11-epi-sinulariolide acetate reduces cell migration and invasion of human hepatocellular carcinoma by reducing the activation of ERK1/2, p38MAPK and FAK/PI3K/AKT/mTOR signaling pathways

Marine Drugs

Volumn 12, Issue 9, 2014, Pages 4783-4798

  Lin, Jen Jie ^a   Su, Jui Hsin ^b   Tsai, Chi Chu ^c   Chen, Yi Jen ^d   Liao, Ming Hui ^a   Wu, Yu Jen ^e  

^a NATIONAL PINGTUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b NATIONAL MUSEUM OF MARINE BIOLOGY AND AQUARIUM   (Taiwan)

^c FISHERIES RESEARCH INSTITUTE   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e MEIHO UNIVERSITY   (Taiwan)

Author keywords

11 epi sinulariolide acetate; ERK1 2; Hepatocellular carcinoma; Invasion; Matrix metalloproteinase; Migration; p38MAPK

Indexed keywords

11 EPI SINULARIOLIDE ACETATE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTINEOPLASTIC AGENT; FOCAL ADHESION KINASE; GELATINASE A; GELATINASE B; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C; RAS PROTEIN; RHO KINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; UNCLASSIFIED DRUG; UROKINASE; DITERPENE; MTOR PROTEIN, HUMAN; SINULARIOLIDE; TARGET OF RAPAMYCIN KINASE; TIMP2 PROTEIN, HUMAN; TUMOR PROTEIN;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL INVASION; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LIVER CANCER CELL LINE; LIVER CELL CARCINOMA; METASTASIS INHIBITION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; ANTHOZOA; BIOSYNTHESIS; CELL MOTION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; LIVER TUMOR; NEOPLASM METASTASIS; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION;

ANIMALS; ANTHOZOA; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; DITERPENES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LIVER NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; SIGNAL TRANSDUCTION; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TOR SERINE-THREONINE KINASES;

EID: 84908047015     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md12094783     Document Type: Article

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