Crystal structure of the Src family kinase Hck SH3-SH2 linker regulatory region supports an SH3-dominant activation mechanism

Journal of Biological Chemistry

Volumn 285, Issue 46, 2010, Pages 35455-35461

  Alvarado, John J ^a   Betts, Laurie ^a   Moroco, Jamie A ^a   Smithgall, Thomas E ^a   Yeh, Joanne I ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION MECHANISMS; AMINO ACID SEQUENCE; CELLULAR FUNCTION; CONFORMATIONAL STATE; CONFORMATIONAL SWITCHES; DOMAIN-BINDING PROTEINS; DOWN-REGULATION; HELICAL CONFORMATION; HIV-1 NEF; INTRAMOLECULAR ASSOCIATION; KINASE ACTIVITY; KINASE DOMAINS; KINASE REGULATION; LINKER REGION; MAMMALIAN CELLS; NEW STRUCTURES; NON-CATALYTIC; POLYPROLINE; REGULATORY REGIONS; RELATIVE ORIENTATION; SIGNALING PATHWAYS; SRC FAMILY; SRC-FAMILY KINASE; SRC-HOMOLOGY; STRUCTURAL INSIGHTS; TYPE II; X RAY CRYSTAL STRUCTURES;

AMINO ACIDS; DISEASE CONTROL; LAWS AND LEGISLATION; LIGANDS; MAMMALS; PROTEINS; TOPOLOGY;

CRYSTAL STRUCTURE;

BINDING PROTEIN; HEMATOPOIETIC CELL KINASE; NEF PROTEIN; PROTEIN SH2; PROTEIN SH3;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; DOWN REGULATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-HCK; RECOMBINANT PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; SEQUENCE HOMOLOGY, AMINO ACID; SRC HOMOLOGY DOMAINS;

HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMALIA;

EID: 78149259993     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.145102     Document Type: Article

References (38)

1. Manning, G., Whyte, D. B., Martinez, R., Hunter, T., and Sudarsanam, S. (2002) Science 298, 1912-1934
2. Engen, J. R., Wales, T. E., Hochrein, J. M., Meyn, M. A., 3rd, Banu Ozkan, S., Bahar, I., and Smithgall, T. E. (2008) Cell. Mol. Life Sci. 65, 3058-3073
3. Kim, L. C., Song, L., and Haura, E. B. (2009) Nat. Rev. Clin. Oncol. 6, 587-595
4. Boggon, T. J., and Eck, M. J. (2004) Oncogene 23, 7918-7927
5. Schindler, T., Sicheri, F., Pico, A., Gazit, A., Levitzki, A., and Kuriyan, J. (1999) Mol. Cell 3, 639-648
6. Xu, W., Doshi, A., Lei, M., Eck, M. J., and Harrison, S. C. (1999) Mol. Cell 3, 629-638
7. Chong, Y. P., Ia, K. K., Mulhern, T. D., and Cheng, H. C. (2005) Biochim Biophys. Acta 1754, 210-220
8. Guiet, R., Poincloux, R., Castandet, J., Marois, L., Labrousse, A., Le Cabec, V., and Maridonneau-Parini, I. (2008) Eur. J. Cell Biol. 87, 527-542
9. Briggs, S. D., and Smithgall, T. E. (1999) J. Biol. Chem. 274, 26579-26583
10. Schreiner, S. J., Schiavone, A. P., and Smithgall, T. E. (2002) J. Biol. Chem. 277, 45680-45687
11. Briggs, S. D., Sharkey, M., Stevenson, M., and Smithgall, T. E. (1997) J. Biol. Chem. 272, 17899-17902
12. Lerner, E. C., and Smithgall, T. E. (2002) Nat. Struct. Biol. 9, 365-369
13. Moarefi, I., LaFevre-Bernt, M., Sicheri, F., Huse, M., Lee, C. H., Kuriyan, J., and Miller, W. T. (1997) Nature 385, 650-653
14. Trible, R. P., Emert-Sedlak, L., and Smithgall, T. E. (2006) J. Biol. Chem. 281, 27029-27038
15. Thomas, J. W., Ellis, B., Boerner, R. J., Knight, W. B., White, G. C., 2nd, and Schaller, M. D. (1998) J. Biol. Chem. 273, 577-583
16. Rickles, R. J., Botfield, M. C., Zhou, X. M., Henry, P. A., Brugge, J. S., and Zoller, M. J. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 10909-10913
17. Emert-Sedlak, L., Kodama, T., Lerner, E. C., Dai, W., Foster, C., Day, B. W., Lazo, J. S., and Smithgall, T. E. (2009) ACS Chem. Biol. 4, 939-947
18. Otwinowski, Z., Minor, W., and Carter, C. W., Jr. (1997) Methods Enzymol. 276, 307-326
19. Adams, P. D., Afonine, P. V., Bunkóczi, G., Chen, V. B., Davis, I. W., Echols, N., Headd, J. J., Hung, L. W., Kapral, G. J., Grosse-Kunstleve, R. W., McCoy, A. J., Moriarty, N. W., Oeffner, R., Read, R. J., Richardson, D. C., Richardson, J. S., Terwilliger, T. C., and Zwart, P. H. (2010) Acta Crystallogr. D Biol. Crystallogr. 66, 213-221
20. Emsley, P., and Cowtan, K. (2004) Acta Crystallogr. D Biol. Crystallogr. 60, 2126-2132
21. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
22. Lovell, S. C., Davis, I. W., Arendall, W. B., 3rd, de Bakker, P. I., Word, J. M., Prisant, M. G., Richardson, J. S., and Richardson, D. C. (2003) Proteins 50, 437-450
23. DeLano, W. L. (2002) The PyMOL Molecular Graphics System, DeLano Scientific LLC, Palo Alto, CA
24. Gouet, P., Robert, X., and Courcelle, E. (2003) Nucleic Acids Res. 31, 3320-3323
25. Hochrein, J. M., Lerner, E. C., Schiavone, A. P., Smithgall, T. E., and Engen, J. R. (2006) Protein Sci. 15, 65-73
26. Lerner, E. C., Trible, R. P., Schiavone, A. P., Hochrein, J. M., Engen, J. R., and Smithgall, T. E. (2005) J. Biol. Chem. 280, 40832-40837
27. Arold, S. T., Ulmer, T. S., Mulhern, T. D., Werner, J. M., Ladbury, J. E., Campbell, I. D., and Noble, M. E. (2001) J. Biol. Chem. 276, 17199-17205
28. Eck, M. J., Atwell, S. K., Shoelson, S. E., and Harrison, S. C. (1994) Nature 368, 764-769
29. Sicheri, F., Moarefi, I., and Kuriyan, J. (1997) Nature 385, 602-609
30. Williams, J. C., Weijland, A., Gonfloni, S., Thompson, A., Courtneidge, S. A., Superti-Furga, G., and Wierenga, R. K. (1997) J. Mol. Biol. 274, 757-775
31. Xu, W., Harrison, S. C., and Eck, M. J. (1997) Nature 385, 595-602
32. Nagar, B., Hantschel, O., Seeliger, M., Davies, J. M., Weis, W. I., Superti-Furga, G., and Kuriyan, J. (2006) Mol. Cell 21, 787-798
33. Nagar, B., Hantschel, O., Young, M. A., Scheffzek, K., Veach, D., Bornmann, W., Clarkson, B., Superti-Furga, G., and Kuriyan, J. (2003) Cell 112, 859-871
34. Fushman, D., Xu, R., and Cowburn, D. (1999) Biochemistry 38, 10225-10230
35. Hofmann, G., Schweimer, K., Kiessling, A., Hofinger, E., Bauer, F., Hoffmann, S., Rösch, P., Campbell, I. D., Werner, J. M., and Sticht, H. (2005) Biochemistry 44, 13043-13050
36. Young, M. A., Gonfloni, S., Superti-Furga, G., Roux, B., and Kuriyan, J. (2001) Cell 105, 115-126
37. Cowan-Jacob, S. W., Fendrich, G., Manley, P. W., Jahnke, W., Fabbro, D., Liebetanz, J., and Meyer, T. (2005) Structure 13, 861-871
38. Porter, M., Schindler, T., Kuriyan, J., and Miller, W. T. (2000) J. Biol. Chem. 275, 2721-2726