Induction of apoptosis by sinulariolide from soft coral through mitochondrial-related and p38MAPK pathways on human bladder carcinoma cells

Marine Drugs

Volumn 10, Issue 12, 2012, Pages 2893-2911

  Neoh, Choo Aun ^a   Wang, Robert Y L ^b   Din, Zhong Hao ^c   Su, Jui Hsin ^d   Chen, Yu Kuei ^c   Tsai, Feng Jen ^c   Weng, Shun Hsiang ^c   Wu, Yu Jen ^c  

^a PINGTUNG CHRISTIAN HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c MEIHO UNIVERSITY   (Taiwan)

^d NATIONAL MUSEUM OF MARINE BIOLOGY AND AQUARIUM   (Taiwan)

Author keywords

Bladder cancer cells; Mitochondrial related pathways; Sinulariolide

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ANTIMITOTIC AGENT; CASPASE 3; CASPASE 9; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; SINULARIOLIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BLADDER CARCINOMA; CELL ASSAY; CELL MEMBRANE DEPOLARIZATION; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN CLEAVAGE; PROTEIN DETERMINATION; PROTEIN SECRETION;

ALCYONACEA; SINULARIA FLEXIBILIS;

EID: 84871799483     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md10122893     Document Type: Article

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