N -((1-benzyl-1 H -1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: Synthesis and evaluation of antiproliferative activity against select cancer cell lines

Journal of Medicinal Chemistry

Volumn 53, Issue 8, 2010, Pages 3389-3395

  Stefely, Jonathan A ^a   Palchaudhuri, Rahul ^b   Miller, Patricia A ^a   Peterson, Rebecca J ^a   Moraski, Garrett C ^a   Hergenrother, Paul J ^b   Miller, Marvin J ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYTHIOGUANOSINE; MAYTANSINE; N [(1 BENZYL 1H 1,2,3 TRIAZOL 4 YL)METHYL]AMIDE DERIVATIVE; PACLITAXEL; RHIZOXIN; TRIAZOLE DERIVATIVE; TRIMETREXATE; UNCLASSIFIED DRUG; VINBLASTINE SULFATE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE M PHASE; CELL STRAIN MCF 7; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYCLOADDITION; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; IC 50; MICROTUBULE ASSEMBLY; STRUCTURE ACTIVITY RELATION;

ACRYLAMIDES; CELL DIVISION; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; G2 PHASE; HUMANS; MICROTUBULES; OXAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; TUBULIN; TUBULIN MODULATORS;

EID: 77951103833     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1000979     Document Type: Article

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