-
1
-
-
16844364003
-
A small-molecule agonist of the Wnt signaling pathway
-
Liu J. A small-molecule agonist of the Wnt signaling pathway Angew. Chem. Int. Ed. Engl. 44 2005 1987 1990
-
(2005)
Angew. Chem. Int. Ed. Engl.
, vol.44
, pp. 1987-1990
-
-
Liu, J.1
-
2
-
-
2342454415
-
Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation
-
Peterson R.T. Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation Nat Biotechnol. 22 2004 595 599
-
(2004)
Nat Biotechnol.
, vol.22
, pp. 595-599
-
-
Peterson, R.T.1
-
3
-
-
3343021518
-
High throughput siRNA-based functional target identification
-
Xin H. High throughput siRNA-based functional target identification J. Biomol. Screen 9 2004 286 293
-
(2004)
J. Biomol. Screen
, vol.9
, pp. 286-293
-
-
Xin, H.1
-
4
-
-
5644255981
-
Photoaffinity labeling strategies in identifying the protein ligands of bioactive small molecules: Examples of targeted synthesis of drug analog photoprobes
-
Colca J.R., Harrigan G.G. Photoaffinity labeling strategies in identifying the protein ligands of bioactive small molecules: examples of targeted synthesis of drug analog photoprobes Comb. Chem. High Throughput Screen 7 2004 699 704
-
(2004)
Comb. Chem. High Throughput Screen
, vol.7
, pp. 699-704
-
-
Colca, J.R.1
Harrigan, G.G.2
-
6
-
-
2642553258
-
Target identification in chemical genetics: The (often) missing link
-
Burdine L., Kodadek T. Target identification in chemical genetics: the (often) missing link Chem. Biol. 11 2004 593 597
-
(2004)
Chem. Biol.
, vol.11
, pp. 593-597
-
-
Burdine, L.1
Kodadek, T.2
-
7
-
-
20344374894
-
Small-molecule kinase-inhibitor target assessment
-
Kung C., Shokat K.M. Small-molecule kinase-inhibitor target assessment ChemBioChem 6 2005 523 526
-
(2005)
ChemBioChem
, vol.6
, pp. 523-526
-
-
Kung, C.1
Shokat, K.M.2
-
8
-
-
11144294717
-
Chemical genetics for therapeutic target mining
-
Shim J.S., Kwon H.J. Chemical genetics for therapeutic target mining Expert Opin. Ther. Targets 8 2004 653 661
-
(2004)
Expert Opin. Ther. Targets
, vol.8
, pp. 653-661
-
-
Shim, J.S.1
Kwon, H.J.2
-
9
-
-
7644243551
-
Chemical genomics: Probing protein function using small molecules
-
Wagner B.K. Chemical genomics: probing protein function using small molecules Am. J. Pharmacogenomics 4 2004 313 320
-
(2004)
Am. J. Pharmacogenomics
, vol.4
, pp. 313-320
-
-
Wagner, B.K.1
-
10
-
-
0346251243
-
Forward and reverse chemical genetics using SPOS based combinatorial chemistry
-
Thorpe D.S. Forward and reverse chemical genetics using SPOS based combinatorial chemistry Comb. Chem. High Throughput Screen 6 2004 623 647
-
(2004)
Comb. Chem. High Throughput Screen
, vol.6
, pp. 623-647
-
-
Thorpe, D.S.1
-
11
-
-
6344226672
-
Chemical genetics: Toward the next generation of molecular medicines
-
Halazy S. Chemical genetics: toward the next generation of molecular medicines Pharmacogenomics 5 2004 757 761
-
(2004)
Pharmacogenomics
, vol.5
, pp. 757-761
-
-
Halazy, S.1
-
12
-
-
4544334518
-
Strategies for facilitated forward chemical genomics
-
Khersonsky S.M., Chang Y.T. Strategies for facilitated forward chemical genomics ChemBioChem 5 2004 903 908
-
(2004)
ChemBioChem
, vol.5
, pp. 903-908
-
-
Khersonsky, S.M.1
Chang, Y.T.2
-
13
-
-
1042298842
-
From large networks to small molecules
-
Sharom J.R. From large networks to small molecules Curr. Opin. Chem. Biol. 8 2004 81 90
-
(2004)
Curr. Opin. Chem. Biol.
, vol.8
, pp. 81-90
-
-
Sharom, J.R.1
-
14
-
-
4844220944
-
Zebrafish as a genomics research model
-
Chen E., Ekker S.C. Zebrafish as a genomics research model Curr. Pharm. Biotechnol. 5 2004 409 413
-
(2004)
Curr. Pharm. Biotechnol.
, vol.5
, pp. 409-413
-
-
Chen, E.1
Ekker, S.C.2
-
15
-
-
2942616604
-
Complex phenotypic assays in high-throughput screening
-
Clemons P.A. Complex phenotypic assays in high-throughput screening Curr. Opin. Chem. Biol. 8 2004 334 338
-
(2004)
Curr. Opin. Chem. Biol.
, vol.8
, pp. 334-338
-
-
Clemons, P.A.1
-
16
-
-
0347626254
-
Design and synthesis of novel bioactive peptides and peptidomimetics
-
Freidinger R. Design and synthesis of novel bioactive peptides and peptidomimetics J. Med. Chem. 46 2003 5553 5565
-
(2003)
J. Med. Chem.
, vol.46
, pp. 5553-5565
-
-
Freidinger, R.1
-
17
-
-
0037392942
-
The specificities of protein kinase inhibitors: An update
-
Bain J. The specificities of protein kinase inhibitors: an update Biochem. J. 371 2003 199 204
-
(2003)
Biochem. J.
, vol.371
, pp. 199-204
-
-
Bain, J.1
-
18
-
-
1642512639
-
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex
-
Lepourcelet M. Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex Cancer Cell 5 2004 91 102
-
(2004)
Cancer Cell
, vol.5
, pp. 91-102
-
-
Lepourcelet, M.1
-
19
-
-
0021352840
-
Amphiphilic secondary structure: Design of peptide hormones
-
Kaiser E.T., Kedzy F.J. Amphiphilic secondary structure: design of peptide hormones Science 223 1984 249 255
-
(1984)
Science
, vol.223
, pp. 249-255
-
-
Kaiser, E.T.1
Kedzy, F.J.2
-
20
-
-
77957079236
-
Peptide secondary structure mimetics: Recent advances and future challenges
-
Kahn M. Peptide secondary structure mimetics: recent advances and future challenges Synlett 11 1993 821 826
-
(1993)
Synlett
, vol.11
, pp. 821-826
-
-
Kahn, M.1
-
21
-
-
0032497355
-
Highly efficient and versatile synthesis of libraries of constrained beta-strand mimetics
-
Ogbu C.O. Highly efficient and versatile synthesis of libraries of constrained beta-strand mimetics Bioorg. Med. Chem. Lett. 8 1998 2321 2326
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 2321-2326
-
-
Ogbu, C.O.1
-
22
-
-
0033616089
-
Solid phase synthesis and structural analysis of bicyclic b-turn mimetics incorporating functionality at the i to i+3 positions
-
Eguchi M. Solid phase synthesis and structural analysis of bicyclic b-turn mimetics incorporating functionality at the i to i+3 positions J. Am. Chem. Soc. 121 1999 12204 12205
-
(1999)
J. Am. Chem. Soc.
, vol.121
, pp. 12204-12205
-
-
Eguchi, M.1
-
23
-
-
0012126166
-
Recent developments in peptide secondary structure mimetics
-
Kim H.O., Kahn M. Recent developments in peptide secondary structure mimetics Res Adv In Organic Chem. 1 2000 43 59
-
(2000)
Res Adv in Organic Chem.
, vol.1
, pp. 43-59
-
-
Kim, H.O.1
Kahn, M.2
-
24
-
-
3142781225
-
Small-molecule inhibitors of protein-protein interactions: Progressing toward the dream
-
Arkin M.R., Wells J.A. Small-molecule inhibitors of protein-protein interactions: progressing toward the dream Nat. Rev. Drug Discov. 3 2004 301
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 301
-
-
Arkin, M.R.1
Wells, J.A.2
-
25
-
-
3342908718
-
Emerging classes of protein-protein inhibitors and new tools for development
-
Pagliaro L. Emerging classes of protein-protein inhibitors and new tools for development Curr. Opin. Chem. Biol. 8 2004 442 449
-
(2004)
Curr. Opin. Chem. Biol.
, vol.8
, pp. 442-449
-
-
Pagliaro, L.1
-
27
-
-
0037205007
-
The promise and perils of Wnt signaling through beta-catenin
-
Moon R.T. The promise and perils of Wnt signaling through beta-catenin Science 296 2002 1644 1646
-
(2002)
Science
, vol.296
, pp. 1644-1646
-
-
Moon, R.T.1
-
28
-
-
0036124896
-
TCF: Lady Justice casting the final verdict on the outcome of Wnt signaling
-
Brantjes H. TCF: Lady Justice casting the final verdict on the outcome of Wnt signaling Biol. Chem. 383 2002 255 261
-
(2002)
Biol. Chem.
, vol.383
, pp. 255-261
-
-
Brantjes, H.1
-
29
-
-
1542347695
-
Convergence of Wnt, beta-catenin, and cadherin pathways
-
Nelson W.J., Nusse R. Convergence of Wnt, beta-catenin, and cadherin pathways Science 303 2004 1483 1487
-
(2004)
Science
, vol.303
, pp. 1483-1487
-
-
Nelson, W.J.1
Nusse, R.2
-
30
-
-
4344584730
-
WNT and beta-catenin signaling: Diseases and therapies
-
Moon R.T. WNT and beta-catenin signaling: diseases and therapies Nat. Rev. Genet. 5 2004 691 701
-
(2004)
Nat. Rev. Genet.
, vol.5
, pp. 691-701
-
-
Moon, R.T.1
-
31
-
-
0036033274
-
Genetics of colorectal cancer: Hereditary aspects and overview of colorectal tumorigenesis
-
Fearnhead N.S. Genetics of colorectal cancer: hereditary aspects and overview of colorectal tumorigenesis Br. Med. Bull. 64 2002 27 43
-
(2002)
Br. Med. Bull.
, vol.64
, pp. 27-43
-
-
Fearnhead, N.S.1
-
32
-
-
0033545845
-
The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
-
Shtutman M. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway Proc. Natl. Acad. Sci. U. S. A. 96 1999 5522 5527
-
(1999)
Proc. Natl. Acad. Sci. U. S. A.
, vol.96
, pp. 5522-5527
-
-
Shtutman, M.1
-
33
-
-
0033119801
-
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
-
Tetsu O., McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells Nature 398 1999 422 426
-
(1999)
Nature
, vol.398
, pp. 422-426
-
-
Tetsu, O.1
McCormick, F.2
-
34
-
-
0032483439
-
Identification of c-MYC as a target of the APC pathway
-
He T.C. Identification of c-MYC as a target of the APC pathway Science 281 1998 1509 1512
-
(1998)
Science
, vol.281
, pp. 1509-1512
-
-
He, T.C.1
-
35
-
-
4344587136
-
A small molecule inhibitor of beta-catenin/CREB-binding protein transcription
-
Emami K.H. A small molecule inhibitor of beta-catenin/CREB-binding protein transcription Proc. Natl. Acad. Sci. U. S. A. 101 2004 12682 12687
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 12682-12687
-
-
Emami, K.H.1
-
36
-
-
0034678610
-
The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates
-
Hecht A. The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates EMBO J. 19 2000 1839 1850
-
(2000)
EMBO J.
, vol.19
, pp. 1839-1850
-
-
Hecht, A.1
-
37
-
-
0034678357
-
The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression
-
Takemaru K.I., Moon R.T. The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression J. Cell Biol. 149 2000 249 254
-
(2000)
J. Cell Biol.
, vol.149
, pp. 249-254
-
-
Takemaru, K.I.1
Moon, R.T.2
-
38
-
-
0034234237
-
CBP/p300 in cell growth, transformation and development
-
Goodman R.H., Smolik S. CBP/p300 in cell growth, transformation and development Genes Dev. 14 2000 1553 1577
-
(2000)
Genes Dev.
, vol.14
, pp. 1553-1577
-
-
Goodman, R.H.1
Smolik, S.2
-
39
-
-
0032706622
-
Analysis of human transcriptomes
-
Velculescu V.E. Analysis of human transcriptomes Nat. Genet. 23 1999 387 388
-
(1999)
Nat. Genet.
, vol.23
, pp. 387-388
-
-
Velculescu, V.E.1
-
40
-
-
0030746636
-
A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
-
Ambrosini G. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma Nat. Med. 3 1997 917 921
-
(1997)
Nat. Med.
, vol.3
, pp. 917-921
-
-
Ambrosini, G.1
-
41
-
-
0141595100
-
Survivin study: What is the next wave?
-
Li F. Survivin study: what is the next wave? J. Cell. Physiol. 197 2003 8 29
-
(2003)
J. Cell. Physiol.
, vol.197
, pp. 8-29
-
-
Li, F.1
-
42
-
-
0037267333
-
Validating survivin as a cancer therapeutic target
-
Altieri D.C. Validating survivin as a cancer therapeutic target Nat. Rev. Cancer 3 2003 46 54
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 46-54
-
-
Altieri, D.C.1
-
43
-
-
0035893568
-
Evidence that APC regulates survivin expression: A possible mechanism contributing to the stem cell origin of colon cancer
-
Zhang T. Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer Cancer Res. 61 2001 8664 8667
-
(2001)
Cancer Res.
, vol.61
, pp. 8664-8667
-
-
Zhang, T.1
-
44
-
-
0038498213
-
Survivin and molecular pathogenesis of colorectal cancer
-
Kim P.J. Survivin and molecular pathogenesis of colorectal cancer Lancet 362 2003 205 209
-
(2003)
Lancet
, vol.362
, pp. 205-209
-
-
Kim, P.J.1
-
45
-
-
19944422429
-
Differential roles for the coactivators CBP and p300 on TCF/b-catenin mediated survivin gene expression
-
Ma H. Differential roles for the coactivators CBP and p300 on TCF/b-catenin mediated survivin gene expression Oncogene 24 2005 3619 3631
-
(2005)
Oncogene
, vol.24
, pp. 3619-3631
-
-
Ma, H.1
-
46
-
-
0037961625
-
P300 transcriptional repression is mediated by SUMO modification
-
Girdwood D. P300 transcriptional repression is mediated by SUMO modification Mol. Cell 11 2003 1043 1054
-
(2003)
Mol. Cell
, vol.11
, pp. 1043-1054
-
-
Girdwood, D.1
-
47
-
-
0345826116
-
Promyelocytic leukemia protein 4 induces apoptosis by inhibition of survivin expression
-
Xu Z.X. Promyelocytic leukemia protein 4 induces apoptosis by inhibition of survivin expression J. Biol. Chem. 279 2004 1838 1844
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 1838-1844
-
-
Xu, Z.X.1
-
48
-
-
0038517899
-
Beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system
-
Zechner D. beta-Catenin signals regulate cell growth and the balance between progenitor cell expansion and differentiation in the nervous system Dev. Biol. 258 2003 406 418
-
(2003)
Dev. Biol.
, vol.258
, pp. 406-418
-
-
Zechner, D.1
-
49
-
-
4444361024
-
Beta-catenin signaling is required for neural differentiation of embryonic stem cells
-
Otero J.J. Beta-catenin signaling is required for neural differentiation of embryonic stem cells Development 131 2004 3545 3557
-
(2004)
Development
, vol.131
, pp. 3545-3557
-
-
Otero, J.J.1
-
50
-
-
3242889925
-
The Wnt/beta-catenin pathway directs neuronal differentiation of cortical neural precursor cells
-
Hirabayashi Y. The Wnt/beta-catenin pathway directs neuronal differentiation of cortical neural precursor cells Development 131 2004 2791 2801
-
(2004)
Development
, vol.131
, pp. 2791-2801
-
-
Hirabayashi, Y.1
-
51
-
-
0033230623
-
Neuroplasticity failure in Alzheimer's disease: Bridging the gap between plaques and tangles
-
Mesulam M.M. Neuroplasticity failure in Alzheimer's disease: bridging the gap between plaques and tangles Neuron 24 1999 521 529
-
(1999)
Neuron
, vol.24
, pp. 521-529
-
-
Mesulam, M.M.1
-
52
-
-
0035232145
-
Presenilin function: Connections to Alzheimer's disease and signal transduction
-
Fraser P.E. Presenilin function: connections to Alzheimer's disease and signal transduction Biochem. Soc. Symp. 67 2001 89 100
-
(2001)
Biochem. Soc. Symp.
, vol.67
, pp. 89-100
-
-
Fraser, P.E.1
-
53
-
-
0032556859
-
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
-
De Strooper B. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein Nature 391 1998 387 390
-
(1998)
Nature
, vol.391
, pp. 387-390
-
-
De Strooper, B.1
-
54
-
-
0031847249
-
Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease
-
Berezovska O. Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease J. Neuropathol. Exp. Neurol. 57 1998 738 745
-
(1998)
J. Neuropathol. Exp. Neurol.
, vol.57
, pp. 738-745
-
-
Berezovska, O.1
-
55
-
-
0032972547
-
Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin
-
Levesque G. Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin J. Neurochem. 72 1999 999 1008
-
(1999)
J. Neurochem.
, vol.72
, pp. 999-1008
-
-
Levesque, G.1
-
56
-
-
0033151570
-
Presenilin 1 facilitates the constitutive turnover of beta-catenin: Differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway
-
Kang D.E. Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway J. Neurosci. 19 1999 4229 4237
-
(1999)
J. Neurosci.
, vol.19
, pp. 4229-4237
-
-
Kang, D.E.1
-
57
-
-
11144354047
-
Dual control of neurogenesis by PC3 through cell cycle inhibition and induction of Math1
-
Canzoniere D. Dual control of neurogenesis by PC3 through cell cycle inhibition and induction of Math1 J. Neurosci. 24 2004 3355 3369
-
(2004)
J. Neurosci.
, vol.24
, pp. 3355-3369
-
-
Canzoniere, D.1
-
58
-
-
7244248573
-
The critical role of cyclin D2 in adult neurogenesis
-
Kowalczyk A. The critical role of cyclin D2 in adult neurogenesis J. Cell Biol. 167 2004 209 213
-
(2004)
J. Cell Biol.
, vol.167
, pp. 209-213
-
-
Kowalczyk, A.1
-
59
-
-
24744470274
-
Specific inhibition of CBP/b-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation
-
Teo J. Specific inhibition of CBP/b-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation Proc. Natl. Acad. Sci. U. S. A. 102 2005 12171 12176
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 12171-12176
-
-
Teo, J.1
-
60
-
-
0345059767
-
Applying thr principles of stem-cell biology to cancer
-
Pardal R. Applying thr principles of stem-cell biology to cancer Nat. Rev. Cancer 3 2003 895 902
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 895-902
-
-
Pardal, R.1
-
61
-
-
0026498426
-
Neural computing in cancer drug development: Predicting mechanism of action
-
Weinstein J.N. Neural computing in cancer drug development: predicting mechanism of action Science 258 1992 447
-
(1992)
Science
, vol.258
, pp. 447
-
-
Weinstein, J.N.1
-
62
-
-
0028576841
-
Use of the Kohonen self-organizing map to study the mechanisms of action of chemotherapeutic agents
-
van Osdol W.W. Use of the Kohonen self-organizing map to study the mechanisms of action of chemotherapeutic agents J. Natl. Cancer Inst. 86 1994 1853 1859
-
(1994)
J. Natl. Cancer Inst.
, vol.86
, pp. 1853-1859
-
-
Van Osdol, W.W.1
|