Structure-dependent Ah receptor agonist activities of chlorinated biphenylenes

Toxicology in Vitro

Volumn 20, Issue 7, 2006, Pages 1234-1237

  Khan, Shaheen ^a   Konstantinov, Alex ^b   Chittim, Brock ^b   McAlees, Alan ^b   Yeo, Brian ^b   Safe, Stephen ^a,c  

^a TEXAS A AND M UNIVERSITY   (United States)

^b Research Division   (Canada)

^c TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Ah receptor; MCF 7; Polychlorinated biphenylenes; ZR 75

Indexed keywords

2,3 DICHLOROBIPHENYLENE; 2,3,6 TRICHLOROBIPHENYLENE; 2,3,6,7 TETRACHLOROBIPHENYLENE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ANTIESTROGEN; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; LUCIFERASE; POLYCHLORINATED BIPHENYL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN MCF 7; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PROTEIN EXPRESSION;

BLOTTING, WESTERN; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; GENE EXPRESSION; HUMANS; LUCIFERASES; POLYCHLORINATED BIPHENYLS; RECEPTORS, ARYL HYDROCARBON; STRUCTURE-ACTIVITY RELATIONSHIP; TETRACHLORODIBENZODIOXIN; TIME FACTORS; TRANSFECTION;

EID: 33745997736     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2006.04.003     Document Type: Article

References (20)

1. Alcock R.E., Behnisch P.A., Jones K.C., and Hagenmaier H. Dioxin-like PCBs in the environment-human exposure and the significance of sources. Chemosphere 37 (1998) 1457-1472
2. Baker W., Barton J.W., and McOmie J.F.W. Diphenylenes. Part III. Substitution in the nucleus. J. Chem. Soc. 1958 (1958) 2666-2674
3. Denison M.S., and Nagy S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu. Rev. Pharmacol. Toxicol. 43 (2003) 309-334
4. Goldstein J.A., and Safe S. Mechanism of action and structure-activity relationships for the chlorinated dibenzo-p-dioxins and related compounds. In: Kimbrough R.D., and Jensen A.A. (Eds). Halogenated Biphenyls, Naphthalenes, Dibenzodioxins and Related Compounds (1989), Elsevier-North Holland, Amsterdam 239-293
5. Harris M., Piskorska-Pliszczynska J., Zacharewski T., Romkes M., and Safe S. Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor. Cancer Res. 49 (1989) 4531-4535
6. Kutz F.W., Wood P.H., and Bottimore D.P. Organochlorine pesticides and polychlorinated biphenyls in human adipose tissue. Rev. Environ. Contamin. Toxicol. 120 (1991) 1-82
7. Mason G., Farrell K., Keys B., Piskorska-Pliszczynska J., Safe L., and Safe S. Polychlorinated dibenzo-p-dioxins: quantitative in vitro and in vivo structure-activity relationships. Toxicology 41 (1986) 21-31
8. Noren K., and Meironyte D. Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20-30 years. Chemosphere 40 (2000) 1111-1123
9. Poland A., and Knutson J.C. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons. Examinations of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 22 (1982) 517-554
10. Poland A., Greenlee W.F., and Kende A.S. Studies on the mechanism of action of the chlorinated dibenzo- p-dioxins and related compounds. Annu. N.Y. Acad. Sci. 320 (1979) 214-230
11. Rappe C. Dietary exposure and human levels of PCDDs and PCDFs. Chemosphere 25 (1992) 231-234
12. Rappe C. Sources of exposure, environmental concentrations and exposure assessment of PCDDs and PCDFs. Chemosphere 27 (1993) 211-225
13. Rappe C., Marklund S., Bergqvist P.A., and Hansson M. Polychlorinated dioxins (PCDDs), dibenzofurans (PCDFs) and other polynuclear aromatics (PCPNAs) formed during PCB fires. Chem. Scripta 20 (1982) 56-61
14. Safe S. Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans. Annu. Rev. Pharmacol. Toxicol. 26 (1986) 371-399
15. Safe S. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). CRC Crit. Rev. Toxicol. 21 (1990) 51-88
16. Safe S., and Wormke M. Inhibitory aryl hydrocarbon-estrogen receptor a crosstalk and mechanisms of action. Chem. Res. Toxicol. 16 (2003) 807-816
17. Schecter A., Cramer P., Boggess K., Stanley J., Papke O., Olson J., Silver A., and Schmitz M. Intake of dioxins and related compounds from food in the US population. J. Toxicol. Environ. Health A 63 (2001) 1-18
18. Seidel S.D., Li V., Winter G.M., Rogers W.J., Martinez E.I., and Denison M.S. Ah receptor-based chemical screening bioassays: application and limitations for the detection of Ah receptor of Ah receptor agonsists. Toxicol. Sci. 55 (2000) 107-115
19. van Leeuwen F.X.R., Feeley M., Schrenk D., Larsen J.C., Farland W.H., and Younes M. Dioxins: WHO's tolerable daily intake (TDI) revisited. Chemosphere 40 (2000) 1095-1101
20. Zhang S., Qin C., and Safe S.H. Flavonoids as aryl hydrocarbon receptor agonists/antagonsits: effects of structure and cell context. Environ. Health Persp. 111 (2003) 1877-1882