On the importance of a funneled energy landscape for the assembly and regulation of multidomain Src tyrosine kinases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 34, 2007, Pages 13643-13648

  Faraldo Gómez, José D ^a   Roux, Benoît ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Allostery; Binding domains; Modular proteins; SH2 SH3; Signaling

Indexed keywords

PROTEIN SH2; PROTEIN SH3; PROTEIN TYROSINE KINASE;

ARTICLE; COMPLEX FORMATION; COMPUTER SIMULATION; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME REGULATION; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PROTEIN TERTIARY STRUCTURE; SURFACE PROPERTY;

COMPUTER SIMULATION; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; SRC-FAMILY KINASES; SURFACE PROPERTIES;

EID: 35348911804     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0704041104     Document Type: Article

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