Flavanone and 2′-OH flavanone inhibit metastasis of lung cancer cells via down-regulation of proteinases activities and MAPK pathway

Chemico-Biological Interactions

Volumn 167, Issue 3, 2007, Pages 193-206

  Hsiao, Yung Chin ^a   Kuo, Wu Hsien ^b,c   Chen, Pei Ni ^a,b   Chang, Horng Rong ^d   Lin, Tseng Hsi ^e   Yang, Wei En ^a   Hsieh, Yih Shou ^a   Chu, Shu Chen ^b  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c Division of Gastroenterology   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

A549 cells; Flavanone; Invasion; Metastasis; MMP 2; u PA

Indexed keywords

2' HYDROXYFLAVONONE; 4' HYDROXYFLAVANONE; 6 HYDROXYFLAVANONE; AURANTIIN; FLAVANONE; GELATINASE A; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NARINGENIN; PROTEINASE; UNCLASSIFIED DRUG; UROKINASE; 2' HYDROXYFLAVANONE; 2'-HYDROXYFLAVANONE; ENZYME INHIBITOR; FLAVANONE DERIVATIVE; PEPTIDE HYDROLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL INVASION; CELL MOTILITY; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; LUNG CANCER; LUNG METASTASIS; MALE; METASTASIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL ADHESION; CELL MOTION; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; LUNG TUMOR; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE;

CITRUS;

ANIMALS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVANONES; HUMANS; LUNG NEOPLASMS; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; NEOPLASM METASTASIS; PEPTIDE HYDROLASES; PHOSPHORYLATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 34047149367     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2007.02.012     Document Type: Article

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