Quinazolino linked 4β-amidopodophyllotoxin conjugates regulate angiogenic pathway and control breast cancer cell proliferation

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 21, 2013, Pages 6414-6426

  Kamal, Ahmed ^a   Tamboli, Jaki R ^a   Ramaiah, M Janaki ^a   Adil, S F ^b   Pushpavalli, S N C V L ^a   Ganesh, Raksha ^a   Sarma, Pranjal ^a   Bhadra, Utpal ^a   Pal Bhadra, Manika ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Angiogenesis; Anticancer activity; Caspase 9; Cell cycle arrest; Integrin; Mitochondrial membrane potential (MMP); Quinazolino linked podophyllotoxin conjugates; VEGF A

Indexed keywords

4BETA [5 [3 (3,4 DICHLOROPHENYL) 3,4 DIHYDRO 2 METHYL 4 OXOQUINAZOLIN 6 YLOXY]PENTANAMIDE] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [5 [3 (4 FLUOROPHENYL) 3,4 DIHYDRO 2 METHYL 4 OXOQUINAZOLIN 6 YLOXY]PENTANAMIDE] 4 DESOXYDESOXYPODOPHYLLOTOXIN; 4BETA [5 [3,4 DIHYDRO 2 METHYL 3 (4 NITROPHENYL) 4 OXOQUINAZOLIN 6 YLOXY]PENTANAMIDE] 4 DESOXYDESOXYPODOPHYLLOTOXIN; 4BETA [5 [3,4 DIHYDRO 3 (3,4,5 TRIMETHOXYPHENYL) 2 METHYL 4 OXOQUINAZOLIN 6 YLOXY]PENTANAMIDE] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [5 [3,4 DIHYDRO 3 (3,5 DIMETHOXYPHENYL) 2 METHYL 4 OXOQUINAZOLIN 6 YLOXY]PENTANAMIDE] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [5 [3,4 DIHYDRO 3 (4 METHOXYPHENYL) 2 METHYL 4 OXOQUINAZOLIN 6 YLOXY]PENTANAMIDE] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [6 [3,4 DIHYDRO 2 METHYL 3 (4 NITROPHENYL) 4 OXOQUINAZOLIN 6 YLOXY]HEXANAMIDE] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [6 [3,4 DIHYDRO 3 (3,4,5 TRIMETHOXYPHENYL) 2 METHYL 4 OXOQUINAZOLIN 6 YLOXY]HEXANAMIDE] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [6 [3,4 DIHYDRO 3 (3,5 DIMETHOXYPHENYL) 2 METHYL 4 OXOQUINAZOLIN 6 YLOXY]HEXANAMIDE] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [6 [3,4 DIHYDRO 3 (4 METHOXYPHENYL) 2 METHYL 4 OXOQUINAZOLIN 6 YLOXY]HEXANAMIDE] 4 DESOXYPODOPHYLLOTOXIN; 4BETA AMIDOPODOPHYLLOTOXIN CONJUGATE; ANGIOGENESIS INHIBITOR; CASPASE; CASPASE 9; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; ETOPOSIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PODOPHYLLOTOXIN DERIVATIVE; PROTEIN AKT 1; PROTEIN KINASE B; PROTEIN P53; QUINAZOLINONE DERIVATIVE; SERINE; STAT3 PROTEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN A; VITRONECTIN RECEPTOR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CONTROL; CANCER INHIBITION; CARCINOMA CELL; CELL CYCLE REGULATION; CELL PROLIFERATION; CELL STRAIN; CELL STRAIN MCF 7; CELL STRAIN MDA MB 231; CELL STRAIN PANC 1; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; IN VITRO STUDY; MITOSIS; PANCREAS CARCINOMA; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR INVASION; TUMOR MICROENVIRONMENT; TUMOR VASCULARIZATION;

ANGIOGENESIS; ANTICANCER ACTIVITY; CASPASE-9; CELL CYCLE ARREST; INTEGRIN; MITOCHONDRIAL MEMBRANE POTENTIAL (MMP); QUINAZOLINO LINKED PODOPHYLLOTOXIN CONJUGATES; VEGF-A;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; FEMALE; G2 PHASE CELL CYCLE CHECKPOINTS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MCF-7 CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEOVASCULARIZATION, PHYSIOLOGIC; PODOPHYLLOTOXIN; QUINAZOLINONES; SIGNAL TRANSDUCTION;

EID: 84885182962     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.08.051     Document Type: Article

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