Synthesis, DNA-binding abilities and anticancer activities of triazole-pyrrolo[2,1-c][1,4]benzodiazepines hybrid scaffolds

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6854-6859

  Chen, Chung Yu ^a   Lee, Pei Hua ^a   Lin, Yong Yong ^a   Yu, Wen Ting ^a   Hu, Wan Ping ^a   Hsu, Chia Chen ^a   Lin, Ying Ting ^a   Chang, Long Sen ^b   Hsiao, Cheng Tien ^a   Wang, Jeh Jeng ^a   Chung, Mei Ing ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Anticancer; Apoptosis; Cytotoxicity; Pyrrolo 2,1 c 1,4 benzodiazepine; Triazole

Indexed keywords

BENZODIAZEPINE DERIVATIVE; CASPASE; CYCLIN D1; LIPOCORTIN 5; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROPIDIUM IODIDE; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN P21; PROTEIN P27; PROTEIN P53; TRIAZOLE DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DNA BINDING; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN DEGRADATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANTICANCER; APOPTOSIS; CYTOTOXICITY; PYRROLO[2,1-C][1,4]BENZODIAZEPINE; TRIAZOLE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZODIAZEPINES; CELL LINE, TUMOR; CYCLIN D1; DNA; DOWN-REGULATION; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; ISOMERISM; MICE; PYRROLES; TRIAZOLES; UP-REGULATION;

EID: 84888877426     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.10.004     Document Type: Article

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