Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor

Molecular Pharmaceutics

Volumn 7, Issue 1, 2010, Pages 237-244

  Boado, Ruben J ^a,b   Zhou, Qing Hui ^b   Lu, Jeff Zhiqiang ^a   Hui, Eric Ka Wai ^a   Pardridge, William M ^b  

^a ArmaGen Technologies Inc   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Blood brain barrier; Drug targeting; Monoclonal antibody; Transferrin receptor

Indexed keywords

AMYLOID A PROTEIN; AMYLOID BETA PROTEIN; BOLTON HUNTER REAGENT I 125; CARRIER PROTEIN; CHIMERIC ANTIBODY; HYBRID PROTEIN; MONOCLONAL ANTIBODY; PROTEIN G; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; TRANSFERRIN RECEPTOR;

AFFINITY CHROMATOGRAPHY; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; CARBOXY TERMINAL SEQUENCE; CELL CLONE; CELL LINE; CHO CELL; CONTROLLED STUDY; CULTURE MEDIUM; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC ENGINEERING; GENETIC TRANSFECTION; HEAVY CHAIN; IN VIVO STUDY; MEAN RESIDENCE TIME; MOUSE; NONHUMAN; PLASMA CLEARANCE; PLASMA VOLUME; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN TARGETING; PROTEIN TRANSPORT; RADIOIODINATION; RADIORECEPTOR ASSAY; SECRETORY CELL; STEADY STATE; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTIBODIES, MONOCLONAL; BLOOD-BRAIN BARRIER; BRAIN; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DELIVERY SYSTEMS; IMMUNOGLOBULIN FRAGMENTS; MALE; MICE; MICE, INBRED BALB C; PROTEIN ENGINEERING; RADIOLIGAND ASSAY; RATS; RECEPTORS, TRANSFERRIN; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

EID: 76249087751     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp900235k     Document Type: Article

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