Toxic effects of extracellular histones and their neutralization by vitreous in retinal detachment

Laboratory Investigation

Volumn 94, Issue 5, 2014, Pages 569-585

  Kawano, Hiroki ^a   Ito, Takashi ^a   Yamada, Shingo ^b   Hashiguchi, Teruto ^a   Maruyama, Ikuro ^a   Hisatomi, Toshio ^c   Nakamura, Makoto ^d   Sakamoto, Taiji ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b SHINO TEST CORPORATION   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

^d KOBE UNIVERSITY   (Japan)

Author keywords

cytokine; cytotoxicity; DAMPs; extracellular histones; retinal detachment

Indexed keywords

HISTONE H3; HYALURONIC ACID; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DAMAGE; CELL DEATH; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE TOXICITY; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIMIT OF DETECTION; MALE; MICROENVIRONMENT; NONHUMAN; OXIDATIVE STRESS; PHOTORECEPTOR; PRIORITY JOURNAL; RAT; RETINA DETACHMENT; RETINA INJURY; STEM CELL; VITRECTOMY; VITREOUS BODY;

ANIMALS; CASE-CONTROL STUDIES; CELL DEATH; CELL LINE; EXTRACELLULAR FLUID; HISTONES; HUMANS; HYALURONIC ACID; INTERLEUKIN-8; MAP KINASE SIGNALING SYSTEM; OXIDATIVE STRESS; RATS; RETINA; RETINAL DETACHMENT; TOLL-LIKE RECEPTOR 4; VITREOUS BODY;

EID: 84899576020     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2014.46     Document Type: Article

References (43)

1. Brinkmann V, Reichard U, Goosmann C, et al. Neutrophil extracellular traps kill bacteria. Science 2004;303:1532-1535.
2. Kaplan MJ, Radic M. Neutrophil extracellular traps: double-edged swords of innate immunity. J Immunol 2012;189:2689-2695.
3. Chaput C, Zychlinsky A. Sepsis: the dark side of histones. Nat Med 2009;15:1245-1246.
4. Xu J, Zhang X, Pelayo R, et al. Extracellular histones are major mediators of death in sepsis. Nat Med 2009;15:1318-1321.
5. Huang H, Evankovich J, Yan W, et al. Endogenous histones function as alarmins in sterile inflammatory liver injury through Toll-like receptor 9 in mice. Hepatology 2011;54:999-1008.
6. Xu J, Zhang X, Monestier M, et al. Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury. J Immunol 2011;187:2626-2631.
7. Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol 1994;12:991-1045.
8. Yang L, Bula D, Arroyo JG, et al. Preventing retinal detachmentassociated photoreceptor cell loss in Bax-deficient mice. Invest Ophthalmol Vis Sci 2004;45:648-654.
9. Cook B, Lewis GP, Fisher SK, et al. Apoptotic photoreceptor degeneration in experimental retinal detachment. Invest Ophthalmol Vis Sci 1995;36:990-996.
10. Arimura N, Ki-i Y, Hashiguchi T, et al. Intraocular expression and release of high-mobility group box 1 protein in retinal detachment. Lab Invest 2009;89:278-289.
11. Otsuka H, Arimura N, Sonoda S, et al. Stromal cell-derived factor-1 is essential for photoreceptor cell protection in retinal detachment. Am J Pathol 2010;177:2268-2277.
12. Kleinberg TT, Tzekov RT, Stein L, et al. Vitreous substitutes: a comprehensive review. Surv Ophthalmol 2011;56:300-323.
13. Sebag J. Imaging vitreous. Eye 2002;16:429-439.
14. Arimura N, Otsuka H, Yamakiri K, et al. Vitreous mediators after intravitreal bevacizumab or triamcinolone acetonide in eyes with proliferative diabetic retinopathy. Ophthalmology 2009;116:921-926.
15. Otsuka H, Kawano H, Sonoda S, et al. Particle-induced endophthalmitis: possible mechanisms of sterile endophthalmitis after intravitreal triamcinolone. Invest Ophthalmol Vis Sci 2013;54:1758-1766.
16. Uchino E, Sonoda S, Kinukawa N, et al. Alteration pattern of tear cytokines during the course of a day: diurnal rhythm analyzed by multicytokine assay. Cytokine 2006;33:36-40.
17. Hisatomi T, Sakamoto T, Murata T, et al. Relocalization of apoptosisinducing factor in photoreceptor apoptosis induced by retinal detachment in vivo. Am J Pathol 2001;158:1271-1278.
18. Murakami Y, Ikeda Y, Yonemitsu Y, et al. Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of the neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration. Am J Pathol 2008;173:1326-1338.
19. Neekhra A, Luthra S, Chwa M, et al. Caspase-8,-12, and-3 activation by 7-ketocholesterol in retinal neurosensory cells. Invest Ophthalmol Vis Sci 2007;48:1362-1367.
20. Shirasawa M, Sonoda S, Terasaki H, et al. TNF-alpha disrupts morphologic and functional barrier properties of polarized retinal pigment epithelium. Exp Eye Res 2013;110:59-69.
21. Terasaki H, Kase S, Shirasawa M, et al. TNF-alpha decreases VEGF secretion in highly polarized RPE cells but increases it in non-polarized RPE cells related to crosstalk between JNK and NF-kappaB pathways. PLoS One 2013;8:e69994.
22. Larrayoz IM, Huang JD, Lee JW, et al. 7-ketocholesterol-induced inflammation: involvement of multiple kinase signaling pathways via NFkappaB but independently of reactive oxygen species formation. Invest Ophthalmol Vis Sci 2010;51:4942-4955.
23. Wang Y, Bian ZM, Yu WZ, et al. Induction of interleukin-8 gene expression and protein secretion by C-reactive protein in ARPE-19 cells. Exp Eye Res 2010;91:135-142.
24. Yuan Z, Feng W, Hong J, et al. p38MAPK and ERK promote nitric oxide production in cultured human retinal pigmented epithelial cells induced by high concentration glucose. Nitric Oxide 2009; 20:9-15.
25. Spitzer MS, Mlynczak T, Schultheiss M, et al. Preservative-free triamcinolone acetonide injectable suspension versus 'traditional' triamcinolone preparations: impact of aggregate size on retinal biocompatibility. Retina 2011;31:2050-2057.
26. Harooni M, McMillan T, Refojo M. Efficacy and safety of enzymatic posterior vitreous detachment by intravitreal injection of hyaluronidase. Retina 1998;18:16-22.
27. Hikichi T, Kado M, Yoshida A. Intravitreal injection of hyaluronidase cannot induce posterior vitreous detachment in the rabbit. Retina 2000;20:195-198.
28. Hisatomi T, Sakamoto T, Sonoda KH, et al. Clearance of apoptotic photoreceptors: elimination of apoptotic debris into the subretinal space and macrophage-mediated phagocytosis via phosphatidylserine receptor and integrin alphavbeta3. Am J Pathol 2003;162: 1869-1879.
29. Thalhamer T, McGrath MA, Harnett MM. MAPKs and their relevance to arthritis and inflammation. Rheumatology 2008;47:409-414.
30. Guha M, Mackman N. LPS induction of gene expression in human monocytes. Cell Signal 2001;13:85-94.
31. Abrams ST, Zhang N, Manson J, et al. Circulating histones are mediators of trauma-associated lung injury. Am J Respir Crit Care Med 2013;187:160-169.
32. Allam R, Scherbaum CR, Darisipudi MN, et al. Histones from dying renal cells aggravate kidney injury via TLR2 and TLR4. J Am Soc Nephrol 2012;23:1375-1388.
33. Yoshimura T, Sonoda KH, Sugahara M, et al. Comprehensive analysis of inflammatory immune mediators in vitreoretinal diseases. PloS one 2009;4:e8158.
34. Ricker LJ, Kijlstra A, Kessels AG, et al. Interleukin and growth factor levels in subretinal fluid in rhegmatogenous retinal detachment: a case-control study. PLoS One 2011;6:e19141.
35. Symeonidis C, Androudi S, Tsaousis KT, et al. Comparison of interleukin IL-6 levels in the subretinal fluid and the vitreous during rhegmatogenous retinal detachment. Cytokine 2012;57:17-18.
36. Symeonidis C, Papakonstantinou E, Androudi S, et al. Interleukin-6 and matrix metalloproteinase expression in the subretinal fluid during proliferative vitreoretinopathy: correlation with extent, duration of RRD and PVR grade. Cytokine 2012;59:184-190.
37. Erta M, Quintana A, Hidalgo J. Interleukin-6, a major cytokine in the central nervous system. Int J Biol Sci 2012;8:1254-1266.
38. Ghasemi H, Ghazanfari T, Yaraee R, et al. Roles of IL-8 in ocular inflammations: a review. Ocul Immunol Inflamm 2011;19:401-412.
39. Goczalik I, Ulbricht E, Hollborn M, et al. Expression of CXCL8, CXCR1, and CXCR2 in neurons and glial cells of the human and rabbit retina. Invest Ophthalmol Vis Sci 2008;49:4578-4589.
40. Fink SL, Cookson BT. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun 2005; 73:1907-1916.
41. Huang H, Chen HW, Evankovich J, et al. Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury. J Immunol 2013;191:2665-2679.
42. Pemberton AD, Brown JK, Inglis NF. Proteomic identification of interactions between histones and plasma proteins: implications for cytoprotection. Proteomics 2010;10:1484-1493.
43. Sinusas K. Osteoarthritis: diagnosis and treatment. Am Fam Physician 2012;85:49-56.