Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Nakahara, Mayumi ^a   Ito, Takashi ^a   Kawahara, Ko ichi ^b   Yamamoto, Mika ^a   Nagasato, Tomoka ^a   Shrestha, Binita ^a   Yamada, Shingo ^c   Miyauchi, Takahiro ^a   Higuchi, Koji ^a   Takenaka, Toshihiro ^a   Yasuda, Tomotsugu ^a   Matsunaga, Akira ^a   Kakihana, Yasuyuki ^a   Hashiguchi, Teruto ^a   Kanmura, Yuichi ^a   Maruyama, Ikuro ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b OSAKA INSTITUTE OF TECHNOLOGY   (Japan)

^c SHINO TEST CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIN; FIBRINOGEN; HISTONE; HISTONE H3; RECOMBINANT THROMBOMODULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEEDING; CLINICAL ARTICLE; CONTROLLED STUDY; DEATH; DISSEMINATED INTRAVASCULAR CLOTTING; DRUG EFFECT; DRUG EFFICACY; FIBRIN DEPOSITION; HEART RIGHT VENTRICLE FAILURE; HISTOPATHOLOGY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LETHALITY; LUNG CAPILLARY; LUNG EMBOLISM; MALE; MOUSE; NONHUMAN; PROTECTION; PROTEIN BLOOD LEVEL; PROTHROMBIN TIME; SEPSIS; SURVIVOR; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTOPENIA; THROMBOEMBOLISM;

ANIMALS; DISSEMINATED INTRAVASCULAR COAGULATION; ELECTROCARDIOGRAPHY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HISTONES; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MALE; MICE; MICE, INBRED C57BL; RECOMBINANT PROTEINS; SEPSIS; THROMBOEMBOLISM; THROMBOMODULIN;

EID: 84884752631     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075961     Document Type: Article

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