Isohericenone, a new cytotoxic isoindolinone alkaloid from Hericium erinaceum

Journal of Antibiotics

Volumn 65, Issue 11, 2012, Pages 575-577

  Kim, Ki Hyun ^a   Noh, Hyung Jun ^b   Choi, Sang Un ^c   Lee, Kang Ro ^a  

^a Sungkyunkwan University   (South Korea)

^b Rural Development Administration   (South Korea)

^c Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIHYDRO 5 METHOXY 2 METHYL 2 (4' METHYL 2' OXO 3' PENTENYL) 9(7H) OXO 2H FURO[3,4 H]BENZOPYRAN; CYTOTOXIC AGENT; DOXORUBICIN; ERINACERIN A; ERINACERIN B; HERICENONE A; HERICENONE D; HERICENONE E; HERICENONE F; HERICENONE J; INDOLE ALKALOID; ISOHERICENONE; ISOHERICERIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOASSAY; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG SCREENING; ELECTROSPRAY MASS SPECTROMETRY; FRUITING BODY; HERICIUM ERINACEUS; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTINEOPLASTIC AGENTS; BASIDIOMYCOTA; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLE ALKALOIDS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR;

HERICIUM ERINACEUM;

EID: 84870310049     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2012.65     Document Type: Article

References (15)

1. Kim, K.H., Choi, S.U., Park, K.M., Seok, S.J. & Lee, K.R. Cytotoxic constituents of Amanita subjunquillea. Arch. Pharm. Res. 31, 579-586 (2008).
2. Kim, K.H., Park, K.M., Choi, S.U. & Lee, K.R. Macrolepiotin, a new indole alkaloid from Macrolepiota neomastoidea. J. Antibiot. 62, 335-338 (2009).
3. Kim, K. H. et al. Russulfoen, a new cytotoxic marasmane sesquiterpene from Russula foetens. J. Antibiot. 63, 575-577 (2010).
4. Kim, K.H. et al. Lactarane sesquiterpenoids from Lactarius subvellereus and their cytotoxicity. Bioorg. Med. Chem. Lett. 20, 5385-5388 (2010).
5. Kim, K.H., Choi, S.U. & Lee, K.R. Gymnopilin K, a new cytotoxic gymnopilin from Gymnopilus spectabilis. J. Antibiot. 65, 135-137 (2012).
6. Miyazawa, M., Takahashi, T., Horibe, I. & Ishikawa, R. Two new aromatic compounds and a new D-arabinitol ester from the mushroom Hericium erinaceum. Tetrahedron 68, 2007-2010 (2012).
7. Kawagishi, H., Ando, M. & Mizuno, T. Hericenone A and B as cytotoxic principles from the mushroom Hericium erinaceum. Tetrahedron Lett. 31, 373-376 (1990). (Pubitemid 20048154)
8. Kawagishi, H. et al. Hericenone C, D and E, stimulators of nerve growth factor(NGF)- synthesis, from the mushroom Hericium erinaceum. Tetrahedron Lett. 32, 4561-4564 (1991).
9. Ueda, K. et al. An endoplasmic reticulum (ER) stress-suppressive compound and its analogues from the mushroom Hericium erinaceum. Bioorg. Med. Chem. 16, 9467- 9470 (2008).
10. Kimura, Y. et al. Hericerin, a new pollen growth inhibitor from the mushroom Hericium erinaceum. Agric. Biol. Chem. 55, 2673-2674 (1991).
11. Mizuno, T., Wasa, T., Ito, H., Suzuki, C. & Ukai, N. Antitumor-active polysaccharides isolated from the fruiting body of Hericium erinaceum, an edible and medicinal mushroom called yamabushitake or houtou. Biosci. Biotechnol. Biochem. 56, 347-348 (1992).
12. Yaoita, Y., Danbara, K. & Kikuchi, M. Two new aromatic compounds from Hericium erinaceum (BULL.: FR.) PERS. Chem. Pharm. Bull. 53, 1202-1203 (2005). (Pubitemid 41330493)
13. Yaoita, Y. & Kikuchi, M. Constituents of mushrooms. XXV. Structures of new aromatic compounds from the fruiting bodies of Hericium erinaceum. Pers. J. Tohoku. Pharm. Uni. 52, 39-42 (2005).
14. Kawagishi, H. et al. Chromans, hericenones F, G and H from the mushroom Hericium erinaceum. Phytochemistry 32, 175-178 (1993).
15. Skehan, P. et al. New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl Cancer Inst. 82, 1107-1112 (1990). (Pubitemid 20213250)