Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment

Journal of Biological Chemistry

Volumn 289, Issue 41, 2014, Pages 28539-28553

  Alvarado, John Jeff ^a   Tarafdar, Sreya ^a,b   Yeh, Joanne I ^a   Smithgall, Thomas E ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; CRYSTAL STRUCTURE;

COMPLEX FORMATIONS; FUNCTIONAL INTERACTION; KINASE ACTIVATION; REGULATORY REGIONS; SRC-FAMILY KINASE; SRC-HOMOLOGY; VIRAL REPLICATION; X RAY CRYSTAL STRUCTURES;

ENZYMES;

ARGININE; ASPARTIC ACID; DIMER; GLUTAMIC ACID; HEMATOPOIETIC CELL KINASE; NEF PROTEIN; PROTEIN SH2; PROTEIN SH3; PROTEIN TYROSINE KINASE; HCK PROTEIN, HUMAN; NEF PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; RECOMBINANT PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME BINDING; ENZYME CONFORMATION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; X RAY; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ESCHERICHIA COLI; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HOST PATHOGEN INTERACTION; METABOLISM; PLASMID; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; ESCHERICHIA COLI; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEK293 CELLS; HIV-1; HOST-PATHOGEN INTERACTIONS; HUMANS; MODELS, MOLECULAR; NEF GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; PLASMIDS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS C-HCK; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

EID: 84907835262     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.600031     Document Type: Article

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