124I-labeled engineered anti-CEA minibodies and diabodies allow high-contrast, antigen-specific small-animal PET imaging of xenografts in athymic mice

Journal of Nuclear Medicine

Volumn 44, Issue 12, 2003, Pages 1962-1969

  Sundaresan, Gobalakrishnan ^a   Yazaki, Paul J ^b   Shively, John E ^b   Finn, Ronald D ^c   Larson, Steven M ^c   Raubitschek, Andrew A ^b   Williams, Lawrence E ^b   Chatziioannou, Arion F ^a   Gambhir, Sanjiv S ^a,d   Wu, Anna M ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d STANFORD UNIVERSITY   (United States)

Author keywords

124I; Carcinoembryonic antigen; Engineered antibody fragments; PET; Radioimmunoimaging

Indexed keywords

IODINE 124; NEOEMBRYONIC ANTIGEN; PROTEIN; RADIOISOTOPE; UNCLASSIFIED DRUG; ANTI CEA SCFV; ANTI-CEA SCFV; ANTIBODY CONJUGATE; ANTIGEN; CARCINOEMBRYONIC ANTIGEN; DIAGNOSTIC AGENT; MONOCLONAL ANTIBODY; PRODRUG; RADIOACTIVE IODINE; RADIOPHARMACEUTICAL AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY ENGINEERING; ANTIGEN SPECIFICITY; ARTICLE; COLON CARCINOMA; CONTRAST RADIOGRAPHY; CONTROLLED STUDY; CORRELATION ANALYSIS; FRAGMENTATION REACTION; GLIOMA; HISTOLOGY; IMAGE ANALYSIS; IMAGING SYSTEM; IMMUNOREACTIVITY; IN VIVO STUDY; INJECTION; ISOTOPE LABELING; MOLECULAR PROBE; MOUSE; NONHUMAN; NUDE MOUSE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SOFT TISSUE; TUMOR DIAGNOSIS; XENOGRAFT; ANIMAL; CANCER TRANSPLANTATION; COLORECTAL TUMOR; COMPUTER ASSISTED EMISSION TOMOGRAPHY; FEMALE; HUMAN; METABOLIC CLEARANCE RATE; METABOLISM; METHODOLOGY; PROTEIN ENGINEERING; QUALITY CONTROL; RADIOIMMUNOASSAY; SCINTISCANNING; TISSUE DISTRIBUTION; TUMOR CELL LINE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS; CARCINOEMBRYONIC ANTIGEN; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; FEMALE; GLIOMA; HUMANS; IMMUNOCONJUGATES; IODINE RADIOISOTOPES; ISOTOPE LABELING; METABOLIC CLEARANCE RATE; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PRODRUGS; PROTEIN ENGINEERING; QUALITY CONTROL; RADIOIMMUNOASSAY; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED; TRANSPLANTATION, HETEROLOGOUS;

EID: 1542681650     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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