Benzo[a]pyrene sensitizes MCF7 breast cancer cells to induction of G1 arrest by the natural flavonoid eupatorin-5-methyl ether, via activation of cell signaling proteins and CYP1-mediated metabolism

Toxicology Letters

Volumn 230, Issue 2, 2014, Pages 304-313

  Androutsopoulos, Vasilis P ^a   Tsatsakis, Aristeidis M ^a  

^a UNIVERSITY OF CRETE   (Greece)

Author keywords

Benzo a pyrene; Cancer; Cell cycle; CYP1 induction; Cytochrome P450s; Flavonoids

Indexed keywords

ANTINEOPLASTIC AGENT; AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; CYTOSTATIC AGENT; EUPATORIN 5 METHYL ETHER; FLAVONOID; JANUS KINASE; MESSENGER RNA; PROTEIN P21; UNCLASSIFIED DRUG; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYP1A1 PROTEIN, HUMAN; CYP1B1 PROTEIN, HUMAN; EUPATORIN-5-METHYL ETHER; FLAVONE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DEMETHYLATION; DOSE RESPONSE; DRUG POTENCY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FLUORESCENCE ACTIVATED CELL SORTING; G1 PHASE CELL CYCLE CHECKPOINT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INTRACELLULAR SIGNALING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MCF 7 CELL LINE; PROTEIN EXPRESSION; PROTEIN METABOLISM; WESTERN BLOTTING; DRUG EFFECTS; ENZYME ACTIVATION; FEMALE; METABOLISM; PHYSIOLOGY; TOXICITY;

BENZO(A)PYRENE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1B1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FEMALE; FLAVONES; G1 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MAP KINASE KINASE 4; MCF-7 CELLS;

EID: 84907166991     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.08.005     Document Type: Article

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