750133047 scopus 로고    scopus 로고
    • Regulation of iron metabolism by hepcidin
    • Nemeth E, Ganz T. Regulation of iron metabolism by hepcidin. Annu Rev Nutr. 2006; 26: 323-42.
    • (2006) Annu Rev Nutr , vol.26 , pp. 323-342
    • Nemeth, E.1    Ganz, T.2
  • 34
    • 0036727925 scopus 로고    scopus 로고
    • Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats
    • Frazer DM, Wilkins SJ, Becker EM, et al. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology. 2002; 123: 835-44.
    • (2002) Gastroenterology , vol.123 , pp. 835-844
    • Frazer, D.M.1    Wilkins, S.J.2    Becker, E.M.3
  • 35
    • 0035902605 scopus 로고    scopus 로고
    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    • Nicolas G, Bennoun M, Devaux I, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA. 2001; 98: 8780-5.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8780-8785
    • Nicolas, G.1    Bennoun, M.2    Devaux, I.3
  • 36
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem. 2001; 276: 7811-9.
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3
  • 37
    • 0037460697 scopus 로고    scopus 로고
    • Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
    • Bridle KR, Frazer DM, Wilkins SJ, et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet. 2003; 361: 669-73.
    • (2003) Lancet , vol.361 , pp. 669-673
    • Bridle, K.R.1    Frazer, D.M.2    Wilkins, S.J.3
  • 38
    • 34147197662 scopus 로고    scopus 로고
    • Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications
    • Kemna EH, Tjalsma H, Podust VN, et al. Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications. Clin Chem. 2007; 53: 620-8.
    • (2007) Clin Chem , vol.53 , pp. 620-628
    • Kemna, E.H.1    Tjalsma, H.2    Podust, V.N.3
  • 39
    • 13544250486 scopus 로고    scopus 로고
    • Hepcidin is decreased in TFR2 hemochromatosis
    • Nemeth E, Roetto A, Garozzo G, et al. Hepcidin is decreased in TFR2 hemochromatosis. Blood. 2005; 105: 1803-6.
    • (2005) Blood , vol.105 , pp. 1803-1806
    • Nemeth, E.1    Roetto, A.2    Garozzo, G.3
  • 40
    • 33644773569 scopus 로고    scopus 로고
    • Hepcidin is down-regulated in alcoholic liver injury: implications for the pathogenesis of alcoholic liver disease
    • Bridle K, Cheung TK, Murphy T, et al. Hepcidin is down-regulated in alcoholic liver injury: implications for the pathogenesis of alcoholic liver disease. Alcohol Clin Exp Res. 2006; 30: 106-12.
    • (2006) Alcohol Clin Exp Res , vol.30 , pp. 106-112
    • Bridle, K.1    Cheung, T.K.2    Murphy, T.3
  • 41
    • 33747359666 scopus 로고    scopus 로고
    • Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression
    • Harrison-Findik DD, Schafer D, Klein E, et al. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem. 2006; 281: 22974-82.
    • (2006) J Biol Chem , vol.281 , pp. 22974-22982
    • Harrison-Findik, D.D.1    Schafer, D.2    Klein, E.3
  • 42
    • 34848838993 scopus 로고    scopus 로고
    • Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol
    • Harrison-Findik DD, Klein E, Crist C, et al. Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol. Hepatology. 2007; 46: 1979-85.
    • (2007) Hepatology , vol.46 , pp. 1979-1985
    • Harrison-Findik, D.D.1    Klein, E.2    Crist, C.3
  • 43
    • 68149094347 scopus 로고    scopus 로고
    • Hepcidin regulation in wild-type and Hfe knockout mice in response to alcohol consumption: evidence for an alcohol-induced hypoxic response
    • Heritage ML, Murphy TL, Bridle KR, et al. Hepcidin regulation in wild-type and Hfe knockout mice in response to alcohol consumption: evidence for an alcohol-induced hypoxic response. Alcohol Clin Exp Res. 2009; 33: 1391-400.
    • (2009) Alcohol Clin Exp Res , vol.33 , pp. 1391-1400
    • Heritage, M.L.1    Murphy, T.L.2    Bridle, K.R.3
  • 44
    • 84864381336 scopus 로고    scopus 로고
    • Duodenal expression of iron transport molecules in patients with hereditary hemochromatosis or iron deficiency
    • Dostalikova-Cimburova M, Kratka K, Balusikova K, et al. Duodenal expression of iron transport molecules in patients with hereditary hemochromatosis or iron deficiency. J Cell Mol Med. 2012; 16: 1816-26.
    • (2012) J Cell Mol Med , vol.16 , pp. 1816-1826
    • Dostalikova-Cimburova, M.1    Kratka, K.2    Balusikova, K.3
  • 45
    • 30344479814 scopus 로고    scopus 로고
    • S65C and other mutations in the haemochromatosis gene in the Czech population
    • Cimburova M, Putova I, Provaznikova H, et al. S65C and other mutations in the haemochromatosis gene in the Czech population. Folia Biol (Praha). 2005; 51: 172-6.
    • (2005) Folia Biol (Praha) , vol.51 , pp. 172-176
    • Cimburova, M.1    Putova, I.2    Provaznikova, H.3
  • 46
    • 33748782518 scopus 로고    scopus 로고
    • Stimulation of non-transferrin iron uptake by iron deprivation in K562 cells
    • Kovar J, Neubauerova J, Cimburova M, et al. Stimulation of non-transferrin iron uptake by iron deprivation in K562 cells. Blood Cells Mol Dis. 2006; 37: 95-9.
    • (2006) Blood Cells Mol Dis , vol.37 , pp. 95-99
    • Kovar, J.1    Neubauerova, J.2    Cimburova, M.3
  • 47
    • 0037126002 scopus 로고    scopus 로고
    • Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function
    • Hubert N, Hentze MW. Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc Natl Acad Sci USA. 2002; 99: 12345-50.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12345-12350
    • Hubert, N.1    Hentze, M.W.2
  • 48
    • 37449009448 scopus 로고    scopus 로고
    • Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum
    • Galy B, Ferring-Appel D, Kaden S, et al. Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. Cell Metab. 2008; 7: 79-85.
    • (2008) Cell Metab , vol.7 , pp. 79-85
    • Galy, B.1    Ferring-Appel, D.2    Kaden, S.3
  • 49
    • 58149158220 scopus 로고    scopus 로고
    • Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2
    • Foot NJ, Dalton HE, Shearwin-Whyatt LM, et al. Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. Blood. 2008; 112: 4268-75.
    • (2008) Blood , vol.112 , pp. 4268-4275
    • Foot, N.J.1    Dalton, H.E.2    Shearwin-Whyatt, L.M.3
  • 50
    • 84861181705 scopus 로고    scopus 로고
    • DMT1 (IRE) expression in intestinal and erythroid cells is regulated by peripheral benzodiazepine receptor-associated protein 7
    • Okazaki Y, Ma Z, Yeh M, et al. DMT1 (IRE) expression in intestinal and erythroid cells is regulated by peripheral benzodiazepine receptor-associated protein 7. Am J Physiol Gastrointest Liver Physiol. 2012; 302: G1180-90.
    • (2012) Am J Physiol Gastrointest Liver Physiol , vol.302 , pp. G1180-G1190
    • Okazaki, Y.1    Ma, Z.2    Yeh, M.3
  • 51
    • 77956054423 scopus 로고    scopus 로고
    • Regulation of divalent metal transporter 1 (DMT1) non-IRE isoform by the microRNA Let-7d in erythroid cells
    • Andolfo I, De Falco L, Asci R, et al. Regulation of divalent metal transporter 1 (DMT1) non-IRE isoform by the microRNA Let-7d in erythroid cells. Haematologica. 2010; 95: 1244-52.
    • (2010) Haematologica , vol.95 , pp. 1244-1252
    • Andolfo, I.1    De Falco, L.2    Asci, R.3
  • 52
    • 3242735594 scopus 로고    scopus 로고
    • Increased DMT1 but not IREG1 or HFE mRNA following iron depletion therapy in hereditary haemochromatosis
    • Kelleher T, Ryan E, Barrett S, et al. Increased DMT1 but not IREG1 or HFE mRNA following iron depletion therapy in hereditary haemochromatosis. Gut. 2004; 53: 1174-9.
    • (2004) Gut , vol.53 , pp. 1174-1179
    • Kelleher, T.1    Ryan, E.2    Barrett, S.3
  • 53
    • 73549092684 scopus 로고    scopus 로고
    • Relationship between gene expression of duodenal iron transporters and iron stores in hemochromatosis subjects
    • Nelson JE, Mugford VR, Kilcourse E, et al. Relationship between gene expression of duodenal iron transporters and iron stores in hemochromatosis subjects. Am J Physiol Gastrointest Liver Physiol. 2010; 298: G57-62.
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.298 , pp. G57-G62
    • Nelson, J.E.1    Mugford, V.R.2    Kilcourse, E.3
  • 54
    • 0038460956 scopus 로고    scopus 로고
    • Duodenal expression of iron transport molecules in untreated haemochromatosis subjects
    • Stuart KA, Anderson GJ, Frazer DM, et al. Duodenal expression of iron transport molecules in untreated haemochromatosis subjects. Gut. 2003; 52: 953-9.
    • (2003) Gut , vol.52 , pp. 953-959
    • Stuart, K.A.1    Anderson, G.J.2    Frazer, D.M.3
  • 55
    • 78649634981 scopus 로고    scopus 로고
    • Hepcidin in human iron disorders: therapeutic implications
    • Pietrangelo A. Hepcidin in human iron disorders: therapeutic implications. J Hepatol. 2011; 54: 173-81.
    • (2011) J Hepatol , vol.54 , pp. 173-181
    • Pietrangelo, A.1
  • 56
    • 69949088488 scopus 로고    scopus 로고
    • Hepcidin, the iron watcher
    • Viatte L, Vaulont S. Hepcidin, the iron watcher. Biochimie. 2009; 91: 1223-8.
    • (2009) Biochimie , vol.91 , pp. 1223-1228
    • Viatte, L.1    Vaulont, S.2
  • 57
    • 67149084949 scopus 로고    scopus 로고
    • Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications
    • Theurl I, Aigner E, Theurl M, et al. Regulation of iron homeostasis in anemia of chronic disease and iron deficiency anemia: diagnostic and therapeutic implications. Blood. 2009; 113: 5277-86.
    • (2009) Blood , vol.113 , pp. 5277-5286
    • Theurl, I.1    Aigner, E.2    Theurl, M.3
  • 58
    • 47049116150 scopus 로고    scopus 로고
    • Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha
    • Pinto JP, Ribeiro S, Pontes H, et al. Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha. Blood. 2008; 111: 5727-33.
    • (2008) Blood , vol.111 , pp. 5727-5733
    • Pinto, J.P.1    Ribeiro, S.2    Pontes, H.3
  • 59
    • 0026567061 scopus 로고
    • Regulation of transferrin, transferrin receptor, and ferritin genes in human duodenum
    • Pietrangelo A, Rocchi E, Casalgrandi G, et al. Regulation of transferrin, transferrin receptor, and ferritin genes in human duodenum. Gastroenterology. 1992; 102: 802-9.
    • (1992) Gastroenterology , vol.102 , pp. 802-809
    • Pietrangelo, A.1    Rocchi, E.2    Casalgrandi, G.3
  • 60
    • 32044456491 scopus 로고    scopus 로고
    • Iron accumulation in alcoholic liver diseases
    • Kohgo Y, Ohtake T, Ikuta K, et al. Iron accumulation in alcoholic liver diseases. Alcohol Clin Exp Res. 2005; 29: 189S-93S.
    • (2005) Alcohol Clin Exp Res , vol.29 , pp. 189S-193S
    • Kohgo, Y.1    Ohtake, T.2    Ikuta, K.3
  • 61
    • 0036667812 scopus 로고    scopus 로고
    • Up-regulation of transferrin receptor expression in hepatocytes by habitual alcohol drinking is implicated in hepatic iron overload in alcoholic liver disease
    • Suzuki Y, Saito H, Suzuki M, et al. Up-regulation of transferrin receptor expression in hepatocytes by habitual alcohol drinking is implicated in hepatic iron overload in alcoholic liver disease. Alcohol Clin Exp Res. 2002; 26: 26S-31S.
    • (2002) Alcohol Clin Exp Res , vol.26 , pp. 26S-31S
    • Suzuki, Y.1    Saito, H.2    Suzuki, M.3
  • 62
    • 1242291929 scopus 로고    scopus 로고
    • Increased duodenal expression of divalent metal transporter 1 and iron-regulated gene 1 in cirrhosis
    • Stuart KA, Anderson GJ, Frazer DM, et al. Increased duodenal expression of divalent metal transporter 1 and iron-regulated gene 1 in cirrhosis. Hepatology. 2004; 39: 492-9.
    • (2004) Hepatology , vol.39 , pp. 492-499
    • Stuart, K.A.1    Anderson, G.J.2    Frazer, D.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.