Novel combretastatin A-4 derivative XN0502 induces cell cycle arrest and apoptosis in A549 cells

Investigational New Drugs

Volumn 28, Issue 4, 2010, Pages 493-501

  Zhu, Hong ^a   Zhang, Jun ^a   Xue, Na ^a   Hu, Yongzhou ^a   Yang, Bo ^a   He, Qiaojun ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Anti tubulin agent; Apoptosis; Cell cycle arrest; Combretastatin A 4; XN0502

Indexed keywords

4 (4 METHOXYPHENYL) 5 (3,4,5 TRIMETHOXYPHENYL) 1H PYRAZOL 3 AMINE; ANTINEOPLASTIC AGENT; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 7; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 3; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; XN 0502; ANISOLE DERIVATIVE; CASPASE; COMBRETASTATIN A 4; COMBRETASTATIN A-4; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE ACTIVATING KINASE; CYCLIN-DEPENDENT KINASE-ACTIVATING KINASE; PYRAZOLE DERIVATIVE; STILBENE DERIVATIVE; TUBULIN MODULATOR;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; MICROTUBULE ASSEMBLY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; WESTERN BLOTTING; CELL CYCLE; CELL LINE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; LUNG NON SMALL CELL CANCER; LUNG TUMOR; METHODOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANISOLES; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CASPASES; CELL CYCLE; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LUNG NEOPLASMS; PYRAZOLES; SIGNAL TRANSDUCTION; STILBENES; TUBULIN MODULATORS;

EID: 77956637589     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10637-010-9424-4     Document Type: Article

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