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Volumn , Issue OCT, 2013, Pages

Neuronal dark matter: The emerging role of microRNAs in neurodegeneration

Author keywords

Alzheimer's disease; Amyotrophic lateral sclerosis; Huntington's disease; MicroRNA; Neurodegeneration; Parkinson's disease

Indexed keywords

ARGONAUTE PROTEIN; BETA SECRETASE 1; COPPER ZINC SUPEROXIDE DISMUTASE; LEVODOPA; MICRORNA; MICRORNA 106A; MICRORNA 106B; MICRORNA 107; MICRORNA 124A; MICRORNA 125B; MICRORNA 132; MICRORNA 133B; MICRORNA 146A; MICRORNA 150; MICRORNA 153; MICRORNA 181C; MICRORNA 184; MICRORNA 200A; MICRORNA 200C; MICRORNA 205; MICRORNA 206; MICRORNA 21; MICRORNA 224; MICRORNA 29; MICRORNA 34A; MICRORNA 9; RNA INDUCED SILENCING COMPLEX; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

EID: 84886847678     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2013.00178     Document Type: Review
Times cited : (152)

References (152)
  • 1
    • 84865843186 scopus 로고    scopus 로고
    • The genetics and neuropathology of amyotrophic lateral sclerosis
    • doi: 10.1007/s00401-012-1022-4
    • Al-Chalabi, A., Jones, A., Troakes, C., King, A., Al-Sarraj, S., and van den Berg, L. H. (2012). The genetics and neuropathology of amyotrophic lateral sclerosis. Acta Neuropathol. 124, 339-352. doi: 10.1007/s00401-012-1022-4
    • (2012) Acta Neuropathol , vol.124 , pp. 339-352
    • Al-Chalabi, A.1    Jones, A.2    Troakes, C.3    King, A.4    Al-Sarraj, S.5    van den Berg, L.H.6
  • 2
    • 84875876495 scopus 로고    scopus 로고
    • Influence of microRNA deregulation on chaperone-mediated autophagy and alpha-synuclein pathology in Parkinson's disease
    • doi: 10.1038/cddis.2013.73
    • Alvarez-Erviti, L., Seow, Y., Schapira, A. H., Rodriguez-Oroz, M. C., Obeso, J. A., and Cooper, J. M. (2013). Influence of microRNA deregulation on chaperone-mediated autophagy and alpha-synuclein pathology in Parkinson's disease. Cell Death Dis. 4, e545. doi: 10.1038/cddis.2013.73
    • (2013) Cell Death Dis , vol.4
    • Alvarez-Erviti, L.1    Seow, Y.2    Schapira, A.H.3    Rodriguez-Oroz, M.C.4    Obeso, J.A.5    Cooper, J.M.6
  • 3
    • 77950188650 scopus 로고    scopus 로고
    • Global microRNA expression profiling of Caenorhabditis elegans Parkinson's disease models
    • doi: 10.1007/s12031-009-9325-1
    • Asikainen, S., Rudgalvyte, M., Heikkinen, L., Louhiranta, K., Lakso, M., Wong, G., et al. (2010). Global microRNA expression profiling of Caenorhabditis elegans Parkinson's disease models. J. Mol. Neurosci. 41, 210-218. doi: 10.1007/s12031-009-9325-1
    • (2010) J. Mol. Neurosci , vol.41 , pp. 210-218
    • Asikainen, S.1    Rudgalvyte, M.2    Heikkinen, L.3    Louhiranta, K.4    Lakso, M.5    Wong, G.6
  • 4
    • 84861017904 scopus 로고    scopus 로고
    • Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10
    • doi: 10.1186/1471-2350-13-35
    • Augustin, R., Endres, K., Reinhardt, S., Kuhn, P. H., Lichtenthaler, S. F., Hansen, J., et al. (2012). Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10. BMC Med. Genet. 13:35. doi: 10.1186/1471-2350-13-35
    • (2012) BMC Med. Genet , vol.13 , pp. 35
    • Augustin, R.1    Endres, K.2    Reinhardt, S.3    Kuhn, P.H.4    Lichtenthaler, S.F.5    Hansen, J.6
  • 5
    • 77953448164 scopus 로고    scopus 로고
    • Genetics of Alzheimer's disease: Recent advances
    • doi: 10.1186/gm34
    • Avramopoulos, D. (2009). Genetics of Alzheimer's disease: recent advances. Genome Med. 1, 34. doi: 10.1186/gm34
    • (2009) Genome Med , vol.1 , pp. 34
    • Avramopoulos, D.1
  • 6
    • 54349104464 scopus 로고    scopus 로고
    • Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs
    • doi: 10.1101/gad.1705308
    • Babiarz, J. E., Ruby, J. G., Wang, Y., Bartel, D. P., and Blelloch, R. (2008). Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes Dev. 22, 2773-2785. doi: 10.1101/gad.1705308
    • (2008) Genes Dev , vol.22 , pp. 2773-2785
    • Babiarz, J.E.1    Ruby, J.G.2    Wang, Y.3    Bartel, D.P.4    Blelloch, R.5
  • 7
    • 79952364512 scopus 로고    scopus 로고
    • Kinetic analysis reveals the fate of a microRNA following target regulation in mammalian cells
    • doi: 10.1016/j.cub.2011.01.067
    • Baccarini, A., Chauhan, H., Gardner, T. J., Jayaprakash, A. D., Sachidanandam, R., and Brown, B. D. (2011). Kinetic analysis reveals the fate of a microRNA following target regulation in mammalian cells. Curr. Biol. 21, 369-376. doi: 10.1016/j.cub.2011.01.067
    • (2011) Curr. Biol , vol.21 , pp. 369-376
    • Baccarini, A.1    Chauhan, H.2    Gardner, T.J.3    Jayaprakash, A.D.4    Sachidanandam, R.5    Brown, B.D.6
  • 8
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • doi: 10.1016/j.cell.2009.01.002
    • Bartel, D. P. (2009). MicroRNAs: target recognition and regulatory functions. Cell136, 215-233. doi: 10.1016/j.cell.2009.01.002
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 9
    • 35348933779 scopus 로고    scopus 로고
    • Mammalian mirtron genes
    • doi: 10.1016/j.molcel.2007.09.028
    • Berezikov, E., Chung, W. J., Willis, J., Cuppen, E., and Lai, E. C. (2007). Mammalian mirtron genes. Mol. Cell 28, 328-336. doi: 10.1016/j.molcel.2007.09.028
    • (2007) Mol. Cell , vol.28 , pp. 328-336
    • Berezikov, E.1    Chung, W.J.2    Willis, J.3    Cuppen, E.4    Lai, E.C.5
  • 10
    • 11844262661 scopus 로고    scopus 로고
    • Phylogenetic shadowing and computational identification of human microRNA genes
    • doi: 10.1016/j.cell.2004.12.031
    • Berezikov, E., Guryev, V., van de Belt, J., Wienholds, E., Plasterk, R. H., and Cuppen, E. (2005). Phylogenetic shadowing and computational identification of human microRNA genes. Cell 120, 21-24. doi: 10.1016/j.cell.2004.12.031
    • (2005) Cell , vol.120 , pp. 21-24
    • Berezikov, E.1    Guryev, V.2    van de Belt, J.3    Wienholds, E.4    Plasterk, R.H.5    Cuppen, E.6
  • 11
    • 77957927865 scopus 로고    scopus 로고
    • The genetics of Alzheimer disease: Back to the future
    • doi: 10.1016/j.neuron.2010.10.013
    • Bertram, L., Lill, C. M., and Tanzi, R. E. (2010). The genetics of Alzheimer disease: back to the future. Neuron 68, 270-281. doi: 10.1016/j.neuron.2010.10.013
    • (2010) Neuron , vol.68 , pp. 270-281
    • Bertram, L.1    Lill, C.M.2    Tanzi, R.E.3
  • 12
    • 33845892752 scopus 로고    scopus 로고
    • Systematic meta-analyses of Alzheimer disease genetic association studies: The AlzGene database
    • doi: 10.1038/ng1934
    • Bertram, L., McQueen, M. B., Mullin, K., Blacker, D., and Tanzi, R. E. (2007). Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat. Genet. 39, 17-23. doi: 10.1038/ng1934
    • (2007) Nat. Genet , vol.39 , pp. 17-23
    • Bertram, L.1    McQueen, M.B.2    Mullin, K.3    Blacker, D.4    Tanzi, R.E.5
  • 13
    • 67749094957 scopus 로고    scopus 로고
    • APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease
    • doi: 10.1002/humu.21027
    • Bettens, K., Brouwers, N., Engelborghs, S., Van Miegroet, H., De Deyn, P. P., Theuns, J., et al. (2009). APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease. Hum. Mutat. 30, 1207-1213. doi: 10.1002/humu.21027
    • (2009) Hum. Mutat , vol.30 , pp. 1207-1213
    • Bettens, K.1    Brouwers, N.2    Engelborghs, S.3    Van Miegroet, H.4    De Deyn, P.P.5    Theuns, J.6
  • 14
    • 33744973775 scopus 로고    scopus 로고
    • Relief of microRNA-mediated translational repression in human cells subjected to stress
    • doi: 10.1016/j.cell.2006.04.031
    • Bhattacharyya, S. N., Habermacher, R., Martine, U., Closs, E. I., and Filipowicz, W. (2006). Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell 125, 1111-1124. doi: 10.1016/j.cell.2006.04.031
    • (2006) Cell , vol.125 , pp. 1111-1124
    • Bhattacharyya, S.N.1    Habermacher, R.2    Martine, U.3    Closs, E.I.4    Filipowicz, W.5
  • 15
    • 0029013727 scopus 로고
    • Staging of Alzheimer's disease-related neurofibrillary changes
    • discussion: 278-284. doi: 10.1016/0197-4580(95)00021-6
    • Braak, H., and Braak, E. (1995). Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol. Aging 16, 271-278. discussion: 278-284. doi: 10.1016/0197-4580(95)00021-6
    • (1995) Neurobiol. Aging , vol.16 , pp. 271-278
    • Braak, H.1    Braak, E.2
  • 16
    • 77951700391 scopus 로고    scopus 로고
    • Nuclear factor TDP-43 can affect selected microRNA levels
    • doi: 10.1111/j.1742-4658.2010.07643.x
    • Buratti, E., De Conti, L., Stuani, C., Romano, M., Baralle, M., and Baralle, F. (2010). Nuclear factor TDP-43 can affect selected microRNA levels. FEBS J. 277, 2268-2281. doi: 10.1111/j.1742-4658.2010.07643.x
    • (2010) FEBS J , vol.277 , pp. 2268-2281
    • Buratti, E.1    De Conti, L.2    Stuani, C.3    Romano, M.4    Baralle, M.5    Baralle, F.6
  • 17
    • 84865987121 scopus 로고    scopus 로고
    • Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
    • doi: 10.1172/JCI62636
    • Butovsky, O., Siddiqui, S., Gabriely, G., Lanser, A. J., Dake, B., Murugaiyan, G., et al. (2012). Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS. J. Clin. Invest. 122, 3063-3087. doi: 10.1172/JCI62636
    • (2012) J. Clin. Invest , vol.122 , pp. 3063-3087
    • Butovsky, O.1    Siddiqui, S.2    Gabriely, G.3    Lanser, A.J.4    Dake, B.5    Murugaiyan, G.6
  • 18
    • 84878005741 scopus 로고    scopus 로고
    • Altered microRNA expression profile in amyotrophic lateral sclerosis: A role in the regulation of NFL mRNA levels
    • doi: 10.1186/1756-6606-6-26
    • Campos-Melo, D., Droppelmann, C. A., He, Z., Volkening, K., and Strong, M. J. (2013). Altered microRNA expression profile in amyotrophic lateral sclerosis: a role in the regulation of NFL mRNA levels. Mol. Brain 6, 26. doi: 10.1186/1756-6606-6-26
    • (2013) Mol. Brain , vol.6 , pp. 26
    • Campos-Melo, D.1    Droppelmann, C.A.2    He, Z.3    Volkening, K.4    Strong, M.J.5
  • 19
    • 84891391234 scopus 로고    scopus 로고
    • Profile of microRNAs in the plasma of Parkinson's disease patients and healthy controls
    • doi: 10.1007/s00415-013-6900-8
    • Cardo, L. F., Coto, E., de Mena, L., Ribacoba, R., Moris, G., Menendez, M., et al. (2013). Profile of microRNAs in the plasma of Parkinson's disease patients and healthy controls. J. Neurol. 260, 1420-1422. doi: 10.1007/s00415-013-6900-8
    • (2013) J. Neurol , vol.260 , pp. 1420-1422
    • Cardo, L.F.1    Coto, E.2    de Mena, L.3    Ribacoba, R.4    Moris, G.5    Menendez, M.6
  • 20
    • 60149088848 scopus 로고    scopus 로고
    • Origins and Mechanisms of miRNAs and siRNAs
    • doi: 10.1016/j.cell.2009.01.035
    • Carthew, R. W., and Sontheimer, E. J. (2009). Origins and Mechanisms of miRNAs and siRNAs. Cell 136, 642-655. doi: 10.1016/j.cell.2009.01.035.
    • (2009) Cell , vol.136 , pp. 642-655
    • Carthew, R.W.1    Sontheimer, E.J.2
  • 21
    • 70349453924 scopus 로고    scopus 로고
    • Active turnover modulates mature microRNA activity in Caenorhabditis elegans
    • doi: 10.1038/nature08349
    • Chatterjee, S., and Grosshans, H. (2009). Active turnover modulates mature microRNA activity in Caenorhabditis elegans. Nature 461, 546-549. doi: 10.1038/nature08349
    • (2009) Nature , vol.461 , pp. 546-549
    • Chatterjee, S.1    Grosshans, H.2
  • 22
    • 77953183812 scopus 로고    scopus 로고
    • A dicer-independent miRNA biogenesis pathway that requires Ago catalysis
    • doi: 10.1038/nature09092
    • Cheloufi, S., Dos Santos, C. O., Chong, M. M., and Hannon, G. J. (2010). A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature 465, 584-589. doi: 10.1038/nature09092
    • (2010) Nature , vol.465 , pp. 584-589
    • Cheloufi, S.1    Dos Santos, C.O.2    Chong, M.M.3    Hannon, G.J.4
  • 23
    • 53349177819 scopus 로고    scopus 로고
    • Characterization of microRNAs in serum: A novel class of biomarkers for diagnosis of cancer and other diseases
    • doi: 10.1038/cr.2008.282
    • Chen, X., Ba, Y., Ma, L., Cai, X., Yin, Y., Wang, K., et al. (2008). Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 18, 997-1006. doi: 10.1038/cr.2008.282
    • (2008) Cell Res , vol.18 , pp. 997-1006
    • Chen, X.1    Ba, Y.2    Ma, L.3    Cai, X.4    Yin, Y.5    Wang, K.6
  • 24
    • 84872394361 scopus 로고    scopus 로고
    • MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein
    • doi: 10.1093/hmg/dds470
    • Cho, H. J., Liu, G., Jin, S. M., Parisiadou, L., Xie, C., Yu, J., et al. (2013). MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein. Hum. Mol. Genet. 22, 608-620. doi: 10.1093/hmg/dds470
    • (2013) Hum. Mol. Genet , vol.22 , pp. 608-620
    • Cho, H.J.1    Liu, G.2    Jin, S.M.3    Parisiadou, L.4    Xie, C.5    Yu, J.6
  • 25
    • 34247540446 scopus 로고    scopus 로고
    • Epigenetics and microRNAs
    • doi: 10.1203/pdr.0b013e3180457684
    • Chuang, J. C., and Jones, P. A. (2007). Epigenetics and microRNAs. Pediatr. Res. 61, 24R-29R. doi: 10.1203/pdr.0b013e3180457684
    • (2007) Pediatr. Res , vol.61
    • Chuang, J.C.1    Jones, P.A.2
  • 26
    • 47849124269 scopus 로고    scopus 로고
    • Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways
    • Cogswell, J. P., Ward, J., Taylor, I. A., Waters, M., Shi, Y., Cannon, B., et al. (2008). Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J. Alzheimers Dis. 14, 27-41.
    • (2008) J. Alzheimers Dis , vol.14 , pp. 27-41
    • Cogswell, J.P.1    Ward, J.2    Taylor, I.A.3    Waters, M.4    Shi, Y.5    Cannon, B.6
  • 27
    • 33144481470 scopus 로고    scopus 로고
    • Reciprocal actions of REST and a microRNA promote neuronal identity
    • doi: 10.1073/pnas.0511041103
    • Conaco, C., Otto, S., Han, J. J., and Mandel, G. (2006). Reciprocal actions of REST and a microRNA promote neuronal identity. Proc. Natl. Acad. Sci. U.S.A. 103, 2422-2427. doi: 10.1073/pnas.0511041103
    • (2006) Proc. Natl. Acad. Sci. U.S. A , vol.103 , pp. 2422-2427
    • Conaco, C.1    Otto, S.2    Han, J.J.3    Mandel, G.4
  • 28
    • 84862317109 scopus 로고    scopus 로고
    • Genetics and epigenetics of Parkinson's disease
    • doi: 10.1100/2012/489830
    • Coppede, F. (2012). Genetics and epigenetics of Parkinson's disease. ScientificWorldJournal 2012, 489830. doi: 10.1100/2012/489830
    • (2012) ScientificWorldJournal , vol.2012 , pp. 489830
    • Coppede, F.1
  • 29
    • 78650306521 scopus 로고    scopus 로고
    • Small RNA sorting: Matchmaking for Argonautes
    • doi: 10.1038/nrg2916
    • Czech, B., and Hannon, G. J. (2011). Small RNA sorting: matchmaking for Argonautes. Nat. Rev. Genet. 12, 19-31. doi: 10.1038/nrg2916
    • (2011) Nat. Rev. Genet , vol.12 , pp. 19-31
    • Czech, B.1    Hannon, G.J.2
  • 30
    • 34547093726 scopus 로고    scopus 로고
    • Identification of potential protein interactors of Lrrk2
    • doi: 10.1016/j.parkreldis.2007.01.008
    • Dachsel, J. C., Taylor, J. P., Mok, S. S., Ross, O. A., Hinkle, K. M., Bailey, R. M., et al. (2007). Identification of potential protein interactors of Lrrk2. Parkinsonism Relat. Disord. 13, 382-385. doi: 10.1016/j.parkreldis.2007.01.008
    • (2007) Parkinsonism Relat. Disord , vol.13 , pp. 382-385
    • Dachsel, J.C.1    Taylor, J.P.2    Mok, S.S.3    Ross, O.A.4    Hinkle, K.M.5    Bailey, R.M.6
  • 31
    • 84865536102 scopus 로고    scopus 로고
    • A miRNA signature in leukocytes from sporadic amyotrophic lateral sclerosis
    • doi: 10.1016/j.gene.2012.07.058
    • De Felice, B., Guida, M., Coppola, C., De Mieri, G., and Cotrufo, R. (2012). A miRNA signature in leukocytes from sporadic amyotrophic lateral sclerosis. Gene 508, 35-40. doi: 10.1016/j.gene.2012.07.058
    • (2012) Gene , vol.508 , pp. 35-40
    • De Felice, B.1    Guida, M.2    Coppola, C.3    De Mieri, G.4    Cotrufo, R.5
  • 32
    • 84859503786 scopus 로고    scopus 로고
    • MicroRNAs in Alzheimer's disease
    • doi: 10.1016/j.nbd.2012.01.003
    • Delay, C., Mandemakers, W., and Hebert, S. S. (2012). MicroRNAs in Alzheimer's disease. Neurobiol. Dis. 46, 285-290. doi: 10.1016/j.nbd.2012.01.003
    • (2012) Neurobiol. Dis , vol.46 , pp. 285-290
    • Delay, C.1    Mandemakers, W.2    Hebert, S.S.3
  • 33
    • 9144224451 scopus 로고    scopus 로고
    • Processing of primary microRNAs by the Microprocessor complex
    • doi: 10.1038/nature03049
    • Denli, A. M., Tops, B. B., Plasterk, R. H., Ketting, R. F., and Hannon, G. J. (2004). Processing of primary microRNAs by the Microprocessor complex. Nature 432, 231-235. doi: 10.1038/nature03049
    • (2004) Nature , vol.432 , pp. 231-235
    • Denli, A.M.1    Tops, B.B.2    Plasterk, R.H.3    Ketting, R.F.4    Hannon, G.J.5
  • 34
    • 36849048778 scopus 로고    scopus 로고
    • Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression
    • doi: 10.1016/j.cell.2007.10.032
    • Diederichs, S., and Haber, D. A. (2007). Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression. Cell 131, 1097-1108. doi: 10.1016/j.cell.2007.10.032
    • (2007) Cell , vol.131 , pp. 1097-1108
    • Diederichs, S.1    Haber, D.A.2
  • 35
    • 77951249562 scopus 로고    scopus 로고
    • Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153
    • doi: 10.1074/jbc.M109.086827
    • Doxakis, E. (2010). Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153. J. Biol. Chem. 285, 12726-12734. doi: 10.1074/jbc.M109.086827
    • (2010) J. Biol. Chem , vol.285 , pp. 12726-12734
    • Doxakis, E.1
  • 36
    • 78149303249 scopus 로고    scopus 로고
    • MicroRNA sponges: Progress and possibilities
    • doi: 10.1261/rna.2414110
    • Ebert, M. S., and Sharp, P. A. (2010). MicroRNA sponges: progress and possibilities. RNA 16, 2043-2050. doi: 10.1261/rna.2414110
    • (2010) RNA , vol.16 , pp. 2043-2050
    • Ebert, M.S.1    Sharp, P.A.2
  • 37
    • 84860324470 scopus 로고    scopus 로고
    • Roles for microRNAs in conferring robustness to biological processes
    • doi: 10.1016/j.cell.2012.04.005
    • Ebert, M. S., and Sharp, P. A. (2012). Roles for microRNAs in conferring robustness to biological processes. Cell 149, 515-524. doi: 10.1016/j.cell.2012.04.005
    • (2012) Cell , vol.149 , pp. 515-524
    • Ebert, M.S.1    Sharp, P.A.2
  • 38
    • 42249093319 scopus 로고    scopus 로고
    • LNA-mediated microRNA silencing in non-human primates
    • doi: 10.1038/nature06783
    • Elmen, J., Lindow, M., Schutz, S., Lawrence, M., Petri, A., Obad, S., et al. (2008). LNA-mediated microRNA silencing in non-human primates. Nature 452, 896-899. doi: 10.1038/nature06783
    • (2008) Nature , vol.452 , pp. 896-899
    • Elmen, J.1    Lindow, M.2    Schutz, S.3    Lawrence, M.4    Petri, A.5    Obad, S.6
  • 39
    • 55949112523 scopus 로고    scopus 로고
    • A human snoRNA with microRNA-like functions
    • doi: 10.1016/j.molcel.2008.10.017
    • Ender, C., Krek, A., Friedlander, M. R., Beitzinger, M., Weinmann, L., Chen, W., et al. (2008). A human snoRNA with microRNA-like functions. Mol. Cell 32, 519-528. doi: 10.1016/j.molcel.2008.10.017
    • (2008) Mol. Cell , vol.32 , pp. 519-528
    • Ender, C.1    Krek, A.2    Friedlander, M.R.3    Beitzinger, M.4    Weinmann, L.5    Chen, W.6
  • 40
    • 82755187564 scopus 로고    scopus 로고
    • Extracellular microRNA: A new source of biomarkers
    • doi: 10.1016/j.mrfmmm.2011.03.004
    • Etheridge, A., Lee, I., Hood, L., Galas, D., and Wang, K. (2011). Extracellular microRNA: a new source of biomarkers. Mutat. Res. 717, 85-90. doi: 10.1016/j.mrfmmm.2011.03.004
    • (2011) Mutat. Res , vol.717 , pp. 85-90
    • Etheridge, A.1    Lee, I.2    Hood, L.3    Galas, D.4    Wang, K.5
  • 41
    • 84884134423 scopus 로고    scopus 로고
    • Increased micro-RNA 29b in the aged brain correlates with the reduction of insulin-like growth factor-1 and fractalkine ligand
    • doi: 10.1016/j.neurobiolaging.2013.06.007
    • Fenn, A. M., Smith, K. M., Lovett-Racke, A. E., Guerau-de-Arellano, M., Whitacre, C. C., and Godbout, J. P. (2013). Increased micro-RNA 29b in the aged brain correlates with the reduction of insulin-like growth factor-1 and fractalkine ligand. Neurobiol. Aging 34, 2748-2758. doi: 10.1016/j.neurobiolaging.2013.06.007
    • (2013) Neurobiol. Aging , vol.34 , pp. 2748-2758
    • Fenn, A.M.1    Smith, K.M.2    Lovett-Racke, A.E.3    Guerau-de-Arellano, M.4    Whitacre, C.C.5    Godbout, J.P.6
  • 42
    • 60149095444 scopus 로고    scopus 로고
    • Most mammalian mRNAs are conserved targets of microRNAs
    • doi: 10.1101/gr.082701.108
    • Friedman, R. C., Farh, K. K., Burge, C. B., and Bartel, D. P. (2009). Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 19, 92-105. doi: 10.1101/gr.082701.108
    • (2009) Genome Res , vol.19 , pp. 92-105
    • Friedman, R.C.1    Farh, K.K.2    Burge, C.B.3    Bartel, D.P.4
  • 43
    • 79956032718 scopus 로고    scopus 로고
    • Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease
    • doi: 10.1093/hmg/ddr111
    • Gaughwin, P. M., Ciesla, M., Lahiri, N., Tabrizi, S. J., Brundin, P., and Bjorkqvist, M. (2011). Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease. Hum. Mol. Genet. 20, 2225-2237. doi: 10.1093/hmg/ddr111
    • (2011) Hum. Mol. Genet , vol.20 , pp. 2225-2237
    • Gaughwin, P.M.1    Ciesla, M.2    Lahiri, N.3    Tabrizi, S.J.4    Brundin, P.5    Bjorkqvist, M.6
  • 44
    • 84860369464 scopus 로고    scopus 로고
    • Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease
    • doi: 10.1016/j.expneurol.2011.11.026
    • Geekiyanage, H., Jicha, G. A., Nelson, P. T., and Chan, C. (2012). Blood serum miRNA: non-invasive biomarkers for Alzheimer's disease. Exp. Neurol. 235, 491-496. doi: 10.1016/j.expneurol.2011.11.026
    • (2012) Exp. Neurol , vol.235 , pp. 491-496
    • Geekiyanage, H.1    Jicha, G.A.2    Nelson, P.T.3    Chan, C.4
  • 45
    • 77955152366 scopus 로고    scopus 로고
    • Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
    • doi: 10.1038/nature09191
    • Gehrke, S., Imai, Y., Sokol, N., and Lu, B. (2010). Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. Nature 466, 637-641. doi: 10.1038/nature09191
    • (2010) Nature , vol.466 , pp. 637-641
    • Gehrke, S.1    Imai, Y.2    Sokol, N.3    Lu, B.4
  • 46
    • 80052041448 scopus 로고    scopus 로고
    • Regulation of miR-146a by RelA/NFkB and p53 in STHdh(Q111)/Hdh(Q111) cells, a cell model of Huntington's disease
    • doi: 10.1371/journal.pone.0023837
    • Ghose, J., Sinha, M., Das, E., Jana, N. R., and Bhattacharyya, N. P. (2011). Regulation of miR-146a by RelA/NFkB and p53 in STHdh(Q111)/Hdh(Q111) cells, a cell model of Huntington's disease. PLoS ONE 6:e23837. doi: 10.1371/journal.pone.0023837
    • (2011) PLoS ONE , vol.6
    • Ghose, J.1    Sinha, M.2    Das, E.3    Jana, N.R.4    Bhattacharyya, N.P.5
  • 47
    • 34047110144 scopus 로고    scopus 로고
    • Therapeutic RNA interference for neurodegenerative diseases: From promise to progress
    • doi: 10.1016/j.pharmthera.2007.01.003
    • Gonzalez-Alegre, P. (2007). Therapeutic RNA interference for neurodegenerative diseases: From promise to progress. Pharmacol. Ther. 114, 34-55. doi: 10.1016/j.pharmthera.2007.01.003
    • (2007) Pharmacol. Ther , vol.114 , pp. 34-55
    • Gonzalez-Alegre, P.1
  • 48
    • 84886816341 scopus 로고    scopus 로고
    • Genetics of familial amyotrophic lateral sclerosis, amyotrophic lateral sclerosis
    • ined M. H. Maurer (Rijeka: InTech), doi: 10.5772/32498
    • Goodall, E. F., Bury, J. J., Cooper-Knock, J., Shaw, P. J., and Kirby, J. (2012). "Genetics of familial amyotrophic lateral sclerosis, amyotrophic lateral sclerosis, " inAmyotrophic Lateral Sclerosis, ed M. H. Maurer (Rijeka: InTech), 517-536. doi: 10.5772/32498
    • (2012) Amyotrophic Lateral Sclerosis , pp. 517-536
    • Goodall, E.F.1    Bury, J.J.2    Cooper-Knock, J.3    Shaw, P.J.4    Kirby, J.5
  • 49
    • 9144225636 scopus 로고    scopus 로고
    • The Microprocessor complex mediates the genesis of microRNAs
    • doi: 10.1038/nature03120
    • Gregory, R. I., Yan, K. P., Amuthan, G., Chendrimada, T., Doratotaj, B., Cooch, N., et al. (2004). The Microprocessor complex mediates the genesis of microRNAs. Nature432, 235-240. doi: 10.1038/nature03120
    • (2004) Nature , vol.432 , pp. 235-240
    • Gregory, R.I.1    Yan, K.P.2    Amuthan, G.3    Chendrimada, T.4    Doratotaj, B.5    Cooch, N.6
  • 52
    • 68649097307 scopus 로고    scopus 로고
    • The genetics of Parkinson's syndromes: A critical review
    • doi: 10.1016/j.gde.2009.03.008
    • Hardy, J., Lewis, P., Revesz, T., Lees, A., and Paisan-Ruiz, C. (2009). The genetics of Parkinson's syndromes: a critical review. Curr. Opin. Genet. Dev. 19, 254-265. doi: 10.1016/j.gde.2009.03.008
    • (2009) Curr. Opin. Genet. Dev , vol.19 , pp. 254-265
    • Hardy, J.1    Lewis, P.2    Revesz, T.3    Lees, A.4    Paisan-Ruiz, C.5
  • 53
    • 77950202393 scopus 로고    scopus 로고
    • Human tRNA-derived small RNAs in the global regulation of RNA silencing
    • doi: 10.1261/rna.2000810
    • Haussecker, D., Huang, Y., Lau, A., Parameswaran, P., Fire, A. Z., and Kay, M. A. (2010). Human tRNA-derived small RNAs in the global regulation of RNA silencing. RNA 16, 673-695. doi: 10.1261/rna.2000810
    • (2010) RNA , vol.16 , pp. 673-695
    • Haussecker, D.1    Huang, Y.2    Lau, A.3    Parameswaran, P.4    Fire, A.Z.5    Kay, M.A.6
  • 54
    • 61349110680 scopus 로고    scopus 로고
    • MicroRNA regulation of Alzheimer's Amyloid precursor protein expression
    • doi: 10.1016/j.nbd.2008.11.009
    • Hebert, S. S., Horre, K., Nicolai, L., Bergmans, B., Papadopoulou, A. S., Delacourte, A., et al. (2009). MicroRNA regulation of Alzheimer's Amyloid precursor protein expression. Neurobiol. Dis. 33, 422-428. doi: 10.1016/j.nbd.2008.11.009
    • (2009) Neurobiol. Dis , vol.33 , pp. 422-428
    • Hebert, S.S.1    Horre, K.2    Nicolai, L.3    Bergmans, B.4    Papadopoulou, A.S.5    Delacourte, A.6
  • 55
    • 44049108170 scopus 로고    scopus 로고
    • Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression
    • doi: 10.1073/pnas.0710263105
    • Hebert, S. S., Horre, K., Nicolai, L., Papadopoulou, A. S., Mandemakers, W., Silahtaroglu, A. N., et al. (2008). Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc. Natl. Acad. Sci. U.S.A. 105, 6415-6420. doi: 10.1073/pnas.0710263105
    • (2008) Proc. Natl. Acad. Sci. U.S. A , vol.105 , pp. 6415-6420
    • Hebert, S.S.1    Horre, K.2    Nicolai, L.3    Papadopoulou, A.S.4    Mandemakers, W.5    Silahtaroglu, A.N.6
  • 56
    • 84864862893 scopus 로고    scopus 로고
    • Normal midbrain dopaminergic neuron development and function in miR-133b mutant mice
    • doi: 10.1523/JNEUROSCI.1732-12.2012
    • Heyer, M. P., Pani, A. K., Smeyne, R. J., Kenny, P. J., and Feng, G. (2012). Normal midbrain dopaminergic neuron development and function in miR-133b mutant mice.J. Neurosci. 32, 10887-10894. doi: 10.1523/JNEUROSCI.1732-12.2012
    • (2012) J. Neurosci , vol.32 , pp. 10887-10894
    • Heyer, M.P.1    Pani, A.K.2    Smeyne, R.J.3    Kenny, P.J.4    Feng, G.5
  • 57
    • 0037786542 scopus 로고    scopus 로고
    • Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice
    • doi: 10.1016/S0169-328X(03)00162-1
    • Hwang, D. Y., Ardayfio, P., Kang, U. J., Semina, E. V., and Kim, K. S. (2003). Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice. Brain Res. Mol. Brain Res. 114, 123-131. doi: 10.1016/S0169-328X(03)00162-1
    • (2003) Brain Res. Mol. Brain Res , vol.114 , pp. 123-131
    • Hwang, D.Y.1    Ardayfio, P.2    Kang, U.J.3    Semina, E.V.4    Kim, K.S.5
  • 58
    • 44449131447 scopus 로고    scopus 로고
    • Huntington's disease: From pathology and genetics to potential therapies
    • doi: 10.1042/BJ20071619
    • Imarisio, S., Carmichael, J., Korolchuk, V., Chen, C. W., Saiki, S., Rose, C., et al. (2008). Huntington's disease: from pathology and genetics to potential therapies. Biochem. J. 412, 191-209. doi: 10.1042/BJ20071619
    • (2008) Biochem. J , vol.412 , pp. 191-209
    • Imarisio, S.1    Carmichael, J.2    Korolchuk, V.3    Chen, C.W.4    Saiki, S.5    Rose, C.6
  • 59
    • 84878318898 scopus 로고    scopus 로고
    • Roles of FGF20 in dopaminergic neurons and Parkinson's disease
    • doi: 10.3389/fnmol.2013.00015
    • Itoh, N., and Ohta, H. (2013). Roles of FGF20 in dopaminergic neurons and Parkinson's disease. Front. Mol. Neurosci. 6:15. doi: 10.3389/fnmol.2013.00015
    • (2013) Front. Mol. Neurosci , vol.6 , pp. 15
    • Itoh, N.1    Ohta, H.2
  • 60
    • 84867582241 scopus 로고    scopus 로고
    • Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin
    • doi: 10.1111/j.1471-4159.2012.07925.x
    • Jin, J., Cheng, Y., Zhang, Y., Wood, W., Peng, Q., Hutchison, E., et al. (2012). Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin. J. Neurochem. 123, 477-490. doi: 10.1111/j.1471-4159.2012.07925.x
    • (2012) J. Neurochem , vol.123 , pp. 477-490
    • Jin, J.1    Cheng, Y.2    Zhang, Y.3    Wood, W.4    Peng, Q.5    Hutchison, E.6
  • 61
    • 39649092720 scopus 로고    scopus 로고
    • A microRNA-based gene dysregulation pathway in Huntington's disease
    • doi: 10.1016/j.nbd.2007.11.001
    • Johnson, R., Zuccato, C., Belyaev, N. D., Guest, D. J., Cattaneo, E., and Buckley, N. J. (2008). A microRNA-based gene dysregulation pathway in Huntington's disease. Neurobiol. Dis. 29, 438-445. doi: 10.1016/j.nbd.2007.11.001
    • (2008) Neurobiol. Dis , vol.29 , pp. 438-445
    • Johnson, R.1    Zuccato, C.2    Belyaev, N.D.3    Guest, D.J.4    Cattaneo, E.5    Buckley, N.J.6
  • 62
    • 69149102628 scopus 로고    scopus 로고
    • Repression of alpha-synuclein expression and toxicity by microRNA-7
    • doi: 10.1073/pnas.0906277106
    • Junn, E., Lee, K. W., Jeong, B. S., Chan, T. W., Im, J. Y., and Mouradian, M. M. (2009). Repression of alpha-synuclein expression and toxicity by microRNA-7. Proc. Natl. Acad. Sci. U.S.A. 106, 13052-13057. doi: 10.1073/pnas.0906277106
    • (2009) Proc. Natl. Acad. Sci. U.S. A , vol.106 , pp. 13052-13057
    • Junn, E.1    Lee, K.W.2    Jeong, B.S.3    Chan, T.W.4    Im, J.Y.5    Mouradian, M.M.6
  • 63
    • 84870238817 scopus 로고    scopus 로고
    • Dark matter RNA: Existence, function, and controversy
    • doi: 10.3389/fgene.2012.00060
    • Kapranov, P., and St Laurent, G. (2012). Dark matter RNA: existence, function, and controversy. Front. Genet. 3:60. doi: 10.3389/fgene.2012.00060
    • (2012) Front. Genet , vol.3 , pp. 60
    • Kapranov, P.1    St. Laurent, G.2
  • 64
    • 84857772495 scopus 로고    scopus 로고
    • TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes
    • doi: 10.1073/pnas.1112427109
    • Kawahara, Y., and Mieda-Sato, A. (2012). TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes. Proc. Natl. Acad. Sci. U.S.A. 109, 3347-3352. doi: 10.1073/pnas.1112427109
    • (2012) Proc. Natl. Acad. Sci. U.S. A , vol.109 , pp. 3347-3352
    • Kawahara, Y.1    Mieda-Sato, A.2
  • 65
    • 67149115119 scopus 로고    scopus 로고
    • Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs
    • doi: 10.1038/nbt.1543
    • Khan, A. A., Betel, D., Miller, M. L., Sander, C., Leslie, C. S., and Marks, D. S. (2009). Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs. Nat. Biotechnol. 27, 549-555. doi: 10.1038/nbt.1543
    • (2009) Nat. Biotechnol , vol.27 , pp. 549-555
    • Khan, A.A.1    Betel, D.2    Miller, M.L.3    Sander, C.4    Leslie, C.S.5    Marks, D.S.6
  • 66
    • 84874894477 scopus 로고    scopus 로고
    • Plasma-based circulating MicroRNA biomarkers for parkinson's disease
    • doi: 10.3233/JPD-012144
    • Khoo, S. K., Petillo, D., Kang, U. J., Resau, J. H., Berryhill, B., Linder, J., et al. (2012). Plasma-based circulating MicroRNA biomarkers for parkinson's disease. J. Parkinsons Dis. 2, 321-331. doi: 10.3233/JPD-012144
    • (2012) J. Parkinsons Dis , vol.2 , pp. 321-331
    • Khoo, S.K.1    Petillo, D.2    Kang, U.J.3    Resau, J.H.4    Berryhill, B.5    Linder, J.6
  • 67
    • 34548537573 scopus 로고    scopus 로고
    • A MicroRNA feedback circuit in midbrain dopamine neurons
    • doi: 10.1126/science.1140481
    • Kim, J., Inoue, K., Ishii, J., Vanti, W. B., Voronov, S. V., Murchison, E., et al. (2007). A MicroRNA feedback circuit in midbrain dopamine neurons. Science 317, 1220-1224. doi: 10.1126/science.1140481
    • (2007) Science , vol.317 , pp. 1220-1224
    • Kim, J.1    Inoue, K.2    Ishii, J.3    Vanti, W.B.4    Voronov, S.V.5    Murchison, E.6
  • 68
    • 84860377430 scopus 로고    scopus 로고
    • MiR-106b impairs cholesterol efflux and increases Abeta levels by repressing ABCA1 expression
    • doi: 10.1016/j.expneurol.2011.11.010
    • Kim, J., Yoon, H., Ramirez, C. M., Lee, S. M., Hoe, H. S., and Fernandez-Hernando, C. (2012). MiR-106b impairs cholesterol efflux and increases Abeta levels by repressing ABCA1 expression. Exp. Neurol. 235, 476-483. doi: 10.1016/j.expneurol.2011.11.010
    • (2012) Exp. Neurol , vol.235 , pp. 476-483
    • Kim, J.1    Yoon, H.2    Ramirez, C.M.3    Lee, S.M.4    Hoe, H.S.5    Fernandez-Hernando, C.6
  • 69
    • 33846945735 scopus 로고    scopus 로고
    • Processing of intronic microRNAs
    • doi: 10.1038/sj.emboj.7601512
    • Kim, Y. K., and Kim, V. N. (2007). Processing of intronic microRNAs. EMBO J. 26, 775-783. doi: 10.1038/sj.emboj.7601512
    • (2007) EMBO J , vol.26 , pp. 775-783
    • Kim, Y.K.1    Kim, V.N.2
  • 70
    • 84884712642 scopus 로고    scopus 로고
    • Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice
    • doi: 10.1093/hmg/ddt261
    • Koval, E. D., Shaner, C., Zhang, P., du Maine, X., Fischer, K., Tay, J., et al. (2013). Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice. Hum. Mol. Genet. 22, 4127-4135. doi: 10.1093/hmg/ddt261
    • (2013) Hum. Mol. Genet , vol.22 , pp. 4127-4135
    • Koval, E.D.1    Shaner, C.2    Zhang, P.3    du Maine, X.4    Fischer, K.5    Tay, J.6
  • 71
    • 20944450160 scopus 로고    scopus 로고
    • Combinatorial microRNA target predictions
    • doi: 10.1038/ng1536
    • Krek, A., Grun, D., Poy, M. N., Wolf, R., Rosenberg, L., Epstein, E. J., et al. (2005). Combinatorial microRNA target predictions. Nat. Genet. 37, 495-500. doi: 10.1038/ng1536
    • (2005) Nat. Genet , vol.37 , pp. 495-500
    • Krek, A.1    Grun, D.2    Poy, M.N.3    Wolf, R.4    Rosenberg, L.5    Epstein, E.J.6
  • 72
    • 77952479722 scopus 로고    scopus 로고
    • Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs
    • doi: 10.1016/j.cell.2010.03.039
    • Krol, J., Busskamp, V., Markiewicz, I., Stadler, M. B., Ribi, S., Richter, J., et al. (2010a). Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs. Cell 141, 618-631. doi: 10.1016/j.cell.2010.03.039
    • (2010) Cell , vol.141 , pp. 618-631
    • Krol, J.1    Busskamp, V.2    Markiewicz, I.3    Stadler, M.B.4    Ribi, S.5    Richter, J.6
  • 73
    • 77955902024 scopus 로고    scopus 로고
    • The widespread regulation of microRNA biogenesis, function and decay
    • doi: 10.1038/nrg2843
    • Krol, J., Loedige, I., and Filipowicz, W. (2010b). The widespread regulation of microRNA biogenesis, function and decay. Nat. Rev. Genet. 11, 597-610. doi: 10.1038/nrg2843
    • (2010) Nat. Rev. Genet , vol.11 , pp. 597-610
    • Krol, J.1    Loedige, I.2    Filipowicz, W.3
  • 74
    • 0037197803 scopus 로고    scopus 로고
    • Identification of tissue-specific microRNAs from mouse
    • doi: 10.1016/S0960-9822(02)00809-6
    • Lagos-Quintana, M., Rauhut, R., Yalcin, A., Meyer, J., Lendeckel, W., and Tuschl, T. (2002). Identification of tissue-specific microRNAs from mouse. Curr. Biol. 12, 735-739. doi: 10.1016/S0960-9822(02)00809-6
    • (2002) Curr. Biol , vol.12 , pp. 735-739
    • Lagos-Quintana, M.1    Rauhut, R.2    Yalcin, A.3    Meyer, J.4    Lendeckel, W.5    Tuschl, T.6
  • 75
    • 78650954319 scopus 로고    scopus 로고
    • Altered microRNA regulation in Huntington's disease models
    • doi: 10.1016/j.expneurol.2010.10.012
    • Lee, S. T., Chu, K., Im, W. S., Yoon, H. J., Im, J. Y., Park, J. E., et al. (2011). Altered microRNA regulation in Huntington's disease models. Exp. Neurol. 227, 172-179. doi: 10.1016/j.expneurol.2010.10.012
    • (2011) Exp. Neurol , vol.227 , pp. 172-179
    • Lee, S.T.1    Chu, K.2    Im, W.S.3    Yoon, H.J.4    Im, J.Y.5    Park, J.E.6
  • 76
    • 0037009364 scopus 로고    scopus 로고
    • MicroRNA maturation: Stepwise processing and subcellular localization
    • doi: 10.1093/emboj/cdf476
    • Lee, Y., Jeon, K., Lee, J. T., Kim, S., and Kim, V. N. (2002). MicroRNA maturation: stepwise processing and subcellular localization. EMBO J. 21, 4663-4670. doi: 10.1093/emboj/cdf476
    • (2002) EMBO J , vol.21 , pp. 4663-4670
    • Lee, Y.1    Jeon, K.2    Lee, J.T.3    Kim, S.4    Kim, V.N.5
  • 77
    • 72749089855 scopus 로고    scopus 로고
    • A novel class of small RNAs: TRNA-derived RNA fragments (tRFs)
    • doi: 10.1101/gad.1837609
    • Lee, Y. S., Shibata, Y., Malhotra, A., and Dutta, A. (2009). A novel class of small RNAs: tRNA-derived RNA fragments (tRFs). Genes Dev. 23, 2639-2649. doi: 10.1101/gad.1837609
    • (2009) Genes Dev , vol.23 , pp. 2639-2649
    • Lee, Y.S.1    Shibata, Y.2    Malhotra, A.3    Dutta, A.4
  • 78
    • 84861577379 scopus 로고    scopus 로고
    • An unconventional role for miRNA: Let-7 activates Toll-like receptor 7 and causes neurodegeneration
    • doi: 10.1038/nn.3113
    • Lehmann, S. M., Kruger, C., Park, B., Derkow, K., Rosenberger, K., Baumgart, J., et al. (2012). An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat. Neurosci. 15, 827-835. doi: 10.1038/nn.3113
    • (2012) Nat. Neurosci , vol.15 , pp. 827-835
    • Lehmann, S.M.1    Kruger, C.2    Park, B.3    Derkow, K.4    Rosenberger, K.5    Baumgart, J.6
  • 79
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • doi: 10.1016/j.cell.2004.12.035
    • Lewis, B. P., Burge, C. B., and Bartel, D. P. (2005). Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120, 15-20. doi: 10.1016/j.cell.2004.12.035
    • (2005) Cell , vol.120 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 80
    • 0346094457 scopus 로고    scopus 로고
    • Prediction of mammalian microRNA targets
    • doi: 10.1016/S0092-8674(03)01018-3
    • Lewis, B. P., Shih, I. H., Jones-Rhoades, M. W., Bartel, D. P., and Burge, C. B. (2003). Prediction of mammalian microRNA targets. Cell 115, 787-798. doi: 10.1016/S0092-8674(03)01018-3
    • (2003) Cell , vol.115 , pp. 787-798
    • Lewis, B.P.1    Shih, I.H.2    Jones-Rhoades, M.W.3    Bartel, D.P.4    Burge, C.B.5
  • 81
    • 79959379335 scopus 로고    scopus 로고
    • Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells
    • doi: 10.1016/j.neulet.2011.05.044
    • Li, Y. Y., Cui, J. G., Dua, P., Pogue, A. I., Bhattacharjee, S., and Lukiw, W. J. (2011). Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells. Neurosci. Lett. 499, 109-113. doi: 10.1016/j.neulet.2011.05.044
    • (2011) Neurosci. Lett , vol.499 , pp. 109-113
    • Li, Y.Y.1    Cui, J.G.2    Dua, P.3    Pogue, A.I.4    Bhattacharjee, S.5    Lukiw, W.J.6
  • 82
    • 84860387544 scopus 로고    scopus 로고
    • MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2
    • doi: 10.1016/j.brainres.2011.10.051
    • Liang, C., Zhu, H., Xu, Y., Huang, L., Ma, C., Deng, W., et al. (2012). MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2. Brain Res. 1455, 103-113. doi: 10.1016/j.brainres.2011.10.051
    • (2012) Brain Res , vol.1455 , pp. 103-113
    • Liang, C.1    Zhu, H.2    Xu, Y.3    Huang, L.4    Ma, C.5    Deng, W.6
  • 83
    • 13944282215 scopus 로고    scopus 로고
    • Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    • doi: 10.1038/nature03315
    • Lim, L. P., Lau, N. C., Garrett-Engele, P., Grimson, A., Schelter, J. M., Castle, J., et al. (2005). Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433, 769-773. doi: 10.1038/nature03315
    • (2005) Nature , vol.433 , pp. 769-773
    • Lim, L.P.1    Lau, N.C.2    Garrett-Engele, P.3    Grimson, A.4    Schelter, J.M.5    Castle, J.6
  • 84
    • 79960481207 scopus 로고    scopus 로고
    • The recent updates of therapeutic approaches against abeta for the treatment of Alzheimer's disease
    • doi: 10.1002/ar.21425
    • Ling, S., Zhou, J., Rudd, J. A., Hu, Z., and Fang, M. (2011). The recent updates of therapeutic approaches against abeta for the treatment of Alzheimer's disease. Anat. Rec. (Hoboken) 294, 1307-1318. doi: 10.1002/ar.21425
    • (2011) Anat. Rec. (Hoboken) , vol.294 , pp. 1307-1318
    • Ling, S.1    Zhou, J.2    Rudd, J.A.3    Hu, Z.4    Fang, M.5
  • 85
    • 4444368187 scopus 로고    scopus 로고
    • Argonaute2 is the catalytic engine of mammalian RNAi
    • doi: 10.1126/science.1102513
    • Liu, J., Carmell, M. A., Rivas, F. V., Marsden, C. G., Thomson, J. M., Song, J. J., et al. (2004). Argonaute2 is the catalytic engine of mammalian RNAi. Science 305, 1437-1441. doi: 10.1126/science.1102513
    • (2004) Science , vol.305 , pp. 1437-1441
    • Liu, J.1    Carmell, M.A.2    Rivas, F.V.3    Marsden, C.G.4    Thomson, J.M.5    Song, J.J.6
  • 86
    • 84862776753 scopus 로고    scopus 로고
    • The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila
    • doi: 10.1038/nature10810
    • Liu, N., Landreh, M., Cao, K., Abe, M., Hendriks, G. J., Kennerdell, J. R., et al. (2012). The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila. Nature 482, 519-523. doi: 10.1038/nature10810
    • (2012) Nature , vol.482 , pp. 519-523
    • Liu, N.1    Landreh, M.2    Cao, K.3    Abe, M.4    Hendriks, G.J.5    Kennerdell, J.R.6
  • 87
    • 80053515856 scopus 로고    scopus 로고
    • Neurofilamentopathy in neurodegenerative diseases
    • doi: 10.2174/1874205X01105010058
    • Liu, Q., Xie, F., Alvarado-Diaz, A., Smith, M. A., Moreira, P. I., Zhu, X., et al. (2011). Neurofilamentopathy in neurodegenerative diseases. Open Neurol. J. 5, 58-62. doi: 10.2174/1874205X01105010058
    • (2011) Open Neurol. J , vol.5 , pp. 58-62
    • Liu, Q.1    Xie, F.2    Alvarado-Diaz, A.3    Smith, M.A.4    Moreira, P.I.5    Zhu, X.6
  • 88
    • 84866134171 scopus 로고    scopus 로고
    • MicroRNA-153 physiologically inhibits expression of amyloid-beta precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients
    • doi: 10.1074/jbc.M112.366336
    • Long, J. M., Ray, B., and Lahiri, D. K. (2012). MicroRNA-153 physiologically inhibits expression of amyloid-beta precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients. J. Biol. Chem. 287, 31298-31310. doi: 10.1074/jbc.M112.366336
    • (2012) J. Biol. Chem , vol.287 , pp. 31298-31310
    • Long, J.M.1    Ray, B.2    Lahiri, D.K.3
  • 89
    • 57649119790 scopus 로고    scopus 로고
    • An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells
    • doi: 10.1074/jbc.M805371200
    • Lukiw, W. J., Zhao, Y., and Cui, J. G. (2008). An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J. Biol. Chem. 283, 31315-31322. doi: 10.1074/jbc.M805371200
    • (2008) J. Biol. Chem , vol.283 , pp. 31315-31322
    • Lukiw, W.J.1    Zhao, Y.2    Cui, J.G.3
  • 90
    • 79952898846 scopus 로고    scopus 로고
    • Identification of blood microRNAs associated to Parkinson's disease
    • doi: 10.1016/j.jbiotec.2011.01.023
    • Margis, R., and Rieder, C. R. (2011). Identification of blood microRNAs associated to Parkinson's disease. J. Biotechnol. 152, 96-101. doi: 10.1016/j.jbiotec.2011.01.023
    • (2011) J. Biotechnol , vol.152 , pp. 96-101
    • Margis, R.1    Rieder, C.R.2
  • 91
    • 77958471215 scopus 로고    scopus 로고
    • A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing
    • doi: 10.1093/nar/gkq575
    • Marti, E., Pantano, L., Banez-Coronel, M., Llorens, F., Minones-Moyano, E., Porta, S., et al. (2010). A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing. Nucleic Acids Res. 38, 7219-7235. doi: 10.1093/nar/gkq575
    • (2010) Nucleic Acids Res , vol.38 , pp. 7219-7235
    • Marti, E.1    Pantano, L.2    Banez-Coronel, M.3    Llorens, F.4    Minones-Moyano, E.5    Porta, S.6
  • 92
    • 80053925209 scopus 로고    scopus 로고
    • Convergence of miRNA expression profiling, alpha-synuclein interacton and GWAS in Parkinson's disease
    • doi: 10.1371/journal.pone.0025443
    • Martins, M., Rosa, A., Guedes, L. C., Fonseca, B. V., Gotovac, K., Violante, S., et al. (2011). Convergence of miRNA expression profiling, alpha-synuclein interacton and GWAS in Parkinson's disease. PLoS ONE 6:e25443. doi: 10.1371/journal.pone.0025443
    • (2011) PLoS ONE , vol.6
    • Martins, M.1    Rosa, A.2    Guedes, L.C.3    Fonseca, B.V.4    Gotovac, K.5    Violante, S.6
  • 93
    • 24644443227 scopus 로고    scopus 로고
    • The functional genomics of noncoding RNA
    • doi: 10.1126/science.1117806
    • Mattick, J. S. (2005). The functional genomics of noncoding RNA. Science 309, 1527-1528. doi: 10.1126/science.1117806
    • (2005) Science , vol.309 , pp. 1527-1528
    • Mattick, J.S.1
  • 94
    • 44449121785 scopus 로고    scopus 로고
    • Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi
    • doi: 10.1073/pnas.0801775105
    • McBride, J. L., Boudreau, R. L., Harper, S. Q., Staber, P. D., Monteys, A. M., Martins, I., et al. (2008). Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAi. Proc. Natl. Acad. Sci. U.S.A. 105, 5868-5873. doi: 10.1073/pnas.0801775105
    • (2008) Proc. Natl. Acad. Sci. U.S. A , vol.105 , pp. 5868-5873
    • McBride, J.L.1    Boudreau, R.L.2    Harper, S.Q.3    Staber, P.D.4    Monteys, A.M.5    Martins, I.6
  • 95
    • 55249117284 scopus 로고    scopus 로고
    • MicroRNA-206: The skeletal muscle-specific myomiR
    • doi: 10.1016/j.bbagrm.2008.03.001
    • McCarthy, J. J. (2008). MicroRNA-206: the skeletal muscle-specific myomiR. Biochim. Biophys. Acta 1779, 682-691. doi: 10.1016/j.bbagrm.2008.03.001
    • (2008) Biochim. Biophys. Acta , vol.1779 , pp. 682-691
    • McCarthy, J.J.1
  • 96
    • 41449118875 scopus 로고    scopus 로고
    • Diagnosis and management of motor neurone disease
    • doi: 10.1136/bmj.39493.511759.BE
    • McDermott, C. J., and Shaw, P. J. (2008). Diagnosis and management of motor neurone disease. BMJ 336, 658-662. doi: 10.1136/bmj.39493.511759.BE
    • (2008) BMJ , vol.336 , pp. 658-662
    • McDermott, C.J.1    Shaw, P.J.2
  • 97
    • 79960135400 scopus 로고    scopus 로고
    • MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function
    • doi: 10.1093/hmg/ddr210
    • Minones-Moyano, E., Porta, S., Escaramis, G., Rabionet, R., Iraola, S., Kagerbauer, B., et al. (2011). MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function. Hum. Mol. Genet. 20, 3067-3078. doi: 10.1093/hmg/ddr210
    • (2011) Hum. Mol. Genet , vol.20 , pp. 3067-3078
    • Minones-Moyano, E.1    Porta, S.2    Escaramis, G.3    Rabionet, R.4    Iraola, S.5    Kagerbauer, B.6
  • 98
    • 77955290050 scopus 로고    scopus 로고
    • Many ways to generate microRNA-like small RNAs: Non-canonical pathways for microRNA production
    • doi: 10.1007/s00438-010-0556-1
    • Miyoshi, K., Miyoshi, T., and Siomi, H. (2010). Many ways to generate microRNA-like small RNAs: non-canonical pathways for microRNA production. Mol. Genet. Genomics. 284, 95-103. doi: 10.1007/s00438-010-0556-1
    • (2010) Mol. Genet. Genomics , vol.284 , pp. 95-103
    • Miyoshi, K.1    Miyoshi, T.2    Siomi, H.3
  • 99
    • 84874833693 scopus 로고    scopus 로고
    • Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1
    • doi: 10.1074/jbc.M112.410944
    • Morel, L., Regan, M., Higashimori, H., Ng, S. K., Esau, C., Vidensky, S., et al. (2013). Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1. J. Biol. Chem. 288, 7105-7116. doi: 10.1074/jbc.M112.410944
    • (2013) J. Biol. Chem , vol.288 , pp. 7105-7116
    • Morel, L.1    Regan, M.2    Higashimori, H.3    Ng, S.K.4    Esau, C.5    Vidensky, S.6
  • 100
    • 84871002507 scopus 로고    scopus 로고
    • FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment
    • doi: 10.1038/emboj.2012.319
    • Morlando, M., Dini Modigliani, S., Torrelli, G., Rosa, A., Di Carlo, V., Caffarelli, E., et al. (2012). FUS stimulates microRNA biogenesis by facilitating co-transcriptional Drosha recruitment. EMBO J. 31, 4502-4510. doi: 10.1038/emboj.2012.319
    • (2012) EMBO J , vol.31 , pp. 4502-4510
    • Morlando, M.1    Dini Modigliani, S.2    Torrelli, G.3    Rosa, A.4    Di Carlo, V.5    Caffarelli, E.6
  • 101
    • 84871346487 scopus 로고    scopus 로고
    • Clinical applications for microRNAs in cancer
    • doi: 10.1038/clpt.2012.192
    • Nana-Sinkam, S. P., and Croce, C. M. (2013). Clinical applications for microRNAs in cancer. Clin. Pharmacol. Ther. 93, 98-104. doi: 10.1038/clpt.2012.192
    • (2013) Clin. Pharmacol. Ther , vol.93 , pp. 98-104
    • Nana-Sinkam, S.P.1    Croce, C.M.2
  • 102
    • 77954996105 scopus 로고    scopus 로고
    • MiR-107 is reduced in Alzheimer's disease brain neocortex: Validation study
    • doi: 10.3233/JAD-2010-091603
    • Nelson, P. T., and Wang, W. X. (2010). MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study. J. Alzheimers Dis. 21, 75-79. doi: 10.3233/JAD-2010-091603
    • (2010) J. Alzheimers Dis , vol.21 , pp. 75-79
    • Nelson, P.T.1    Wang, W.X.2
  • 103
    • 84864317150 scopus 로고    scopus 로고
    • Unique preservation of neural cells in Hutchinson-Gilford progeria syndrome is due to the expression of the neural-specific miR-9 microRNA
    • doi: 10.1016/j.celrep.2012.05.015
    • Nissan, X., Blondel, S., Navarro, C., Maury, Y., Denis, C., Girard, M., et al. (2012). Unique preservation of neural cells in Hutchinson-Gilford progeria syndrome is due to the expression of the neural-specific miR-9 microRNA. Cell Rep. 2, 1-9. doi: 10.1016/j.celrep.2012.05.015
    • (2012) Cell Rep , vol.2 , pp. 1-9
    • Nissan, X.1    Blondel, S.2    Navarro, C.3    Maury, Y.4    Denis, C.5    Girard, M.6
  • 104
    • 43449090367 scopus 로고    scopus 로고
    • MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation
    • doi: 10.1016/j.molcel.2008.05.001
    • Orom, U. A., Nielsen, F. C., and Lund, A. H. (2008). MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. Mol. Cell 30, 460-471. doi: 10.1016/j.molcel.2008.05.001
    • (2008) Mol. Cell , vol.30 , pp. 460-471
    • Orom, U.A.1    Nielsen, F.C.2    Lund, A.H.3
  • 105
    • 56549129538 scopus 로고    scopus 로고
    • Chromatin structure analyses identify miRNA promoters
    • doi: 10.1101/gad.1706508
    • Ozsolak, F., Poling, L. L., Wang, Z., Liu, H., Liu, X. S., Roeder, R. G., et al. (2008). Chromatin structure analyses identify miRNA promoters. Genes Dev. 22, 3172-3183. doi: 10.1101/gad.1706508
    • (2008) Genes Dev , vol.22 , pp. 3172-3183
    • Ozsolak, F.1    Poling, L.L.2    Wang, Z.3    Liu, H.4    Liu, X.S.5    Roeder, R.G.6
  • 106
    • 58149375393 scopus 로고    scopus 로고
    • The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease
    • doi: 10.1523/JNEUROSCI.2390-08.2008
    • Packer, A. N., Xing, Y., Harper, S. Q., Jones, L., and Davidson, B. L. (2008). The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease. J. Neurosci. 28, 14341-14346. doi: 10.1523/JNEUROSCI.2390-08.2008
    • (2008) J. Neurosci , vol.28 , pp. 14341-14346
    • Packer, A.N.1    Xing, Y.2    Harper, S.Q.3    Jones, L.4    Davidson, B.L.5
  • 108
    • 67650519133 scopus 로고    scopus 로고
    • The RNA-induced silencing complex: A versatile gene-silencing machine
    • doi: 10.1074/jbc.R900012200
    • Pratt, A. J., and MacRae, I. J. (2009). The RNA-induced silencing complex: a versatile gene-silencing machine. J. Biol. Chem. 284, 17897-17901. doi: 10.1074/jbc.R900012200
    • (2009) J. Biol. Chem , vol.284 , pp. 17897-17901
    • Pratt, A.J.1    McRae, I.J.2
  • 109
    • 51749093103 scopus 로고    scopus 로고
    • Degradation of microRNAs by a family of exoribonucleases in Arabidopsis
    • doi: 10.1126/science.1163728
    • Ramachandran, V., and Chen, X. (2008). Degradation of microRNAs by a family of exoribonucleases in Arabidopsis. Science 321, 1490-1492. doi: 10.1126/science.1163728
    • (2008) Science , vol.321 , pp. 1490-1492
    • Ramachandran, V.1    Chen, X.2
  • 110
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: Exosomes, microvesicles, and friends
    • doi: 10.1083/jcb.201211138
    • Raposo, G., and Stoorvogel, W. (2013). Extracellular vesicles: exosomes, microvesicles, and friends. J. Cell Biol. 200, 373-383. doi: 10.1083/jcb.201211138
    • (2013) J. Cell Biol , vol.200 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 111
    • 84875441083 scopus 로고    scopus 로고
    • The changing scene of amyotrophic lateral sclerosis
    • doi: 10.1038/nrn3430
    • Robberecht, W., and Philips, T. (2013). The changing scene of amyotrophic lateral sclerosis. Nat. Rev. Neurosci. 14, 248-264. doi: 10.1038/nrn3430
    • (2013) Nat. Rev. Neurosci , vol.14 , pp. 248-264
    • Robberecht, W.1    Philips, T.2
  • 112
    • 6344281172 scopus 로고    scopus 로고
    • Identification of mammalian microRNA host genes and transcription units
    • doi: 10.1101/gr.2722704
    • Rodriguez, A., Griffiths-Jones, S., Ashurst, J. L., and Bradley, A. (2004). Identification of mammalian microRNA host genes and transcription units. Genome Res. 14, 1902-1910. doi: 10.1101/gr.2722704
    • (2004) Genome Res , vol.14 , pp. 1902-1910
    • Rodriguez, A.1    Griffiths-Jones, S.2    Ashurst, J.L.3    Bradley, A.4
  • 113
    • 34447097693 scopus 로고    scopus 로고
    • Intronic microRNA precursors that bypass Drosha processing
    • doi: 10.1038/nature05983
    • Ruby, J. G., Jan, C. H., and Bartel, D. P. (2007). Intronic microRNA precursors that bypass Drosha processing. Nature 448, 83-86. doi: 10.1038/nature05983
    • (2007) Nature , vol.448 , pp. 83-86
    • Ruby, J.G.1    Jan, C.H.2    Bartel, D.P.3
  • 114
    • 84866491615 scopus 로고    scopus 로고
    • Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis
    • doi: 10.1016/j.nbd.2012.08.015
    • Russell, A. P., Wada, S., Vergani, L., Hock, M. B., Lamon, S., Leger, B., et al. (2012). Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis. Neurobiol. Dis. 49C, 107-117. doi: 10.1016/j.nbd.2012.08.015
    • (2012) Neurobiol. Dis , vol.49 C , pp. 107-117
    • Russell, A.P.1    Wada, S.2    Vergani, L.3    Hock, M.B.4    Lamon, S.5    Leger, B.6
  • 115
    • 79961170994 scopus 로고    scopus 로고
    • A ceRNA hypothesis: The rosetta stone of a hidden RNA language
    • doi: 10.1016/j.cell.2011.07.014
    • Salmena, L., Poliseno, L., Tay, Y., Kats, L., and Pandolfi, P. P. (2011). A ceRNA hypothesis: the rosetta stone of a hidden RNA language. Cell 146, 353-358. doi: 10.1016/j.cell.2011.07.014
    • (2011) Cell , vol.146 , pp. 353-358
    • Salmena, L.1    Poliseno, L.2    Tay, Y.3    Kats, L.4    Pandolfi, P.P.5
  • 116
    • 57149094023 scopus 로고    scopus 로고
    • SnoRNA, a novel precursor of microRNA in Giardia lamblia
    • doi: 10.1371/journal.ppat.1000224
    • Saraiya, A. A., and Wang, C. C. (2008). snoRNA, a novel precursor of microRNA in Giardia lamblia. PLoS Pathog. 4:e1000224. doi: 10.1371/journal.ppat.1000224
    • (2008) PLoS Pathog , vol.4
    • Saraiya, A.A.1    Wang, C.C.2
  • 117
    • 78650843340 scopus 로고    scopus 로고
    • MiRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues
    • Saunders, L. R., Sharma, A. D., Tawney, J., Nakagawa, M., Okita, K., Yamanaka, S., et al. (2010). miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY) 2, 415-431.
    • (2010) Aging (Albany NY) , vol.2 , pp. 415-431
    • Saunders, L.R.1    Sharma, A.D.2    Tawney, J.3    Nakagawa, M.4    Okita, K.5    Yamanaka, S.6
  • 118
    • 49449091708 scopus 로고    scopus 로고
    • Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies
    • doi: 10.1073/pnas.0800658105
    • Savas, J. N., Makusky, A., Ottosen, S., Baillat, D., Then, F., Krainc, D., et al. (2008). Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies. Proc. Natl. Acad. Sci. U.S.A. 105, 10820-10825. doi: 10.1073/pnas.0800658105
    • (2008) Proc. Natl. Acad. Sci. U.S. A , vol.105 , pp. 10820-10825
    • Savas, J.N.1    Makusky, A.2    Ottosen, S.3    Baillat, D.4    Then, F.5    Krainc, D.6
  • 120
    • 84869228626 scopus 로고    scopus 로고
    • Variants in the 3'UTR of SNCA do not affect miRNA-433 binding and alpha-synuclein expression
    • doi: 10.1038/ejhg.2012.84
    • Schmitt, I., Wullner, U., van Rooyen, J. P., Khazneh, H., Becker, J., Volk, A., et al. (2012). Variants in the 3'UTR of SNCA do not affect miRNA-433 binding and alpha-synuclein expression. Eur. J. Hum. Genet. 20, 1265-1269. doi: 10.1038/ejhg.2012.84
    • (2012) Eur. J. Hum. Genet , vol.20 , pp. 1265-1269
    • Schmitt, I.1    Wullner, U.2    van Rooyen, J.P.3    Khazneh, H.4    Becker, J.5    Volk, A.6
  • 121
    • 84867888439 scopus 로고    scopus 로고
    • Decoding the non-coding RNAs in Alzheimer's disease
    • doi: 10.1007/s00018-012-1125-z
    • Schonrock, N., and Gotz, J. (2012). Decoding the non-coding RNAs in Alzheimer's disease. Cell. Mol. Life Sci. 69, 3543-3559. doi: 10.1007/s00018-012-1125-z
    • (2012) Cell. Mol. Life Sci , vol.69 , pp. 3543-3559
    • Schonrock, N.1    Gotz, J.2
  • 122
    • 84864778051 scopus 로고    scopus 로고
    • Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-beta
    • doi: 10.1007/s12031-011-9587-2
    • Schonrock, N., Humphreys, D. T., Preiss, T., and Gotz, J. (2012). Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-beta. J. Mol. Neurosci. 46, 324-335. doi: 10.1007/s12031-011-9587-2
    • (2012) J. Mol. Neurosci , vol.46 , pp. 324-335
    • Schonrock, N.1    Humphreys, D.T.2    Preiss, T.3    Gotz, J.4
  • 123
    • 77956195348 scopus 로고    scopus 로고
    • Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta
    • doi: 10.1371/journal.pone.0011070
    • Schonrock, N., Ke, Y. D., Humphreys, D., Staufenbiel, M., Ittner, L. M., Preiss, T., et al. (2010). Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta. PLoS ONE 5:e11070. doi: 10.1371/journal.pone.0011070
    • (2010) PLoS ONE , vol.5
    • Schonrock, N.1    Ke, Y.D.2    Humphreys, D.3    Staufenbiel, M.4    Ittner, L.M.5    Preiss, T.6
  • 124
    • 81955162960 scopus 로고    scopus 로고
    • What have we learned from gene expression profiles in Huntington's disease
    • doi: 10.1016/j.nbd.2011.07.001
    • Seredenina, T., and Luthi-Carter, R. (2012). What have we learned from gene expression profiles in Huntington's disease. Neurobiol. Dis. 45, 83-98. doi: 10.1016/j.nbd.2011.07.001
    • (2012) Neurobiol. Dis , vol.45 , pp. 83-98
    • Seredenina, T.1    Luthi-Carter, R.2
  • 125
    • 65749093295 scopus 로고    scopus 로고
    • Micro-RNA abundance and stability in human brain: Specific alterations in Alzheimer's disease temporal lobe neocortex
    • doi: 10.1016/j.neulet.2009.04.052
    • Sethi, P., and Lukiw, W. J. (2009). Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex. Neurosci. Lett. 459, 100-104. doi: 10.1016/j.neulet.2009.04.052
    • (2009) Neurosci. Lett , vol.459 , pp. 100-104
    • Sethi, P.1    Lukiw, W.J.2
  • 126
    • 71749084011 scopus 로고    scopus 로고
    • MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase
    • doi: 10.1016/j.immuni.2009.09.019
    • Shaked, I., Meerson, A., Wolf, Y., Avni, R., Greenberg, D., Gilboa-Geffen, A., et al. (2009). MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase. Immunity 31, 965-973. doi: 10.1016/j.immuni.2009.09.019
    • (2009) Immunity , vol.31 , pp. 965-973
    • Shaked, I.1    Meerson, A.2    Wolf, Y.3    Avni, R.4    Greenberg, D.5    Gilboa-Geffen, A.6
  • 127
    • 67649544381 scopus 로고    scopus 로고
    • Biomarker discovery in neurodegenerative diseases: A proteomic approach
    • doi: 10.1016/j.nbd.2008.09.004
    • Shi, M., Caudle, W. M., and Zhang, J. (2009). Biomarker discovery in neurodegenerative diseases: a proteomic approach. Neurobiol. Dis. 35, 157-164. doi: 10.1016/j.nbd.2008.09.004
    • (2009) Neurobiol. Dis , vol.35 , pp. 157-164
    • Shi, M.1    Caudle, W.M.2    Zhang, J.3
  • 128
    • 77952336221 scopus 로고    scopus 로고
    • Aberrant microRNA expression in the brains of neurodegenerative diseases: MiR-29a decreased in Alzheimer disease brains targets neurone navigator 3
    • doi: 10.1111/j.1365-2990.2010.01076.x
    • Shioya, M., Obayashi, S., Tabunoki, H., Arima, K., Saito, Y., Ishida, T., et al. (2010). Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3. Neuropathol. Appl. Neurobiol. 36, 320-330. doi: 10.1111/j.1365-2990.2010.01076.x
    • (2010) Neuropathol. Appl. Neurobiol , vol.36 , pp. 320-330
    • Shioya, M.1    Obayashi, S.2    Tabunoki, H.3    Arima, K.4    Saito, Y.5    Ishida, T.6
  • 129
    • 84868132813 scopus 로고    scopus 로고
    • Silencing of Parkinson's disease-associated genes with artificial mirtron mimics of miR-1224
    • doi: 10.1093/nar/gks712
    • Sibley, C. R., Seow, Y., Curtis, H., Weinberg, M. S., and Wood, M. J. (2012). Silencing of Parkinson's disease-associated genes with artificial mirtron mimics of miR-1224. Nucleic Acids Res. 40, 9863-9875. doi: 10.1093/nar/gks712
    • (2012) Nucleic Acids Res , vol.40 , pp. 9863-9875
    • Sibley, C.R.1    Seow, Y.2    Curtis, H.3    Weinberg, M.S.4    Wood, M.J.5
  • 130
    • 81255197809 scopus 로고    scopus 로고
    • Micro RNA-214,-150,-146a and-125b target Huntingtin gene
    • doi: 10.4161/rna.8.6.16035
    • Sinha, M., Ghose, J., and Bhattarcharyya, N. P. (2011). Micro RNA-214,-150,-146a and-125b target Huntingtin gene. RNA Biol. 8, 1005-1021. doi: 10.4161/rna.8.6.16035
    • (2011) RNA Biol , vol.8 , pp. 1005-1021
    • Sinha, M.1    Ghose, J.2    Bhattarcharyya, N.P.3
  • 131
    • 77953025795 scopus 로고    scopus 로고
    • Altered microRNAs in STHdh(Q111)/Hdh(Q111) cells: MiR-146a targets TBP
    • doi: 10.1016/j.bbrc.2010.05.007
    • Sinha, M., Ghose, J., Das, E., and Bhattarcharyya, N. P. (2010). Altered microRNAs in STHdh(Q111)/Hdh(Q111) cells: miR-146a targets TBP. Biochem. Biophys. Res. Commun. 396, 742-747. doi: 10.1016/j.bbrc.2010.05.007
    • (2010) Biochem. Biophys. Res. Commun , vol.396 , pp. 742-747
    • Sinha, M.1    Ghose, J.2    Das, E.3    Bhattarcharyya, N.P.4
  • 132
    • 78650692019 scopus 로고    scopus 로고
    • In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs
    • doi: 10.1111/j.1471-4159.2010.07097.x
    • Smith, P., Al Hashimi, A., Girard, J., Delay, C., and Hebert, S. S. (2011). In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs. J. Neurochem. 116, 240-247. doi: 10.1111/j.1471-4159.2010.07097.x
    • (2011) J. Neurochem , vol.116 , pp. 240-247
    • Smith, P.1    Al Hashimi, A.2    Girard, J.3    Delay, C.4    Hebert, S.S.5
  • 133
    • 80053563273 scopus 로고    scopus 로고
    • NeurimmiRs: MicroRNAs in the neuroimmune interface
    • doi: 10.1016/j.molmed.2011.06.009
    • Soreq, H., and Wolf, Y. (2011). NeurimmiRs: microRNAs in the neuroimmune interface. Trends Mol. Med. 17, 548-555. doi: 10.1016/j.molmed.2011.06.009
    • (2011) Trends Mol. Med , vol.17 , pp. 548-555
    • Soreq, H.1    Wolf, Y.2
  • 134
    • 84876435649 scopus 로고    scopus 로고
    • Small RNA sequencing-microarray analyses in Parkinson leukocytes reveal deep brain stimulation-induced splicing changes that classify brain region transcriptomes
    • doi: 10.3389/fnmol.2013.00010
    • Soreq, L., Salomonis, N., Bronstein, M., Greenberg, D. S., Israel, Z., Bergman, H., et al. (2013). Small RNA sequencing-microarray analyses in Parkinson leukocytes reveal deep brain stimulation-induced splicing changes that classify brain region transcriptomes. Front. Mol. Neurosci. 6:10. doi: 10.3389/fnmol.2013.00010
    • (2013) Front. Mol. Neurosci , vol.6 , pp. 10
    • Soreq, L.1    Salomonis, N.2    Bronstein, M.3    Greenberg, D.S.4    Israel, Z.5    Bergman, H.6
  • 135
    • 67649639645 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the 3'UTR of the SNCA gene encoding alpha-synuclein is a new potential susceptibility locus for Parkinson disease
    • doi: 10.1016/j.neulet.2009.06.034
    • Sotiriou, S., Gibney, G., Baxevanis, A. D., and Nussbaum, R. L. (2009). A single nucleotide polymorphism in the 3'UTR of the SNCA gene encoding alpha-synuclein is a new potential susceptibility locus for Parkinson disease. Neurosci. Lett. 461, 196-201. doi: 10.1016/j.neulet.2009.06.034
    • (2009) Neurosci. Lett , vol.461 , pp. 196-201
    • Sotiriou, S.1    Gibney, G.2    Baxevanis, A.D.3    Nussbaum, R.L.4
  • 136
    • 55049142524 scopus 로고    scopus 로고
    • The art of microRNA: Various strategies leading to gene silencing via an ancient pathway
    • doi: 10.1016/j.bbagrm.2008.06.006
    • Tang, G., Tang, X., Mendu, V., Jia, X., Chen, Q. J., and He, L. (2008). The art of microRNA: various strategies leading to gene silencing via an ancient pathway. Biochim. Biophys. Acta 1779, 655-662. doi: 10.1016/j.bbagrm.2008.06.006
    • (2008) Biochim. Biophys. Acta , vol.1779 , pp. 655-662
    • Tang, G.1    Tang, X.2    Mendu, V.3    Jia, X.4    Chen, Q.J.5    He, L.6
  • 137
    • 84867608942 scopus 로고    scopus 로고
    • The genetics of Alzheimer disease
    • doi: 10.1101/cshperspect.a006296
    • Tanzi, R. E. (2012). The genetics of Alzheimer disease. Cold Spring Harb. Perspect. Med. 2, 6296-6306. doi: 10.1101/cshperspect.a006296
    • (2012) Cold Spring Harb. Perspect. Med , vol.2 , pp. 6296-6306
    • Tanzi, R.E.1
  • 138
    • 36749026906 scopus 로고    scopus 로고
    • Switching from repression to activation: MicroRNAs can up-regulate translation
    • doi: 10.1126/science.1149460
    • Vasudevan, S., Tong, Y., and Steitz, J. A. (2007). Switching from repression to activation: microRNAs can up-regulate translation. Science 318, 1931-1934. doi: 10.1126/science.1149460
    • (2007) Science , vol.318 , pp. 1931-1934
    • Vasudevan, S.1    Tong, Y.2    Steitz, J.A.3
  • 139
    • 84880244044 scopus 로고    scopus 로고
    • Expression of the transcription factor Sp1 and its regulatory hsa-miR-29b in peripheral blood mononuclear cells from patients with Alzheimer's disease
    • doi: 10.3233/JAD-122263
    • Villa, C., Ridolfi, E., Fenoglio, C., Ghezzi, L., Vimercati, R., Clerici, F., et al. (2013). Expression of the transcription factor Sp1 and its regulatory hsa-miR-29b in peripheral blood mononuclear cells from patients with Alzheimer's disease. J. Alzheimers Dis. 35, 487-494. doi: 10.3233/JAD-122263
    • (2013) J. Alzheimers Dis , vol.35 , pp. 487-494
    • Villa, C.1    Ridolfi, E.2    Fenoglio, C.3    Ghezzi, L.4    Vimercati, R.5    Clerici, F.6
  • 140
    • 84862174920 scopus 로고    scopus 로고
    • MiR-212/132 expression and functions: Within and beyond the neuronal compartment
    • doi: 10.1093/nar/gks151
    • Wanet, A., Tacheny, A., Arnould, T., and Renard, P. (2012). miR-212/132 expression and functions: within and beyond the neuronal compartment. Nucleic Acids Res. 40, 4742-4753. doi: 10.1093/nar/gks151
    • (2012) Nucleic Acids Res , vol.40 , pp. 4742-4753
    • Wanet, A.1    Tacheny, A.2    Arnould, T.3    Renard, P.4
  • 141
    • 40749145370 scopus 로고    scopus 로고
    • Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein
    • doi: 10.1016/j.ajhg.2007.09.021
    • Wang, G., van der Walt, J. M., Mayhew, G., Li, Y. J., Zuchner, S., Scott, W. K., et al. (2008a). Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. Am. J. Hum. Genet. 82, 283-289. doi: 10.1016/j.ajhg.2007.09.021
    • (2008) Am. J. Hum. Genet , vol.82 , pp. 283-289
    • Wang, G.1    van der Walt, J.M.2    Mayhew, G.3    Li, Y.J.4    Zuchner, S.5    Scott, W.K.6
  • 142
    • 38749095507 scopus 로고    scopus 로고
    • The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1
    • doi: 10.1523/JNEUROSCI.5065-07.2008
    • Wang, W. X., Rajeev, B. W., Stromberg, A. J., Ren, N., Tang, G., Huang, Q., et al. (2008b). The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J. Neurosci. 28, 1213-1223. doi: 10.1523/JNEUROSCI.5065-07.2008
    • (2008) J. Neurosci , vol.28 , pp. 1213-1223
    • Wang, W.X.1    Rajeev, B.W.2    Stromberg, A.J.3    Ren, N.4    Tang, G.5    Huang, Q.6
  • 143
    • 84856450535 scopus 로고    scopus 로고
    • The potential role of microRNA-146 in Alzheimer's disease: Biomarker or therapeutic target
    • doi: 10.1016/j.mehy.2011.11.019
    • Wang, L. L., Huang, Y., Wang, G., and Chen, S. D. (2012). The potential role of microRNA-146 in Alzheimer's disease: biomarker or therapeutic target. Med. Hypotheses 78, 398-401. doi: 10.1016/j.mehy.2011.11.019
    • (2012) Med. Hypotheses , vol.78 , pp. 398-401
    • Wang, L.L.1    Huang, Y.2    Wang, G.3    Chen, S.D.4
  • 144
    • 79451474371 scopus 로고    scopus 로고
    • Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: White matter versus gray matter
    • doi: 10.1007/s00401-010-0756-0
    • Wang, W. X., Huang, Q., Hu, Y., Stromberg, A. J., and Nelson, P. T. (2011). Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: white matter versus gray matter. Acta Neuropathol. 121, 193-205. doi: 10.1007/s00401-010-0756-0
    • (2011) Acta Neuropathol , vol.121 , pp. 193-205
    • Wang, W.X.1    Huang, Q.2    Hu, Y.3    Stromberg, A.J.4    Nelson, P.T.5
  • 145
    • 70349558133 scopus 로고    scopus 로고
    • MiR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation
    • doi: 10.1016/j.brainresbull.2009.08.006
    • Wang, X., Liu, P., Zhu, H., Xu, Y., Ma, C., Dai, X., et al. (2009). miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation. Brain Res. Bull. 80, 268-273. doi: 10.1016/j.brainresbull.2009.08.006
    • (2009) Brain Res. Bull , vol.80 , pp. 268-273
    • Wang, X.1    Liu, P.2    Zhu, H.3    Xu, Y.4    Ma, C.5    Dai, X.6
  • 146
    • 72149131804 scopus 로고    scopus 로고
    • MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice
    • doi: 10.1126/science.1181046
    • Williams, A. H., Valdez, G., Moresi, V., Qi, X., McAnally, J., Elliott, J. L., et al. (2009). MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science 326, 1549-1554. doi: 10.1126/science.1181046
    • (2009) Science , vol.326 , pp. 1549-1554
    • Williams, A.H.1    Valdez, G.2    Moresi, V.3    Qi, X.4    McAnally, J.5    Elliott, J.L.6
  • 147
    • 79953653114 scopus 로고    scopus 로고
    • The Parkinson disease protein alpha-synuclein inhibits autophagy
    • doi: 10.4161/auto.7.4.14393
    • Winslow, A. R., and Rubinsztein, D. C. (2011). The Parkinson disease protein alpha-synuclein inhibits autophagy. Autophagy 7, 429-431. doi: 10.4161/auto.7.4.14393
    • (2011) Autophagy , vol.7 , pp. 429-431
    • Winslow, A.R.1    Rubinsztein, D.C.2
  • 148
    • 84880290282 scopus 로고    scopus 로고
    • De-repression of FOXO3a death axis by microRNA-132 and-212 causes neuronal apoptosis in Alzheimer's disease
    • doi: 10.1093/hmg/ddt164
    • Wong, H. K., Veremeyko, T., Patel, N., Lemere, C. A., Walsh, D. M., Esau, C., et al. (2013). De-repression of FOXO3a death axis by microRNA-132 and-212 causes neuronal apoptosis in Alzheimer's disease. Hum. Mol. Genet. 22, 3077-3092. doi: 10.1093/hmg/ddt164
    • (2013) Hum. Mol. Genet , vol.22 , pp. 3077-3092
    • Wong, H.K.1    Veremeyko, T.2    Patel, N.3    Lemere, C.A.4    Walsh, D.M.5    Esau, C.6
  • 149
    • 34047234690 scopus 로고    scopus 로고
    • Characterization and identification of microRNA core promoters in four model species
    • doi: 10.1371/journal.pcbi.0030037
    • Zhou, X., Ruan, J., Wang, G., and Zhang, W. (2007). Characterization and identification of microRNA core promoters in four model species. PLoS Comput. Biol. 3:e37. doi: 10.1371/journal.pcbi.0030037
    • (2007) PLoS Comput. Biol , vol.3
    • Zhou, X.1    Ruan, J.2    Wang, G.3    Zhang, W.4
  • 150
    • 79957907210 scopus 로고    scopus 로고
    • MiR-29c regulates BACE1 protein expression
    • doi: 10.1016/j.brainres.2011.04.035
    • Zong, Y., Wang, H., Dong, W., Quan, X., Zhu, H., Xu, Y., et al. (2011). miR-29c regulates BACE1 protein expression. Brain Res. 1395, 108-115. doi: 10.1016/j.brainres.2011.04.035
    • (2011) Brain Res , vol.1395 , pp. 108-115
    • Zong, Y.1    Wang, H.2    Dong, W.3    Quan, X.4    Zhu, H.5    Xu, Y.6
  • 151
    • 34347364706 scopus 로고    scopus 로고
    • Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease
    • doi: 10.1523/JNEUROSCI.4278-06.2007
    • Zuccato, C., Belyaev, N., Conforti, P., Ooi, L., Tartari, M., Papadimou, E., et al. (2007). Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease. J. Neurosci. 27, 6972-6983. doi: 10.1523/JNEUROSCI.4278-06.2007
    • (2007) J. Neurosci , vol.27 , pp. 6972-6983
    • Zuccato, C.1    Belyaev, N.2    Conforti, P.3    Ooi, L.4    Tartari, M.5    Papadimou, E.6
  • 152
    • 77955643169 scopus 로고    scopus 로고
    • Molecular mechanisms and potential therapeutical targets in Huntington's disease
    • doi: 10.1152/physrev.00041.2009
    • Zuccato, C., Valenza, M., and Cattaneo, E. (2010). Molecular mechanisms and potential therapeutical targets in Huntington's disease. Physiol. Rev. 90, 905-981. doi: 10.1152/physrev.00041.2009
    • (2010) Physiol. Rev , vol.90 , pp. 905-981
    • Zuccato, C.1    Valenza, M.2    Cattaneo, E.3


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