메뉴 건너뛰기




Volumn 53, Issue 8, 2004, Pages 1174-1179

Increase DMT1 but not IREG1 or HFE mRNA following iron depletion therapy in hereditary haemochromatosis

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; FERROPORTIN 1; HFE PROTEIN; IRON; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; CATION TRANSPORT PROTEIN; HFE PROTEIN, HUMAN; HLA ANTIGEN CLASS 1; IRON BINDING PROTEIN; MEMBRANE PROTEIN; METAL TRANSPORTING PROTEIN 1; SOLUTE CARRIER FAMILY 11 (PROTON COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2; SOLUTE CARRIER FAMILY 11- (PROTON-COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2;

EID: 3242735594     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2003.033811     Document Type: Article
Times cited : (23)

References (40)
  • 1
    • 0036077111 scopus 로고    scopus 로고
    • Molecular pathogenesis of iron overload
    • Trinder D, Fox C, Vautier G, et al. Molecular pathogenesis of iron overload. Gut 2002;51:290-5.
    • (2002) Gut , vol.51 , pp. 290-295
    • Trinder, D.1    Fox, C.2    Vautier, G.3
  • 2
    • 0036196205 scopus 로고    scopus 로고
    • Mechanisms of iron accumulation in hereditary haemochromatosis
    • Fleming RE, Sly WS. Mechanisms of iron accumulation in hereditary haemochromatosis. Annu Rev Physiol 2002;64:663-80.
    • (2002) Annu Rev Physiol , vol.64 , pp. 663-680
    • Fleming, R.E.1    Sly, W.S.2
  • 3
    • 0028049495 scopus 로고
    • Regulators of iron balance in humans
    • Finch C. Regulators of iron balance in humans. Blood 1994;84:1697-702.
    • (1994) Blood , vol.84 , pp. 1697-1702
    • Finch, C.1
  • 4
  • 5
    • 9344224529 scopus 로고    scopus 로고
    • A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
    • Feder JN, Gnirke A, Thomas W, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996;13:399-408.
    • (1996) Nat Genet , vol.13 , pp. 399-408
    • Feder, J.N.1    Gnirke, A.2    Thomas, W.3
  • 6
    • 0035902586 scopus 로고    scopus 로고
    • Hepcidin: A putative iron-regulatory hormone relevant to hereditary haemochromatosis and the anemia of chronic disease
    • Fleming RE, Sly WS. Hepcidin: a putative iron-regulatory hormone relevant to hereditary haemochromatosis and the anemia of chronic disease. Proc Natl Acad Sci USA 2001;98:8160-2.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8160-8162
    • Fleming, R.E.1    Sly, W.S.2
  • 7
    • 0030755366 scopus 로고    scopus 로고
    • Cloning and characterization of a mammalian proton-coupled metal ion transporter
    • Gunshin H, Mackenzie B, Berger UV, et al. Cloning and characterization of a mammalian proton-coupled metal ion transporter. Nature 1997;388:482-8.
    • (1997) Nature , vol.388 , pp. 482-488
    • Gunshin, H.1    Mackenzie, B.2    Berger, U.V.3
  • 8
    • 0032477866 scopus 로고    scopus 로고
    • Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport
    • Fleming MD, Romano MA, Su MA, et al. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci U S A 1998;95:1148-53.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 1148-1153
    • Fleming, M.D.1    Romano, M.A.2    Su, M.A.3
  • 9
    • 0030763856 scopus 로고    scopus 로고
    • Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
    • Fleming MD, Trenor CC iii, Su MA, et al. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 1997;16:383-6.
    • (1997) Nat Genet , vol.16 , pp. 383-386
    • Fleming, M.D.1    Trenor III, C.C.2    Su, M.A.3
  • 10
    • 0034677467 scopus 로고    scopus 로고
    • Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
    • Donovan A, Brownlie A, Zhou Y, et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature 2000;403:776-81.
    • (2000) Nature , vol.403 , pp. 776-781
    • Donovan, A.1    Brownlie, A.2    Zhou, Y.3
  • 11
    • 0033861745 scopus 로고    scopus 로고
    • A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
    • McKie AT, Marciani P, Rolfs A, et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 2000;5:299-309.
    • (2000) Mol Cell , vol.5 , pp. 299-309
    • McKie, A.T.1    Marciani, P.2    Rolfs, A.3
  • 12
    • 0034733635 scopus 로고    scopus 로고
    • A novel mammalian iron-regulated protein involved in intracellular iron metabolism
    • Abboud S, Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 2000;275:19906-12.
    • (2000) J Biol Chem , vol.275 , pp. 19906-19912
    • Abboud, S.1    Haile, D.J.2
  • 13
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    • Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 2002;110:1037-44.
    • (2002) J Clin Invest , vol.110 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3
  • 14
    • 0035902605 scopus 로고    scopus 로고
    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    • Nicolas G, Bennoun M, Devaux I, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A 2001;98:8780-5.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 8780-8785
    • Nicolas, G.1    Bennoun, M.2    Devaux, I.3
  • 15
    • 0036727925 scopus 로고    scopus 로고
    • Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats
    • Frazer DM, Wilkins SJ, Becker EM, et al. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 2002;123:835-44.
    • (2002) Gastroenterology , vol.123 , pp. 835-844
    • Frazer, D.M.1    Wilkins, S.J.2    Becker, E.M.3
  • 16
    • 0344085880 scopus 로고    scopus 로고
    • Duodenal metal-transporter (DMT1, Nramp-2) expression in patients with hereditary haemochromatosis
    • Zoller H, Pietrangelo A, Vogel W, et al. Duodenal metal-transporter (DMT1, Nramp-2) expression in patients with hereditary haemochromatosis. Lancet 1999;353:2120-3.
    • (1999) Lancet , vol.353 , pp. 2120-2123
    • Zoller, H.1    Pietrangelo, A.2    Vogel, W.3
  • 18
    • 0036923888 scopus 로고    scopus 로고
    • Increased duodenal DMT1 expression and unchanged HFE mRNA levels in HFE associated hereditary haemochromatosis and iron deficiency
    • Byrnes V, Barrett S, Ryan E, et al. Increased duodenal DMT1 expression and unchanged HFE mRNA levels in HFE associated hereditary haemochromatosis and iron deficiency. Blood Cells Mol Dis 2002;29:251-60.
    • (2002) Blood Cells Mol Dis , vol.29 , pp. 251-260
    • Byrnes, V.1    Barrett, S.2    Ryan, E.3
  • 19
    • 0035049419 scopus 로고    scopus 로고
    • Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in ID and iron overload
    • Zoller H, Koch RO, Theurl I, et al. Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in ID and iron overload. Gastroenterology 2001;120:1412-19.
    • (2001) Gastroenterology , vol.120 , pp. 1412-1419
    • Zoller, H.1    Koch, R.O.2    Theurl, I.3
  • 20
    • 0038460956 scopus 로고    scopus 로고
    • Duodenal expression of iron transporter molecules in untreated haemochromatosis subjects
    • Stuart KA, Anaerson GJ, Frazer DM, et al. Duodenal expression of iron transporter molecules in untreated haemochromatosis subjects. Gut 2003;52:953-9.
    • (2003) Gut , vol.52 , pp. 953-959
    • Stuart, K.A.1    Anaerson, G.J.2    Frazer, D.M.3
  • 21
    • 0035048737 scopus 로고    scopus 로고
    • Intestinal iron uptake determined by divalent metal transporter is enhanced in HFE deficient mice with haemochromatosis
    • Griffiths WJH, Sly WS, Cox TM. Intestinal iron uptake determined by divalent metal transporter is enhanced in HFE deficient mice with haemochromatosis. Gastroenterology 2001;120:1420-9.
    • (2001) Gastroenterology , vol.120 , pp. 1420-1429
    • Griffiths, W.J.H.1    Sly, W.S.2    Cox, T.M.3
  • 22
    • 13044317291 scopus 로고    scopus 로고
    • Mechanism of increased iron absorption in murine model of hereditary haemochromatosis: Increased duodenal expression of the iron transporter DMT1
    • Fleming RE, Migas M, Zhou XY, et al. Mechanism of increased iron absorption in murine model of hereditary haemochromatosis: increased duodenal expression of the iron transporter DMT1. Proc Natl Acad Sci U S A 1999;96:3143-8.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3143-3148
    • Fleming, R.E.1    Migas, M.2    Zhou, X.Y.3
  • 23
    • 0036182842 scopus 로고    scopus 로고
    • Inactivation of the haemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains
    • Dupic F, Fruchon S, Bensaid M, et al. Inactivation of the haemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains. Gastroenterology 2002;122:745-51.
    • (2002) Gastroenterology , vol.122 , pp. 745-751
    • Dupic, F.1    Fruchon, S.2    Bensaid, M.3
  • 24
    • 0035865527 scopus 로고    scopus 로고
    • Expression of the DMT1 (Nramp2/DCT1) iron transporter in mice with genetic iron overload disorders
    • Cannone-Hergaux F, Levy JE, Fleming MD, et al. Expression of the DMT1 (Nramp2/DCT1) iron transporter in mice with genetic iron overload disorders. Blood 2001;97:1138-40.
    • (2001) Blood , vol.97 , pp. 1138-1140
    • Cannone-Hergaux, F.1    Levy, J.E.2    Fleming, M.D.3
  • 25
    • 0037509928 scopus 로고    scopus 로고
    • Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse haemochromatosis
    • Muckenthaler M, Roy CN, Custodio AO, et al. Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse haemochromatosis. Nat Genet 2003;34:102-7.
    • (2003) Nat Genet , vol.34 , pp. 102-107
    • Muckenthaler, M.1    Roy, C.N.2    Custodio, A.O.3
  • 26
    • 0037164344 scopus 로고    scopus 로고
    • Genetics of haemochromatosis
    • Bomford A. Genetics of haemochromatosis. Lancet 2002;360:1673-81.
    • (2002) Lancet , vol.360 , pp. 1673-1681
    • Bomford, A.1
  • 27
    • 0038181003 scopus 로고    scopus 로고
    • Milestones in liver disease: The discovery of the new haemochromatosis gene
    • Brissot P. Milestones in liver disease: the discovery of the new haemochromatosis gene. J Hepatol 2003;38:704-9.
    • (2003) J Hepatol , vol.38 , pp. 704-709
    • Brissot, P.1
  • 28
    • 0037103357 scopus 로고    scopus 로고
    • Regulation of iron absorption in Hfe mutant mice
    • Ajioka RS, Levy JE, Andrews NC, et al. Regulation of iron absorption in Hfe mutant mice. Blood 2002;100:1465-9.
    • (2002) Blood , vol.100 , pp. 1465-1469
    • Ajioka, R.S.1    Levy, J.E.2    Andrews, N.C.3
  • 29
    • 0037460697 scopus 로고    scopus 로고
    • Disrupted hepcidin regulation in HFE associated haemochromatosis and the liver as a regulator of body iron homeostasis
    • Bridle KR, Frazer DM, Wilkins SJ, et al. Disrupted hepcidin regulation in HFE associated haemochromatosis and the liver as a regulator of body iron homeostasis. Lancet 2003;361:669-73.
    • (2003) Lancet , vol.361 , pp. 669-673
    • Bridle, K.R.1    Frazer, D.M.2    Wilkins, S.J.3
  • 30
    • 0034883430 scopus 로고    scopus 로고
    • HFE mutations, iron deficiency and overload in 10,500 blood donors
    • Jackson HA, Carter K, Darke C, et al. HFE mutations, iron deficiency and overload in 10,500 blood donors. Br J Haematol 2001;114:474-84.
    • (2001) Br J Haematol , vol.114 , pp. 474-484
    • Jackson, H.A.1    Carter, K.2    Darke, C.3
  • 32
    • 0026567061 scopus 로고
    • Regulation of transferrin, transferrin receptor and ferritin genes in human duodenum
    • Pietrangelo A, Rocchi E, Casalgrandi G, et al. Regulation of transferrin, transferrin receptor and ferritin genes in human duodenum. Gastroenterology 1992;102:802-9.
    • (1992) Gastroenterology , vol.102 , pp. 802-809
    • Pietrangelo, A.1    Rocchi, E.2    Casalgrandi, G.3
  • 33
    • 0025233620 scopus 로고
    • Differential expression of transferrin receptor in duodenal mucosa in iron overload:evidence for a site specific defect in genetic haemochromatosis
    • Lombard ML, Bomford AB, Polson RJ, et al. Differential expression of transferrin receptor in duodenal mucosa in iron overload:evidence for a site specific defect in genetic haemochromatosis. Gastroenterology 1990;98:976-84.
    • (1990) Gastroenterology , vol.98 , pp. 976-984
    • Lombard, M.L.1    Bomford, A.B.2    Polson, R.J.3
  • 34
    • 0014850302 scopus 로고
    • Intestinal mucosal uptake of iron and iron retention in idiopathic haemochromatosis as evidence for a mucosal abnormality
    • Powell LW, Campbell CB, Wilson E. Intestinal mucosal uptake of iron and iron retention in idiopathic haemochromatosis as evidence for a mucosal abnormality. Gut 1970;11:727-31.
    • (1970) Gut , vol.11 , pp. 727-731
    • Powell, L.W.1    Campbell, C.B.2    Wilson, E.3
  • 35
    • 0024446959 scopus 로고
    • Food iron absorption in idiopathic haemochromatosis
    • Lynch SR, Skikne BS, Cook JD. Food iron absorption in idiopathic haemochromatosis. Blood 1989;74:2187-93.
    • (1989) Blood , vol.74 , pp. 2187-2193
    • Lynch, S.R.1    Skikne, B.S.2    Cook, J.D.3
  • 36
    • 0025824547 scopus 로고
    • Regulation of intestinal iron absorption and mucosal iron kinetics in hereditary haemochromatosis
    • McLaren GD, Nathanson MH, Jacobs A, et al. Regulation of intestinal iron absorption and mucosal iron kinetics in hereditary haemochromatosis. J Lab Clin Med 1991;117:390-401.
    • (1991) J Lab Clin Med , vol.117 , pp. 390-401
    • McLaren, G.D.1    Nathanson, M.H.2    Jacobs, A.3
  • 37
    • 0035038147 scopus 로고    scopus 로고
    • Diagnosis and management of haemochromatosis
    • Tavill S. Diagnosis and management of haemochromatosis. Hepatology 2001;33:1321-8.
    • (2001) Hepatology , vol.33 , pp. 1321-1328
    • Tavill, S.1
  • 38
    • 0036238428 scopus 로고    scopus 로고
    • Relationship of body iron stores to levels of serum ferritin, unsaturated iron binding capacity and transferrin saturation in patients with iron storage disease
    • Beutler E, Felitti V, Ho NJ, et al. Relationship of body iron stores to levels of serum ferritin, unsaturated iron binding capacity and transferrin saturation in patients with iron storage disease. Acta Haematol 2002;107:145-9.
    • (2002) Acta Haematol , vol.107 , pp. 145-149
    • Beutler, E.1    Felitti, V.2    Ho, N.J.3
  • 39
    • 0037847496 scopus 로고    scopus 로고
    • Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis
    • Nicolas G, Viatte L, Lou D-Q, et al. Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. Nat Genet 2003;34:97-101.
    • (2003) Nat Genet , vol.34 , pp. 97-101
    • Nicolas, G.1    Viatte, L.2    Lou, D.-Q.3
  • 40
    • 0037962795 scopus 로고    scopus 로고
    • The orchestration of body iron intake: How and where do enterocytes receive their cues
    • Frazer DM, Anderson GJ. The orchestration of body iron intake: how and where do enterocytes receive their cues. Blood Cells Mol Dis 2003;30:288-97.
    • (2003) Blood Cells Mol Dis , vol.30 , pp. 288-297
    • Frazer, D.M.1    Anderson, G.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.