메뉴 건너뛰기




Volumn 14, Issue 10, 2013, Pages 20768-20792

Crosstalk between beta-catenin and snail in the induction of epithelial to mesenchymal transition in hepatocarcinoma: Role of the ERK1/2 pathway

Author keywords

catenin; Epithelial mesenchymal transition; ERK1 2; Hepatocellular carcinoma; Snail

Indexed keywords

12 O TERT RADECANOYLPHORBOL 13 ACETATE; BETA CATENIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG; UVOMORULIN; WNT PROTEIN;

EID: 84885926400     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms141020768     Document Type: Article
Times cited : (55)

References (78)
  • 1
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • El-Serag, H.B.; Rudolph, K.L. Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology 2007, 132, 2557-2576.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 3
    • 7044260782 scopus 로고    scopus 로고
    • Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: Old and new paradigms
    • Bréchot, C. Pathogenesis of hepatitis B virus-related hepatocellular carcinoma: Old and new paradigms. Gastroenterology 2004, 127, S56-S61.
    • (2004) Gastroenterology , vol.127
    • Bréchot, C.1
  • 4
    • 0141828970 scopus 로고    scopus 로고
    • Mechanisms of human hepatocarcinogenesis
    • Coleman, W.B. Mechanisms of human hepatocarcinogenesis. Curr. Mol. Med. 2003, 3, 573-588.
    • (2003) Curr. Mol. Med. , vol.3 , pp. 573-588
    • Coleman, W.B.1
  • 5
    • 7044272621 scopus 로고    scopus 로고
    • Pathogenesis of hepatitis C-associated hepatocellular carcinoma
    • Liang, T.J.; Heller, T. Pathogenesis of hepatitis C-associated hepatocellular carcinoma. Gastroenterology 2004, 127, S62-S71.
    • (2004) Gastroenterology , vol.127
    • Liang, T.J.1    Heller, T.2
  • 6
    • 0036699940 scopus 로고    scopus 로고
    • Molecular pathogenesis of human hepatocellular carcinoma
    • Thorgeirsson, S.S.; Grisham, J.W. Molecular pathogenesis of human hepatocellular carcinoma. Nat. Genet. 2002, 31, 339-346.
    • (2002) Nat. Genet. , vol.31 , pp. 339-346
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 7
    • 0038049137 scopus 로고    scopus 로고
    • Tumour-cell invasion and migration: Diversity and escape mechanisms
    • Friedl, P.; Wolf, K. Tumour-cell invasion and migration: Diversity and escape mechanisms. Nat. Rev. Cancer 2003, 3, 362-374.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 362-374
    • Friedl, P.1    Wolf, K.2
  • 10
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri, R.; Weinberg, R.A. The basics of epithelial-mesenchymal transition. J. Clin. Investig. 2009, 119, 1420-1428.
    • (2009) J. Clin. Investig. , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 11
    • 0344845003 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and pathologies
    • Thiery, J.P. Epithelial-mesenchymal transitions in development and pathologies. Curr. Opin. Cell Biol. 2003, 15, 740-746.
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 740-746
    • Thiery, J.P.1
  • 12
    • 14844364701 scopus 로고    scopus 로고
    • Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity
    • Ozdamar, B.; Bose, R.; Barrios-Rodiles, M.; Wang, H.R.; Zhang, Y.; Wrana, J.L. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Science 2005, 307, 1603-1609.
    • (2005) Science , vol.307 , pp. 1603-1609
    • Ozdamar, B.1    Bose, R.2    Barrios-Rodiles, M.3    Wang, H.R.4    Zhang, Y.5    Wrana, J.L.6
  • 13
    • 5444230567 scopus 로고    scopus 로고
    • Transcriptional regulation of cadherins during development and carcinogenesis
    • Peinado, H.; Portillo, F.; Cano, A. Transcriptional regulation of cadherins during development and carcinogenesis. Int. J. Dev. Biol. 2004, 48, 365-375.
    • (2004) Int. J. Dev. Biol. , vol.48 , pp. 365-375
    • Peinado, H.1    Portillo, F.2    Cano, A.3
  • 14
    • 24644480749 scopus 로고    scopus 로고
    • Molecular requirements for epithelial-mesenchymal transition during tumor progression
    • Huber, M.A.; Kraut, N.; Beug, H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell Biol. 2005, 17, 548-558.
    • (2005) Curr. Opin. Cell Biol. , vol.17 , pp. 548-558
    • Huber, M.A.1    Kraut, N.2    Beug, H.3
  • 15
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • Zeisberg, M.; Neilson, E.G. Biomarkers for epithelial-mesenchymal transitions. J. Clin. Investig. 2009, 119, 1429-1437.
    • (2009) J. Clin. Investig. , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 16
    • 2342603498 scopus 로고    scopus 로고
    • Multitasking in tumor progression: Signaling functions of cell adhesion molecules
    • Cavallaro, U.; Christofori, G. Multitasking in tumor progression: Signaling functions of cell adhesion molecules. Ann. N. Y. Acad. Sci. 2004, 1014, 58-66.
    • (2004) Ann. N. Y. Acad. Sci. , vol.1014 , pp. 58-66
    • Cavallaro, U.1    Christofori, G.2
  • 17
    • 0034067979 scopus 로고    scopus 로고
    • Immunoreactive E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin proteins in hepatocellular carcinoma: Relationships with tumor grade, clinicopathologic parameters, and patients' survival
    • Endo, K.; Ueda, T.; Ueyama, J.; Ohta, T.; Terada, T. Immunoreactive E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin proteins in hepatocellular carcinoma: Relationships with tumor grade, clinicopathologic parameters, and patients' survival. Hum. Pathol. 2000, 31, 558-565.
    • (2000) Hum. Pathol. , vol.31 , pp. 558-565
    • Endo, K.1    Ueda, T.2    Ueyama, J.3    Ohta, T.4    Terada, T.5
  • 18
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • Peinado, H.; Olmeda, D.; Cano, A. Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype? Nat. Rev. Cancer 2007, 7, 415-428.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 19
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
    • Yang, J.; Weinberg, R.A. Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis. Dev. Cell 2008, 14, 818-829.
    • (2008) Dev. Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 20
    • 43949140575 scopus 로고    scopus 로고
    • Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells
    • Fransvea, E.; Angelotti, U.; Antonaci, S.; Giannelli, G. Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells. Hepatology 2008, 47, 1557-1566.
    • (2008) Hepatology , vol.47 , pp. 1557-1566
    • Fransvea, E.1    Angelotti, U.2    Antonaci, S.3    Giannelli, G.4
  • 21
    • 0030779038 scopus 로고    scopus 로고
    • Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin
    • Orford, K.; Crockett, C.; Jensen, J.P.; Weissman, A.M.; Byers, S.W. Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin. J. Biol. Chem. 1997, 272, 24735-24738.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24735-24738
    • Orford, K.1    Crockett, C.2    Jensen, J.P.3    Weissman, A.M.4    Byers, S.W.5
  • 22
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers, H. Wnt/beta-catenin signaling in development and disease. Cell 2006, 127, 469-480.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 25
    • 0032884884 scopus 로고    scopus 로고
    • Beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer
    • Brabletz, T.; Jung, A.; Dag, S.; Hlubek, F.; Kirchner, T. Beta-catenin regulates the expression of the matrix metalloproteinase-7 in human colorectal cancer. Am. J. Pathol. 1999, 155, 1033-1038.
    • (1999) Am. J. Pathol. , vol.155 , pp. 1033-1038
    • Brabletz, T.1    Jung, A.2    Dag, S.3    Hlubek, F.4    Kirchner, T.5
  • 26
    • 0033119801 scopus 로고    scopus 로고
    • Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    • Tetsu, O.; McCormick, F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999, 398, 422-426.
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 27
    • 42449160928 scopus 로고    scopus 로고
    • The transcriptional factor Snail simultaneously triggers cell cycle arrest and migration of human hepatoma HepG2
    • Hu, C.T.; Wu, J.R.; Chang, T.Y.; Cheng, C.C.; Wu, W.S. The transcriptional factor Snail simultaneously triggers cell cycle arrest and migration of human hepatoma HepG2. J. Biomed. Sci. 2008, 15, 343-355.
    • (2008) J. Biomed. Sci. , vol.15 , pp. 343-355
    • Hu, C.T.1    Wu, J.R.2    Chang, T.Y.3    Cheng, C.C.4    Wu, W.S.5
  • 28
    • 35948945337 scopus 로고    scopus 로고
    • Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts
    • Zeisberg, E.M.; Potenta, S.; Xie, L.; Zeisberg, M.; Kalluri, R. Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res. 2007, 67, 10123-10128.
    • (2007) Cancer Res. , vol.67 , pp. 10123-10128
    • Zeisberg, E.M.1    Potenta, S.2    Xie, L.3    Zeisberg, M.4    Kalluri, R.5
  • 31
    • 0032869760 scopus 로고    scopus 로고
    • Fibronectin fibrillogenesis: A paradigm for extracellular matrix assembly
    • Schwarzbauer, J.E.; Sechler, J.L. Fibronectin fibrillogenesis: A paradigm for extracellular matrix assembly. Curr. Opin. Cell Biol. 1999, 11, 622-627.
    • (1999) Curr. Opin. Cell Biol. , vol.11 , pp. 622-627
    • Schwarzbauer, J.E.1    Sechler, J.L.2
  • 32
    • 0037105039 scopus 로고    scopus 로고
    • PKCalpha-mediated ERK, JNK and p38 activation regulates the myogenic program in human rhabdomyosarcoma cells
    • Mauro, A.; Ciccarelli, C.; de Cesaris, P.; Scoglio, A.; Bouché, M.; Molinaro, M.; Aquino, A.; Zani, B.M. PKCalpha-mediated ERK, JNK and p38 activation regulates the myogenic program in human rhabdomyosarcoma cells. J. Cell Sci. 2002, 115, 3587-3599.
    • (2002) J. Cell Sci. , vol.115 , pp. 3587-3599
    • Mauro, A.1    Ciccarelli, C.2    de Cesaris, P.3    Scoglio, A.4    Bouché, M.5    Molinaro, M.6    Aquino, A.7    Zani, B.M.8
  • 33
    • 5444269904 scopus 로고    scopus 로고
    • Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
    • Zhou, B.P.; Deng, J.; Xia, W.; Xu, J.; Li, Y.M.; Gunduz, M.; Hung, M.C. Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol. 2004, 6, 931-940.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 931-940
    • Zhou, B.P.1    Deng, J.2    Xia, W.3    Xu, J.4    Li, Y.M.5    Gunduz, M.6    Hung, M.C.7
  • 35
    • 77956272475 scopus 로고    scopus 로고
    • Functional roles of multiple feedback loops in extracellular signal-regulated kinase and Wnt signaling pathways that regulate epithelial-mesenchymal transition
    • Shin, S.Y.; Rath, O.; Zebisch, A.; Choo, S.M.; Kolch, W.; Cho, K.H. Functional roles of multiple feedback loops in extracellular signal-regulated kinase and Wnt signaling pathways that regulate epithelial-mesenchymal transition. Cancer Res. 2010, 70, 6715-6724.
    • (2010) Cancer Res. , vol.70 , pp. 6715-6724
    • Shin, S.Y.1    Rath, O.2    Zebisch, A.3    Choo, S.M.4    Kolch, W.5    Cho, K.H.6
  • 36
    • 0032926411 scopus 로고    scopus 로고
    • Spatial response to fibroblast growth factor signalling in Xenopus embryos
    • Christen, B.; Slack, J.M. Spatial response to fibroblast growth factor signalling in Xenopus embryos. Development 1999, 126, 119-125.
    • (1999) Development , vol.126 , pp. 119-125
    • Christen, B.1    Slack, J.M.2
  • 38
    • 0035872426 scopus 로고    scopus 로고
    • Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation
    • Ellenrieder, V.; Hendler, S.F.; Boeck, W.; Seufferlein, T.; Menke, A.; Ruhland, C.; Adler, G.; Gress, T.M. Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation. Cancer Res. 2001, 61, 4222-4228.
    • (2001) Cancer Res. , vol.61 , pp. 4222-4228
    • Ellenrieder, V.1    Hendler, S.F.2    Boeck, W.3    Seufferlein, T.4    Menke, A.5    Ruhland, C.6    Adler, G.7    Gress, T.M.8
  • 39
    • 18744362996 scopus 로고    scopus 로고
    • Transforming growth factor-beta and epidermal growth factor synergistically stimulate epithelial to mesenchymal transition (EMT) through a MEK-dependent mechanism in primary cultured pig thyrocytes
    • Grände, M.; Franzen, A.; Karlsson, J.O.; Ericson, L.E.; Heldin, N.E.; Nilsson, M. Transforming growth factor-beta and epidermal growth factor synergistically stimulate epithelial to mesenchymal transition (EMT) through a MEK-dependent mechanism in primary cultured pig thyrocytes. J. Cell Sci. 2002, 115, 4227-4236.
    • (2002) J. Cell Sci. , vol.115 , pp. 4227-4236
    • Grände, M.1    Franzen, A.2    Karlsson, J.O.3    Ericson, L.E.4    Heldin, N.E.5    Nilsson, M.6
  • 40
    • 0037572319 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids
    • Bates, R.C.; Mercurio, A.M. Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Mol. Biol. Cell 2003, 14, 1790-1800.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 1790-1800
    • Bates, R.C.1    Mercurio, A.M.2
  • 41
    • 0038756636 scopus 로고    scopus 로고
    • Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: Mechanisms for epithelial mesenchymal transitions
    • Peinado, H.; Quintanilla, M.; Cano, A. Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: Mechanisms for epithelial mesenchymal transitions. J. Biol. Chem. 2003, 278, 21113-21123.
    • (2003) J. Biol. Chem. , vol.278 , pp. 21113-21123
    • Peinado, H.1    Quintanilla, M.2    Cano, A.3
  • 42
    • 0030715557 scopus 로고    scopus 로고
    • Altered expression of mitogen-activated protein kinases in a rat model of experimental hepatocellular carcinoma
    • McKillop, I.H.; Schmidt, C.M.; Cahill, P.A.; Sitzmann, J.V. Altered expression of mitogen-activated protein kinases in a rat model of experimental hepatocellular carcinoma. Hepatology 1997, 26, 1484-1491.
    • (1997) Hepatology , vol.26 , pp. 1484-1491
    • McKillop, I.H.1    Schmidt, C.M.2    Cahill, P.A.3    Sitzmann, J.V.4
  • 43
    • 17344372847 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma
    • Ito, Y.; Sasaki, Y.; Horimoto, M.; Wada, S.; Tanaka, Y.; Kasahara, A.; Ueki, T.; Hirano, T.; Yamamoto, H.; Fujimoto, J.; et al. Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma. Hepatology 1998, 27, 951-958.
    • (1998) Hepatology , vol.27 , pp. 951-958
    • Ito, Y.1    Sasaki, Y.2    Horimoto, M.3    Wada, S.4    Tanaka, Y.5    Kasahara, A.6    Ueki, T.7    Hirano, T.8    Yamamoto, H.9    Fujimoto, J.10
  • 44
    • 36549013178 scopus 로고    scopus 로고
    • Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection
    • Schmitz, K.J.; Wohlschlaeger, J.; Lang, H.; Sotiropoulos, G.C.; Malago, M.; Steveling, K.; Reis, H.; Cicinnati, V.R.; Schmid, K.W.; Baba, H.A. Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. J. Hepatol. 2008, 48, 83-90.
    • (2008) J. Hepatol. , vol.48 , pp. 83-90
    • Schmitz, K.J.1    Wohlschlaeger, J.2    Lang, H.3    Sotiropoulos, G.C.4    Malago, M.5    Steveling, K.6    Reis, H.7    Cicinnati, V.R.8    Schmid, K.W.9    Baba, H.A.10
  • 47
    • 0037033693 scopus 로고    scopus 로고
    • Inverse correlation between E-cadherin and Snail expression in hepatocellular carcinoma cell lines in vitro and in vivo
    • Jiao, W.; Miyazaki, K.; Kitajima, Y. Inverse correlation between E-cadherin and Snail expression in hepatocellular carcinoma cell lines in vitro and in vivo. Br. J. Cancer 2002, 86, 98-101.
    • (2002) Br. J. Cancer , vol.86 , pp. 98-101
    • Jiao, W.1    Miyazaki, K.2    Kitajima, Y.3
  • 50
    • 0027685701 scopus 로고
    • Cadherins in cancer: Implications for invasion and metastasis
    • Takeichi, M. Cadherins in cancer: Implications for invasion and metastasis. Curr. Opin. Cell Biol. 1993, 5, 806-811.
    • (1993) Curr. Opin. Cell Biol. , vol.5 , pp. 806-811
    • Takeichi, M.1
  • 51
    • 0033079605 scopus 로고    scopus 로고
    • The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene
    • Christofori, G.; Semb, H. The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem. Sci. 1999, 24, 73-76.
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 73-76
    • Christofori, G.1    Semb, H.2
  • 53
    • 58849153401 scopus 로고    scopus 로고
    • Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas
    • Zhai, B.; Yan, H.X.; Liu, S.Q.; Chen, L.; Wu, M.C.; Wang, H.Y. Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas. World J. Gastroenterol. 2008, 14, 5665-5673.
    • (2008) World J. Gastroenterol. , vol.14 , pp. 5665-5673
    • Zhai, B.1    Yan, H.X.2    Liu, S.Q.3    Chen, L.4    Wu, M.C.5    Wang, H.Y.6
  • 54
    • 14844297318 scopus 로고    scopus 로고
    • Snail accelerates cancer invasion by upregulating MMP expression and is associated with poor prognosis of hepatocellular carcinoma
    • Miyoshi, A.; Kitajima, Y.; Kido, S.; Shimonishi, T.; Matsuyama, S.; Kitahara, K.; Miyazaki, K. Snail accelerates cancer invasion by upregulating MMP expression and is associated with poor prognosis of hepatocellular carcinoma. Br. J. Cancer 2005, 92, 252-258.
    • (2005) Br. J. Cancer , vol.92 , pp. 252-258
    • Miyoshi, A.1    Kitajima, Y.2    Kido, S.3    Shimonishi, T.4    Matsuyama, S.5    Kitahara, K.6    Miyazaki, K.7
  • 56
    • 0036513626 scopus 로고    scopus 로고
    • The snail superfamily of zinc-finger transcription factors
    • Nieto, M.A. The snail superfamily of zinc-finger transcription factors. Nat. Rev. Mol. Cell Biol. 2002, 3, 155-166.
    • (2002) Nat. Rev. Mol. Cell Biol. , vol.3 , pp. 155-166
    • Nieto, M.A.1
  • 57
    • 0035167812 scopus 로고    scopus 로고
    • The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition
    • Carver, E.A.; Jiang, R.; Lan, Y.; Oram, K.F.; Gridley, T. The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition. Mol. Cell. Biol. 2001, 21, 8184-8188.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 8184-8188
    • Carver, E.A.1    Jiang, R.2    Lan, Y.3    Oram, K.F.4    Gridley, T.5
  • 58
    • 70449527638 scopus 로고    scopus 로고
    • Hypoxia, Snail and incomplete epithelial-mesenchymal transition in breast cancer
    • Lundgren, K.; Nordenskjöld, B.; Landberg, G. Hypoxia, Snail and incomplete epithelial-mesenchymal transition in breast cancer. Br. J. Cancer 2009, 101, 1769-1781.
    • (2009) Br. J. Cancer , vol.101 , pp. 1769-1781
    • Lundgren, K.1    Nordenskjöld, B.2    Landberg, G.3
  • 59
    • 24644487312 scopus 로고    scopus 로고
    • TGF-beta and epithelial-to-mesenchymal transitions
    • Zavadil, J.; Böttinger, E.P. TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 2005, 24, 5764-5774.
    • (2005) Oncogene , vol.24 , pp. 5764-5774
    • Zavadil, J.1    Böttinger, E.P.2
  • 60
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery, J.P. Epithelial-mesenchymal transitions in tumour progression. Nat. Rev. Cancer 2002, 2, 442-454.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 61
    • 0043092191 scopus 로고    scopus 로고
    • Wnt pathway activation in mesothelioma: Evidence of Dishevelled overexpression and transcriptional activity of beta-catenin
    • Uematsu, K.; Kanazawa, S.; You, L.; He, B.; Xu, Z.; Li, K.; Peterlin, B.M.; McCormick, F.; Jablons, D.M. Wnt pathway activation in mesothelioma: Evidence of Dishevelled overexpression and transcriptional activity of beta-catenin. Cancer Res. 2003, 63, 4547-4551.
    • (2003) Cancer Res. , vol.63 , pp. 4547-4551
    • Uematsu, K.1    Kanazawa, S.2    You, L.3    He, B.4    Xu, Z.5    Li, K.6    Peterlin, B.M.7    McCormick, F.8    Jablons, D.M.9
  • 62
    • 15744374449 scopus 로고    scopus 로고
    • Wnt-dependent regulation of the E-cadherin repressor snail
    • Yook, J.I.; Li, X.Y.; Ota, I.; Fearon, E.R.; Weiss, S.J. Wnt-dependent regulation of the E-cadherin repressor snail. J. Biol. Chem. 2005, 280, 11740-11748.
    • (2005) J. Biol. Chem. , vol.280 , pp. 11740-11748
    • Yook, J.I.1    Li, X.Y.2    Ota, I.3    Fearon, E.R.4    Weiss, S.J.5
  • 63
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, beta-catenin, and cadherin pathways
    • Nelson, W.J.; Nusse, R. Convergence of Wnt, beta-catenin, and cadherin pathways. Science 2004, 303, 1483-1487.
    • (2004) Science , vol.303 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 64
    • 0036120562 scopus 로고    scopus 로고
    • The cadherin-catenin adhesion system in signaling and cancer
    • Conacci-Sorrell, M.; Zhurinsky, J.; Ben-Ze'ev, A. The cadherin-catenin adhesion system in signaling and cancer. J. Clin. Investig. 2002, 109, 987-991.
    • (2002) J. Clin. Investig. , vol.109 , pp. 987-991
    • Conacci-Sorrell, M.1    Zhurinsky, J.2    Ben-Ze'ev, A.3
  • 65
    • 50649103964 scopus 로고    scopus 로고
    • Snail promotes Wnt target gene expression and interacts with beta-catenin
    • Stemmer, V.; de Craene, B.; Berx, G.; Behrens, J. Snail promotes Wnt target gene expression and interacts with beta-catenin. Oncogene 2008, 27, 5075-5080.
    • (2008) Oncogene , vol.27 , pp. 5075-5080
    • Stemmer, V.1    de Craene, B.2    Berx, G.3    Behrens, J.4
  • 66
    • 34248674146 scopus 로고    scopus 로고
    • WNT/beta-catenin signaling in liver health and disease
    • Thompson, M.D.; Monga, S.P. WNT/beta-catenin signaling in liver health and disease. Hepatology 2007, 45, 1298-1305.
    • (2007) Hepatology , vol.45 , pp. 1298-1305
    • Thompson, M.D.1    Monga, S.P.2
  • 67
    • 59049093707 scopus 로고    scopus 로고
    • Wnt signaling in liver cancer
    • Takigawa, Y.; Brown, A.M. Wnt signaling in liver cancer. Curr. Drug Targets 2008, 9, 1013-1024.
    • (2008) Curr. Drug Targets , vol.9 , pp. 1013-1024
    • Takigawa, Y.1    Brown, A.M.2
  • 70
    • 0142028054 scopus 로고    scopus 로고
    • GSK-3beta phosphorylation and alteration of beta-catenin in hepatocellular carcinoma
    • Ban, K.C.; Singh, H.; Krishnan, R.; Seow, H.F. GSK-3beta phosphorylation and alteration of beta-catenin in hepatocellular carcinoma. Cancer Lett. 2003, 199, 201-208.
    • (2003) Cancer Lett. , vol.199 , pp. 201-208
    • Ban, K.C.1    Singh, H.2    Krishnan, R.3    Seow, H.F.4
  • 73
    • 36048967529 scopus 로고    scopus 로고
    • siRNA-mediated beta-catenin knockdown in human hepatoma cells results in decreased growth and survival
    • Zeng, G.; Apte, U.; Cieply, B.; Singh, S.; Monga, S.P. siRNA-mediated beta-catenin knockdown in human hepatoma cells results in decreased growth and survival. Neoplasia 2007, 9, 951-959.
    • (2007) Neoplasia , vol.9 , pp. 951-959
    • Zeng, G.1    Apte, U.2    Cieply, B.3    Singh, S.4    Monga, S.P.5
  • 74
    • 0028928485 scopus 로고
    • Overexpression of matrix metalloproteinase-7 mRNA in human colon carcinomas
    • Mori, M.; Barnard, G.F.; Mimori, K.; Ueo, H.; Akiyoshi, T.; Sugimachi, K. Overexpression of matrix metalloproteinase-7 mRNA in human colon carcinomas. Cancer 1995, 75, 1516-1519.
    • (1995) Cancer , vol.75 , pp. 1516-1519
    • Mori, M.1    Barnard, G.F.2    Mimori, K.3    Ueo, H.4    Akiyoshi, T.5    Sugimachi, K.6
  • 76
    • 58149239745 scopus 로고    scopus 로고
    • Lindane and cell death: At the crossroads between apoptosis, necrosis and autophagy
    • Zucchini-Pascal, N.; de Sousa, G.; Rahmani, R. Lindane and cell death: At the crossroads between apoptosis, necrosis and autophagy. Toxicology 2009, 256, 32-41.
    • (2009) Toxicology , vol.256 , pp. 32-41
    • Zucchini-Pascal, N.1    de Sousa, G.2    Rahmani, R.3
  • 77
    • 67650504966 scopus 로고    scopus 로고
    • TScratch: A novel and simple software tool for automated analysis of monolayer wound healing assays
    • Gebäck, T.; Schulz, M.M.; Koumoutsakos, P.; Detmar, M. TScratch: A novel and simple software tool for automated analysis of monolayer wound healing assays. Biotechniques 2009, 46, 265-274.
    • (2009) Biotechniques , vol.46 , pp. 265-274
    • Gebäck, T.1    Schulz, M.M.2    Koumoutsakos, P.3    Detmar, M.4
  • 78
    • 33746906998 scopus 로고    scopus 로고
    • SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by snail and slug: A potential mechanism for aberrant mesenchymal to epithelial transition in human synovial sarcoma
    • Saito, T.; Nagai, M.; Ladanyi, M. SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by snail and slug: A potential mechanism for aberrant mesenchymal to epithelial transition in human synovial sarcoma. Cancer Res. 2006, 66, 6919-6927.
    • (2006) Cancer Res. , vol.66 , pp. 6919-6927
    • Saito, T.1    Nagai, M.2    Ladanyi, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.