Mode of action of diterpene and characterization of related metabolites from the soft coral, Xeniaelongata

Marine Drugs

Volumn 12, Issue 2, 2014, Pages 1102-1115

  Andrianasolo, Eric H ^a   Haramaty, Liti ^a   White, Eileen ^b   Lutz, Richard ^a   Falkowski, Paul ^a  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

Bioactive compounds and bioproducts; Drug discovery and development; Marine biotechnology; Structural and functional characterization of marine drug

Indexed keywords

DITERPENE; DRUG METABOLITE; HISTONE DEACETYLASE 6; PROTEIN BAK; PROTEIN BAX;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CORAL; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; XENIA ELONGATA;

ANIMALS; ANTHOZOA; APOPTOSIS; CELL LINE; DITERPENES; EPITHELIAL CELLS; GENETIC ENGINEERING; HISTONE DEACETYLASES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE;

EID: 84896712703     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md12021102     Document Type: Article

References (18)

1. Newman, D.J.; Cragg, G.M. Natural products as sources of new drugs over the last 25 years. J. Nat. Prod. 2007, 70, 461-477.
2. Simmons, T.L.; Andrianasolo, E.H.; McPhail, K.; Flatt, P.; Gerwick, W.H. Marine natural products as anticancer drugs. Mol. Cancer Ther. 2005, 4, 333-342.
3. Andrianasolo, E.H.; Haramaty, L.; Degenhardt, K.; Mathew, R.; White, E.; Lutz, R.; Falkowski, P. Induction of apoptosis by diterpenes from the soft coral Xenia elongata. J. Nat. Prod. 2007, 70, 1551-1557.
4. Duh, C.-Y.; El-Gamal, A.A.H.; Chiang, C.-Y.; Chu, C.-J.; Wang, S.-K.; Dai, C.-F. New cytotoxic xenia diterpenoids from the formosan soft coral Xenia umbellata. J. Nat. Prod. 2002, 65, 1882-1885.
5. Pollex, A.; Hiersemann, M. Catalytic asymmetric claisen rearrangement in natural product synthesis: Synthetic studies toward (-)-xeniolide F. Org. Lett. 2005, 7, 5705-5708.
6. Mushti, C.S.; Kim, J.-H.; Corey, E.J. Total synthesis of antheliolide A. J. Am. Chem. Soc. 2006, 128, 14050-14052.
7. Kashman, Y.; Groweiss, A. New diterpenoids from the soft corals Xenia macrospiculata and Xenia obscuronata. J. Org. Chem. 1980, 45, 3814-3824.
8. Davies-Coleman, M.T.; Beukes, D.R. Ten years of marine natural products research at Rhodes University. S. Afr. J. Sci. 2004, 100, 539-543.
9. Hooper, G.J.; Davies-Coleman, M.T.; Schleyer, M. New diterpenes from the South African soft coral Eleutherobia aurea. J. Nat. Prod. 1997, 60, 889-893.
10. Coval, S.J.; Scheuer, P.J.; Matsumoto, G.K.; Clardy, J. Two new xenicin diterpenoids from the octocoral Anthelia edmondsoni. Tetrahedron 1984, 40, 3823-3828.
11. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Meth. 1983, 65, 55-63.
12. Drahl, M.A.; Akhmedov, N.G.; Williams, L.J. Selective conversion of an enantioenriched cyclononadienone to the xeniolide, xenibellol, and florlide cores: An integrated routing strategy. Tetrahedron Lett. 2011, 52, 325-328.
13. Connectivity MAP 02. Available online: http://www.broad.mit.edu/cmap/ (accessed on 12 December 2007).
14. Schwender, H.; Krause, A.; Ickstadt, K. Identifying Interesting Genes with siggenes. RNews 2006, 6, 45-50.
15. Tusher, V.G.; Tibshirani, R.; Chu, G. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. USA 2001, 98, 5116-5121.
16. Efron, B.; Tibshirani, R.; Storey, J.D.; Tusher, V. Empirical bayes analysis of a microarray experiment. J. Am. Statist. Assoc. 2001, 96, 1151-1160.
17. Thomas, S.; Munster, P.N. Histone deacetylase inhibitor induced modulation of anti-estrogen therapy. Cancer Lett. 2009, 280, 184-191.
18. Su, H.; Altucci, L.; You, Q. Competitive or noncompetitive, that's the question: Research toward histone deacetylase inhibitors. Mol. Cancer Ther. 2008, 7, 1007-1012.