Sinulariolide induced hepatocellular carcinoma apoptosis through activation of mitochondrial-related apoptotic and PERK/eIF2α/ATF4/CHOP pathway

Molecules

Volumn 18, Issue 9, 2013, Pages 10146-10161

  Chen, Yi Jen ^a   Su, Jui Hsin ^b   Tsao, Chia Yu ^c   Hung, Chun Tzu ^d   Chao, Hsiang Hao ^e   Lin, Jen Jie ^c   Liao, Ming Hui ^c   Yang, Zih Yan ^c   Huang, Han Hisang ^f   Tsai, Feng Jen ^f   Weng, Shun Hsiang ^f   Wu, Yu Jen ^f  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL MUSEUM OF MARINE BIOLOGY AND AQUARIUM   (Taiwan)

^c NATIONAL PINGTUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^d YUAN'S GENERAL HOSPITAL   (Taiwan)

^e MEDICAL UNIVERSITY OF WARSAW   (Poland)

^f MEIHO UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Hepatocellular carcinoma; Mitochondrial; PERK eIF2 ATF4 CHOP; Sinulariolide

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ANTINEOPLASTIC AGENT; ATF4 PROTEIN, HUMAN; CASPASE; DDIT3 PROTEIN, HUMAN; DITERPENE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2; MITOGEN ACTIVATED PROTEIN KINASE; SINULARIOLIDE;

APOPTOSIS; CELL SURVIVAL; DRUG EFFECTS; DRUG SCREENING; ENDOPLASMIC RETICULUM STRESS; HEPG2 CELL LINE; HUMAN; IC50; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; SIGNAL TRANSDUCTION; ARTICLE; CELL STRAIN HEPG2; DRUG EFFECT; IC 50;

ACTIVATING TRANSCRIPTION FACTOR 4; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL SURVIVAL; DITERPENES; DRUG SCREENING ASSAYS, ANTITUMOR; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEP G2 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LIVER NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; TRANSCRIPTION FACTOR CHOP;

EID: 84885090885     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules180910146     Document Type: Article

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