Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 19, 2014, Pages 5155-5167

  Kamal, Ahmed ^a,b   Shaik, Bajee ^a   Nayak, V Lakshma ^a   Nagaraju, Burri ^a   Kapure, Jeevak Sopanrao ^a,b   Shaheer Malik, M ^a   Shaik, Thokhir Basha ^a   Prasad, B ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

CA 4; Cell cycle; Cytotoxicity; Triazoles; Tubulin polymerization

Indexed keywords

1 (4 FLUOROBENZYL) N (2 HYDROXY 3 METHOXY 6 (3,4,5 TRIMETHOXYSTYRYL)PHENYL) 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; 1 (4 FLUOROBENZYL) N (2 METHOXY 5 (3,4,5 TRIMETHOXYSTYRYL)PHENYL) 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; 1,2,3 TRIAZOLE DERIVATIVE; CASPASE 3; COMBRETASTATIN; COMBRETASTATIN A4; N (2 HYDROXY 3 METHOXY 6 (3,4,5 TRIMETHOXYSTYRYL)PHENYL) 1 (3 METHOXYBENZYL) 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; N (2 HYDROXY 3 METHOXY 6 (3,4,5 TRIMETHOXYSTYRYL)PHENYL) 1 (3 PHENOXYBENZYL) 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; N (2 HYDROXY 3 METHOXY 6 (3,4,5 TRIMETHOXYSTYRYL)PHENYL) 1 (3,4,5 TRIMETHOXYBENZYL) 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; N (2 HYDROXY 3 METHOXY 6 (3,4,5 TRIMETHOXYSTYRYL)PHENYL) 1 (4 METHOXYBENZYL) 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; N (2 METHOXY 5 (3,4,5 TRIMETHOXYSTYRYL)PHENYL) 1 (3 METHOXYBENZYL) 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; N (2 METHOXY 5 (3,4,5 TRIMETHOXYSTYRYL)PHENYL) 1 (3 PHENOXYBENZYL) 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; N (2 METHOXY 5 (3,4,5 TRIMETHOXYSTYRYL)PHENYL) 1 (3,4,5 TRIMETHOXYBENZYL) 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; N (2 METHOXY 5 (3,4,5 TRIMETHOXYSTYRYL)PHENYL) 1 (4 METHOXYBENZYL) 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; N (2,3 DIMETHOXY 5 (3,4,5 TRIMETHOXYSTYRYL)PHENYL) 1 (3 METHOXYBENZYL) 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; N (2,3 DIMETHOXY 5 (3,4,5 TRIMETHOXYSTYRYL)PHENYL) 1 (3 PHENOXYBENZYL) 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; N (2,3 DIMETHOXY 5 (3,4,5 TRIMETHOXYSTYRYL)PHENYL) 1 (3,4,5 TRIMETHOXYBENZYL) 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; N (2,3 DIMETHOXY 5 (3,4,5 TRIMETHOXYSTYRYL)PHENYL) 1 (4 FLUOROBENZYL) 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; N (2,3 DIMETHOXY 5 (3,4,5 TRIMETHOXYSTYRYL)PHENYL) 1 (4 METHOXYBENZYL) 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL LINE; COMPETITIVE BINDING ASSAY; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ENZYME ACTIVITY; FEMALE; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; M PHASE CELL CYCLE CHECKPOINT; MICROTUBULE ASSEMBLY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DOCKING; TUBULIN POLYMERIZATION ASSAY;

EID: 84907524981     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.08.008     Document Type: Article

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