Neuroregenerative potential of lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Higher Basidiomycetes), in the treatment of peripheral nerve injury (review)

International Journal of Medicinal Mushrooms

Volumn 14, Issue 5, 2012, Pages 427-446

  Wong, Kah Hui ^a   Naidu, Murali ^a   David, Pamela ^a   Bakar, Robiah ^a   Sabaratnam, Vikineswary ^a,b  

^a UNIVERSITY OF MALAYA   (Malaysia)

^b UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Axonal regeneration; Axonal reinnervation; Crush injury; Dorsal root ganglia; Extensor digitorum longus muscle; Functional recovery; Hericium erinaceus; Medicinal mushrooms; Peripheral nerve; Toespreading reflex

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FLICE INHIBITORY PROTEIN; FUNGAL EXTRACT; HERICIUM ERINACEUS EXTRACT; MECOBALAMIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NERVE GROWTH FACTOR; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL SURVIVAL; CENTER FOR EPIDEMIOLOGICAL STUDIES DEPRESSION SCALE; CRUSH TRAUMA; GENE EXPRESSION; HERICIUM ERINACEUS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NERVE DEGENERATION; NERVE REGENERATION; NEUROPROTECTION; NONHUMAN; ONCOGENE C FOS; ONCOGENE C JUN; PERIPHERAL NERVE INJURY; SYSTEMATIC REVIEW (TOPIC);

ANIMALS; BASIDIOMYCOTA; COMPLEX MIXTURES; FRUITING BODIES, FUNGAL; HUMANS; MODELS, BIOLOGICAL; PERIPHERAL NERVE INJURIES;

BASIDIOMYCOTA; ERINACEUS; HERICIUM ERINACEUM; RATTUS;

EID: 84872032207     PISSN: 15219437     EISSN: 19404344     Source Type: Journal    
DOI: 10.1615/IntJMedMushr.v14.i5.10     Document Type: Article

References (117)

1. Mizuno T. Yamabushitake, Hericium erinaceum: bioactive substances and medicinal utilization. Food Rev Int. 1995;11:173-78.
2. Rodriguez FJ, Valero-Cabré A, Navarro X. Regeneration and functional recovery following peripheral nerve injury. Drug Dis Today: Dis Models. 2004;1:177-85.
3. Bagdatoglu C, Saray A, Surucu HS, Ozturk H, Tamer L. Effect of trapidil in ischemia/reperfusion injury of peripheral nerves. Neurosurgery. 2002;51:212-20.
4. Oberlin C, Beal D, Leechavengvongs S, Salon A, Dauge MC, Sarcy JJ. Nerve transfer to biceps muscle using a part of ulnar nerve for C5-C6 avulsion of the brachial plexus: anatomical study and report of 4 cases. J Hand Surg. 1994;19A:232-37.
5. Chen ZY, Chai YF, Cao L, Lu CL, He C. Glial cell linederived neurotrophic factor enhances axonal regeneration following sciatic nerve transection in adult rats. Brain Res. 2001;902:272-76.
6. ALS CNTF Treatment group. A double-blind placebocontrolled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. Neurology. 1996;46:1244-49.
7. Wasser SP, Weis AI. Medicinal properties of substances occurring in higher Basidiomycetes mushrooms: current perspective (review). Int J Med Mushr. 1999;1:31-62.
8. Moldavan, MG, Grygansky A, Kolotushkina OV, Kirchhoff B, Skibo GC, Pedarzani P. Neurotropic and trophic action of lion's mane mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae) extracts on nerve cells in vitro. Int J Med Mushr. 2007;1:15-28.
9. Kawagishi H, Zhuang C, Yunoki R. Compounds for dementia from Hericium erinaceum. Drugs Fut. 2008;33:149-55.
10. Wong KH, Sabaratnam V, Abdullah N, Naidu M, Keynes R. Activity of aqueous extracts of lion's mane mushroom Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) on the neural cell line NG108-15. Int J Med Mushr. 2007;9:57-65.
11. Stamets P. Growing gourmet and medicinal mushrooms. 3rd ed. Berkeley, CA: Ten Speed Press, 2000.
12. Suzuki C, Mizuno T. XI. Cultivation of Yamabushitake (Hericium erinaceum). Food Rev Int. 1997;13:419-21.
13. Mizuno T. Bioactive substances in Hericium erinaceus (Bull.: Fr.) Pers. (Yamabushitake), and its medicinal utilization. Int J Med Mushr. 1999;1: 105-19.
14. GL. Studies on the cultivation and medicinal efficacy of Hericium erinaceus. Shanghai, China: The Edible Fungus Research Institute of The Shanghai Academy of Agricultural Science, 1992.
15. Ying JZ, Mao XL, Ma QH, Zong YC, Wen HA. Icons of medicinal fungi from China (translation Xu YH). Beijing, China: Science Press, 1987.
16. Liu X, Lu Y, Xu X, Suo Y. A study on preparation of sandwich biscuits with hedgehog fungus and therapeutic approach for nutritional anemia of preschool children. Acta Nutrim Sin. 1992;14:109-11.
17. Kawagishi H, Ando M, Mizuno T. Hericenone A and B as cytotoxic principles from the mushroom Hericium erinaceum. Tetrahedr Lett. 1990;31:373-76.
18. Kawagishi H, Ando M., Mizuno T, Yokota H, Konishi S. A novel fatty acid from the mushroom Hericium erinaceum. Agric Biol Chem. 1990;54:1329-31.
19. Kuwahara S, Mohihiro E, Nemoto A, Hiramatsu A. Synthesis and absolute configuration of a cytotoxic fatty acid isolated from the mushroom, Hericium erinaceum. Biosci Biotechnol Biochem. 1992;56:1417-19.
20. Kawagishi H, Shirai R, Sakamoto H, Yoshida S, Ojima F, Ishiguro Y. Erinapyrones A and B from the cultured mycelia of Hericium erinaceum. Chem Lett. 1992;21:2475-76.
21. Arnone A, Cardillo R, Nasini G, De Pava OR. Secondary mold metabolites: Part 46. Hericenes A-C and erinapyrone C, new metabolites produced by the fungus Hericium erinaceus. J Nat Prod. 1994;57:602-6.
22. Mori K, Kikuchi H, Obara Y, Iwashita M, Azumi Y, Kinugasa S, Inatomi S, Oshima Y, Nakahata N. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomed. 2010;17:1082-85.
23. Kawagishi H, Mori H, Uno K, Kimura A, Chiba S. A sialic acid-binding lectin from the mushroom Hericium erinaceum. FEBS Lett. 1994;340:56-58.
24. Kimura Y, Nishibe M, Nikajima H, Hamasaki T, Shigematsu M. Hericerin, a new pollen growth inhibitor from the mushroom Hericium erinaceum. Agric Biol Chem. 1991;55:2673-75.
25. Dong Q, Jia LM, Fan JN. A β-D-glucan isolated from the fruiting bodies of Hericium erinaceus and its aqueous conformation. Carbohydr Res. 2006;341:791-95.
26. Xu H, Wu PR, Shen ZY, Chen XD. Chemical analysis of Hericium erinaceum polysaccharides and effect of the polysaccharides on derma antioxidant enzymes, MMP-1 and TIMP-1 activities. Int J Biol Macromol. 2010;47:33-36.
27. Wang JC, Hu SH, Lee WL, Tsai LY. Antimutagenicity of extracts of Hericium erinaceus. Kaohsiung J Med Sci. 2001;17:230-38.
28. Wang JC, Hu SH, Wang JT, Chen KS, Chia YC. Hypoglycemic effect of extract of Hericium erinaceus. J Sci Food Agric. 2005;85:641-46.
29. Yang BK, Park JB, Song CH. Hypolipidemic effect of an exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus. Biosci Biotechnol Biochem. 2003;67:1292-98.
30. Lee JS, Hong EK. Hericium erinaceus enhances doxorubicin- induced apoptosis in human hepatocellular carcinoma cells. Cancer Lett. 2010;297:144-54.
31. Kawagishi H. Anti-MRSA compounds from Hericium erinaceus (Bull.: Fr.) Pers. Int J Med Mushr. 2005;7:350.
32. Kawagishi H, Masui A, Tokuyama S, Nakamura T. Erinacines J and K from the mycelia of Hericium erinaceum. Tetrahedron. 2006;62:8463-66.
33. Okamoto K, Shimada A, Shirai R, Sakamoto H, Yoshida S, Ojima F, Ishiguro Y, Sakai T, Kawagishi H. Antimicrobial chlorinated orcinol derivatives from mycelia of Hericium erinaceum. Phytochem. 1993;34:1445-46.
34. Wong KH, Sabaratnam V, Abdullah N, Kuppusamy UR, Naidu M. Effects of cultivation techniques and processing on antimicrobial and antioxidant activities of Hericium erinaceus (Bull.: Fr.) Pers. extracts. Food Tech Biotechnol. 2009;47:47-55.
35. Abdulla MA, Mohd Noor S, Sabaratnam V, Abdullah N, Wong KH, Mohd Ali H. Effect of culinary-medicinal lion's mane mushroom Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae), on ethanol-induced gastric ulcers in rats. Int J Med Mushr. 2008;10:325-30.
36. Abdulla MA, Abdollahi A, Sabaratnam V, Wong KH, Kuppusamy UR, Abdullah N, Ismail S. Potential activity of aqueous extract of culinary-medicinal Lion's Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats. Int J Med Mushr. 2011;13:33-39.
37. Wong KH, Naidu M, David RP, Abdulla MA, Abdullah N, Kuppusamy UR, Vikineswary S. Functional recovery enhancement following injury to rodent peroneal nerve by Lion's Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae). Int J Med Mushr. 2009;11: 225-36.
38. Wong KH, Naidu M, David P, Abdulla MA, Abdullah N, Kuppusamy UR, Sabaratnam V. Peripheral nerve regeneration following crush injury to rat peroneal nerve by aqueous extract of medicinal mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evid Based Compl Alt Med. 2011;580752.
39. Bunge RP. Expanding roles for the Schwann cell: ensheathment, myelination, trophism and regeneration. Curr Opin Neurobiol. 1993;3:805-9.
40. Smit M, Leng J, Klemke RL. Assay for neurite outgrowth quantification. Biotechniques. 2003;35:254-56.
41. Filbin MT. Axon regeneration: vaccinating against spinal cord injury. Curr Biol. 2000;10:R100-R103.
42. Lundborg G. Intraneural microcirculation. Orthop Clin North Am. 1988;19:1-12.
43. Zochodne DW, Ho LT. Endoneurial microenvironment and acute nerve crush injury in the rat sciatic nerve. Brain Res. 1990;535:43-48.
44. Peripheral Neuropathy [updated 2004 March 20; cited 2010 Aug]. Available from http://www.masterdocs.com/fact_sheet_files/pdf/peripheral_neuropathy_pain.pdf.
45. Schumacher M, Guennoun R, Stein DG, De Nicola AF. Progesterone: therapeutic opportunities for neuroprotection and myelin repair. Pharmacol Ther. 2007;116:77-106.
46. Wierzba K, Wańkowicz B, Piekarczyk A, Danysz A. Cytostatics and immunosuppressive drugs. Side Effects Drugs Ann. 1984;8:395-425.
47. Shibata H, Tokunaga T, Karasawa D, Hirota A, Nakayama M, Nozaki H, Tada T. Isolation and characterization of new bitter diterpenoids from the fungus Sarcodon scabrosus. Agric Biol Chem. 1989;53:3373-75.
48. Ohta T, Kita T, Kobayashi N, Obara Y, Nakahata N, Ohizumi Y, Takaya Y, Oshima Y. Scabronine A, a novel diterpenoid having a potent inductive activity of nerve growth factor synthesis isolated from the mushroom Sarcodon scabrosus. Tetrahedron Lett. 1998;39:6229-32.
49. Kita T, Takaya Y, Oshima Y, Ohta T, Aizawa K, Hirano T, Inakuma T. Scabronines B, C, D, E and F, novel diterpenoids showing stimulating activity of nerve growth factor-synthesis, from the mushroom Sarcodon scabrosus. Tetrahedron. 1998;54:11877-86.
50. Obara Y, Nakahata N, Kita T, Takaya Y, Kobayashi H, Hosoi S, Kiuchi F, Ohta T, Oshima Y, Ohizumi Y. Stimulation of neurotrophic factor secretion from 1321N1 human astrocytoma cells by novel diterpenoids, scabronines A and G. Eur J Pharmacol. 1999;370:79-84.
51. Shi XW, Liu L, Gao JM, Zhang AL. Cyathane diterpenes from Chinese mushroom Sarcodon scabrosus and their neurite outgrowth-promoting activity. Eur J Med Chem. 2011;46:3112-17.
52. Marcotullio MC, Pagiott R, Maltese F, Obara Y, Hoshino T, Nakahata N, Curini M. Neurite outgrowth activity of cyathane diterpenes from Sarcodon cyrneus, cyrneines A and B. Planta Med. 2006;72:819-23.
53. Marcotullio MC, Pagiotti R, Maltese F, Oball-Mond Mwankie GN, Hoshino T, Obara Y, Nakahata N. Cyathane diterpenes from Sarcodon cyrneus and evaluation of their activities of neuritegenesis and nerve growth factor production. Bioorg Med Chem. 2007;15:2878-82.
54. Marcotullio MC, Pagiotti R, Campagna V, Maltese F, Fardella G, Altinier G, Tubaro A. Glaucopine C, a new diterpene from diterpene from the fruiting bodies of Sarcodon glaucopus. Nat Prod Res. 2006;20:917-21.
55. Nishina A, Kimura H, Sekiguchi A, Fukumoto R, Nakajima S, Furukawa S. Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAP kinase. J Lipid Res. 2006;47:1434-43.
56. Cheung WMW, Hui WS, Chu PWK, Chiu SW, Ip NY. Ganoderma extract activates MAP kinases and induces neuronal differentiation of rat pheochromocytoma PC12 cells. FEBS Lett. 2000;486:291-96.
57. Russell R, Paterson M. Cordyceps-a traditional Chinese medicine and another fungal therapeutic biofactory? Phytochem. 2008;69:1469-95.
58. Qi J, Ojika M, Sakagami Y. Termitomycesphins A-D, novel neuritogenic cerebrosides from the edible chinese mushroom Termitomyces albuminosus. Tetrahedron. 2000;56:5835-41.
59. Eik LK, Naidu M, David P, Wong KH, YS Tan, Sabaratnam V. Lignosus rhinocerus (Cooke) Ryvarden: a medicinal mushroom that stimulates neurite outgrowth in PC-12 cells. Evid Based Compl Alt Med. 2012;320308.
60. Yavorsky VA, Lukyanetz EA. Blocking of the leakage potassium current mediated by activation of muscarinic receptors. Neurophysiol. 1997;29:205-11.
61. Grygansky AP, Moldavan MG, Kolotushkina O, Kirchhoff B, Skibo GG. Hericium erinaceus (Bull.: Fr.) Pers. extract effect on nerve cells. Int J Med Mushr. 2001;3:152.
62. Moldavan MG, Grygansky AP, Kirchoff B. Hericium erinaceus (Bull.: Fr.) Pers. extracts effect on the neurons impulse activity in stratum pyramidale of zone CA1 hippocampal slices in rats. Third International Conference on Mushroom Biology & Mushroom Products; 1999 Oct 12-16; Sydney, Australia.
63. Moldavan MG, Grodzinskaya AA, Wasser SP, Storozhuk VM. Effects of Amanita species extracts on neuron responses in the rat hippocampal stratum pyramidal (CA1 region) in vitro. Int J Med Mushr. 1999;1:337-44.
64. Moldavan MG, Grodzinskaya AA, Wasser SP, Storozhuk VM. Activation of hippocampal pyramidal neurons Nmethyl- D-aspartate receptors and M-cholinoreceptors during the application of Amanita (Pers.: Fr.) Hook. species extracts. Int J Med Mushr. 2000;2:55-61.
65. Moldavan MG, Grodzinskaya AA, Wasser SP, Storozhuk VM, Grygansky AP. Neurotropic effect of the edible and medicinal mushroom Lentinus edodes (Berk.) Sing. extracts on hippocampal slices in rats. Int J Med Mushr. 2001;3:182.
66. Moldavan MG, Grodzinskaya AA, Wasser SP, Storozhuk VM, Grygansky AP. Neurotropic effect of the edible and medicinal mushroom Lentinus edodes (Berk.) Sing. extracts on the neurons of hippocampal slices in rats. Int J Med Mushr. 2002;4:43-48.
67. Moldavan MG, Solomko EF, Grodzinskaya AA, Wasser SP, Storozhuk VM, Lomberg, ML. Neurotropic effect of extracts from hallucinogenic mushroom Psilocybe cubensis (Earle) Sing. (Agaricomycetideae) in vitro studies. Int J Med Mushr. 2000;2:329-38.
68. Moldavan MG, Grodzinskaya AA, Wasser SP, Storozhuk VM. Effects of higher Basidiomycetes mushrooms on the hippocampal slices in rats. Int J Med Mushr. 1999;2:173-80.
69. Moldavan MG, Grodzinskaya AA, Wasser SP, Solomko EF, Storozhuk VM. Higher Basidiomycetes mushroom extract effects on nerve cell spike activity in vitro. Int J Med Mushr. 2001;3:183.
70. Kawagishi H, Ando M, Sakamoto H, Yoshida S, Ojima F, Ishiguro Y, Ukai N, Furukawa S. Hericenones C, D, and E, stimulators of nerve growth factor (NGF)-synthesis, from mushroom Hericium erinaceum. Tetrahedron Lett. 1991;32: 4561-64.
71. Kawagishi H, Ando M, Shinba K, Sakamoto H, Yoshida S, Ojima F, Ishiguro Y, Ukai N, Furukawa S. Chromans, hericenones F, G and H from the mushroom Hericium erinaceum. Phytochemistry. 1993;32:175-78.
72. Kawagishi H, Shimada A, Shirai R, Okamoto K, Ojima F, Sakamoto H, Ishiguro Y, Furukawa S. Erinacines A, B, and C, strong stimulators of nerve growth factor (NGF)- synthesis, from the mycelia of Hericium erinaceum. Tetrahedron Lett. 1994; 35:1569-72.
73. Kawagishi H, Shimada A, Shizuki K, Mori H, Okamoto K, Sakamoto H, Furukawa S. Erinacine D, a stimulator of NGF-synthesis, from the mycelia of Hericium erinaceum. Heterocycl Comm. 1996;2:51-54.
74. Kawagishi H, Shimada A, Hosokawa S, Mori H, Sakamoto H, Ishiguro Y, Sakemi S, Bordner J, Kojima N, Furukawa S. Erinacines E, F and G, stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum. Tetrahedr Lett. 1996;37:7399-402.
75. Lee EW, Shizuki K, Hosokawa S, Suzuki M, Suganuma H, Inakuma T, Li J, Ohnishi-Kameyama M, Nagata Y, Furukawa S, Kawagishi H. Two novel diterpenoids, erinacines H and I from the mycelia of Hericium erinaceum. Biosci Biotechnol Biochem. 2000;64:2402-5.
76. Kenmoku H, Sassa T, Kato N. Isolation of erinacine P, a parental metabolite of cyathane-xylosides, from Hericium erinaceum and its biomimetic conversion into erinacines A and B. Tetrahedr Lett. 2000;41:4389-93.
77. Kenmoku H, Shimai T, Toyomasu T, Kato N, Sassa T. Erinacine Q, a new erinacine from Hericium erinaceum and its biosynthetic route to erinacine C in the baidiomycete. Biosci Biotechnol Biochem. 2002;66:571-75.
78. Ma BJ, Zhou Y, Li LZ, Li HM, Gao ZM, Ruan Y. A new cyathane-xyloside from the mycelia of Hericium erinaceum. Z Naturforsch. 2008;63b:1241-42.
79. Kenmoku H, Tanaka K, Okada K, Kato N, Sassa T. Erinacol (cyatha-3,12-dien-14b-ol) and 11-O-acetylcyathin A3, new cyathane metabolites from an erinacine Q producing Hericium erinaceum. Biosci Biotechnol Biochem. 2004;68:1786-89.
80. Shimbo M, Kawagishi K, Yokogoshi H. Erinacine A increases catecholamine and nerve growth factor content in the central nervous system of rat. Nutr Res. 2005;25:617-23.
81. Kalb R. The protean actions of neurotrophins and their receptors on the life and death of neurons. Trends in Neurosci. 2005;28:5-11.
82. Park YS, Lee HS, Won MH, Lee JH, Lee SY, Lee HY. Effect of an exo-polysaccharide from the culture broth of Hericium erinaceus on enhancement of growth and differentiation of rat adrenal nerve cells. Cytotechnology. 2002;39:155-62.
83. Ueda K, Tsujimori M, Kodani S, Chiba A, Kubo M, Masuno K, Sekiya A, Nagai K, Kawagishi H. An endoplasmic reticulum (ER) stress-suppressive compound and its analogues from the mushroom Hericium erinaceum. Bioorg Med Chem. 2008;16:9467-70.
84. Nagai K, Chiba A, Nishino T, Kubota T, Kawagishi H. Dilinoleoyl-phosphatidylethanolamine from Hericium erinaceum protects against ER stress-dependent Neuro2a cell death via protein kinase C pathway. J Nutr Biochem. 2006; 17:525-30.
85. Mori K, Obara Y, Hirota M, Azumi Y, Kinugasa S, Inatomi, S, Nakahata N. Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells. Biol Pharm Bull. 2008;31:1727-32.
86. Hazekawa M, Kataoka A, Hayakawa K, Uchimasu T, Furuta R, Irie K, Akitake Y, Yoshida M, Fujioka T, Egashira N, Oishi R, Mishima K, Mishima K, Uchida T, Iwasaki K, Fujiwara M. Neuroprotective effect of repeated treatment with Hericium erinaceum in mice subjected to middle cerebral artery occlusion. J Health Sci. 2010;56:296-303.
87. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a doubleblind placebo-controlled clinical trial. Phytother Res. 2009;23:367-72.
88. Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki K. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. 2010;31:231-37.
89. Mori K, Obara Y, Moriya T, Inatomi S, Nakahata N. Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice. Biomed Res. 2011;32:67-72.
90. Artemenko DP, Gerasimov BD. The blocked effect of adenosine and ATP on the synaptic transmitting in the isolated rat brain slices. Neurophysiol. 1983;15:639-47.
91. Kolotushkina EV, Moldavan MG, Voronin KY, Skibo GG. The influence of Hericium erinaceus extract on myelination process in vitro. Fiziol Zh. 2003;49:38-45.
92. Stengler M. The health benefits of medicinal mushrooms. North Bergen, NJ: Basic Health Publications, 2005.
93. Hare GM, Evans PJ, Mackinnon SE, Best TJ, Bain JR, Szalai JP, Hunter DA. Walking track analysis: a long term assessment of peripheral nerve recovery. Plast Reconstr Surg. 1992;89:251-58.
94. Gutmann E. Factors affecting recovery of motor function after nerve lesion. J Neurol Psychiatry. 1942;5:81-95.
95. Namba T, Nakamura T, Grob D. Staining for nerve fiber and cholinesterase activity in fresh frozen sections. Am J Clin Path. 1967;47:74-77.
96. Verma P, Chierzi S, Codd AM, Campbell DS, Meyer RL, Holt CE, Fawcett JW. Axonal protein synthesis and degradation are necessary for efficient growth cone regeneration. J Neurosci. 2005;25:331-42.
97. Algora J, Chen LE, Seaber AV, Wong GH, Urbaniak JR. Functional effects of lymphotoxin on crushed peripheral nerve. Microsurgery. 1996;17:131-35.
98. Li Y, Bickel KD, Im MJ, Hu L, Dellon AL, Vander Kolk CA, Manson PN. Effects of deferoxamine in ischemia/reperfusion injury after peripheral nerve compression. Ann Plast Surg. 1996;36:365-69.
99. Garcia ML, Rao MV, Fujimoto J, Garcia VB, Shah SB, Crum J, Gotow T, Uchiyama Y, Ellisman M, Calcutt NA, Cleveland DW. Phosphorylation of highly conserved neurofilament medium KSP repeats is not required for myelin dependent radial axonal growth. J Neurosci. 2009;29:1277-84.
100. Beránek R, Hník P, Vrbová G. Denervation atrophy and reinnervation of various skeletal muscles in the rat. Physiol Bohemoslov. 1957;6:200-4.
101. Gutmann E, Young JZ. The reinnervation of muscles after various periods of atrophy. J Anat. 1944;78:15-43.
102. Navarro X, Vivó M, Valero-Cabré A. Neural plasticity after peripheral nerve injury and regeneration. Prog Neurobiol. 2007;82:163-201.
103. Wen YR, Suter MR, Ji RR, Yeh GC, Wu YS, Wang KC, Kohno T, Sun WZ, Wang CC. Activation of p38 mitogenactivated protein kinase in spinal microglia contributes to incision-induced mechanical allodynia. Anesthesiology. 2009;110(1):155-65.
104. Naidu M, David P. Major cellular events in peripheral nerve regeneration: a brief overview. Int Med J. 2009;8:163-201.
105. Ito Y, Sakagami H, Kondo H. Enhanced gene expression for phosphatidylinositol 3-kinase in the hypoglossal motoneurons following axonal crush. Mol Brain Res. 1996;37:329-32.
106. Broude E, McAtee M, Kelley MS, Bregman BS. c-Jun expression in adult rat dorsal root ganglion neurons: differential response after central or peripheral axotomy. Exp Neurol. 1997;148:367-77.
107. Chi SI, Levine JD, Basbaum AI. Peripheral and central contributions to the persistent expression of spinal cord fos-like immunoreactivity produced by sciatic nerve transection in the rat. Brain Res. 1993;617:225-37.
108. Oblinger MM, Szumlas RA, Wang J, Liuzzi FJ. Changes in cytoskeletal gene expression affect the composition of regenerating axonal sprouts elaborated by dorsal root ganglion neurons in vivo. J Neurosci. 1989;9:2645-53.
109. Greenberg S, Lasek R. Neurofilament protein synthesis in DRG neurons decreases more after peripheral axotomy than after central axotomy. J Neurosci. 1988;8:739-46.
110. Lasek RJ, Oblinger MM, Drake PF. Molecular biology of neuronal geometry: expression of neurofilament genes influences axonal diameter. Cold Spring Harb Symp Quant Biol. 1983;46:731-44.
111. Wachter BG, Leonetti JP, Lee JM, Wurster RD, Young MRI. Silver nitrate injury in the rat sciatic nerve: a model of facial nerve injury. Otolaryngol Head Neck Surg. 2002;127:48-54.
112. Willis DE, Twiss JL. The evolving roles of axonally synthesized proteins in regeneration. Curr Opin Neurobiol. 2006;16:111-18.
113. Bamburg JR, McGough A, Ono S. Putting a new twist on actin: ADF/cofilins modulate actin dynamics. Trends Cell Biol. 1999;9:364-70.
114. Giuditta A, Kaplan BB, van Minnen J, Alvarez J, Koenig E. Axonal and presynaptic protein synthesis: new insights into the biology of the neuron. Trends Neurosci. 2002;25:400-4.
115. Willis D, Li KW, Zheng JQ, Smit AB, Kelly TK, Merianda TT, Sylvester J, van Minnen J, Twiss JL. Differential transport and local translation of cytoskeletal, injury-response, and neurodegeneration protein mRNAs in axons. J Neurosci. 2005;25:778-91.
116. Cyanocobalamin Side Effects [cited 2010 June]. Available from: http://www.drugs.com/sfx/cyanocobalaminside-effects.html.
117. Chang ST. The need for scientific validation of culinarymedicinal mushroom products. Int J Med Mushr. 2006; 8:187-95.