Synthesis and biological evaluation of benzo[b]furans as inhibitors of tubulin polymerization and inducers of apoptosis

ChemMedChem

Volumn 9, Issue 1, 2014, Pages 117-128

  Kamal, Ahmed ^a,b   Reddy, N V Subba ^a   Nayak, V Lakshma ^a   Reddy, V Saidi ^a   Prasad, B ^a   Nimbarte, Vijaykumar D ^b   Srinivasulu, Vunnam ^a   Vishnuvardhan, M V P S ^a   Reddy, C Suresh ^c  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^c SRI VENKATESWARA UNIVERSITY   (India)

Author keywords

antiproliferation; antitumor agents; apoptosis; benzofurans; tubulin polymerization

Indexed keywords

(6 METHOXY 3 METHYL 5 PHENYLBENZOFURAN 2 YL)(3,4,5 TRIMETHOXYPHENYL)METHANONE; 3 [6 METHOXY 3 METHYL 2 [1 (3,4,5 TRIMETHOXYPHENYL)VINYL]BENZOFURAN 5 YL]PROP 2 EN 1 OL; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; 5 (2,4 DICHLOROPHENYL) 6 METHOXY 3 METHYL 2 [1 (3,4,5 TRIMETHOXYPHENYL)VINYL)BENZOFURAN; 5 (2,4 DIMETHOXYPHENYL) 6 METHOXY 3 METHYL 2 [1 (3,4,5 TRIMETHOXYPHENYL)VINYL]BENZOFURAN; 5 (4 BROMOPHENYL) 6 METHOXY 3 METHYL 2 [1 (3,4,5 TRIMETHOXYPHENYL)VINYL]BENZOFURAN; 5 (4 CHLOROPHENYL) 6 METHOXY 3 METHYL 2 [1 (3,4,5 TRIMETHOXYPHENYL)VINYL]BENZOFURAN; 6 METHOXY 3 METHYL 5 (3,4,5 TRIMETHOXYPHENYL) 2 [1 (3,4,5 TRIMETHOXYPHENYL)VINYL]BENZOFURAN; 6 METHOXY 3 METHYL 5 (PHENYLETHYNYL) 2 [1 (3,4,5 TRIMETHOXYPHENYL)VINYL]BENZOFURAN; 6 METHOXY 3 METHYL 5 [4 (TRIFLUOROMETHYL)PHENYL] 2 [1 (3,4,5 TRIMETHOXYPHENYL)VINYL]BENZOFURAN; 6 METHOXY 3 METHYL 5 PHENYL 2 [1 (3,4,5 TRIMETHOXYPHENYL)VINYL]BENZOFURAN; 6 METHOXY 5 (4 METHOXYPHENYL) 3 METHYL 2 [1 (3,4,5 TRIMETHOXYPHENYL)VINYL]BENZOFURAN; [5 (2,4 DICHLOROPHENYL) 6 METHOXY 3 METHYLBENZOFURAN 2YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [5 (2,4 DIMETHOXYPHENYL) 6 METHOXY 3 METHYLBENZOFURAN 2YL](3,4,5 TRIMETHOXYPHENY)METHANONE; [5 (3 HYDROXYPROP 1 YNYL) 6 METHOXY 3 METHYLBENZOFURAN 2YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [5 (4 BROMOPHENYL) 6 METHOXY 3 METHYLBENZOFURAN 2 YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [5 (4 CHLOROPHENYL) 6 METHOXY 3 METHYLBENZOFURAN 2 YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [5 [(4 FLUOROPHENYL)ETHYNYL] 6 METHOXY 3 METHYLBENZOFURAN 2YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [6 METHOXY 3 METHYL 5 (3,4,5 TRIMETHOXYPHENYL)BENZOFURAN 2YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [6 METHOXY 3 METHYL 5 (PHENYLETHYNYL)BENZOFURAN 2 YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [6 METHOXY 3 METHYL 5 [4 (TRIFLUOROMETHYL)PHENYL]BENZOFURAN 2YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [6 METHOXY 5 (4 METHOXYPHENYL) 3 METHYLBENZOFURAN 2YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; [6 METHOXY 5 [(4 METHOXYPHENYL)ETHYNYL] 3 METHYLBENZOFURAN 2 YL](3,4,5 TRIMETHOXYPHENYL)METHANONE; APOPTOSIS INDUCING FACTOR; BENZOFURAN DERIVATIVE; CASPASE 3; COMBRETASTATIN A4; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACYLATION; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE PROGRESSION; CELL GROWTH; CONTROLLED STUDY; CYCLIZATION; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IC 50; KIDNEY CARCINOMA; LUNG CANCER; M PHASE CELL CYCLE CHECKPOINT; MICROTUBULE ASSEMBLY; MOLECULAR DOCKING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING; WITTIG REACTION;

ANTIPROLIFERATION; ANTITUMOR AGENTS; APOPTOSIS; BENZOFURANS; TUBULIN POLYMERIZATION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZOFURANS; BINDING SITES; CASPASE 3; CELL LINE, TUMOR; DNA FRAGMENTATION; HUMANS; MOLECULAR DOCKING SIMULATION; POLYMERIZATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN; TUBULIN MODULATORS;

EID: 84891738932     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300366     Document Type: Article

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