CYP1A1 and CYP1A2 expression: Comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines

Toxicology and Applied Pharmacology

Volumn 237, Issue 1, 2009, Pages 119-126

  Uno, Shigeyuki ^a   Endo, Kaori ^a   Ishida, Yuji ^b   Tateno, Chise ^b   Makishima, Makoto ^a   Yoshizato, Katsutoshi ^b   Nebert, Daniel W ^c  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b PhoenixBio USA Corporation   (Japan)

^c UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin (TCDD, dioxin) as P450 inducer; Bacterial artificial chromosome (BAC); Benzo a pyrene hydroxylase, ethoxyresorufin O deethylase, acetanilide 4 hydroxylase and methoxyresorufin O demethylase as CYP1A1 and CYP1A2 substrates; Cytochrome P450 1 (CYP1) genes; hCYP1A1_1A2_Cyp1a1 1a2( ) BAC transgenic mouse line; Human HepG2 cell culture; Human risk assessment; Mouse Hepa 1c1c7 cell culture; uPA SCID chimeric mouse line carrying human hepatocytes; Western immunoblot

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; COMPLEMENTARY DNA; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; ETHOXYRESORUFIN DEETHYLASE; MESSENGER RNA; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CHIMERA; CONTROLLED STUDY; ENZYME ASSAY; ENZYME INDUCTION; ENZYME SUBSTRATE; GENE EXPRESSION; HEPATOMA CELL; HUMAN; HUMAN CELL; LIVER; LIVER CELL; MOUSE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SPECIES COMPARISON; TARGET ORGAN; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; CELL LINE; CHIMERA; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; DIOXINS; ENVIRONMENTAL POLLUTANTS; ENZYME INDUCTION; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; LIVER; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, ANIMAL; RNA, MESSENGER; SPECIES SPECIFICITY;

BACTERIA (MICROORGANISMS); MUS; MUS MUSCULUS; RODENTIA;

EID: 67349231225     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.03.001     Document Type: Article

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