메뉴 건너뛰기




Volumn 2, Issue 2, 2013, Pages 193-208

In vivo applications of single chain Fv (variable domain) (scFv) fragments

Author keywords

Adeno associated virus (AAV); Immunotherapy; In vivo expression; Recombinant antibodies; ScFv

Indexed keywords

AMYLOID BETA PROTEIN; CD7 ANTIGEN; CHEMOKINE RECEPTOR CCR4; GLUCOSE REGULATED PROTEIN 78; INSULIN RECEPTOR; RECOMBINANT IMMUNOTOXIN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; TENASCIN; TRANSCRIPTION FACTOR PAX6; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG;

EID: 84907983837     PISSN: 20734468     EISSN: None     Source Type: Journal    
DOI: 10.3390/antib2020193     Document Type: Review
Times cited : (97)

References (84)
  • 1
    • 16344376889 scopus 로고    scopus 로고
    • From sorting endosomes to exocytosis: Association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, During recycling
    • Ward, E. S.; Martinez, C.; Vaccaro, C.; Zhou, J.; Tang, Q.; Ober, R. J. From sorting endosomes to exocytosis: Association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, During recycling. Mol. Biol. Cell 2005, 16, 2028-2038.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 2028-2038
    • Ward, E.S.1    Martinez, C.2    Vaccaro, C.3    Zhou, J.4    Tang, Q.5    Ober, R.J.6
  • 2
    • 1142298744 scopus 로고    scopus 로고
    • Human antibody-Fc receptor interactions illuminated by crystal structures
    • Woof, J. M.; Burton, D. R. Human antibody-Fc receptor interactions illuminated by crystal structures. Nat. Rev. Immunol. 2004, 4, 89-99.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 89-99
    • Woof, J.M.1    Burton, D.R.2
  • 3
    • 27144449009 scopus 로고    scopus 로고
    • Monoclonal antibody therapy of cancer
    • Adams, G. P.; Weiner, L. M. Monoclonal antibody therapy of cancer. Nat. Biotechnol. 2005, 23, 1147-1157.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 1147-1157
    • Adams, G.P.1    Weiner, L.M.2
  • 4
    • 27144550160 scopus 로고    scopus 로고
    • Arming antibodies: Prospects and challenges for immunoconjugates
    • Wu, A. M.; Senter, P. D. Arming antibodies: Prospects and challenges for immunoconjugates. Nat. Biotechnol. 2005, 23, 1137-1146.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 1137-1146
    • Wu, A.M.1    Senter, P.D.2
  • 5
    • 27144432842 scopus 로고    scopus 로고
    • Engineered antibody fragments and the rise of single domains
    • Holliger, P.; Hudson, P. J. Engineered antibody fragments and the rise of single domains. Nat. Biotechnol. 2005, 23, 1126-1136.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 1126-1136
    • Holliger, P.1    Hudson, P.J.2
  • 6
    • 70449276523 scopus 로고
    • The hydrolysis of rabbit y-globulin and antibodies with crystalline papain
    • Porter, R. R. The hydrolysis of rabbit y-globulin and antibodies with crystalline papain. Biochem. J. 1959, 73, 119-126.
    • (1959) Biochem. J. , vol.73 , pp. 119-126
    • Porter, R.R.1
  • 7
    • 0032146225 scopus 로고    scopus 로고
    • Recombinant antibody fragments
    • Hudson, P. J. Recombinant antibody fragments. Curr. Opin. Biotechnol. 1998, 9, 395-402.
    • (1998) Curr. Opin. Biotechnol. , vol.9 , pp. 395-402
    • Hudson, P.J.1
  • 9
    • 0024292736 scopus 로고
    • Assembly of a functional immunoglobulin Fv fragment in Escherichia coli
    • Skerra, A.; Pluckthun, A. Assembly of a functional immunoglobulin Fv fragment in Escherichia coli. Science 1988, 240, 1038-1041.
    • (1988) Science , vol.240 , pp. 1038-1041
    • Skerra, A.1    Pluckthun, A.2
  • 11
    • 78650151812 scopus 로고    scopus 로고
    • Enhancing the thermal stability of a single-chain Fv fragment by in vivo global fluorination of the proline residues
    • Edwardraja, S.; Sriram, S.; Govindan, R.; Budisa, N.; Lee, S. G. Enhancing the thermal stability of a single-chain Fv fragment by in vivo global fluorination of the proline residues. Mol. Biosyst. 2011, 7, 258-265.
    • (2011) Mol. Biosyst. , vol.7 , pp. 258-265
    • Edwardraja, S.1    Sriram, S.2    Govindan, R.3    Budisa, N.4    Lee, S.G.5
  • 12
    • 77953653252 scopus 로고    scopus 로고
    • Antibody fragments: Hope and hype
    • Nelson, A. L. Antibody fragments: Hope and hype. MAbs 2010, 2, 77-83.
    • (2010) MAbs , vol.2 , pp. 77-83
    • Nelson, A.L.1
  • 13
    • 64349107630 scopus 로고    scopus 로고
    • Development trends for therapeutic antibody fragments
    • Nelson, A. L.; Reichert, J. M. Development trends for therapeutic antibody fragments. Nat. Biotechnol. 2009, 27, 331-337.
    • (2009) Nat. Biotechnol. , vol.27 , pp. 331-337
    • Nelson, A.L.1    Reichert, J.M.2
  • 19
    • 0028846149 scopus 로고
    • Properties of a single-chain antibody containing different linker peptides
    • Alfthan, K.; Takkinen, K.; Sizmann, D.; Soderlund, H.; Teeri, T. T. Properties of a single-chain antibody containing different linker peptides. Protein Eng. 1995, 8, 725-731.
    • (1995) Protein Eng. , vol.8 , pp. 725-731
    • Alfthan, K.1    Takkinen, K.2    Sizmann, D.3    Soderlund, H.4    Teeri, T.T.5
  • 20
    • 0032884573 scopus 로고    scopus 로고
    • Recombinant protein expression in Escherichia coli
    • Baneyx, F. Recombinant protein expression in Escherichia coli. Curr. Opin. Biotechnol. 1999, 10, 411-421.
    • (1999) Curr. Opin. Biotechnol. , vol.10 , pp. 411-421
    • Baneyx, F.1
  • 21
    • 33745464891 scopus 로고    scopus 로고
    • Isolation of anti-CD22 Fv with high affinity by Fv display on human cells
    • Ho, M.; Nagata, S.; Pastan, I. Isolation of anti-CD22 Fv with high affinity by Fv display on human cells. Proc. Natl. Acad. Sci. USA 2006, 103, 9637-9642.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 9637-9642
    • Ho, M.1    Nagata, S.2    Pastan, I.3
  • 23
    • 0036451715 scopus 로고    scopus 로고
    • Soluble expression of a functional recombinant cytolytic immunotoxin in insect cells
    • Choo, A. B.; Dunn, R. D.; Broady, K. W.; Raison, R. L. Soluble expression of a functional recombinant cytolytic immunotoxin in insect cells. Protein Expres. Purif. 2002, 24, 338-347.
    • (2002) Protein Expres. Purif. , vol.24 , pp. 338-347
    • Choo, A.B.1    Dunn, R.D.2    Broady, K.W.3    Raison, R.L.4
  • 24
    • 0031931487 scopus 로고    scopus 로고
    • Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity
    • Chowdhury, P. S.; Viner, J. L.; Beers, R.; Pastan, I. Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity. Proc. National. Acad. Sci. USA 1998, 95, 669-674.
    • (1998) Proc. National. Acad. Sci. USA , vol.95 , pp. 669-674
    • Chowdhury, P.S.1    Viner, J.L.2    Beers, R.3    Pastan, I.4
  • 25
    • 64249112661 scopus 로고    scopus 로고
    • Current constructs and targets in clinical development for antibody-based cancer therapy
    • Deckert, P. M. Current constructs and targets in clinical development for antibody-based cancer therapy. Curr. Drug Targets 2009, 10, 158-175.
    • (2009) Curr. Drug Targets , vol.10 , pp. 158-175
    • Deckert, P.M.1
  • 26
    • 85136046795 scopus 로고    scopus 로고
    • Radioiodinated-anti-TAG-72 covalently linked CC49 divalent single-chain Fv antibody
    • In; National Center for Biotechnology Information: Bethesda, MD, USA
    • Cheng, K. T. Radioiodinated-anti-TAG-72 covalently linked CC49 divalent single-chain Fv antibody. In Molecular Imaging and Contrast Agent Database (MICAD); National Center for Biotechnology Information: Bethesda, MD, USA, 2004.
    • (2004) Molecular Imaging and Contrast Agent Database (MICAD)
    • Cheng, K.T.1
  • 28
    • 13944266719 scopus 로고    scopus 로고
    • Quantitative immuno-positron emission tomography imaging of HER2-positive tumor xenografts with an iodine-124 labeled anti-HER2 diabody
    • Robinson, M. K.; Doss, M.; Shaller, C.; Narayanan, D.; Marks, J. D.; Adler, L. P.; Gonzalez Trotter, D. E.; Adams, G. P. Quantitative immuno-positron emission tomography imaging of HER2-positive tumor xenografts with an iodine-124 labeled anti-HER2 diabody. Cancer Res. 2005, 65, 1471-1478.
    • (2005) Cancer Res. , vol.65 , pp. 1471-1478
    • Robinson, M.K.1    Doss, M.2    Shaller, C.3    Narayanan, D.4    Marks, J.D.5    Adler, L.P.6    Gonzalez Trotter, D.E.7    Adams, G.P.8
  • 30
    • 0032489812 scopus 로고    scopus 로고
    • Targeted delivery of chemotherapeutics: Tumor-activated prodrug therapy
    • Chari, R. V. Targeted delivery of chemotherapeutics: Tumor-activated prodrug therapy. Adv. Drug Deliv. Rev. 1998, 31, 89-104.
    • (1998) Adv. Drug Deliv. Rev. , vol.31 , pp. 89-104
    • Chari, R.V.1
  • 31
    • 84858645667 scopus 로고    scopus 로고
    • A human recombinant autoantibody-based immunotoxin specific for the fetal acetylcholine receptor inhibits rhabdomyosarcoma growth in vitro and in a murine transplantation model
    • Gattenlohner, S.; Jorissen, H.; Huhn, M.; Vincent, A.; Beeson, D.; Tzartos, S.; Mamalaki, A.; Etschmann, B.; Muller-Hermelink, H. K.; Koscielniak, E.; et al. A human recombinant autoantibody-based immunotoxin specific for the fetal acetylcholine receptor inhibits rhabdomyosarcoma growth in vitro and in a murine transplantation model. J. Biomed. Biotechnol. 2010, 2010, 187621.
    • (2010) J. Biomed. Biotechnol. , vol.2010 , pp. 187621
    • Gattenlohner, S.1    Jorissen, H.2    Huhn, M.3    Vincent, A.4    Beeson, D.5    Tzartos, S.6    Mamalaki, A.7    Etschmann, B.8    Muller-Hermelink, H.K.9    Koscielniak, E.10
  • 32
    • 77951687530 scopus 로고    scopus 로고
    • Construction and characterization of a novel fusion protein MG7-scFv/SEB against gastric cancer
    • Tong, Q.; Liu, K.; Lu, X. M.; Shu, X. G.; Wang, G. B. Construction and characterization of a novel fusion protein MG7-scFv/SEB against gastric cancer. J. Biomed. Biotechnol. 2010, 2010, 121094.
    • (2010) J. Biomed. Biotechnol. , vol.2010 , pp. 121094
    • Tong, Q.1    Liu, K.2    Lu, X.M.3    Shu, X.G.4    Wang, G.B.5
  • 33
    • 59649130081 scopus 로고    scopus 로고
    • Sustained in vivo inhibition of protein domains using single-chain Fv recombinant antibodies and its application to dissect rgma activity on axonal outgrowth
    • Tassew, N. G.; Charish, J.; Chestopalova, L.; Monnier, P. P. Sustained in vivo inhibition of protein domains using single-chain Fv recombinant antibodies and its application to dissect rgma activity on axonal outgrowth. J. Neurosci. 2009, 29, 1126-1131.
    • (2009) J. Neurosci. , vol.29 , pp. 1126-1131
    • Tassew, N.G.1    Charish, J.2    Chestopalova, L.3    Monnier, P.P.4
  • 34
    • 80054892346 scopus 로고    scopus 로고
    • Paracrine Pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube
    • Di Lullo, E.; Haton, C.; Le Poupon, C.; Volovitch, M.; Joliot, A.; Thomas, J. L.; Prochiantz, A. Paracrine Pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube. Development 2011, 138, 4991-5001.
    • (2011) Development , vol.138 , pp. 4991-5001
    • Di Lullo, E.1    Haton, C.2    Le Poupon, C.3    Volovitch, M.4    Joliot, A.5    Thomas, J.L.6    Prochiantz, A.7
  • 36
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • Bard, F.; Cannon, C.; Barbour, R.; Burke, R. L.; Games, D.; Grajeda, H.; Guido, T.; Hu, K.; Huang, J.; Johnson-Wood, K.; et al. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 2000, 6, 916-919.
    • (2000) Nat. Med. , vol.6 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3    Burke, R.L.4    Games, D.5    Grajeda, H.6    Guido, T.7    Hu, K.8    Huang, J.9    Johnson-Wood, K.10
  • 37
    • 33751080719 scopus 로고    scopus 로고
    • Synthetic therapeutic antibodies
    • Sidhu, S. S.; Fellouse, F. A. Synthetic therapeutic antibodies. Nat. Chem. Biol. 2006, 2, 682-688.
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 682-688
    • Sidhu, S.S.1    Fellouse, F.A.2
  • 38
    • 79952399087 scopus 로고    scopus 로고
    • Beyond natural antibodies: The power of in vitro display technologies
    • Bradbury, A. R.; Sidhu, S.; Dubel, S.; McCafferty, J. Beyond natural antibodies: The power of in vitro display technologies. Nat. Biotechnol. 2011, 29, 245-254.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 245-254
    • Bradbury, A.R.1    Sidhu, S.2    Dubel, S.3    McCafferty, J.4
  • 39
    • 84860692601 scopus 로고    scopus 로고
    • Engineered antibody therapies to counteract mutant huntingtin and related toxic intracellular proteins
    • Butler, D. C.; McLear, J. A.; Messer, A. Engineered antibody therapies to counteract mutant huntingtin and related toxic intracellular proteins. Prog. Neurobiol. 2012, 97, 190-204.
    • (2012) Prog. Neurobiol. , vol.97 , pp. 190-204
    • Butler, D.C.1    McLear, J.A.2    Messer, A.3
  • 40
    • 50549104374 scopus 로고    scopus 로고
    • Delivery of single-chain antibodies (scFvs) directed against the 37/67 kDa laminin receptor into mice via recombinant adeno-associated viral vectors for prion disease gene therapy
    • Zuber, C.; Mitteregger, G.; Schuhmann, N.; Rey, C.; Knackmuss, S.; Rupprecht, W.; Reusch, U.; Pace, C.; Little, M.; Kretzschmar, H. A.; et al. Delivery of single-chain antibodies (scFvs) directed against the 37/67 kDa laminin receptor into mice via recombinant adeno-associated viral vectors for prion disease gene therapy. J. Gen. Virol. 2008, 89, 2055-2061.
    • (2008) J. Gen. Virol. , vol.89 , pp. 2055-2061
    • Zuber, C.1    Mitteregger, G.2    Schuhmann, N.3    Rey, C.4    Knackmuss, S.5    Rupprecht, W.6    Reusch, U.7    Pace, C.8    Little, M.9    Kretzschmar, H.A.10
  • 41
    • 54249126862 scopus 로고    scopus 로고
    • Gene therapy using adeno-associated virus vectors
    • Daya, S.; Berns, K. I. Gene therapy using adeno-associated virus vectors. Clin. Microbiol. Rev. 2008, 21, 583-593.
    • (2008) Clin. Microbiol. Rev. , vol.21 , pp. 583-593
    • Daya, S.1    Berns, K.I.2
  • 43
    • 0023265819 scopus 로고
    • Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors
    • Hughes, S. H.; Greenhouse, J. J.; Petropoulos, C. J.; Sutrave, P. Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors. J. Virol. 1987, 61, 3004-3012.
    • (1987) J. Virol. , vol.61 , pp. 3004-3012
    • Hughes, S.H.1    Greenhouse, J.J.2    Petropoulos, C.J.3    Sutrave, P.4
  • 46
    • 76249087751 scopus 로고    scopus 로고
    • Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor
    • Boado, R. J.; Zhou, Q. H.; Lu, J. Z.; Hui, E. K.; Pardridge, W. M. Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor. Mol. Pharm. 2010, 7, 237-244.
    • (2010) Mol. Pharm. , vol.7 , pp. 237-244
    • Boado, R.J.1    Zhou, Q.H.2    Lu, J.Z.3    Hui, E.K.4    Pardridge, W.M.5
  • 47
    • 74849088013 scopus 로고    scopus 로고
    • IgG-single chain Fv fusion protein therapeutic for Alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey
    • Boado, R. J.; Lu, J. Z.; Hui, E. K.; Pardridge, W. M. IgG-single chain Fv fusion protein therapeutic for Alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey. Biotechnol. Bioeng. 2010, 105, 627-635.
    • (2010) Biotechnol. Bioeng. , vol.105 , pp. 627-635
    • Boado, R.J.1    Lu, J.Z.2    Hui, E.K.3    Pardridge, W.M.4
  • 49
    • 84873085590 scopus 로고    scopus 로고
    • Recombinant single-chain antibody with the Trojan peptide penetratin positioned in the linker region enables cargo transfer across the blood-brain barrier
    • Skrlj, N.; Drevensek, G.; Hudoklin, S.; Romih, R.; Curin Serbec, V.; Dolinar, M. Recombinant single-chain antibody with the Trojan peptide penetratin positioned in the linker region enables cargo transfer across the blood-brain barrier. Appl. Biochem. Biotechnol. 2013, 169, 159-169.
    • (2013) Appl. Biochem. Biotechnol. , vol.169 , pp. 159-169
    • Skrlj, N.1    Drevensek, G.2    Hudoklin, S.3    Romih, R.4    Curin Serbec, V.5    Dolinar, M.6
  • 50
    • 33746786005 scopus 로고    scopus 로고
    • Chemically modified short interfering hybrids (siHYBRIDS): Nanoimmunoliposome delivery in vitro and in vivo for RNAi of HER-2
    • Hogrefe, R. I.; Lebedev, A. V.; Zon, G.; Pirollo, K. F.; Rait, A.; Zhou, Q.; Yu, W.; Chang, E. H. Chemically modified short interfering hybrids (siHYBRIDS): Nanoimmunoliposome delivery in vitro and in vivo for RNAi of HER-2. Nucleos. Nucleot. Nucl. 2006, 25, 889-907.
    • (2006) Nucleos. Nucleot. Nucl. , vol.25 , pp. 889-907
    • Hogrefe, R.I.1    Lebedev, A.V.2    Zon, G.3    Pirollo, K.F.4    Rait, A.5    Zhou, Q.6    Yu, W.7    Chang, E.H.8
  • 51
    • 78049427830 scopus 로고    scopus 로고
    • Tumor antigen-targeted, monoclonal antibody-based immunotherapy: Clinical response, cellular immunity, and immunoescape
    • Ferris, R. L.; Jaffee, E. M.; Ferrone, S. Tumor antigen-targeted, monoclonal antibody-based immunotherapy: Clinical response, cellular immunity, and immunoescape. J. Clin. Oncol. 2010, 28, 4390-4399.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 4390-4399
    • Ferris, R.L.1    Jaffee, E.M.2    Ferrone, S.3
  • 52
    • 85136010217 scopus 로고    scopus 로고
    • Production and characterization of a CD25-specific scFv-Fc antibody secreted from Pichia pastoris
    • in press
    • Wan, L.; Zhu, S.; Zhu, J.; Yang, H.; Li, S.; Li, Y.; Cheng, J.; Lu, X. Production and characterization of a CD25-specific scFv-Fc antibody secreted from Pichia pastoris. Appl. Microbiol. Biotechnol. 2012, in press.
    • (2012) Appl. Microbiol. Biotechnol.
    • Wan, L.1    Zhu, S.2    Zhu, J.3    Yang, H.4    Li, S.5    Li, Y.6    Cheng, J.7    Lu, X.8
  • 53
    • 10744227326 scopus 로고    scopus 로고
    • Tailoring structure-function and pharmacokinetic properties of single-chain Fv proteins by site-specific PEGylation
    • Yang, K.; Basu, A.; Wang, M.; Chintala, R.; Hsieh, M. C.; Liu, S.; Hua, J.; Zhang, Z.; Zhou, J.; Li, M.; et al. Tailoring structure-function and pharmacokinetic properties of single-chain Fv proteins by site-specific PEGylation. Protein Eng. 2003, 16, 761-770.
    • (2003) Protein Eng. , vol.16 , pp. 761-770
    • Yang, K.1    Basu, A.2    Wang, M.3    Chintala, R.4    Hsieh, M.C.5    Liu, S.6    Hua, J.7    Zhang, Z.8    Zhou, J.9    Li, M.10
  • 54
    • 0034682480 scopus 로고    scopus 로고
    • Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-TAC(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity
    • Tsutsumi, Y.; Onda, M.; Nagata, S.; Lee, B.; Kreitman, R. J.; Pastan, I. Site-specific chemical modification with polyethylene glycol of recombinant immunotoxin anti-TAC(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity. Proc. Natl. Acad. Sci. USA 2000, 97, 8548-8553.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 8548-8553
    • Tsutsumi, Y.1    Onda, M.2    Nagata, S.3    Lee, B.4    Kreitman, R.J.5    Pastan, I.6
  • 57
    • 84863957822 scopus 로고    scopus 로고
    • Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes
    • Liu, W.; Onda, M.; Lee, B.; Kreitman, R. J.; Hassan, R.; Xiang, L.; Pastan, I. Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes. Proc. Natl. Acad. Sci. USA 2012, 109, 11782-11787.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 11782-11787
    • Liu, W.1    Onda, M.2    Lee, B.3    Kreitman, R.J.4    Hassan, R.5    Xiang, L.6    Pastan, I.7
  • 59
    • 34548858453 scopus 로고    scopus 로고
    • Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus i. V. Infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers
    • Hassan, R.; Bullock, S.; Premkumar, A.; Kreitman, R. J.; Kindler, H.; Willingham, M. C.; Pastan, I. Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus i. V. Infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers. Clin. Cancer Res. 2007, 13, 5144-5149.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 5144-5149
    • Hassan, R.1    Bullock, S.2    Premkumar, A.3    Kreitman, R.J.4    Kindler, H.5    Willingham, M.C.6    Pastan, I.7
  • 60
    • 84871599777 scopus 로고    scopus 로고
    • Immunotherapy strategies in the treatment of breast cancer
    • Soliman, H. Immunotherapy strategies in the treatment of breast cancer. Cancer Control 2013, 20, 17-21.
    • (2013) Cancer Control , vol.20 , pp. 17-21
    • Soliman, H.1
  • 61
    • 80052266213 scopus 로고    scopus 로고
    • The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics
    • Karran, E.; Mercken, M.; De Strooper, B. The amyloid cascade hypothesis for Alzheimer's disease: An appraisal for the development of therapeutics. Nat. Rev. Drug Discov. 2011, 10, 698-712.
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 698-712
    • Karran, E.1    Mercken, M.2    De Strooper, B.3
  • 62
    • 77951782384 scopus 로고    scopus 로고
    • Current therapeutic targets for the treatment of Alzheimer's disease
    • Grill, J. D.; Cummings, J. L. Current therapeutic targets for the treatment of Alzheimer's disease. Expert Rev. Neurother. 2010, 10, 711-728.
    • (2010) Expert Rev. Neurother. , vol.10 , pp. 711-728
    • Grill, J.D.1    Cummings, J.L.2
  • 63
    • 0037203825 scopus 로고    scopus 로고
    • Nerve inflammation halts trial for Alzheimer's drug
    • Check, E. Nerve inflammation halts trial for Alzheimer's drug. Nature 2002, 415, 462.
    • (2002) Nature , vol.415 , pp. 462
    • Check, E.1
  • 65
    • 84865676982 scopus 로고    scopus 로고
    • Engineered antibody approaches for Alzheimer's disease immunotherapy
    • Robert, R.; Wark, K. L. Engineered antibody approaches for Alzheimer's disease immunotherapy. Arch. Biochem. Biophys. 2012, 526, 132-138.
    • (2012) Arch. Biochem. Biophys. , vol.526 , pp. 132-138
    • Robert, R.1    Wark, K.L.2
  • 66
    • 77957233161 scopus 로고    scopus 로고
    • Intramuscular delivery of a single chain antibody gene prevents brain abeta deposition and cognitive impairment in a mouse model of Alzheimer's disease
    • Wang, Y. J.; Gao, C. Y.; Yang, M.; Liu, X. H.; Sun, Y.; Pollard, A.; Dong, X. Y.; Wu, X. B.; Zhong, J. H.; Zhou, H. D.; et al. Intramuscular delivery of a single chain antibody gene prevents brain abeta deposition and cognitive impairment in a mouse model of Alzheimer's disease. Brain Behav. Immun. 2010, 24, 1281-1293.
    • (2010) Brain Behav. Immun. , vol.24 , pp. 1281-1293
    • Wang, Y.J.1    Gao, C.Y.2    Yang, M.3    Liu, X.H.4    Sun, Y.5    Pollard, A.6    Dong, X.Y.7    Wu, X.B.8    Zhong, J.H.9    Zhou, H.D.10
  • 67
    • 58549116371 scopus 로고    scopus 로고
    • Intramuscular delivery of a single chain antibody gene reduces brain abeta burden in a mouse model of Alzheimer's disease
    • Wang, Y. J.; Pollard, A.; Zhong, J. H.; Dong, X. Y.; Wu, X. B.; Zhou, H. D.; Zhou, X. F. Intramuscular delivery of a single chain antibody gene reduces brain abeta burden in a mouse model of Alzheimer's disease. Neurobiol. Aging 2009, 30, 364-376.
    • (2009) Neurobiol. Aging , vol.30 , pp. 364-376
    • Wang, Y.J.1    Pollard, A.2    Zhong, J.H.3    Dong, X.Y.4    Wu, X.B.5    Zhou, H.D.6    Zhou, X.F.7
  • 69
    • 77955175395 scopus 로고    scopus 로고
    • Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice
    • Ryan, D. A.; Mastrangelo, M. A.; Narrow, W. C.; Sullivan, M. A.; Federoff, H. J.; Bowers, W. J. Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice. Mol. Ther. 2010, 18, 1471-1481.
    • (2010) Mol. Ther. , vol.18 , pp. 1471-1481
    • Ryan, D.A.1    Mastrangelo, M.A.2    Narrow, W.C.3    Sullivan, M.A.4    Federoff, H.J.5    Bowers, W.J.6
  • 70
    • 84875698008 scopus 로고    scopus 로고
    • Muscle-directed anti-abeta single-chain antibody delivery via AAV1 reduces cerebral abeta load in an Alzheimer's disease mouse model
    • Yang, J.; Pattanayak, A.; Song, M.; Kou, J.; Taguchi, H.; Paul, S.; Ponnazhagan, S.; Lalonde, R.; Fukuchi, K. Muscle-directed anti-abeta single-chain antibody delivery via AAV1 reduces cerebral abeta load in an Alzheimer's disease mouse model. J. Mol. Neurosci. 2013, 49, 277-288.
    • (2013) J. Mol. Neurosci. , vol.49 , pp. 277-288
    • Yang, J.1    Pattanayak, A.2    Song, M.3    Kou, J.4    Taguchi, H.5    Paul, S.6    Ponnazhagan, S.7    Lalonde, R.8    Fukuchi, K.9
  • 71
    • 79953699669 scopus 로고    scopus 로고
    • Chronic intranasal treatment with an antiabeta (30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease
    • Cattepoel, S.; Hanenberg, M.; Kulic, L.; Nitsch, R. M. Chronic intranasal treatment with an antiabeta (30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease. PLoS One 2011, 6, e18296.
    • (2011) PLoS One , vol.6
    • Cattepoel, S.1    Hanenberg, M.2    Kulic, L.3    Nitsch, R.M.4
  • 72
    • 79551655290 scopus 로고    scopus 로고
    • Huntington's disease: Can mice lead the way to treatment?
    • Crook, Z. R.; Housman, D. Huntington's disease: Can mice lead the way to treatment? Neuron 2011, 69, 423-435.
    • (2011) Neuron , vol.69 , pp. 423-435
    • Crook, Z.R.1    Housman, D.2
  • 73
    • 17544377783 scopus 로고    scopus 로고
    • A human single-chain v intrabody preferentially targets amino-terminal Huntingtin's fragments in striatal models of Huntington's disease
    • Miller, T. W.; Zhou, C.; Gines, S.; MacDonald, M. E.; Mazarakis, N. D.; Bates, G. P.; Huston, J. S.; Messer, A. A human single-chain v intrabody preferentially targets amino-terminal Huntingtin's fragments in striatal models of Huntington's disease. Neurobiol. Dis. 2005, 19, 47-56.
    • (2005) Neurobiol. Dis. , vol.19 , pp. 47-56
    • Miller, T.W.1    Zhou, C.2    Gines, S.3    McDonald, M.E.4    Mazarakis, N.D.5    Bates, G.P.6    Huston, J.S.7    Messer, A.8
  • 74
    • 84055182535 scopus 로고    scopus 로고
    • Bifunctional anti-huntingtin proteasome-directed intrabodies mediate efficient degradation of mutant huntingtin exon 1 protein fragments
    • Butler, D. C.; Messer, A. Bifunctional anti-huntingtin proteasome-directed intrabodies mediate efficient degradation of mutant huntingtin exon 1 protein fragments. PLoS One 2011, 6, e29199.
    • (2011) PLoS One , vol.6
    • Butler, D.C.1    Messer, A.2
  • 75
    • 77957930942 scopus 로고    scopus 로고
    • Early or late-stage anti-N-terminal huntingtin intrabody gene therapy reduces pathological features in B6. HDR6/1 mice
    • Snyder-Keller, A.; McLear, J. A.; Hathorn, T.; Messer, A. Early or late-stage anti-N-terminal huntingtin intrabody gene therapy reduces pathological features in B6. HDR6/1 mice. J. Neuropathol. Exp. Neurol. 2010, 69, 1078-1085.
    • (2010) J. Neuropathol. Exp. Neurol. , vol.69 , pp. 1078-1085
    • Snyder-Keller, A.1    McLear, J.A.2    Hathorn, T.3    Messer, A.4
  • 76
    • 44649113841 scopus 로고    scopus 로고
    • Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin
    • Wang, C. E.; Zhou, H.; McGuire, J. R.; Cerullo, V.; Lee, B.; Li, S. H.; Li, X. J. Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin. J. Cell Biol. 2008, 181, 803-816.
    • (2008) J. Cell Biol. , vol.181 , pp. 803-816
    • Wang, C.E.1    Zhou, H.2    McGuire, J.R.3    Cerullo, V.4    Lee, B.5    Li, S.H.6    Li, X.J.7
  • 77
    • 84868108817 scopus 로고    scopus 로고
    • Self-assembling complexes of quantum dots and scFv antibodies for cancer cell targeting and imaging
    • Zdobnova, T. A.; Stremovskiy, O. A.; Lebedenko, E. N.; Deyev, S. M. Self-assembling complexes of quantum dots and scFv antibodies for cancer cell targeting and imaging. PLoS One 2012, 7, e48248.
    • (2012) PLoS One , vol.7
    • Zdobnova, T.A.1    Stremovskiy, O.A.2    Lebedenko, E.N.3    Deyev, S.M.4
  • 78
    • 84862967037 scopus 로고    scopus 로고
    • Quantum dot-conjugated anti-GRP78 scFv inhibits cancer growth in mice
    • Xu, W.; Liu, L.; Brown, N. J.; Christian, S.; Hornby, D. Quantum dot-conjugated anti-GRP78 scFv inhibits cancer growth in mice. Molecules 2012, 17, 796-808.
    • (2012) Molecules , vol.17 , pp. 796-808
    • Xu, W.1    Liu, L.2    Brown, N.J.3    Christian, S.4    Hornby, D.5
  • 79
    • 34248571826 scopus 로고    scopus 로고
    • GRP78 induction in cancer: Therapeutic and prognostic implications
    • Lee, A. S. GRP78 induction in cancer: Therapeutic and prognostic implications. Cancer Res. 2007, 67, 3496-3499.
    • (2007) Cancer Res. , vol.67 , pp. 3496-3499
    • Lee, A.S.1
  • 81
    • 77949881963 scopus 로고    scopus 로고
    • Antibody vectors for imaging
    • Olafsen, T.; Wu, A. M. Antibody vectors for imaging. Semin. Nucl. Med. 2010, 40, 167-181.
    • (2010) Semin. Nucl. Med. , vol.40 , pp. 167-181
    • Olafsen, T.1    Wu, A.M.2
  • 83
    • 84864479534 scopus 로고    scopus 로고
    • The antibody-based delivery of interleukin-12 to the tumor neovasculature eradicates murine models of cancer in combination with paclitaxel
    • Pasche, N.; Wulhfard, S.; Pretto, F.; Carugati, E.; Neri, D. The antibody-based delivery of interleukin-12 to the tumor neovasculature eradicates murine models of cancer in combination with paclitaxel. Clin. Cancer Res. 2012, 18, 4092-4103.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 4092-4103
    • Pasche, N.1    Wulhfard, S.2    Pretto, F.3    Carugati, E.4    Neri, D.5
  • 84
    • 84861216409 scopus 로고    scopus 로고
    • Single chain variable fragment CD7 antibody conjugated PLGA/HDAC inhibitor immuno-nanoparticles: Developing human T cell-specific nano-technology for delivery of therapeutic drugs targeting latent HIV
    • Choi, S.; Lee, J.; Kumar, P.; Lee, K. Y.; Lee, S. K. Single chain variable fragment CD7 antibody conjugated PLGA/HDAC inhibitor immuno-nanoparticles: Developing human T cell-specific nano-technology for delivery of therapeutic drugs targeting latent HIV. J. Control Release 2011, 152 (Suppl 1), e9-e10.
    • (2011) J. Control Release , vol.152 , Issue.SUPPL. 1
    • Choi, S.1    Lee, J.2    Kumar, P.3    Lee, K.Y.4    Lee, S.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.