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Volumn 26, Issue 6, 2001, Pages 356-363

Dynamic Nef and Nef dynamics: How structure could explain the complex activities of this small HIV protein

Author keywords

[No Author keywords available]

Indexed keywords

NEF PROTEIN; PROTEIN; VIRUS PROTEIN;

EID: 0035368515     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0004(01)01846-1     Document Type: Review
Times cited : (135)

References (50)
  • 1
    • 0032538278 scopus 로고    scopus 로고
    • Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice
    • (1998) Cell , vol.95 , pp. 163-175
    • Hanna, Z.1
  • 2
    • 0025743306 scopus 로고
    • Importance of the nef gene for maintenance of high virus loads and for development of AIDS
    • (1991) Cell , vol.65 , pp. 651-662
    • Kestler III, H.W.1
  • 3
    • 0028835788 scopus 로고
    • Brief report: Absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection
    • (1995) N. Engl. J. Med. , vol.332 , pp. 228-232
    • Kirchhoff, F.1
  • 7
    • 0032999976 scopus 로고    scopus 로고
    • The downregulation of CD4 and MHC-I by primate lentiviruses: A paradigm for the modulation of cell surface receptors
    • (1999) Immunol. Rev. , vol.168 , pp. 51-63
    • Piguet, V.1
  • 8
    • 0032076086 scopus 로고    scopus 로고
    • Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4
    • (1998) Immunity , vol.8 , pp. 647-656
    • Lu, X.1
  • 9
    • 0033776709 scopus 로고    scopus 로고
    • HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes
    • (2000) Nat. Cell Biol. , vol.2 , pp. 163-167
    • Piguet, V.1
  • 10
    • 0028485232 scopus 로고
    • HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization
    • (1994) Immunity , vol.1 , pp. 373-384
    • Baur, A.S.1
  • 11
    • 0026077650 scopus 로고
    • Expression of the type 1 human immunodeficiency virus Nef protein in Tcells prevents antigen receptor-mediated induction of interleukin 2 mRNA
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5326-5330
    • Luria, S.1
  • 12
    • 0032577444 scopus 로고    scopus 로고
    • HIV-1 auxiliary proteins: Making connections in a dying cell
    • (1998) Cell , vol.93 , pp. 685-692
    • Cullen, B.R.1
  • 13
    • 0031774858 scopus 로고    scopus 로고
    • Zeta chain of the T-cell receptor interacts with nef of simian immunodeficiency virus and human immunodeficiency virus type 2
    • (1998) J. Virol. , vol.72 , pp. 9827-9834
    • Howe, A.Y.1
  • 14
    • 0033519235 scopus 로고    scopus 로고
    • Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain
    • (1999) J. Exp. Med. , vol.189 , pp. 1489-1496
    • Xu, X.N.1
  • 16
    • 0029881450 scopus 로고    scopus 로고
    • The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase
    • (1996) Nat. Struct. Biol. , vol.3 , pp. 340-345
    • Grzesiek, S.1
  • 17
    • 0031572847 scopus 로고    scopus 로고
    • The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling
    • (1997) Structure , vol.5 , pp. 1361-1372
    • Arold, S.1
  • 18
    • 0343494918 scopus 로고    scopus 로고
    • Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain
    • (1996) Cell , vol.85 , pp. 931-942
    • Lee, C.H.1
  • 19
    • 0032553012 scopus 로고    scopus 로고
    • RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef
    • (1998) Biochemistry , vol.37 , pp. 14683-14691
    • Arold, S.1
  • 20
    • 0028878783 scopus 로고
    • Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4
    • (1995) EMBO J. , vol.14 , pp. 484-491
    • Saksela, K.1
  • 21
    • 0034711735 scopus 로고    scopus 로고
    • Affinity of Src family kinase SH3 domains for HIV Nef in vitro does not predict kinase activation by Nef in vivo
    • (2000) Biochemistry , vol.39 , pp. 489-495
    • Briggs, S.D.1
  • 22
    • 0032145709 scopus 로고    scopus 로고
    • The human immunodeficiency virus type 1 Nef protein binds the Src-related tyrosine kinase Lck SH2 domain through a novel phosphotyrosine independent mechanism
    • (1998) Virology , vol.247 , pp. 200-211
    • Dutartre, H.1
  • 23
    • 0032566903 scopus 로고    scopus 로고
    • SH3-domain binding function of HIV-1 Nef is required for association with a PAK-related kinase
    • (1998) Virology , vol.250 , pp. 273-282
    • Manninen, A.1
  • 24
    • 19244382596 scopus 로고    scopus 로고
    • Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions
    • (2000) J. Virol. , vol.74 , pp. 5310-5319
    • Liu, L.X.1
  • 25
    • 0029795040 scopus 로고    scopus 로고
    • The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR
    • (1996) Biochemistry , vol.35 , pp. 10256-10261
    • Grzesiek, S.1
  • 26
    • 0033917035 scopus 로고    scopus 로고
    • Characterization and molecular basis of the oligomeric structure of HIV-1 Nef protein
    • (2000) Protein Sci. , vol.6 , pp. 1137-1148
    • Arold, S.1
  • 27
    • 0033013962 scopus 로고    scopus 로고
    • Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal α helix and proline repeat of Nef selectively regulate MHC-I trafficking
    • (1999) J. Virol. , vol.73 , pp. 1964-1973
    • Mangasarian, A.1
  • 28
    • 0031716336 scopus 로고    scopus 로고
    • Virion incorporation of human immunodeficiency virus type 1 Nef is mediated by a bipartite membrane-targeting signal: Analysis of its role in enhancement of viral infectivity
    • (1998) J. Virol. , vol.72 , pp. 8833-8840
    • Welker, R.1
  • 29
    • 0030887932 scopus 로고    scopus 로고
    • The N-terminus of Nef from HIV-1/SIV associates with a protein complex containing Lck and a serine kinase
    • (1997) Immunity , vol.6 , pp. 283-291
    • Baur, A.S.1
  • 30
    • 0034001233 scopus 로고    scopus 로고
    • Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation
    • (2000) J. Virol. , vol.74 , pp. 2907-2912
    • Akari, H.1
  • 31
    • 0032525137 scopus 로고    scopus 로고
    • The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes
    • (1998) EMBO J. , vol.17 , pp. 2777-2789
    • Greenberg, M.E.1
  • 32
    • 0033612388 scopus 로고    scopus 로고
    • Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein
    • (1999) J. Mol.Biol. , vol.289 , pp. 123-138
    • Geyer, M.1
  • 33
    • 0033515427 scopus 로고    scopus 로고
    • Nef-induced CD4 degradation: A diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of β-COP in endosomes
    • (1999) Cell , vol.97 , pp. 63-73
    • Piguet, V.1
  • 34
    • 0028200761 scopus 로고
    • Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4
    • (1994) J. Virol. , vol.68 , pp. 5156-5163
    • Rhee, S.S.1    Marsh, J.W.2
  • 35
    • 0030924947 scopus 로고    scopus 로고
    • Protein kinase C-mediated phosphorylation of HIV-I nef in human cell lines
    • (1997) J. Biol. Chem. , vol.272 , pp. 12289-12294
    • Coates, K.1
  • 36
    • 0031901558 scopus 로고    scopus 로고
    • The proteolytic cleavage of human immunodeficiency virus type 1 Nef does not correlate with its ability to stimulate virion infectivity
    • (1998) J. Virol. , vol.72 , pp. 3178-3184
    • Chen, Y.L.1
  • 37
    • 0034595806 scopus 로고    scopus 로고
    • Synergistic activation of NFAT by HIV-1 nef and the Ras/MAPK pathway
    • (2000) J. Biol. Chem. , vol.275 , pp. 16513-16517
    • Manninen, A.1
  • 38
    • 0029671333 scopus 로고    scopus 로고
    • NF-κB-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro
    • (1996) Genes Dev. , vol.10 , pp. 37-49
    • Pazin, M.J.1
  • 39
    • 0031925898 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 genome activation induced by human T-cell leukemia virus type 1 Tax protein is through cooperation of NF-κB and Tat
    • (1998) J. Virol. , vol.72 , pp. 6911-6916
    • Cheng, H.1
  • 40
    • 0032567042 scopus 로고    scopus 로고
    • Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells
    • (1998) Cell , vol.95 , pp. 595-604
    • Kinoshita, S.1
  • 41
    • 0032556872 scopus 로고    scopus 로고
    • HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes
    • (1998) Nature , vol.391 , pp. 397-401
    • Collins, K.L.1
  • 42
    • 0028006247 scopus 로고
    • The human immunodeficiency virus-1 nef gene product: A positive factor for viral infection and replication in primary lymphocytes and macrophages
    • (1994) J. Exp. Med. , vol.179 , pp. 101-113
    • Miller, M.D.1
  • 43
    • 0031550805 scopus 로고    scopus 로고
    • Human immunodeficiency virus type I Nef independently affects virion incorporation of major histocompatibility complex class I molecules and virus infectivity
    • (1997) Virology , vol.229 , pp. 295-301
    • Le Gall, S.1
  • 44
    • 0029953176 scopus 로고    scopus 로고
    • The HIV nef protein associates with protein kinase C theta
    • (1996) J.Biol. Chem. , vol.271 , pp. 16753-16757
    • Smith, B.L.1
  • 45
    • 0029819124 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity
    • (1996) J. Virol. , vol.70 , pp. 6701-6708
    • Greenway, A.1
  • 46
    • 0032546958 scopus 로고    scopus 로고
    • Binding of c-Raf1 kinase to a conserved acidic sequence within the carboxyl-terminal region of the HIV-1 Nef protein
    • (1998) J. Biol. Chem. , vol.273 , pp. 15727-15733
    • Hodge, D.R.1
  • 47
    • 0033153464 scopus 로고    scopus 로고
    • Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions
    • (1999) Mol. Cell , vol.3 , pp. 729-739
    • Fackler, O.T.1
  • 48
    • 0032530773 scopus 로고    scopus 로고
    • Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 11229-11234
    • Craig, H.M.1
  • 49
    • 0030684068 scopus 로고    scopus 로고
    • Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation
    • (1997) EMBO J. , vol.16 , pp. 6964-6976
    • Greenberg, M.E.1
  • 50
    • 0034725614 scopus 로고    scopus 로고
    • The human thioesterase II protein binds to a site on HIV 1 Nef critical for CD4 downregulation
    • (2000) J. Biol. Chem. , vol.275 , pp. 23097-23105
    • Cohen, G.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.