Proteomic investigation of the sinulariolide-treated melanoma cells A375: Effects on the cell apoptosis through mitochondrial-related pathway and activation of caspase cascade

Marine Drugs

Volumn 11, Issue 7, 2013, Pages 2625-2642

  Li, Hsing Hui ^a   Su, Jui Hsin ^a   Chiu, Chien Chih ^b   Lin, Jen Jie ^c   Yang, Zih Yan ^c   Hwang, Wen Ing ^d   Chen, Yu Kuei ^d   Lo, Yu Hsuan ^e   Wu, Yu Jen ^b  

^a NATIONAL MUSEUM OF MARINE BIOLOGY AND AQUARIUM   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL PINGTUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^d MEIHO UNIVERSITY   (Taiwan)

^e Excellence Biotech Co   (Taiwan)

Author keywords

Apoptosis; Caspase cascade; Melanoma; Mitochondria; Proteomic; Sinulariolide

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; CASPASE 3; CASPASE 9; CHAPERONIN 60; CYTOCHROME C; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN BETA 1; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE SUBUNIT ALPHA; PROHIBITIN; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; SINULARIOLIDE; UBIQUINOL CYTOCHROME C REDUCTASE; UBIQUINOL CYTOCHROME C REDUCTASE COMPLEX CORE PROTEIN 1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; ENZYME ACTIVATION; FLOW CYTOMETRY; MELANOMA; MELANOMA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOSIS INHIBITION; PROTEIN EXPRESSION; PROTEOMICS; SIGNAL TRANSDUCTION; UPREGULATION;

ALCYONACEA; SINULARIA FLEXIBILIS;

ANIMALS; ANTHOZOA; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASES; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DITERPENES; DOWN-REGULATION; HUMANS; MELANOMA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PROTEOME; PROTEOMICS; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84880906605     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md11072625     Document Type: Article

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