Isolation of a high-affinity stable single-chain Fv specific for mesothelin from DNA-immunized mice by phage display and construction of a recombinant immunotoxin with anti-tumor activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 2, 1998, Pages 669-674

  Chowdhury, Partha S ^a   Viner, Jaye L ^a   Beers, Richard ^a   Pastan, Ira ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cancer treatment; Mesothelioma; Ovarian cancer

Indexed keywords

CYTOTOXIC AGENT; DIFFERENTIATION ANTIGEN; IMMUNOTOXIN; MESOTHELIN; MESSENGER RNA; PSEUDOMONAS EXOTOXIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY TITER; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG TARGETING; HUMAN; HUMAN CELL; IMMUNIZATION; MESOTHELIOMA; MOUSE; NONHUMAN; OVARY CARCINOMA; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, NEOPLASM; ANTIGENS, NEOPLASM; DNA; EXOTOXINS; FEMALE; GENE LIBRARY; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOTOXINS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS;

ANIMALIA; EUKARYOTA; PSEUDOMONAS; PSEUDOMONAS EXOTOXIN;

EID: 0031931487     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.2.669     Document Type: Article

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