Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2

Blood

Volumn 112, Issue 10, 2008, Pages 4268-4275

  Foot, Natalie J ^a   Dalton, Hazel E ^a   Shearwin Whyatt, Linda M ^a   Dorstyn, Loretta ^a   Tan, Seong Seng ^b   Yang, Baoli ^c   Kumar, Sharad ^a  

^a HANSON INSTITUTE   (Australia)

^b FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; IRON; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; PROTEIN NDFIP1; PROTEIN NDFIP2; PROTEIN WWP2; UBIQUITIN PROTEIN LIGASE NEDD4; UNCLASSIFIED DRUG; CARRIER PROTEIN; CATION TRANSPORT PROTEIN; MEMBRANE PROTEIN; NDFIP1 PROTEIN, MOUSE; NEDD4 UBIQUITIN PROTEIN LIGASES; SOLUTE CARRIER FAMILY 11 (PROTON COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2; SOLUTE CARRIER FAMILY 11- (PROTON-COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2; UBIQUITIN PROTEIN LIGASE; WWP2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IRON METABOLISM; IRON TRANSPORT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; UBIQUITINATION; ANIMAL; CHO CELL; CRICETULUS; FEMALE; GENETICS; HAMSTER; HOMEOSTASIS; ION TRANSPORT; MALE; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; PROTEIN MOTIF; PROTEIN TERTIARY STRUCTURE;

AMINO ACID MOTIFS; ANIMALS; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; CHO CELLS; CRICETINAE; CRICETULUS; FEMALE; HOMEOSTASIS; ION TRANSPORT; IRON; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PROTEIN STRUCTURE, TERTIARY; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 58149158220     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-04-150953     Document Type: Article

References (41)

1. Dunn LL, Rahmanto YS, Richardson DR. Iron uptake and metabolism in the new millennium. Trends Cell Biol. 2007;17:93-100.
2. Chua AC, Graham RM, Trinder D, Olynyk JK. The regulation of cellular iron metabolism. Crit Rev Clin Lab Sci. 2007;44:413-459.
3. Zecca L, Youdim MB, Riederer P, Connor JR, Crichton RR. Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci. 2004;5:863-873.
4. Andrews NC. Iron homeostasis: insights from genetics and animal models. Nat Rev Genet. 2000; 1:208-217.
5. Deugnier Y, Turlin B. Pathology of hepatic iron overload. World J Gastroenterol. 2007;13:4755-4760.
6. Mims MP, Prchal JT. Divalent metal transporter 1. Hematology. 2005;10:339-345.
7. Canonne-Hergaux F, Zhang AS, Ponka P, Gros P. Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice. Blood. 2001;98:3823-3830.
8. Tchernitchko D, Bourgeois M, Martin ME, Beaumont C. Expression of the two mRNA isoforms of the iron transporter Nramp2/DMTI in mice and function of the iron responsive element. Biochem J. 2002;363:449-455.
9. Hubert N, Hentze MW. Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc Natl Acad Sci U S A. 2002;99: 12345-12350.
10. Fleming MD, Romano MA, Su MA, Garrick LM, Garrick MD, Andrews NC. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci U S A. 1998;95:1148-1153.
11. Fleming MD, Trenor CC 3rd, Su MA, et al. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet. 1997;16:383-386.
12. Pospisilova D, Mims MP, Nemeth E, Ganz T, Prchal JT. DMT1 mutation: response of anemia to darbepoetin administration and implications for iron homeostasis. Blood. 2006;108:404-405.
13. Lam-Yuk-Tseung S, Camaschella C, Iolascon A, Gros P. A novel R416C mutation in human DMT1 (SLC11A2) displays pleiotropic effects on function and causes microcytic anemia and hepatic iron overload. Blood Cells Mol Dis. 2006;36:347-354.
14. Beaumont C, Delaunay J, Hetet G, Grandchamp B, de Montalembert M, Tchernia G. Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload. Blood. 2006;107:4168-4170.
15. Iolascon A, d'Apolito M, Servedio V, Cimmino F, Piga A, Camaschella C. Microcytic anemia and hepatic iron overload in a child with compound heterozygous mutations in DMT1 (SCL11A2). Blood. 2006;107:349-354.
16. Mims MP, Guan Y, Pospisilova D, et al. Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload. Blood. 2005;105:1337-1342.
17. Nunez MT, Nunez-Millacura C, Tapia V, et al. Iron-activated iron uptake: a positive feedback loop mediated by iron regulatory protein 1. Biometals. 2003;16:83-90.
18. Lam-Yuk-Tseung S, Gros P. Distinct targeting and recycling properties of two isoforms of the iron transporter DMT1 (NRAMP2, Slc11A2). Biochemistry. 2006;45:2294-2301.
19. Mukhopadhyay D, Riezman H. Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science. 2007;315:201-205.
20. Fang S, Weissman AM. A field guide to ubiquitylation. Cell Mol Life Sci. 2004;61:1546-1561.
21. Abriel H, Staub O. Ubiquitylation of ion channels. Physiology. 2005;20:398-407.
22. Harvey KF, Kumar S. Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions. Trends Cell Biol. 1999;9:166-169.
23. Shearwin-Whyatt L, Dalton HE, Foot N, Kumar S. Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins. Bioessays. 2006;28:617-628.
24. Snyder PM. Minireview: regulation of epithelial Na+ channel trafficking. Endocrinology. 2005; 146:5079-5085.
25. Sudol M, Hunter T. NeW wrinkles for an old domain. Cell. 2000;103:1001-1004.
26. Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S. Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4. Biochem J. 2000;351:557-565.
27. Harvey KF, Shearwin-Whyatt LM, Fotia A, Parton RG, Kumar S. N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. J Biol Chem. 2002;277:9307-9317.
28. Shearwin-Whyatt LM, Brown DL, Wylie FG, Stow JL, Kumar S. N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking. J Cell Sci. 2004;117:3679-3689.
29. Hettema EH, Valdez-Taubas J, Pelham HR. Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins. EMBO J. 2004;23:1279-1288.
30. Stimpson HE, Lewis MJ, Pelham HR. Transferrin receptor-like proteins control the degradation of a yeast metal transporter. EMBO J. 2006;25:662-672.
31. Fotia AB, Dinudom A, Shearwin KE, et al. The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. FASEB J. 2003;17:70-72.
32. Konstas AA, Shearwin-Whyatt LM, Fotia AB, et al. Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein. J Biol Chem. 2002;277:29406-29416.
33. Oliver PM, Cao X, Worthen GS, et al. Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cellmediated inflammation. Immunity. 2006;25:929-940.
34. Lam-Yuk-Tseung S, Govoni G, Forbes J, Gros P. Iron transport by Nramp2/DMT1: pH regulation of transport by 2 histidines in transmembrane domain 6. Blood. 2003;101:3699-3707.
35. Meguro R, Asano Y, Iwatsuki H, Shoumura K. Perfusion-Perls and -Turnbull methods supplemented by DAB intensification for nonheme iron histochemistry: demonstration of the superior sensitivity of the methods in the liver, spleen, and stomach of the rat. Histochem Cell Biol. 2003; 120:73-82.
36. Beilby JP, Prins AW, Swanson NR. Determination of hepatic iron concentration in fresh and paraffinembedded tissue. Clin Chem. 1999;45:573-574.
37. Nakayama K, Wakatsuki S. The structure and function of GGAs, the traffic controllers at the TGN sorting crossroads. Cell Struct. Funct. 2003; 28:431-442.
38. Trinder D, Oates PS, Thomas C, Sadleir J, Morgan EH. Localisation of divalent metal transporter to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload. Gut. 2000;46:270-276.
39. Pietrangelo A. Hereditary hemochromatosis. Biochim Biophys Acta. 2006;1763:700-710.
40. Levy JE, Montross LK, Andrews NC. Genes that modify the hemochromatosis phenotype in mice. J Clin Invest. 2000;105:1209-1216.
41. Fleming RE, Migas MC, Zhou X, et al. Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1. Proc Natl Acad Sci U S A. 1999;96:3143-3148.