Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals

Applied Microbiology and Biotechnology

Volumn 98, Issue 18, 2014, Pages 7661-7670

  Jiang, Shengjuan ^a   Wang, Songhua ^a   Sun, Yujun ^a   Zhang, Qiang ^a  

^a ANHUI SCIENCE AND TECHNOLOGY UNIVERSITY   (China)

Author keywords

Cytokines; Hericium erinaceus; Immunoregulatory; Inflammation; Physiological system

Indexed keywords

CARDIOVASCULAR SYSTEM; NEURODEGENERATIVE DISEASES;

CYTOKINES; HERICIUM ERINACEUS; IMMUNOREGULATORY; INFLAMMATION; PHYSIOLOGICAL SYSTEMS;

DIGESTIVE SYSTEM;

NATURAL PRODUCT; NUTRACEUTICAL; CYTOKINE;

DISEASE PREVALENCE; DRUG; FRUITING; IMMUNE SYSTEM; MUSHROOM; PHYSIOLOGY;

CARDIOVASCULAR DISEASE; DIGESTIVE SYSTEM DISEASE; FLAVOR; HERICIUM ERINACEUS; HUMAN; IMMUNOPATHOLOGY; NEUROLOGIC DISEASE; NONHUMAN; SHORT SURVEY; THERAPY EFFECT; AGARICALES; ANIMAL; CHEMISTRY; MEDICINAL CHEMISTRY;

BASIDIOMYCOTA; ERINACEUS; HERICIUM ERINACEUM;

AGARICALES; ANIMALS; CHEMISTRY, PHARMACEUTICAL; CYTOKINES; HUMANS;

EID: 84906948262     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-014-5955-5     Document Type: Short Survey

References (116)

1. Abdulla MA, Noor SM, Sabaratnam V, Abdullah N, Wong KH, Ali HM (2008) Effect of culinary-medicinal lion 's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae), on ethanol-induced gastric ulcers in rats. Int J Med Mushrooms 10:325-330
2. Abdulla MA, Fard AA, Sabaratnam V, Wong KH, Kuppusamy UR, Abdullah N, Ismail S (2011) Potential activity of aqueous extract of culinary-medicinal Lion's Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats. Int J Med Mushrooms 13:33-39
3. Abdullah N, Ismail SM, Aminudin N, Shuib AS, Lau BF (2012) Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities. Evid Based Complement Alternat Med 2012:464238
4. Alzoghaibi MA (2013) Concepts of oxidative stress and antioxidant defense in Crohn's disease. World J Gastroenterol 19:6540-6547
5. Anand R, Gill KD, Mahdi AA (2014) Therapeutics of Alzheimer's disease: past, present and future. Neuropharmacology 76:27-50
6. Bhatia P, Aureli F, D'Amato M, Prakash R, Cameotra SS, Nagaraja TP, Cubadda F (2013) Selenium bioaccessibility and speciation in biofortified Pleurotus mushrooms grown on selenium-rich agricultural residues. Food Chem 140:225-230
7. Blaser MJ (2006) Who are we? Indigenous microbes and the ecology of human diseases. EMBO Rep 7:956-960
8. Bungart BL, Dong L, Sobek D, Sun GY, Yao G, Lee JC (2013) Nanoparticle-emitted light attenuates amyloid-beta-induced superoxide and inflammation in astrocytes. Nanomedicine 10:15-17
9. 4-induced hepatic damageof HEAI extract. J Ethnopharmacol 100:176-179
10. Choi WS, Jang DY, Nam SW, Park BS, Lee HS, Lee SE (2012) Antiulcerogenic activity of scoparone on HCl/ethanol-induced gastritis in rats. J Korean Soc Appl Biol Chem 55:159-163
11. Choi BS, Sapkota K, Choi JH, Shin CH, Kim S, Kim SJ (2013a) Herinase: a novel bi-functional fibrinolytic protease from the monkey head mushroom, Hericium erinaceum. Appl Biochem Biotechnol 170:609-622
12. Choi WS, Kim YS, Park BS, Kim JE, Lee SE (2013b) Hypolipidaemic effect of Hericium erinaceum grown in Artemisia capillaris on obese rats. Mycobiology 41:94-99
13. Costantini S, Colonna G, Castello G (2014) A holistic approach to study the effects of natural antioxidants on inflammation and liver cancer. Cancer Treat Res 159:311-323
14. Dong Q, Jia LM, Fang JN (2006) A beta-D-glucan isolated from the fruiting bodies of Hericium erinaceus and its aqueous conformation. Carbohydr Res 341:791-795
15. Du F,Wang HX, Ng TB (2013) An amylase from fresh fruiting bodies of the monkey head mushroom Hericium erinaceum. Prikl Biokhim Mikrobiol 49:29-33
16. Falandysz J (2008) Selenium in edible mushrooms. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 26:256-299
17. Falandysz J, Borovicka J (2013)Macro and tracemineral constituents and radionuclides in mushrooms: health benefits and risks. Appl Microbiol Biotechnol 97:477-501
18. Figlas D, Gonzalez Matute R, Curvetto N (2007) Cultivation of culinary-medicinal lion's mane mushroom Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) on substrate containing sunflower seed hull. Int J Med Mushrooms 9:67-73 (Pubitemid 46573042)
19. Francesca L, Francesca V (2007) Wild food plants of popular use in Sicily. J Ethnobiol Ethnomed 3:15
20. Fui HY, Shieh DE, Ho CT (2002) Antioxidant and free radical scavenging activities of edible mushrooms. J Food Lipids 9:35-46 (Pubitemid 34862181)
21. Goodall EF, Heath PR, Bandmann O, Kirby J, Shaw PJ (2013) Neuronal dark matter: the emerging role of microRNAs in neurodegeneration. Front Cell Neurosci 7:178
22. Gubandru M, Margina D, Tsitsimpikou C, Goutzourelas N, Tsarouhas K, Ilie M, Tsatsakis AM, Kouretas D (2013) Alzheimer 's disease treated patients showed different patterns for oxidative stress and inflammation markers. Food Chem Toxicol 61:209-214
23. Guerder S, Joncker N, Mahiddine K, Serre L (2013) Dendritic cells in tolerance and autoimmune diabetes. Curr Opin Immunol 25:670-675
24. Gzogian LA, Proskuriakov MT, Ievleva EV, Valueva TA (2005) Trypsinlike proteinases and trypsin inhibitors in fruiting bodies of higher fungi. Prikl Biokhim Mikrobiol 41:612-615
25. Han ZH, Ye JM, Wang GF (2013) Evaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharides. Int J Biol Macromol 52:66-71
26. Hiwatashi K, Kosaka Y, Suzuki N, Hata K, Mukaiyama T, Sakamoto K, Shirakawa H, Komai M (2010) Yamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat diet. Biosci Biotechnol Biochem 74:1447-1451
27. Hoesel B, Schmid JA (2013) The complexity of NF-kappaB signaling in inflammation and cancer. Mol Cancer 12:86
28. Holmes C (2013) Review: systemic inflammation and Alzheimer 's disease. Neuropathol Appl Neurobiol 39:51-68
29. Hsiao EY,McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH, Mazmanian SK (2013) Microbiota modulate behavioral and physiological abnormalities associatedwith neurodevelopmental disorders. Cell 155: 1451-1463
30. Hu SH, Wang JC, Wu CY, Hsieh SL, Chen KS, Chang SJ, Liang ZC (2008) Bioconversion of agro wastes for the cultivation of the culinary-medicinal lion's mane mushrooms Hericium erinaceus (Bull.: Fr.) Pers. and H. laciniatum (leers) banker (Aphyllophoromycetideae) in taiwan. Int J Med Mushrooms 10: 385-398
31. Imtiaj A, Jayasinghe C, Lee GW, Shim MJ, Rho HS, Lee HS, Hur H, Lee MW, Lee UY, Lee TS (2008) Vegetative growth of four strains of Hericium erinaceus collected from different habitats. Mycobiology 36:88-92
32. Jin KS, Park JY, Cho MK, Jang JH, Jeong JH, Ok S, Bak MJ, Song YS, KimMJ, Cho CW, JeongWS (2009a)Modulation of Nrf2/ARE and inflammatory signaling pathways by Hericium erinaceus mycelia extract. Food Sci Biotechnol 18:1204-1211
33. Jin KS, Park JY, Cho MK, Jang JH, Ok S, Jeong JH, Kim MJ, Song YS, JeongWS (2009b) Anti-inflammatory effects of Hericium erinaceus mycelia hot water extract in murine macrophage Raw 264.7 cells. Ann Nutr Metab 55:334
34. Jin KS, Park JY, Cho MK, Jang JH, Ok S, Jeong JH, Kim MJ, Song YS, Jeong WS (2009c) Chemopreventive effects of Hericium erinaceus mycelia hot water extract in Hepg2 human hepatocarcinoma cells. Ann Nutr Metab 55:334
35. Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, Lu C, Xie M, Zhang Q, McMichael JF, Wyczalkowski MA, Leiserson MD, Miller CA, Welch JS,Walter MJ,WendlMC, Ley TJ,Wilson RK, Raphael BJ, Ding L (2013) Mutational landscape and significance across 12 major cancer types. Nature 502:333-339
36. Kang KA, Kim KC, Bae SC, Hyun JW (2013) Oxidative stress induces proliferation of colorectal cancer cells by inhibiting RUNX3 and activating the Akt signaling pathway. Int J Oncol 43:1511-1516
37. Kessenbrock K, Plaks V, Werb Z (2010) Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141:52-67
38. Kim EK, Choi EJ (2010) Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta 1802:396-405
39. Kim SK, Son CG, Yun CH, Han SH (2010) Hericium erinaceum induces maturation of dendritic cells derived from human peripheral blood monocytes. Phytother Res 24:14-19
40. Kim SP, Kang MY, Choi YH, Kim JH, Nam SH, Friedman M (2011a) Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells. Food Funct 2:348-356
41. Kim SP, Kang MY, Kim JH, Nam SH, Friedman M (2011b) Composition andmechanism of antitumor effects of Hericium erinaceus mushroom extracts in tumor-bearing mice. J Agric Food Chem 59:9861-9869
42. Kim YS, Jeon JH, ImJ, Kang SS, Choi JN, Ju HR, Yun CH, Son CG, Lee CH, Han SH (2011c) Induction of intercellular adhesion molecule-1 by water-soluble components of Hericium erinaceum in human monocytes. J Ethnopharmacol 133:874-880
43. Kim KH, Noh HJ, Choi SU, Lee KR (2012a) Isohericenone, a new cytotoxic isoindolinone alkaloid from Hericium erinaceum. J Antibiot (Tokyo) 65:575-577
44. Kim SP, Moon E, Nam SH, Friedman M (2012b) Hericium erinaceus mushroom extracts protect infected mice against Salmonella Typhimurium-induced liver damage and mortality by stimulation of innate immune cells. J Agric Food Chem 60:5590-5596
45. Kim YO, Lee SW, Oh CH, Rhee YH (2012c) Hericium erinaceus suppresses LPS-induced pro-inflammation gene activation in RAW264.7 macrophages. Immunopharmacol Immunotoxicol 34: 504-512
46. Kim SP, Nam SH, Friedman M (2013) Hericium erinaceus (Lion'sMane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-tansplantedmice. J Agric Food Chem 61:4898-4904
47. Ko HG, Park HG, Park SH, Choi CW, Kim SH, Park WM (2005) Comparative study of mycelial growth and basidiomata formation in seven different species of the edible mushroom genus Hericium. Bioresour Technol 96:1439-1444
48. Kobayashi S, Inoue T, Ando A, Tamanoi H, Ryu I, Masuyama A (2012) Total synthesis and structural revision of hericerin. J Org Chem 77: 5819-5822
49. Kolotushkina EV, Moldavan MG, Voronin KY, Skibo GG (2003) The influence of Hericium erinaceus extract on myelination process in vitro. Fiziol Zh 49:38-45
50. Laveti D, KumarM, Hemalatha R, Sistla R, Naidu VG, Talla V, Verma V, Kaur N, Nagpal R (2013) Anti-inflammatory treatments for chronic diseases: a review. Inflamm Allergy Drug Targets 12:349-361
51. Lee JS, Hong EK (2010) Hericium erinaceus enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells. Cancer Lett 297:144-154
52. Lee JS, Cho JY, Hong EK (2009a) Study on macrophage activation and structural characteristics of purified polysaccharides from the liquid culture broth of Hericium erinaceus. Carbohydr Polym 78:162-168
53. Lee JS, Min KM, Cho JY, Hong EK (2009b) Study of macrophage activation and structural characteristics of purified polysaccharides from the fruiting body of Hericium erinaceus. J Microbiol Biotechnol 19:951-959
54. Lee SL, Leong JY, Lim RLH (2010) Comparative cytotoxicity and hemagglutination activities of crude protein extracts from culinarymedicinal mushrooms. Int J Med Mushrooms 12:213-222
55. Li Y, Zhang G, Ng TB, Wang H (2010) A novel lectin with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from dried fruiting bodies of themonkey headmushroom Hericium erinaceum. J Biomed Biotechnol 2010:716515
56. Mau JL, Lin HC, Ma JT, Song SF (2001) Non-volatile taste components of several speciality mushrooms. Food Chem 73:461-466
57. Mau JL, Lin HC, Song SF (2002) Antioxidant properties of several specialty mushrooms. Food Res Int 35:519-526
58. McEwen BS, Gianaros PJ (2010) Central role of the brain in stress and adaptation: links to socioeconomic status, health, and disease. Ann N Y Acad Sci 1186:190-222
59. McEwen BS, Gianaros PJ (2011) Stress- and allostasis-induced brain plasticity. Annu Rev Med 62:431-445
60. Mimura K, Shiraishi K, Mueller A, Izawa S, Kua LF, So J, Yong WP, Fujii H, Seliger B, Kiessling R, Kono K (2013) TheMAPK pathway is a predominant regulator of HLA-A expression in esophageal and gastric cancer. J Immunol 191:6261-6272
61. Mishra A, Liu S, Sams GH, Curphey DP, Santhanam R, Rush LJ, Schaefer D, Falkenberg LG, Sullivan L, Jaroncyk L, Yang X, Fisk H, Wu LC, Hickey C, Chandler JC, Wu YZ, Heerema NA, Chan KK, Perrotti D, Zhang J, Porcu P, Racke FK, Garzon R, Lee RJ, Marcucci G, CaligiuriMA (2012) Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation. Cancer Cell 22:645-655
62. Miyazawa M, Matsuda N, Tamura N, Ishikawa R (2008) Characteristic flavor of volatile oil from dried fruiting bodies of Hericium erinaceus (Bull.: Fr.) Pers. J Essent Oil Res 20:420-423
63. Moldavan MG, Gryganski AP, Kolotushkina OV, Kirchhoff B, Skibo GG, Pedarzani P (2007) Neurotropic and trophic action of lion's mane mushroom Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) extracts on nerve cells in vitro. Int J Med Mushrooms 9:15-28 (Pubitemid 46573037)
64. Mori K, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi S, Nakahata N (2008) Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol Pharm Bull 31:1727-1732
65. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T (2009) Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res 23:367-372
66. Mori K, Kikuchi H, Obara Y, Iwashita M, Azumi Y, Kinugasa S, Inatomi S, Oshima Y, Nakahata N (2010) Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine 17:1082-1085
67. Mori K, Obara Y, Moriya T, Inatomi S, Nakahata N (2011) Effects of Hericium erinaceus on amyloid beta (25-35) peptide-induced learning and memory deficits in mice. Biomed Res 32:67-72
68. Nagai K, Chiba A, Nishino T, Kubota T, Kawagishi H (2006) Dilinoleoyl-phosphatidylethanolamine from Hericium erinaceum protects against ER stress-dependent Neuro2a cell death via protein kinase C pathway. J Nutr Biochem 17:525-530 (Pubitemid 44066764)
69. Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki K (2010) Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res 31:231-237
70. Newton K, Dixit VM (2012) Signaling in innate immunity and inflammation. Cold Spring Harb Perspect Biol 4:a006049
71. Park YS, Lee HS,WonMH, Lee JH, Lee SY, Lee HY (2002) Effect of an exo-polysaccharide from the culture broth of Hericium erinaceus on enhancement of growth and differentiation of rat adrenal nerve cells. Cytotechnology 39:155-162 (Pubitemid 36687492)
72. Ramaswami R, Harding V, Newsom-Davis T (2013) Novel cancer therapies: treatments driven by tumour biology. Postgrad Med J 89:652-658
73. Rowan FS (2002) How terrestrial organisms sense, signal, and respond to carbon dioxide. Integr Comp Biol 42:469-480
74. Samaras K, Sachdev PS (2012) Diabetes and the elderly brain: sweet memories? Ther Adv Endocrinol Metab 3:189-196
75. Schott JM, Revesz T (2013) Inflammation in Alzheimer's disease: insights from immunotherapy. Brain 136:2654-2656
76. Shang X, Tan Q, Liu R, Yu K, Li P, Zhao GP (2013) In vitro anti- Helicobacter pylori effects of medicinal mushroom extracts, with special emphasis on the Lion's Mane mushroom, Hericium erinaceus (higher Basidiomycetes). Int J Med Mushrooms 15:165- 174
77. Shen Y, Yang L, Li R (2013) What does complement do in Alzheimer's disease? Old molecules with new insights. Transl Neurodegener 2: 21
78. Siwulski M, Sobieralski K, Mankowski J (2010) Comparison of mycelium growth of selected species of cultivated mushrooms on textile industry wastes. Acta Sci Pol 9:37-43
79. Slattery ML, Lundgreen A, Wolff RK (2013) Dietary influence on MAPK-signaling pathways and risk of colon and rectal cancer. Nutr Cancer 65:729-738
80. Slusarczyk J, Malinowska E, Krzyczkowski W, Kuras M (2013) Influence of inorganic and organic selenium on number of living mycelial cells and their ultrastructure in culture of Hericium erinaceum (Bull.: Fr. Pers.). Acta Biol Hung 64:96-105
81. Son CG, Shin JW, Cho JH, Cho CK, Yun CH, ChungW, Han SH (2006a) Macrophage activation and nitric oxide production by water soluble components of Hericium erinaceum. Int Immunopharmacol 6: 1363-1369 (Pubitemid 43890960)
82. Son CG, Shin JW, Cho JH, Cho CK, Yun CH, Han SH (2006b) Induction of murine interleukin-1 beta expression by water-soluble components from Hericium erinaceum. Acta Pharmacol Sin 27:1058-1064 (Pubitemid 44127916)
83. Sun YJ, Zhou ZY, Chen Y, Zhou LW (2008) Influence of intracellular polysaccharide from Morchella esculenta on acute liver injury caused by carbon tetrachloride in mice. Edible Fungi China 27: 41-42, 45
84. Suzuki C, Mizuno TX (1997) Cultivation of Yamabushitake (Hericium erinaceum). Food Rev Int 13:419-421
85. Ueda K, Tsujimori M, Kodani S, Chiba A, Kubo M, Masuno K, Sekiya A, Nagai K, Kawagishi H (2008) An endoplasmic reticulum (ER) stress-suppressive compound and its analogues from the mushroom Hericium erinaceum. Bioorg Med Chem 16:9467-9470
86. Ulziijargal E, Mau JL (2011) Nutrient compositions of culinary-medicinal mushroom fruiting bodies and mycelia. Int J Med Mushrooms 13:343-349
87. Ulziijargal E, Yang JH, Lin LY, Chen CP,Mau JL (2013) Quality of bread supplemented with mushroom mycelia. Food Chem 138:70-76
88. Vendramini-Costa DB, Carvalho JE (2012) Molecular link mechanisms between inflammation and cancer. Curr Pharm Des 18:3831-3852
89. Viscogliosi G, Marigliano V (2013) Alzheimer's disease: how far have we progressed? Lessons learned from diabetes mellitus, metabolic syndrome, and inflammation. J Am Geriatr Soc 61:845-846
90. Wang JC, Hu SH, Su CH, Lee TM (2001) Antitumor and immunoenhancing activities of polysaccharide from culture broth of Hericium spp. Kaohsiung J Med Sci 17:461-467 (Pubitemid 34031354)
91. Wang JCY, Hu SH, Wang JT, Chen KS, Chia YC (2005) Hypoglycemic effect of extract of Hericium erinaceus. J Sci Food Agric 85:641-646
92. Wang SH, Zhang H, Fu MQ, Chen QY, Zhou ZY, Lu XM (2007) Antioxidative responses of Agrocybe aegerita mycelia to cadmium stress. Chin J Appl Ecol 18:1813-1818 (Pubitemid 47534805)
93. Wang SH, Zhang H, Cui YR, He QY, Zhang Q (2008) Effects of cadmium stress on the antioxidative system in Ganoderma lucidum mycelia. Chin J Appl Ecol 19:1355-1361
94. Wang X,WangW, Li L, Perry G, Lee HG, Zhu X (2013) Oxidative stress and mitochondrial dysfunction in Alzheimer's disease. Biochim Biophys Acta. doi:10.1016/j.bbadis.2013.1010.1015
95. Weijn A, van den Berg-Somhorst DB, Slootweg JC,Vincken JP, Gruppen H, Wichers HJ, Mes JJ (2013) Main phenolic compounds of the melanin biosynthesis pathway in bruising-tolerant and bruising-sensitive button mushroom (Agaricus bisporus) strains. J Agric Food Chem 61:8224-8231
96. Wiernsperger N (2013) Hepatic function and the cardiometabolic syndrome. Diabetes Metab Syndr Obes 6:379-388
97. Woller N, Kuhnel F (2014) Virus infection, inflammation and prevention of cancer. Recent Results Cancer Res 193:33-58
98. Wong KH, Sabaratnam V, Abdullah N, Naidu M, Keynes R (2007) Activity of aqueous extracts of lion's mane mushroom Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) on the neural cell line NG108-15. Int J Med Mushrooms 9:57-65 (Pubitemid 46573041)
99. Wong KH, Naidu M, David RP, Abdulla MA, Abdullah N, Kuppusamy UR, Sabaratnam V (2009a) Functional recovery enhancement following injury to rodent peroneal nerve by lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae). Int J Med Mushrooms 11:225-236
100. Wong KH, Vikineswary S, Noorlidah A, Rani KU, Murali N (2009b) Effects of cultivation techniques and processing on antimicrobial and antioxidant activities of Hericium erinaceus (Bull.: Fr.) Pers. extracts. Food Technol Biotechnol 47:47-55
101. Wong KH, Naidu M, David P, Abdulla MA, Abdullah N, Kuppusamy UR, Sabaratnam V (2011) Peripheral nerve regeneration following crush injury to rat peroneal nerve by aqueous extract of medicinal mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evid Based Complement Alternat Med 2011:580752
102. Wong KH, Naidu M, David RP, Bakar R, Sabaratnam V (2012) Neuroregenerative potential of lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review). Int J MedMushrooms 14:427-446
103. Xie CY, Gu ZX, You XJ, Liu GX, Tan YX, Zhang H (2010) Screening of edible mushrooms for release of ferulic acid from wheat bran by fermentation. Enzyme Microb Technol 46:125-128
104. Xu H,Wu PR, Shen ZY, Chen XD (2010) Chemical analysis of Hericium erinaceum polysaccharides and effect of the polysaccharides on derma antioxidant enzymes, MMP-1 and TIMP-1 activities. Int J Biol Macromol 47:33-36
105. Yang BK, Park JB, Song CH (2002) Hypolipidemic effect of exopolymer produced in submerged mycelial culture of five different mushrooms. J Microbiol Biotechnol 12:957-961 (Pubitemid 36231250)
106. Yang BK, Park JB, Song CH (2003) Hypolipidemic effect of an exobiopolymer produced from a submerged mycelial culture of Hericium erinaceus. Biosci Biotechnol Biochem 67:1292-1298 (Pubitemid 39251825)
107. Yaoita Y, Yonezawa S, KikuchiM,Machida K (2012) A new geranylated aromatic compound from the mushroom Hericium erinaceum. Nat Prod Commun 7:527-528
108. Yeh SP, Hsia LF, Chiu CS, Chiu ST, Liu CH (2011) A smaller particle size improved the oral bioavailability of monkey head mushroom, Hericium erinaceum, powder resulting in enhancement of the immune response and disease resistance of white shrimp, Litopenaeus vannamei. Fish Shellfish Immunol 30:1323-1330
109. Yim MH, Shin JW, Son JY, Oh SM, Han SH, Cho JH, Cho CK, Yoo HS, Lee YW, Son CG (2007) Soluble components of Hericium erinaceum induce NK cell activation via production of interleukin- 12 in mice splenocytes. Acta Pharmacol Sin 28:901-907
110. Zhang ZF, Lv GY, Pan HJ, Pandey A, He WQ, Fan LF (2012) Antioxidant and hepatoprotective potent ial of endopolysaccharides from Hericium erinaceus grown on tofu whey. Int J Biol Macromol 51:1140-1146
111. Zhang M, Zhou S, Zhang L, Ye W, Wen Q, Wang J (2013a) Role of cancer-related inflammation in esophageal cancer. Crit Rev Eukaryot Gene Expr 23:27-35
112. Zhang W, Zhao S, Li Y, Peng G, Han P (2013b) Acute blood glucose fluctuation induces myocardial apoptosis through oxidative stress and nuclear factor-κB activation. Cardiology 124:11-17
113. Zhang Y, Yan W, Collins MA, Bednar F, Rakshit S, Zetter BR, Stanger BZ, Chung I, Rhim AD, di Magliano MP (2013c) Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance. Cancer Res 73: 6359-6374
114. Zhou R, Lin ZH, Jiang CS, Gong JX, Chen LL, Guo YW, Shen X (2013) Marine natural product des-O-methyllasiodiplodin effectively lowers the blood glucose level in db/db mice via ameliorating inflammation. Acta Pharmacol Sin 34:1325-1336
115. Zhu F, Qu L, Fan W, Qiao M, Hao H, Wang X (2011) Assessment of heavy metals in some wild edible mushrooms collected from Yunnan Province, China. Environ Monit Assess 179:191-199
116. Zou YJ, Wang HX, Ng TB, Huang CY, Zhang JX (2012) Purification and characterization of a novel laccase from the edible mushroom Hericium coralloides. J Microbiol 50:72-78