Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation

Planta Medica

Volumn 78, Issue 8, 2012, Pages 779-786

  Laavola, Mirka ^a   Nieminen, Riina ^a   Yam, Munfei ^b,c   Sadikun, Amirin ^b   Asmawi, Mohdzaini ^b   Basir, Rusliza ^c   Welling, Jukka ^a   Vapaatalo, Heikki ^d   Korhonen, Riku ^a   Moilanen, Eeva ^a  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b SCHOOL OF PHARMACEUTICAL SCIENCES   (Malaysia)

^c UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

COX 2; flavonoids; inflammation; iNOS; Labiatae; Orthosiphon aristatus; Orthosiphon stamineus; TNF

Indexed keywords

CARRAGEENAN; CHLOROFORM; DEXAMETHASONE; EUPATORIN; EUPATORIN 5 METHYL ETHER; FLAVONOID; IBUPROFEN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; METHANOL; NITRIC OXIDE; ORTHOSIPHON STAMINEUS EXTRACT; PETROLEUM ETHER; PLANT EXTRACT; PROSTAGLANDIN E2; SINENSETIN; STAT1 PROTEIN; STAT1ALPHA PROTEIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; GENE EXPRESSION; MALE; MOUSE; NONHUMAN; ORTHOSIPHON STAMINEUS; PAW EDEMA; PLANT LEAF; SOLVENT EXTRACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARRAGEENAN; CELL LINE; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; FLAVONOIDS; GENE EXPRESSION; INFLAMMATION; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; ORTHOSIPHON; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLANTS, MEDICINAL; STAT1 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA;

LAMIACEAE; MUS; ORTHOSIPHON ARISTATUS; ORTHOSIPHON STAMINEUS;

EID: 84861460845     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0031-1298458     Document Type: Article

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