Alzheimer's disease: How far have we progressed? Lessons learned from diabetes mellitus, metabolic syndrome, and inflammation

Journal of the American Geriatrics Society

Volumn 61, Issue 5, 2013, Pages 845-846

  Viscogliosi, Giovanni ^a   Marigliano, Vincenzo ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; GLUCOSE; INSULIN RECEPTOR; INTERLEUKIN 1; INTERLEUKIN 6; TAU PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TYROSINE KINASE RECEPTOR;

AGING; ALZHEIMER DISEASE; AMYGDALOID NUCLEUS; BLOOD BRAIN BARRIER; BRAIN FUNCTION; BRAIN METABOLISM; CARDIOVASCULAR RISK; COGNITION; DIABETES MELLITUS; DOWN REGULATION; GLUCOSE METABOLISM; HIPPOCAMPUS; HUMAN; INFLAMMATION; INSULIN RESISTANCE; LETTER; METABOLIC SYNDROME X; MILD COGNITIVE IMPAIRMENT; NEOCORTEX; NONHUMAN; OLFACTORY BULB; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

AGE FACTORS; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; DIABETES MELLITUS; HUMANS; INFLAMMATION; METABOLIC SYNDROME X; PREVALENCE; WORLD HEALTH;

EID: 84877945596     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/jgs.12242     Document Type: Letter

References (8)

1. Omerovic M, Hampel H, Teipel SJ, et al. Pharmacological treatment of Alzheimer's dementia: State of the art and current dilemmas. World J Biol Psychiatry 2008; 9: 69-75.
2. Hommet C, Mondon K, Constans T, et al. Review of cerebral microangiopathy and Alzheimer's disease: Relation between white matter hyperintensities and microbleeds. Dement Geriatr Cogn Disord 2011; 32: 367-378.
3. Marchesi VT,. Alzheimer's dementia begins as a disease of small blood vessels, damaged by oxidative-induced inflammation and dysregulated amyloid metabolism: Implications for early detection and therapy. FASEB J 2011; 25: 5-13.
4. Thal DR,. The pre-capillary segment of the blood-brain barrier and its relation to perivascular drainage in Alzheimer's disease and small vessel disease. Scientific World J 2009; 9: 557-563.
5. Rubio-Perez JM, Morillas-Ruiz JM,. A review: Inflammatory process in Alzheimer's disease, role of cytokines. Mol Neurobiol 2010; 41: 392-409.
6. Krstic D, Madhusudan A, Doehner J, et al. Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice. J Neuroinflammation 2012; 9: 151.
7. Schrijvers EM, Witteman JC, Sijbrands EJ, et al. Insulin metabolism and the risk of Alzheimer disease: The Rotterdam Study. Neurology 2010; 75: 1982-1987.
8. Craft S, Baker LD, Montine TJ, et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: A pilot clinical trial. Arch Neurol 2012; 69: 29-38.